The study is a prospective series of the functional outcomes of total knee arthroplasty (TKA) with a novel bi-cruciate stabilizing prosthesis (BCS TKA) compared to a Posterior stabilized (PS) TKA. Between 2008 and 2012, 63 BCS TKA were performed on 56 patients (71 knees) and 54 patients underwent 56 PS TKA with a primary diagnosis of degenerative osteoarthritis, all performed by a single surgeon. Patients completed the Short-Form 12 and WOMAC Index questionnaires pre-operatively and post-operatively at 3 months, 1 year, and 2 years with range of motion determined in the office setting. Regarding the BCS knees, significant improvements in post-operative range of motion were noted, and results of the WOMAC pain component were promising at all intervals tested. However, measures of overall knee function including the WOMAC physical function and stiffness scores in addition to Knee Society Functional Scores saw a slight decline during the second post-operative year. Results from the PS knee implants showed similar trends, and no statistically significant differences were found between the two cohorts throughout functional follow-up; however the ranges of motions appear to be increased in the BCS knee cohort.