The use of routine sampling for histological analysis during revision hip replacement has been standard practice in our unit for many years. It is used to assess for the presence of inflammatory processes that may represent peri-prosthetic infection.

Our study examines 152 consecutive patients who underwent revision hip replacement in our centre for all reasons, excluding malignant neoplasm or metastasis. We reviewed the cases from a prospectively collated database, comparing microbiology results with histology results. Both microscopic and macroscopic analysis by specialist musculoskeletal histopathologist was included in our study.

We found 17 (11.2%) patients had cultured bacteria from intra-operative samples. Eight patients (5.3%) had histological findings interpreted as infection. Only one patient who had macroscopic and microscopic histology findings suggestive of infection also had culture results that identified a pathogen. Furthermore, the macroscopic analyses by the histopathologist suggested infection in nine patients. Only one patient with positive culture in greater than 2 samples had histological features of infection.

Of the 4 patients who were found to have 3 or more samples where an organism was identified only one had histological features of infection. This represents 25% sensitivity when using histology to analyse samples for infection. Of the 8 patients who had both macroscopic and microscopic features of infection only 1 patients cultured bacteria in more than 3 samples (PPV 12.5%).

Our experience does not support the routine sampling for histology in revision hip replacement. We suggest it is only beneficial in cases where infection is suspected or where a multi-procedure, staged revision is performed and the surgeon is planning return to theatre for the final stage. This is a substantial paradigm shift from the current practice among revision arthroplasty surgeons in the United Kingdom but will equate to a substantial cost saving.

Introduction

Infection following traumatic injury of the tibia is challenging, with surgical debridement and prolonged systemic antibiotic therapy well established. Local delivery via cement beads has shown improved outcome, but these often require further surgery to remove. Osteoset-T is a bone-graft substitute composed of calcium sulphate and 4%-Tobramycin, available in pellets that are packed easily into bone defects. Concerns remain regarding the sterile effluent produced as it resorbs, along with the risk of acute kidney injury following systemic absorption.

Introduction

Fifth metatarsal fractures are a common injury suffered by professional footballers. It is frequently reported in the media that such an injury will result in a 6-week absence from play. The purpose of this study was to assess frequency of media reporting of fifth metatarsal fractures, the time that is predicted by the media before the player will return to soccer and the actual time taken for the player to return to play.

Introduction: Unicompartmental knee replacement (UKR) is a popular alternative to total knee replacement (TKR) in medial compartment disease. Early problems include bearing dislocation, persistent pain, stiffness and infection. Revision to TKR is well described as a late endpoint.

Objective: Investigate the early surgical management of persistent pain and debility following UKR, identify common themes and rate effectiveness of any re-intervention.

Methods: 381 UKRs implanted over 5 years included, and patients requiring re-operation reviewed retrospectively.

Findings: 27 re-operations performed on 17 patients at a mean 16.8 months (95% CI 9.5 to 24.1), with symptom onset post-operatively at 9 months (95% CI 4–14). There were 10 arthroscopies, 10 total knee replacements (revision), 4 manipulations under anaesthesia, 2 bearing exchanges, and 1 tibial-plateau fracture fixation. Manipulation under anaesthesia improved stiffness in 2 of 3 patients. Arthroscopy was successful in 2 patients with loose cement-bodies but did not provide a diagnosis in 8 patients, of whom 7 were revised subsequently after 17.1 months (95% CI 10.1 to 24.1) with 6 reporting symptom resolution. Overall there were 10 revisions: 9 were performed for persistent pain and 9 reported symptom improvement. Intra-operative findings included aseptic loosening (n=4), synovitis (n=2), increased posterior slope of the tibial cut (n=1), dislocated bearing (n=1), and no cause of failure in 2. Only two cases required revision implants with medial augments for bone loss. There were no deep infections.

Conclusions: The early re-intervention rate at our unit is 4.5% (95% CI 2.4 to 6.5), with a revision rate of 2.6% (95% CI 1.0 to 4.2) after a mean (±SD) follow-up of 40.1 (±16) months. Arthroscopy is a poor diagnostic and therapeutic option against persistent pain following UKR. In contrast, the decision to revise, although initially disappointing for both patient and surgeon, gave symptom improvement in 90%.

Chondrosarcoma is treated with respect by oncology surgeons, given that it is relatively resistant to chemotherapy and radiotherapy. The aim was to study the outcomes of surgery for chondrosarcoma and determine the role of initial surgical margins and local recurrence on outcome.

Electronic patient records were retrieved on all patients seen with chondrosarcoma of bone with a minimum of two years follow up. A total of 532 patients were seen with Chondrosarcoma between 1970 and 2006. Patients were excluded if they had initial treatment in another unit (20 patients), a subdiagnosis of dedifferentiated chondrosarcoma (due to very poor prognosis, 43 patients), metastases at presentation (30 patients), if they presented with disseminated metastases prior to local recurrence (12 patients) or were not offered surgery, leaving 402 patients in the study group.

The mean age was 48 years old (range 6–89 years) with the most commonly sites of presentation being in the pelvis in 132 patients (29%), proximal femur in 81 patients (18%), distal femur in 40 patients (9%) and proximal humerus in 40 patients (9%). Grade at presentation was grade 1 in 44%, grade 2 in 44% and grade 3 in 12%. Surgical margins were radical in 3%, wide in 44%, marginal in 29%, planned incisional in 13% and unplanned incisional in 11%. Local recurrence occurred in 87 patients (22%). Local recurrence rates were significantly different for surgical margins on Fisher exact testing (p=0.003), which held true even when stratified by presenting grade of tumour. Surgery for local control was successful in 62% of cases.

Complex relationships exist between surgical margins, local recurrence and survival. Long term survival is possible in 1/3 patients who have local recurrence in intermediate and high grade chondrosarcomas and therefore ever effort should be made to regain local control following local recurrence.

Unicompartmental knee replacement (UKR) is an increasingly popular alternative to total knee replacement in medial compartment disease. Early problems include unexplained pain, stiffness, infection and technical errors leading to dislocation of bearing or fracture. This study is the first to highlight re-intervention as an outcome measure when assessing the success of a partial joint replacement.

All Oxford UKRs undertaken at ROH during November 2002 and December 2007 were reviewed to identify patients who required a further procedure.

383 UKRs were implanted. 21 (5.5%) patients underwent further re-intervention. Twelve (3.1%) were for persistent post-operative pain, three (0.8%) for stiffness and six (1.6%) had a combination of symptoms. one re-intervention was for a tibial plateau fracture. Initial re-interventions included eleven arthroscopies and three manipulations.

Nine (2.4%) patients subsequently underwent revision procedures, eight to a total knee replacement with one revision to a fixed bearing unicompartmental prosthesis. There were no revisions for infection. Manipulation improved stiffness in all the patients. Outcome following re-interventions for persistent pain were less predictable. Arthroscopy improved symptoms in only 36% of patients but eight of the nine (88.9%) patients that were formally revised had an improvement in symptoms.

Our early re-intervention rate of 5.5% and the out-come of subsequent surgery provides a valuable evidence based resource to discuss potential post operative expectations and complications with patients awaiting an Oxford UKR.

Introduction: Chondrosarcoma has always been treated with respect by oncology surgeons, given that it is relatively resistant to chemotherapy and radiotherapy. The importance of the adequacy of surgical resection margins has been previously reported, however, the aim of the study was to study the outcomes of surgery for Chondrosarcoma and determine the role of initial surgical margins and local recurrence on final outcome.

Methods: Electronic patient records were retrieved on all patients seen at a tertiary referral musculoskeletal oncology centre with Chondrosarcoma of bone with a minimum of 2 years follow up. A total of 532 patients were seen with Chondrosarcoma between 1970 and 1/1/2006. Patients were excluded if they had initial treatment in another unit (20 patients), a subdiagnosis of dedifferentiated Chondrosarcoma (due to very poor prognosis, 43 patients), metastases at presentation (6 patients) and if they presented with disseminated metastases prior to local recurrence (12 patients). This left 451 patients in the study group and the clinicopathological records were reviewed on these patients.

Results: Of the 451 patients, the mean age was 48 years old at diagnosis (range 6–89 years) with the most commonly sites of presentation being in the pelvis in 132 patients (29%), proximal femur in 81 patients (18%), distal femur in 40 patients (9%) and proximal humerus in 40 patients (9%). Grade at presentation was grade 1 in 44%, grade 2 in 44% and grade 3 in 12%. Surgical margins were wide in 45%, marginal in 28% and incisional (including curettage procedures) in 27%. Local recurrence occurred in 88 patients (19.5%). Local recurrence rates were significantly different for surgical margins on Fisher exact testing (p=0.003), which held true even when stratified by presenting grade of tumour. Local recurrence occurred at a mean of 2.8 years, however, 12.5% occurred more than 5 years from diagnosis. There was a significant difference in survival compared between those patients with local recurrent disease and those without on Kaplan Meier analysis; 10 year survival for those without recurrence was 73.1% compared to 41% for those with local recurrence(p< 0.0001, Logrank). On cox regression analysis significant factors affecting survival were pelvic location (p=0.004), local recurrence (p=0.007), age at presentation (p=0.01), marginal margins (p=0.04) and initial tumour grade (p=0.043). There was no significant difference between survival and initial surgical margin when stratified by grade of tumour, possibly as further surgery to improve adequacy of margins. Further sub-analysis is being performed.

Conclusions: There is a complex relationship between surgical margins, local recurrence and margins. It appears that long term survival is possible in approximately 1/3 patients who have local recurrence in intermediate and high grade chondrosarcomas and therefore ever effort should be made to regain local control following local recurrence.