Dissolvable antibiotic-loaded calcium sulphate beads have been utilized for management of periprosthetic joint infection (PJI) and for aseptic revision arthroplasty. However, wound drainage and toxic reactive synovitis have been substantial problems in prior studies. Currently a commercially pure, physiologic product has been introduced that may reduce complications associated with this treatment modality. We aim to answer the question: does a commercially pure, physiologic version of antibiotic-loaded calcium sulfate beads reduce wound drainage and provide efficacious treatment for PJI and aseptic revision arthroplasty? Starting January 2010, 756 consecutive procedures were performed utilizing a set protocol of Vancomycin and Tobramycin antibiotics in commercially pure dissolvable antibiotic beads. There were 8 designated study groups: DECRA = Debridement, modular Exchange, Component Retention, iv Antibiotics for acute PJIAim
Method
Aseptic Revision TKA
N = 216
Aseptic Revision THA
N = 185
DECRA
N = 44
DECRA
N = 16
1st Stage Resection TKA
N = 103
1st Stage Resection THA
N = 62
Reimplant TKA
N = 81
Reimplant THA
N = 49
