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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_23 | Pages 10 - 10
1 Dec 2016
McPherson E Czarkowski B McKinney B Dipane M
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Aim

Dissolvable antibiotic-loaded calcium sulphate beads have been utilized for management of periprosthetic joint infection (PJI) and for aseptic revision arthroplasty. However, wound drainage and toxic reactive synovitis have been substantial problems in prior studies. Currently a commercially pure, physiologic product has been introduced that may reduce complications associated with this treatment modality. We aim to answer the question: does a commercially pure, physiologic version of antibiotic-loaded calcium sulfate beads reduce wound drainage and provide efficacious treatment for PJI and aseptic revision arthroplasty?

Method

Starting January 2010, 756 consecutive procedures were performed utilizing a set protocol of Vancomycin and Tobramycin antibiotics in commercially pure dissolvable antibiotic beads. There were 8 designated study groups:

Aseptic Revision TKA N = 216 Aseptic Revision THA N = 185
DECRA* TKA N = 44 DECRA* THA N = 16
1st Stage Resection TKA N = 103 1st Stage Resection THA N = 62
Reimplant TKA N = 81 Reimplant THA N = 49

DECRA = Debridement, modular Exchange, Component Retention, iv Antibiotics for acute PJI