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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 290 - 290
1 Jul 2014
HUMAN BONE-LINEAGE CELL RESPONSES TO ANISOTROPIC TI6AL4V SURFACES ARE DEPENDENT ON THEIR MATURATION STATE
Calzado-Martín A Crespo L Saldaña L Boré A Gómez-Barrena E Vilaboa N
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Summary

Attachment, proliferation and osteogenic maturation of hMSCs are enhanced on a sub-micron grooved Ti6Al4V alloy, while osteoblasts are less sensitive. These effects are attributed to their different maturation stage and may be mediated through differential activation of the RhoA/ROCK pathway.

Introduction

Ti6Al4V alloy is the most widely used titanium-based biomaterial for manufacturing bone-anchoring devices. We report on the interactions of human bone-forming cells, mesenchymal stem cells from bone marrow (hMSCs) and primary osteoblasts (hOBs), with an anisotropic Ti6Al4V alloy that displays submicron grooves.