The development of new prostheses due to large resections has offered important opportunities to orthopedic surgeons mainly in oncology. A medline research can easily underline how poor is the international experience about this cases in nonunion: 75 results for megaprosthesis just 7 works in nonunion. It is proposed the experience of our department, which deals specifically with the treatment of nonunion, in cases of repeated failures to treatment. One of the most significant problems in the treatment of relapsing nonunion is the consequent worsening of joint function. Critical bone defects, sepsis, joint fractures and unclear relapsing nonunions are the most common cases for a megaprosthesis treatment. In these cases, even if it obtains the healing of nonunion the functional result would be presumptively poor. This radiological or clinical situation drove us, in such cases, to drastic solutions following the principles of cancer cases. We implanted megaprosthesis with either techniques: 1 stage or 2 stages depending on the clinical findings. In nonunion the main decision making was the septic or aseptic status. we treated 32 patients with megaprosthesis replacing the nearest joint to the nonunion segment or both the proximal e distal one as follows: proximal femur, distal femur, proximal tibia, and total femur. The mean follow-up of patients is 12 months (2 yrs max, min 3 months). Clinical and serial radiographic evaluations with standard methods (RX in 45 days, 3-6-12-24 months) was performed; as well as monitoring of blood parameters for 2 months.Introduction:
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