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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 530 - 530
1 Oct 2010
Steindl M Brenner M Ritschl P Zweymüller K
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Introduction: Revision surgery for stem loosening and peri-implant bone loss of variable extent is a major challenge for orthopedic surgeons. Our strategy has been to use cementless straight stems of rectangular cross-section for revisions. To ascertain the value of this implant we analyzed the results at a minimum follow-up of 10 years.

Material and Method: Between October 1991 and end 1998, 125 patients (134 hips) underwent revision surgery. Of these, 39 were males and 86 were females. Sixty-seven of the original implants were cemented and as many were cementless. Cementless revision stems (SLR; Plus Orthopedics, Aarau, Switzerland) size 3 to 11 (180 to 223 mm in length) were used for revisions. Patient age at the time of surgery was 37.8 to 89.3 (mean, 71.0) years.

Fifty patients (53 hips) died post revision 0.0 to 13.5 (mean, 6.8) years. Their implants had been followed-up radiographically for 0.0 to 9.2 (mean, 3.6) years. At the time of revision these patients had been 48.9 to 89.3 (mean, 76.7) years old. One of them had undergone stem revision for aseptic loosening one year post surgery. Another 6 were revised 1.4 to 13.9 years post surgery, 5 for low grade infection and 1 for peri-implant fracture.

Seven patients refused to present for follow-up because of advanced age and poor cooperation. Eight were contacted by telephone. These 15 patients were not re-operated. Five patients were altogether lost to follow-up, thus leaving a total of 53 hips (49 patients) for analysis at a follow-up time of at least 10 years. The follow-up time was 10.0 to 16.1 (mean, 11.6) years.

For radiographic follow-ups monitor-guided a.-p. and axial radiographs were recorded. These were analyzed by Gruen zones.

Results: All stems were properly aligned along the long femoral axis, except in 1 patient, who had sustained a peri-implant fracture during a fall with axial stem subsidence responding to conservative treatment. In 38 patients peri-implant bone apposition was detected in all 7 Gruen zones. This was combined with bone resorption in other zones in 2 patients. Four patients presented with osteolytic lesions. In one of them with metal-on-metal articulating surfaces, the lesion extended to several segments and will necessitate revision. All other stems were stable. None of them was at risk.

Conclusion: This analysis showed that the SLR revision stem performs well for an intermediate follow-up time of at least 10 years.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 27 - 28
1 Mar 2009
Zweymüller K Steindl M Schwarzinger U Brenner M
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Intruduction: Cementless cup anchorage for total hip replacement is among the techniques widely accepted today. Attention focuses on hemispheric cups mimicking the anatomical shape of the bony acetabulum. However, the first-generation cementless hemispheric cups had a number of design flaws, which have meanwhile been attended to. We therefore never really turned away from threaded cups and began to implant a cone-shaped version of commercially pure titanium in January 1985. Introduced in January 1993, the redesigned version was unlike any other implant described in the literature in terms of its outer shape, the locking mechanism for the polyethylene liner, the cutting strength of its teeth and the thin wall of the cup shell. We wanted to know whether this implant was generally applicable for all primary THRs irrespective of the underlying anatomy, i.e. whether the exclusive consecutive use of this implant was justified.

Method: Between 1/1/1993 and 30/4/1994, 332 patients underwent primary surgery for osteoarthritis with threaded cups and titanium stems. These self-tapping double-cone cups made of pure titanium feature sharply cutting teeth for anchorage without screws. The PE liner locks into the titanium shell by a 4-level conical locking mechanism obviating the need for indentations for rotational adjustment of the liner. All cups and stems implanted during this period were uncemented. At 10 years plus, clinical and monitor-controlled radiologic follow-ups were conducted to evaluate changes in cup position, radiolucent lines, osseo-integration and revisions.

Results: 209 patients (63 males and 146 females; mean age at surgery: 62.6 years, range: 18.9 to 83.2 years) showed up for follow-up. 71 were dead, 36 without revisions were contacted by phone, 10 were lost to follow-up. The mean follow-up time was 10.2 years (range: 10.0 to 11.1 years). 2 patients had undergone cup revision, one for low-grade infection after 9.6 years and one for cup fracture after 5 years. With cup revision as the endpoint, the Kaplan-Meier survival rate was 99,2 % (CI: 96.6 to 99.8). Radiography showed altered cup inclination in two patients and radiolucent lines signalling absence of osseointegration in one patient. All other implants were stable clinically and radiologically. Gaps between the cup floor and the bone tended to be spontaneously obliterated by newly formed bone. Complete obliteration was observed even in cases with incomplete cranial implant coverage due to hip dysplasia.

Conclusion: The outcome of threaded double-cone cups at 10 years and more compares well with the best results achieved with other implants, particularly hemispheric cups. This documents that their unique design features have so far stood the test of time. It also shows that these cups have a place in all patients candidates for primary total hip arthroplasty.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 52 - 52
1 Mar 2009
Zweymüller K Brenner M Steindl M
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Introduction: Stable cup anchorage in dysplastic hips is a key problem of THA. The pupose of this study was to evaluate the usefulness of a cementless cup without acetabuloplasty based on medium term Results: Method 53 patients, 47 females and 6 males aged 20 to 76 (mean 49) years at surgery were followed-up after 4.9 to 11.4 (mean 8.8) years. Crowe’s dysplasia classification showed 30 hips to be grade I, 23 grade II and 1 grade III pre-operatively. All patients were implanted with threaded pure-titanium double-cone cups. Acetabuloplasty was omitted and care was taken to achieve primary stability in the bone stock available. Pre-operative leg length discrepancy versus contralateral was 0 to 7 (mean 3.9) cm.

Results: On postoperative radiography 45 cups were completely covered by bone in position I. Of 6 cups 3 quarters were covered, of 1 cup 2 thirds and of another one ½ of the cranial circumference. All of the incompletely covered cups were stable at follow-up. Altogether 51 cups had maintained their position by radiographic evidence and were firmly anchored in bone. Cup loosening in Crowe grade I and II necessitated 2 revisions. Leg length was equalized in 39 patients with mean lengthening by 3.4 (1.2 to 4.5) cm.

Conclusion: In the management of dysplastic hips the system used provides stable anchorage in the bone stock without additional acetabuloplasty. Even pronounced soft tissue tension on substantial leg lengthening does not impair implant stability.

Summary: Primary stable implantation of a cementless titanium cup in hip dysplastia cases without additional acetabuloplasty is achieving good medium term results.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 295 - 295
1 Sep 2005
Levine A Naff N Dix G Coleman C Brenner M
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Introduction and Aims: This study examined the feasibility and clinical response of treatment with the Cyberknife Stereotactic Radiosurgery system of patients with spine tumors not amenable to other types of treatment. These included patients with metastases recurrent after previous radiation, those resistant to radiation or those requiring extensive surgery for complete resection.

Method: Twenty-nine patients with tumors of the spine were treated with hypofractionated (one to four fractions) high dose radiation (CyberKnife), delivered using implanted fiducial markers for precise stereotactic localisaton. Patients had either recurrent spinal metastases (19), radio-resistant metastases (seven) or small lesions requiring extensive resection (three). After four to six fiducials were implanted, the patient was immobilised in a custom-moulded cradle and a CT scan was obtained with up to 300 slices at 1.25mm intervals. Inverse plannning was done to minimise dose to critical structures in close proximity to the tumor mass. Patients were followed-up with clinical pain scores, total pain medication, functional assessment and follow-up CT and/or MRI at three-month intervals to assess response to treatment.

Results: The tumors were located in all areas of the spine from C4 to the sacrum, with renal cell carcinoma being the most common diagnosis. The mean tumor volume was 253.4cc, with a range of 0.33 to 678.9 ccs. The maximum radiation dose prescribed to the tumor ranged from 1600cGy to 2500cGy delivered in one to four fractions. The number of fractions was determined by the tumor volume and whether the spinal lesion had been previously treated with radiation. The maximum allowable dose to the adjacent spinal cord was 800cGy and thus for the majority of the tumors prescribed to 2500cGy, 80% of the tumor volume received at least 2000cGy. Patients were treated in an outpatient setting with an average treatment time of 75 minutes. There were no new neurologic deficits or acute radiation toxicity. Patients with lesions in the lumbar spine or sacrum often experienced a brief period of nausea, which was easily controllable with one dose of anti-emetic. Some patients experienced a period of malaise or lethargy with no predictive factors. Pain was markedly improved in all patients with metastatic disease as demonstrated by pain scores, decreased use of narcotic medications and improved function. Repeat radiographic studies at three months generally demonstrated stable tumor volume, while those at six months showed decrease in tumor size.

Conclusion: Stereotactic radiosurgery has distinct advantages over external beam for patients with tumors of the spine, including less toxicity, ability to treat recurrences in previously radiated fields, and shorter treatment durations. While GammaKnife for cranial lesions is a widely accepted technique by neurosurgeons, the use of frameless stereotactic radiosurgery with the Cyberknife is new to the armamentarium of orthopaedic surgeons treating spinal tumors.