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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_15 | Pages 81 - 81
1 Dec 2021
IF, WHEN, AND HOW TO USE RIFAMPIN IN ACUTE STAPHYLOCOCCAL PERIPROSTHETIC JOINT INFECTIONS: A MULTICENTRE OBSERVATIONAL STUDY
Beldman M Löwik C Soriano A Albiach L Zijlstra W Knobben B Jutte P Sousa R Carvalho AD Goswami K Parvizi J Belden K Wouthuyzen-Bakker M
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Aim

Rifampin is considered as the antibiotic corner stone in the treatment of acute staphylococcal periprosthetic joint infections (PJI). However, if, when, and how to use rifampin has been questioned. We evaluated the outcome of patients treated with and without rifampin, and analysed the influence of timing, dose and co-antibiotic.

Method

Acute staphylococcal PJIs treated with surgical debridement between 1999 and 2017, and a minimal follow-up of 1 year were evaluated. Treatment failure was defined as the need for any further surgical procedure related to infection, PJI-related death, or the need for suppressive antimicrobial treatment.

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