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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_10 | Pages 10 - 10
1 Oct 2019
Jensen O Andersen M Østgård R Andersen N Rolving N
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Background and purpose

Modic changes (MC) are a risk factor for development of chronic low back pain (CLBP). There is no agreement about the cause of inflammation in MC, but autoimmunity has been suggested. The aim of the study was to investigate whether treatment with lactic acid bacteria for 100 days was associated with change of disability and pain, via a change in the gut microbiota inducing a change in the immune system, in patients with CLBP and type 1 MC during one year follow-up.

Methods

Eighty-nine patients with CLBP and type 1 MC were randomized to receive either one capsule Lactobacillus Rhamnosis GG or placebo capsules twice daily for 100 days.