Knee dislocations are a rare but serious cause of trauma. The aim of this study was to establish current demographics and injury patterns/associations in multi-ligament (MLI) knee injuries in the United Kingdom. A National survey was sent out to trauma & orthopaedic trainees using the British Orthopaedic Trainees Association sources in 2018. Contributors were asked to retrospectively collect a data for a minimum of 5 cases of knee dislocation, or multi-ligament knee injury, between January 2014 and December 2016. Data was collected regarding injury patterns and surgical reconstructions. 73 cases were available for analysis across 11 acute care NHS Trusts. 77% were male. Mean age was 31.9 (SD 12.4; range 16–69). Mean Body Mass Index (BMI) was 28.3 (SD 7.0; range 19–52). Early (<3 weeks) reconstruction was performed in 53% with 9 (23%) patients under-going procedures for arthrofibrosis. Late (>12 weeks) reconstruction took place in 37% with one (3.7%) patient under-going arthroscopic arthrolysis. 4% had delayed surgery (3–12 weeks) and 5% had early intervention with delayed ACL reconstruction. For injuries involving 3 or more ligament injuries graft choices were ipsilateral hamstring (38%), bone-patella tendon-bone (20%), allograft (20%), contralateral hamstring (17%) and synthetic grafts in 18%. Multi-ligament knee injuries are increasingly being managed early with definitive reconstructions. This is despite significant risk of arthrofibrosis with early surgery. Ipsilateral and contralateral hamstring grafts make up the bulk of graft choice however allograft (20%) and synthetic grafts (18%) remain popular

The rate of fracture and subsequent nonunion after radiation therapy for soft-tissue sarcomas and bone tumors has been demonstrated to quite high. There is a paucity of data describing the optimal treatment for these nonunions. Free vascularized fibular grafts (FVFG) have been used successfully in the treatment of large segmental bone defects in the axial and appendicular skeleton, however, their efficacy with respect to treatment of radiated nonunions remains unclear. The purpose of the study was to assess the 1) union rate, 2) clinical outcomes, and 3) complications following FVFG for radiation-induced femoral fracture nonunions. We identified 24 patients who underwent FVFG for the treatment of radiation-induced femoral fracture nonunion between 1991 and 2015. Medical records were reviewed in order to determine oncologic diagnosis, total preoperative radiation dose, type of surgical treatment for the nonunion, clinical outcomes, and postoperative complications. There were 11 males and 13 females, with a mean age of 59 years (range, 29 – 78) and a mean follow-up duration of 61 months (range, 10 – 183 months). Three patients had a history of diabetes mellitus and three were current tobacco users at the time of FVFG. No patient was receiving chemotherapy during recovery from FVFG. Oncologic diagnoses included unspecified soft tissue sarcomas (n = 5), undifferentiated pleomorphic sarcoma (UPS) (n = 3), myxofibrosarcoma (n = 3), liposarcoma (n = 2), Ewing's sarcoma (n = 2), lymphoma (n = 2), hemangiopericytoma, leiomyosarcoma, multiple myeloma, myxoid chondrosarcoma, myxoid liposarcoma, neurofibrosarcoma, and renal cell carcinoma. Mean total radiation dose was 56.3 Gy (range, 39 – 72.5), given at a mean of 10.2 years prior to FVFG. The average FVFG length was 16.4 cm. In addition to FVFG, 13 patients underwent simultaneous autogenous iliac crest bone grafting, nine had other cancellous autografting, one received cancellous allograft, and three were treated with synthetic graft products. The FVFG was fixed as an onlay graft using lag screws in all cases, additional fixation was obtained with an intramedullary nail (n = 19), dynamic compression plate (n = 2), blade plate (n = 2), or lateral locking plate (n = 1). Nineteen (79%) fractures went on to union at a mean of 13.1 months (range, 4.8 – 28.1 months). Musculoskeletal Tumor Society scores improved from eight preoperatively to 22 at latest follow-up (p < 0.0001). Among the five fractures that failed to unite, two were converted to proximal femoral replacements (PFR), two remained stable pseudarthroses, and one was converted to a total hip arthroplasty. A 6th case did unite initially, however, subsequent failure lead to PFR. Seven patients (29%) required a second operative grafting. There were five additional complications including three infections, one wound dehiscence, and one screw fracture. No patient required amputation. Free vascularized fibular grafts are a reliable treatment option for radiation-induced pathologic femoral fracture nonunions, providing a union rate of 79%. Surgeons should remain cognizant, however, of the elevated rate of infectious complications and need for additional operative grafting procedures

Anterior cruciate ligament (ACL) reconstruction is the current standard of care for ACL tears. However, the results are not consistently successful, autografts or allografts have certain disadvantages, and synthetic grafts have had poor clinical results. The aim of this study was to determine the efficacy of tissue engineering decellularized tibialis tendons by recellularization and culture in a dynamic tissue bioreactor. To determine if recellularization of decellularized tendons combined with mechanical stimulation in a bioreactor could replicate the mechanical properties of the native ACL and be successfully used for ACL reconstruction in vivo. Porcine tibialis tendons were decellularized and then recellularized with human adult bone marrow-derived stem cells. Tendons were cultured in a tissue bioreactor that provided biaxial cyclic loading for up to 7 days. To reproduce mechanical stresses similar to hose experienced by the ACL within the knee joint, the tendons were subjected to simultaneous tension and torsion in the bioreactor. Expression of tendon-specific genes, and newly synthesized collagen and glycosaminoglycan (GAG) were used to quantify the efficacy of recellularization and dynamic bioreactor culture. The mechanical strength of recellularized constructs was measured after dynamic stimulation. Finally, the tissue-engineered tendons were used to reconstruct the ACL in mini-pigs and mechanical strength was assessed after three months. Dynamic bioreactor culture significantly increased the expression of tendon-specific genes, the quantity of newly synthesized collagen and GAG, and the tensile strength of recellularized tendons. After in vivo reconstruction, the tensile strength of the tissue-engineered tendons increased significantly up to 3 months after surgery and were within 80% of the native strength of the ACL. Our translational study indicates that the recellularization and dynamic mechanical stimuli can significantly enhance matrix synthesis and mechanical strength of decellularized porcine tibialis tendons. This approach to tissue engineering can be very useful for ACL reconstruction and may overcome some of the disadvantages of autografts and allografts

Osteolysis has been reported following ACJ reconstruction with a synthetic graft. We present the first study into its prevalence and pattern, and its effect on patient outcome. Patients who underwent treatment of an unstable ACJ injury using the Surgilig/LockDown implant were identified via our database. Patients were invited to attend a dedicated outpatient clinic for clinical examination, radiographic evaluation, and completion of outcome scoring. Patients who were unable to attend were contacted by telephone. 49 patients were identified. We assessed 21 clinically at a mean of 7 years post-procedure (range 3–11 years). All had radiographic evidence of distal clavicle and coracoid osteolysis. We did not observe progression of osteolysis from the final post-operative radiographs. A further 13 were contacted by phone. The mean Oxford Shoulder Score was 43 (range 31–48) and mean DASH score was 8.5 (range 3–71). The average Patient Global Impression of Change score was 6 (range 2–7). Six patients underwent removal of a prominent screw at a mean of 2 years after surgery; the pattern of osteolysis was no different in this group. All patients had comparable abduction, forward flexion and internal rotation to their uninjured shoulder. We did not observe any relationship between patient demographics, position of implant or etiology and the pattern of osteolysis. Osteolysis of the distal clavicle and/or coracoid is always seen following synthetic reconstruction of the ACJ using this implant, but is non-progressive. Range of shoulder movement is largely unaffected and patient outcomes remain high

Complications involving the knee extensor mechanism occur in 1% to 12% of patients following total knee arthroplasty (TKA), and have negative effects on patient outcomes. While multiple reconstruction options have been described, the results in patients with a prior TKA are inferior to those in patients without a TKA. However, optimistic results have been reported by Browne and Hanssen with the use of a synthetic mesh (knitted monofilament polypropylene)3. In this technique, a synthetic graft is created by folding a 10 × 14 inch sheet of mesh and securing it with nonabsorbable sutures. A burr is then used to create a trough in the anterior aspect of the tibia to accept the mesh graft. The graft is inserted into the trough and secured with cement. After the cement cures, a transfixion screw with a washer is placed. A portal is subsequently created in the lateral soft tissues to allow delivery of the graft from deep to superficial. The patella and quadriceps tendon are mobilised, and the graft is secured with sutures to the lateral retinaculum, vastus lateralis, and quadriceps tendon. The vastus medialis is then mobilised in a pants-over-vest manner over the mesh graft, and secured with sutures. Finally, the distal arthrotomy is closed tightly to completely cover the mesh graft with host tissue. In their series, Browne and Hanssen noted that 9 of 13 patients achieved an extensor lag of > 10 degrees with preserved knee flexion and significant improvements in the mean Knee Society scores for pain and function

Complications involving the knee extensor mechanism occur in 1% to 12% of patients following total knee arthroplasty (TKA), and have negative effects on patient outcomes. While multiple reconstruction options have been described, the results in patients with a prior TKA are inferior to those in patients without a TKA. However, optimistic results have been reported by Browne and Hanssen with the use of a synthetic mesh (knitted monofilament polypropylene). In this technique, a synthetic graft is created by folding a 10 × 14 inch sheet of mesh and securing it with nonabsorbable sutures. A burr is then used to create a trough in the anterior aspect of the tibia to accept the mesh graft. The graft is inserted into the trough and secured with cement. After the cement cures, a transfixion screw with a washer is placed. A portal is subsequently created in the lateral soft tissues to allow delivery of the graft from deep to superficial. The patella and quadriceps tendon are mobilised, and the graft is secured with sutures to the lateral retinaculum, vastus lateralis, and quadriceps tendon. The vastus medialis is then mobilised in a pants-over-vest manner over the mesh graft, and secured with sutures. Finally, the distal arthrotomy is closed tightly to completely cover the mesh graft with host tissue. In their series, Browne and Hanssen noted that 9 of 13 patients achieved an extensor lag of <10 degrees with preserved knee flexion and significant improvements in the mean Knee Society scores for pain and function

The purpose of this study is to present a series of soft tissue sarcomas requiring complex vascular reconstructions, and to describe their management and outcomes. Soft tissue sarcomas are rare mesodermal malignancies accounting for approximately 1% of all cancers diagnosed annually. Sarcomas involving the pelvis and extremities are of particular interest to the orthopaedic surgeon. Tumours that encase and invade large calibre vascular structures present a major surgical challenge in terms of safety of excision with acceptability of surgical margins. Technical advances in the fields of both orthopaedic and vascular surgery have resulted in a trend towards limb salvage with vascular reconstruction in preference to amputation. Limb-salvage surgery is now feasible due to the variety of reconstructive options available to the surgeon. Nevertheless, surgery with concomitant vascular reconstruction is associated with higher rates of complications including infection and amputation. We present a case series of soft tissue sarcomas with vascular compromise, requiring resection and vascular reconstruction. We treated four patients (n = 4, three females, and one male) with soft tissue masses, which were found to involve local vascular structures. Histology revealed leiomyosarcoma (n = 2) and alveolar soft part sarcomas (n = 2). Both synthetic graft and autogenous graft (long saphenous vein) techniques were utilised. Arterial reconstruction was undertaken in all cases. Venous reconstruction was performed in one case. One patient required graft thrombectomy at one month post-operatively for thrombosis. We present a series of complex tumour cases with concomitant vascular reconstructions drawn from our institution's experience as a national tertiary referral sarcoma service

Complications involving the knee extensor mechanism occur in 1% to 12% of patients following total knee arthroplasty (TKA), and have negative effects on patient outcomes. While multiple reconstruction options have been described for complete disruption of the extensor mechanism, the results in patients with a prior TKA are inferior to those in patients without a TKA, and frequently have required the use of allograft tendon grafts which can attenuate and stretch over time. However, encouraging results have been reported by Browne and Hanssen in treatment of patellar tendon disruption with the use of a synthetic mesh (knitted monofilament polypropylene). In this technique, a synthetic graft is created by folding a 10 × 14 inch sheet of mesh and securing it with non-absorbable sutures. A burr is then used to create a trough in the anterior aspect of the tibia to accept the mesh graft. The graft is inserted into the trough and secured with cement. After the cement cures, a transfixion screw with a washer is placed. A portal is subsequently created in the soft tissues lateral patellar tendon remnants to allow delivery of the graft from deep to superficial. The patella and quadriceps tendon are mobilised, and the graft is secured with sutures to the lateral retinaculum, vastus lateralis, and quadriceps tendon. The vastus medialis is then mobilised and brought in a pants-over-vest manner over the mesh graft, and secured with additional sutures. Finally, the distal arthrotomy is closed tightly to completely cover the mesh graft with host tissue. In their series, Browne and Hanssen noted that 9 of 13 patients achieved an extensor lag of <10 degrees with preserved knee flexion and significant improvements in the mean Knee Society scores for pain and function. A similar modified method has been used at our institution for chronic quadriceps tendon disruptions as well. The reconstructions have shown less of a tendency to late attenuation, stretch and recurrent extensor lag beyond two years compared to our experience with tendon allograft reconstructions and remains our procedure of choice at our institution for the majority of these challenging problems

The principles of acetabular reconstruction include the creation of a stable acetabular bed, secure prosthetic fixation with freedom of orientation, bony reconstitution, and the restoration of a normal hip centre of rotation with acceptable biomechanics. Acetabular impaction grafting, particularly with cemented implants, has been shown to be a reliable means of acetabular revision. Whilst our practice is heavily weighted towards cementless revision of the acetabulum with impaction grafting, there is a large body of evidence from Tom Slooff and his successors that cemented revision with impaction grafting undertaken with strict attention to technical detail is associated with excellent long terms results in all ages and across a number of underlying pathologies including dysplasia and rheumatoid arthritis. We use revision to a cementless hemispherical porous-coated acetabular cup for most isolated cavitary or segmental defects and for many combined deficiencies. Morsellised allograft is packed in using chips of varied size and a combination of impaction and reverse reaming is used in order to create a hemisphere. There is increasing evidence for the use of synthetic grafts, usually mixed with allograft, in this setting. The reconstruction relies on the ability to achieve biological fixation of the component to the underlying host bone. This requires intimate host bone contact, and rigid implant stability. It is important to achieve host bone contact in a least part of the dome and posterior column – when this is possible, and particularly when there is a good rim fit, we have not found it absolutely necessary to have contact with host bone over 50% of the surface. Once the decision to attempt a cementless reconstruction is made, hemispherical reamers are used to prepare the acetabular cavity. Sequentially larger reamers are used until there is three-point contact with the ilium, ischium and pubis. Acetabular reaming should be performed in the desired orientation of the final implant, with approximately 200 of anteversion and 400 of abduction (or lateral opening). Removing residual posterior column bone should be avoided. Reaming to bleeding bone is desirable. Morsellised allograft is inserted and packed and/or reverse reamed into any cavitary defects. This method can also be applied to medial wall uncontained defects by placing the graft onto the medial membrane or obturator internus muscle, and gently packing it down before inserting the cementless acetabular component. Either the reamer heads or trial cups can be used to trial prior to choosing and inserting the definitive implant. The fixation is augmented with screws in all cases. Incorporation of the graft may be helped by the use of autologous bone marrow. Cementless acetabular components with impaction grafting should not be used when the host biology does not allow for stability or for bone ingrowth. This includes the severely osteopenic pelvis, pelvic osteonecrosis after irradiation, tumours, and metabolic bone disorders. They should also not be used in the presence of pelvic discontinuity unless the structure of the pelvic ring has been restored with a plate, or specialised materials/porous metals are used. The challenge of reconstituting the acetabulum depends on the degree and type of bone loss. The principles of maximising host bone-implant contact and implant stability have borne fruit in our experience with cementless revision. The advantages of bone grafting in acetabular reconstruction include the ability to restore bone stock, to rebuild a normal hip center and hip biomechanics and to increase bone stock for future revisions

Massive proximal femoral bone loss can be a complex problem, despite various modern technical and implant solutions. Due to inadequate bone stock and missing proximal fixation possibilities, including larger segmental osseous defects, the use of a mega prosthesis might become necessary. Coverage of the segmental bone loss in combination with distal fixation, can be achieved in either cemented or non-cemented techniques. Some implant types allow for additional fixation of the gluteal muscles, attached with non-absorbable sutures or synthetic mesh grafts. Although first reports about partial or even complete femoral replacement are available since the 1960's, larger case series or technical reports are rare within the literature and limited to some specialised centers. Most series are reported by oncologic centers, with necessary larger osseous resections of the femur. The final implantation of any mega prosthesis system requires meticulous planning, especially to calculate the appropriate leg length of the implant and resulting leg length. Combination of a posterior hip with a lateral knee approach allows for the enlargement to a total femur replacement, if necessary. The lateral vastus muscle is detached and the entire soft tissues envelope can be displaced medially. After implant and cement removal, non-structural bone might be resected. Trial insertion is important, due to the variation of overall muscle tension intraoperatively and prevention of early or late dislocation. Currently the use of proximal modular systems, including length, offset and anteversion adaption, became the technique of choice for these implant systems. However, just very few companies offer yet such a complete system, which might also be expanded to a total femur solution. We were able to evaluate our Endo-Klinik results of total-femur replacements within 100 consecutive patients in non-infected cases, after a mean follow up time of five years. There we “only” 68% patients without complications, main complications included: 13% revealed a deep infection; dislocation was found in 6%, material failure and consequent breakage in 3%, persistent patellar problems in 2% and finally 1% with peroneal nerve palsy. These results show that a total-femur replacement is associated with a high complication rate, even in non-infected patient cohorts