Low back pain is the single most common cause for disability in individuals aged 45 years or younger, it carries tremendous weight in socioeconomic considerations. Degenerative aging of the structural components of the spine can be associated with genetic aspects, lifetime of tissue exposure to mechanical stress & loads and environmental factors. Mechanical consequences of the disc degenerative include loss of disc height, segment instability and increase the load on facets joints. All these can lead to degenerative changes and osteophytes that can narrow the spinal canal. Surgery is indicated in patients with spinal stenosis who have intractable pain, altered quality of life, substantially diminished functional capacity, failed non-surgical treatment and are not candidates for non-surgical treatment. The aim was to determine the reasons for refusal of surgery in patients with established degenerative lumber spine pathology eligible for surgery. All patients meeting the study criteria, patients older than 18 years, patients with both clinical and radiological established symptomatic degenerative lumbar spine pathology and patients eligible for surgery but refusing it were recruited. Questionnaire used to investigate reasons why they are refusing surgery. Results 59 were recruited, fifty-one (86.4 %) females and eight (13.6 %) males. Twenty (33.8 %) were between the age of 51 and 60 years, followed by nineteen (32.2 %) between 61 and 70 years, and fourteen (23.7 %) between 71 and 80 years. 43 (72 %) patients had lumber spondylosis complicated by lumber spine stenosis, followed by nine (15.2 %) with lumbar spine spondylolisthesis and four (6.7 %) had adjacent level disease. 28 (47.4 %) were scared of surgery, fifteen (25.4 %) claimed that they are too old for surgery and nine (15.2 %) were not ready. Findings from this study outlined that patients lack information about the spinal surgery. Patients education about spine surgery is needed

The spine is a common site of metastasis. Complications include pathologic fracture, spinal cord compression, and neurological deficits. Vertebroplasty (VP) and Balloon Kyphoplasty (KP) are minimally invasive stabilization procedures used as a palliative treatment to improve mechanical stability, quality of life, and reduce pain. Photodynamic therapy (PDT) is a tumour-ablative modality that may complement mechanical stability afforded by VP/KP. This first-in-human study evaluates PDT safety when applied in conjunction with VP/KP. This dose escalation trial involved one light only control group and four light-drug doses (50,100,150,200J;n=6) delivered at 150mW from a 690nm diode laser by 800-micron optical fibers prior to KP/VP. Patients eligible for VP/KP in treating pathologic fracture or at-risk lesions at a single level were recruited. Exclusion criteria included spinal canal compromise or neurologic impairment. PDT is a two-step binary therapy of systemic drug followed by intravertebral light activation. Light was applied via bone trochar prior to cementation. This study used a benzoporphyrin derivative monoacid (BPD-MA), Verteporfin (VisudyneTm), as the photosensitizer drug in the therapy. Drug/light safety, neurologic safety, generic (SF-36), and disease-specific outcomes (VAS, EORTC-QLQ-BM22, EORTC-QLQ-C15-PAL) were recorded through six weeks. Phototoxicity and the side effects of the BPD-MA were also examined following PDT use. Thirty (10 male, 20 female) patients were treated (13 KP, 17 VP). The average age was 61 and significantly different between genders (Male 70yrs vs. Female 57yrs: p 0.05), and tumour status (lytic vs. mixed blastic/lytic: p>0.05). In most cases, fluence rates were similar throughout PDT treatment time, indicating a relatively stable treatment. Twelve (40%) of patients experienced complications during the study, none of which were attributed to PDT therapy. This included two kyphoplasty failures due to progression of disease, one case of shingles, one ankle fracture, one prominent suture, one case of constipation due to a lung lesion, one case of fatigue, and five patients experienced pain that was surgically related or preceded therapy. Vertebral PDT appears safe from pharmaceutical and neurologic perspectives. KP/VP failure rate is broadly in line with reported values and PDT did not compromise efficacy. The 50J group demonstrated an improved response. Ongoing study determining safe dose range and subsequent efficacy studies are necessary

Spinal stenosis is a condition resulting in the compression of the neural elements due to narrowing of the spinal canal. Anatomical factors including enlargement of the facet joints, thickening of the ligaments, and bulging or collapse of the intervertebral discs contribute to the compression. Decompression surgery alleviates spinal stenosis through a laminectomy involving the resection of bone and ligament. Spinal decompression surgery requires appropriate planning and variable strategies depending on the specific situation. Given the potential for neural complications, there exist significant barriers to residents and fellows obtaining adequate experience performing spinal decompression in the operating room. Virtual teaching tools exist for learning instrumentation which can enhance the quality of orthopaedic training, building competency and procedural understanding. However, virtual simulation tools are lacking for decompression surgery. The aim of this work was to develop an open-source 3D virtual simulator as a teaching tool to improve orthopaedic training in spinal decompression. A custom step-wise spinal decompression simulator workflow was built using 3D Slicer, an open-source software development platform for medical image visualization and processing. The procedural steps include multimodal patient-specific loading and fusion of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) data, bone threshold-based segmentation, soft tissue segmentation, surgical planning, and a laminectomy and spinal decompression simulation. Fusion of CT and MRI elements was achieved using Fiducial-Based Registration which aligned the scans based on manually placed points allowing for the identification of the relative position of soft and hard tissues. Soft tissue segmentation of the spinal cord, the cerebrospinal fluid, the cauda equina, and the ligamentum flavum was performed using Simple Region Growing Segmentation (with manual adjustment allowed) involving the selection of structures on T1 and/or T2-weighted scans. A high-fidelity 3D model of the bony and soft tissue anatomy was generated with the resulting surgical exposure defined by labeled vertebrae simulating the central surgical incision. Bone and soft tissue resecting tools were developed by customizing manual 3D segmentation tools. Simulating a laminectomy was enabled through bone and ligamentum flavum resection at the site of compression. Elimination of the stenosis enabled decompression of the neural elements simulated by interpolation of the undeformed anatomy above and below the site of compression using Fill Between Slices to reestablish pre-compression neural tissue anatomy. The completed workflow allows patient specific simulation of decompression procedures by staff surgeons, fellows and residents. Qualitatively, good visualization was achieved of merged soft tissue and bony anatomy. Procedural accuracy, the design of resecting tools, and modeling of the impact of bone and ligament removal was found to adequately encompass important challenges in decompression surgery. This software development project has resulted in a well-characterized freely accessible tool for simulating spinal decompression surgery. Future work will integrate and evaluate the simulator within existing orthopaedic resident competency-based curriculum and fellowship training instruction. Best practices for effectively teaching decompression in tight areas of spinal stenosis using virtual simulation will also be investigated in future work

Aim. Spinal implant-associated infections (SIAI) require combined surgical and antimicrobial treatment and prolonged hospital stay. We evaluated the clinical, laboratory, microbiological and radiological characteristics and treatment approaches in patients with SIAI. Method. Consecutive adult patients with SIAI treated between 2015 and 2017 were prosepctively included. SIAI was defined by: (i) significant microbial growth from intraoperative tissue or sonication fluid, (ii) intraoperative purulence, secondary wound dehiscence or implant on view, (iii) radiographic evidence of infection and fever (>38°C) without other recognized cause, increasing back pain or neurologic impairment, (iv) peri-implant tissue inflammation in histopathology. Results. A total of 60 patients were included, median age was 66 years (range, 28–91 years), 29 (48%) were males. The most common reason for spinal stabilization was spinal canal stenosis in 20 patients (33%) followed by vertebral degenerative disease in 14 (23%). 31 patients (52%) had one or more previous spine surgeries (range, 1–4 interventions). The anatomic site of spinal instrumentation was lumbar/sacral in 26 (43%), cervical in 23 patients (38%), thoracic in 11 (18%). The median number of fused segments was 5 (range, 1–14). Clinical manifestations included wound healing disturbance in 41 patients (68%), increasing back pain in 15 (25%), neurologic impairment in 12 patients (20%) and fever in 14 (23%). Serum CRP was abnormal (>10mg/l) in 46/59 patients (78%). Most (n=54) infections were postsurgical, 5 were hematogenous and 1 was contiguous. Imaging showed epidural, intraspinal or paravertebral abscess in 21/42 patients (50%), implant failure in 9 (21%) and implant loosening in 3 cases (7%). Monomicrobial infection was observed in 41 (68%), polymicrobial in 16 (27%) patients and culture-negative infection in 3 episodes (5%). Predominant causative pathogens were S. aureus (n=19), coagulase-negative staphylococci (n=18) and gram-negative rods (n=16). Surgery was performed in all patients including debridement and implant retention in 39 patients (65%), partial implant exchange in 10 (17%) and complete exchange in 11 (18%). Antimicrobial treatment included biofilm-active substances in 52 patients (87%). The median duration of antimicrobial therapy was 11,7 weeks (range, 6–12 weeks). 14 patients (23%) recieved suppressive therapy for a median duration of 9 months (range 3–12 months). Conclusions. Most SIAI were seen in lumbar/sacral segments and wound healing disturbance and increasing back pain were the most common manifestations. In 95% the causative pathogen was isolated, predominantly staphylococci. In half of the episodes, abscesses were present. All patients underwent surgery and biofilm-active antibiotics were administered in 87%

We all aware about overuse syndrome, as compensation of other parts of body. Our famous poet Sa'adi: when part of our body sustains become painful, the other parts can't tolerate and reciprocate. Among our patients who underwent total Knee arthroplasty few of them have pain especially in 1st 3 months (Anterior Knee pain, effusion, ….) but almost 15 – 20 percents are not satisfied enough by this Procedure. In a Cohort historic study on 301 TKA with at least 2 years follow up 47 patients had not enough satisfaction in our clinic we tried to visit them to find out why?. Criteria's we chose, were:. Age. Osteopenia. Sarcopenia. Low back pain. Spinal canal stenosis. Shoulders. Unstable blood pressure. Neuropathy. Eyes dysfunction. We exclude those who had problem by their new knees. 11 patients, all have been over age 68 years, and duration of start of symptoms in knee (s) to the surgery were more than 12 years, clearly showed painful arch of shoulder motion or frozen shoulder or established gleno humeral alone or G.H. and A.C. joints OA. Conclusion. Because of abnormal stand up of long lasting knee OA patients, they start to put pressure on their shoulder to climb on their body. Even their cane or crutches use are not in regular and academic rules. So, we nominate this entity: shoulder knee syndrome as a negative criteria that interferes in out come

Objectives:. The study goal was to retrospectively evaluate the diagnostic accuracy and complication rates of a fluoroscopically guided motorized core biopsy system in the thoraco-lumbar area. Materials And Methods:. The data of fifty eight (58) patients (28 male & 32 female) with an average age of 42.13 years that underwent biopsy of the spine using a motorized core biopsy system between March 2006 and October 2013 (7.7 years) at a level two teaching institution were retrospectively reviewed. Patient characteristics (age, sex), spinal biopsy level, histology, microbiology and fresh tissue polymerase chain reaction (PCR) diagnosis were considered. Results:. Of the 58 patients biopsied 7 were excluded: three patients had a biopsy taken intra-operatively, two patients had a cervical spine biopsy, one patient had a psoas abscess and one had biopsy of the sacral spine. 38 Lumbar (74%) & 13 thoracic (25.4%) biopsies were evaluated. One patient (1.9%) had slightly more bleeding warranting insertion of Port-o-vac drain. No pneumothorax, paraesthesiae or penetration of the spinal canal was reported. In 35 of 51 histological examinations a diagnosis was achieved (68%); 19 of 51 had positive MC&S (37%). The most common diagnosis was tuberculosis (n=21) 41%, followed by multiple myeloma (n=4) 7.8%, adenocarcinoma (n=3) 5.8%, lymphoma (n=3) 5.8%, chronic osteomyelitis (n=3)5.8%, leiyomyosarcoma (n=1)1.9%. Conclusions:. Our results are comparable to published data with an average of 74% histopathological diagnosis and 0–10% complication rate in published literature. We therefore can conclude that the use of motorized core biopsy system is safe and can achieve acceptable diagnostic yield

Purpose. To evaluate the efficacy of novel biodegradable MAACP/n-HA composite artificial lamina for the prevention of postlaminectomy adhesions and lamina reconstruction. Methods. Goats were randomly divided into three groups: an experimental group consisting of twelve goats that underwent cervical 4 laminectomies, followed by MAACP/n-HA composite artificial lamina implantations; a control group of nine goats whose cervical 4 vertebra plate were removed; and a normal group of three goats that did not receive any operations or treatments. On weeks 4, 12 and 24, two goats, two goats, three goats in the test group and two, two, two in the control group were selected using X-ray, CT, MRI and subsequently killed for histological examinations and SEM (scanning electronic microscopY). On week 24, the adhesion level of scar tissue was examined according to Rydell's degree of adhesion criteria. Biomechanical measurements were carried out at week 24 on 3 goats in the test group, 3 in the control group, and 3 in the normal group. Results. In the experimental group, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed. New goat cervical natural bone formed in the defect and the bony spinal canal had reformed. In contrast, in the control group, fibrous scar tissue filled the defect and the scar tissue continued to exert pressure on the dura. Conclusions. Artificial lamina could prevent the epidural adhesions surrounding the defect and promote effectively bone tissue repair and new bone formation. MULTIPLE DISCLOSURES

Purpose. To perform an Interrater reliability study determining the agreement between an Orthopaedic team and a Radiology team on the MRI features of prolapsed uncontained cervical discs in Flexion-Distraction injuries of the cervical spine. This leads us to determine how many patients demonstrated evidence of a ‘dangerous’ disc: an uncontained disc herniating posteriorly that may be drawn into the spinal canal during closed reduction. Methods. One hundred and ten patients who had pre-reduction MRI scans managed during the last 10 years were included. Variables were chosen and defined by the senior Author and explained to both teams prior to reviewing the scans. The review was performed by each team independently and without any access to clinical information. Data collection and interpretation was designed by a statistician to reduce risk of data entry errors. Interrater reliability/agreement was determined using the Cohen Kappa value. Results. Disc Protrusion across Posterior Body Line, Interrater agreement Cohen-Kappa=0.46 (moderate agreement) Disc protrusion across Inferior Body Line Interrater agreement Cohen-Kappa=0.4 (moderate agreement) Disc protrusion across Corner to Corner Line, Interrater agreement Cohen-Kappa=0.15 (poor agreement) Disc disruption Line, Interrater agreement Cohen-Kappa=0.33 (moderate agreement) Disc Contained, Interrater agreement Cohen-Kappa=0.41 (moderate agreement) PLL, Interrater agreement Cohen Kappa=0.22 (Fair agreement). Prevalence of posterior disc herniation 42% (orthopaedic team), 51%(Radiology team). Prevalence of uncontained discs 70% (orthopaedic team), 76%(Radiology team). The most agreed upon variables were posterior herniation and the impression of whether the disc was contained. Conclusion. Interrater agreement on the presence of an uncontained herniated disc between Orthopaedic surgeons and Radiologists in this study was never excellent. This leads us to believe it imperative for the surgeon to review MRI's in addition to reading the radiologists report. NO DISCLOSURES

Background. High velocity vertical aircraft ejection seat systems are credited with aircrew survival of 80-95% in modern times. Use of these systems is associated with exposure of the aircrew to vertical acceleration forces in the order of 15-25G. The rate of application of these forces may be up to 250G per sceond. Up to 85% of crew ejecting suffer skeletal injury and vertebral fracture is relatively common (20-30%) when diagnosed by plain radiograph. The incidence of subtle spinal injury may not be as apparent. Aim. A prospective study to evaluate spinal injury following high velocity aircraft ejection. Methods. A prospective case series from 1996 to 2006 was evaluated. During this interval 26 ejectees from 20 aircraft were admitted to the spinal studies unit for comprehensive examination, evaluation and management. The investigations included radiographs of the whole spine and Magnetic Resonance Imaging (incorporating T1, T2 weighted and STIR sagittal sequences). All ejections occurred within the ejection envelope and occurred at an altitude under 2000 feet (mean 460 feet) and at an airspeed less than 500 knots (mean 275 knots). Results. in this series 6 ejectees (24%) had clinical and radiographic evidence of vetebral compression fractures. These injuries were located in the thoracic and thoracolumbar spine. 4 cases required surgery (indicated for angular kyphosis greater than 30 degrees, significant spinal canal compromise, greater than 50% or neurological injury. 1 patient had significant neurological compromise, following an AO A3.3 injury involving the L2 vertebra. 11 ejectees (45 %) had MRI evidence of a combined total of 22 occult thoracic and lumbar fractures. The majority of these ejectees with occult injury had multilevel injuries. Conclusion. This study confirms a high incidence of spinal fracture and particularly occult spinal injury

We aimed (1) to determine the factors which influence outcome after surgery for CES and (2) to study CES MRI measurements. 56 patients with evidence of a sphincteric disturbance who underwent urgent surgery (1994-2002) were identified and invited to clinic. 31 MRIs were available for analysis and randomised with 19 MRIs of patients undergoing discectomy for persistent radiculopathy. Observers estimated the percentage of spinal canal compromise and indicated whether they thought the scan findings could produce CES and whether the discs looked degenerate. Measurements were repeated after two weeks. (1) 42 patients attended (mean follow up 60 months; range 25–114). Mean age at onset was 41 years (range 24–67). 26 patients were operated on within 48 hours of onset. Acute onset of sphincteric symptoms and the time to operation did not influence the outcomes. Leg weakness at onset persisted in a significant number at follow-up (p<0.005). Bowel disturbance at presentation was associated with sexual problems (<0.005) at follow-up. Urinary disturbance at presentation did not affect the outcomes. The 13 patients who failed their post-operative trial without catheter had worse outcomes. The SF36 scores at follow-up were reduced compared to age-matched norms in the population. The mean ODI was 29, LBOS 42 and VAS 4.5. (2) No significant correlations were found between MRI canal compromise and clinical outcome. There was moderate to substantial agreement for intra- and inter-observer reproducibility. Conclusions. Due to small numbers we cannot make the conclusion that delay to surgery influences outcome. Based on the SF36, LBOS and ODI scores, patients who have had CES do not return to a normal status. Using MRI alone, the correct identification of CES has sensitivity 68%, specificity 80% positive predictive value 84% and negative predictive value 60%. CES occurs in degenerate discs

Neck pain can be caused by pressure on the spinal cord or nerve roots from bone or disc impingement. This can be treated by surgically decompressing the cervical spine, which involves excising the bone or disc that is impinging on the nerves or widening the spinal canal or neural foramen. Conventional practise is to fuse the adjacent intervertebral joint after surgery to prevent intervertebral motion and subsequent recompression of the spinal cord or nerve root. However fusion procedures cause physiological stress transfer to adjacent segments which may cause Adjacent Segment Degeneration (ASD), a rapid degeneration of the adjacent discs due to increased stress. ASD is more likely to occur in fusions of two or more levels than single level fusions and is more common where there is existing degeneration of the adjacent discs, which is not unusual in people over 30 years of age. Partial dynamic stabilisation, which generally involves a semi-rigid spinal fixation, allows a controlled amount of intervertebral motion (less than physiological, but more than fusion) to prevent increased stress on the adjacent segments (potentially preventing ASD) whilst still preventing neural recompression. Partial dynamic stabilisation is suitable for treating spinal instability after decompression as well as certain degenerative instabilities and chronic pain syndromes. Dynamic stabilisation and semi-rigid fixation systems for the spine are typically fixated posteriorly. However, choice of posterior surgical stabilisation techniques in the cervical spine is limited due to the size of the osseous material available for fixation and the close proximity of the neural structures and the vertebral artery. Posterior dynamic stabilisation systems for stabilisation of the lumbar spine often use the pedicle as an anchor point. Using the pedicle of the cervical spine as an anchor point is technically difficult because of its small size, angulation and proximity to neurovascular structures. Therefore, one of the main challenges to provide stabilisation in the cervical spine is the limitations of the anatomy. This presentation will introduce a novel spinal implant (patent pending) which is proposed for the cervical spine to provide partial dynamic stabilisation in the C3 to T1 region from a posterior approach. The implant is a single unit with a safe and technically simple insertion technique into the lateral masses. The implant uses a simple mechanism to allow limited intervertebral motion at each instrumented level. It is hoped that the simplicity of the device and removing the need to provide a bone graft anteriorly may reduce the cost of the procedure compared to traditional fusion and competing surgeries

Purpose. Degenerative changes of the lumbar motion segment often lead to stenosis of the spinal canal or neuroforamen. Axial lumbar interbody fusion (AxiaLIF) is intended to indirectly increase and stabilize foraminal dimensions by restoring disc height in patients with degenerative disc disease, thereby relieving axial and radicular pain. Therefore, this study investigated the effects of AxiaLIF on anterior disc height, posterior disc height, foraminal height and foraminal width as well as to determine the effectiveness of this minimally-invasive technique for indirect decompression and restoration of disc height. Method. Eighty-one patients who underwent a 360 degree lumbar interbody fusion at L4-S1 and L5-S1 with AxiaLIF between November 2008 and May 2010 and satisfied all inclusion criteria were included. The preoperative and three-month postoperative digital radiographs were reviewed and analyzed. Disc heights were measured in the planes of the anterior and posterior surfaces of the adjacent vertebral bodies. Foraminal height was measured as the maximum distance between the inferior margin of the pedicle of the superior vertebra and the superior margin of the pedicle of the inferior vertebra. Foraminal width was measured as the shortest distance between the edge of the superior facet of the caudal vertebra and the posterior edge of inferior endplate of the cranial vertebra. Potential magnification error between pre- and post-operative radiographs was corrected using the anterior vertebral height of L5 vertebra. Results. Our study shows that there is a mean increase of 42.0% in posterior disc height (PDH) at L4-5 and 21.5% in anterior disc height (ADH) at L4-5 and PDH mean increase of 33.6% and 16.3% in ADH at L5-S1 in two-level AxiaLIF cases. Similarly the mean change in foraminal height (FH) was 12.6% at L4-5 and 10.8% at L5-S1 in 2-levels AxiaLIF. The mean change in foraminal width (FW) at L4-L5 was 19.9% and 29.1% at L5-S1 in 2-levels AxiaLIF. In the single level AxiaLIF group, the mean change in PDH was 43.1%, the ADH change was 17.5%, the average change in FH was 14.4%, and mean change in FW was 25.3%. The change is reflected as a percentage of the preoperative value. All changes from preoperative to postoperative values were statistically significant. Conclusion. AxiaLIF appears to be an effective minimally invasive device to increase disc height and neuroforaminal area. Our findings appear equivalent to anterior lumbar interbody fusion and transforaminal lumbar interbody fusion in terms of indirect decompression and increase in disc height. This, in combination with the added benefit of preserving the annulus, anterior longitudinal ligament, and posterior longitudinal ligament, suggests the AxiaLIF is an excellent alternative for this patient population. However, additional follow-up studies are necessary to confirm the long-term ability of the implant to maintain fusion and preserve the improvements in disc and foraminal area

We reviewed 234 benign solitary schwannomas treated between 1984 and 2004. The mean age of the patients was 45.2 years (11 to 82). There were 170 tumours (73%) in the upper limb, of which 94 (40%) arose from the brachial plexus or other nerves within the posterior triangle of the neck. Six (2.6%) were located within muscle or bone. Four patients (1.7%) presented with tetraparesis due to an intraspinal extension.

There were 198 primary referrals (19 of whom had a needle biopsy in the referring unit) and in these patients the tumour was excised. After having surgery or an open biopsy at another hospital, a further 36 patients were seen because of increased neurological deficit, pain or incomplete excision. In these, a nerve repair was performed in 18 and treatment for pain or paralysis was offered to another 14.

A tender mass was found in 194 (98%) of the primary referrals. A Tinel-like sign was recorded in 155 (81%). Persistent spontaneous pain occurred in 60 (31%) of the 194 with tender mass, impairment of cutaneous sensibility in 39 (20%), and muscle weakness in 24 (12%).

After apparently adequate excision, two tumours recurred. No case of malignant transformation was seen.