Osteoarthritis (OA) is a disease of the synovial joint with synovial inflammation, capsular contracture, articular cartilage degradation, subchondral sclerosis and osteophyte formation contributing to pain and disability. Transcriptomic datasets have identified genetic loci in hip and knee OA demonstrating joint specificity. A limited number of studies have directly investigated transcriptional changes in shoulder OA. Further, gene expression patterns of periarticular tissues in OA have not been thoroughly investigated. This prospective case control series details transcriptomic expression of shoulder OA by analysing periarticular tissues in patients undergoing shoulder replacement for OA as correlated with a validated patient reported outcome measure of shoulder function, an increasing (clinically worsening) QuickDASH score. We then compared transcriptomic expression profiles in capsular tissue biopsies from the OA group (N=6) as compared to patients undergoing shoulder stabilisation for recurrent instability (the control group, N=26). Results indicated that top ranked genes associated with increasing QuickDASH score across all tissues involved inflammation and response to stress, namely interleukins, chemokines, complement components, nuclear response factors and immediate early response genes. Some of these genes were upregulated, and some downregulated, suggestive of a state of flux between inflammatory and anti-inflammatory signalling pathways. We have also described gene expression pathways in shoulder OA not previously identified in hip and knee OA, as well as novel genes involved in shoulder OA

Knowledge of the premorbid glenoid shape and the morphological changes the bone undergoes in patients with glenohumeral arthritis can improve surgical outcomes in total and reverse shoulder arthroplasty. Several studies have previously used scapular statistical shape models (SSMs) to predict premorbid glenoid shape and evaluate glenoid erosion properties. However, current literature suggests no studies have used scapular SSMs to examine the changes in glenoid surface area in patients with glenohumeral arthritis. Therefore, the purpose of this study was to compare the glenoid articular surface area between pathologic glenoid cavities from patients with glenohumeral arthritis and their predicted premorbid shape using a scapular SSM. Furthermore, this study compared pathologic glenoid surface area with that from virtually eroded glenoid models created without influence from internal bone remodelling activity and osteophyte formation. It was hypothesized that the pathologic glenoid cavities would exhibit the greatest glenoid surface area despite the eroded nature of the glenoid and the medialization, which in a vault shape, should logically result in less surface area. Computer tomography (CT) scans from 20 patients exhibiting type A2 glenoid erosion according to the Walch classification [Walch et al., 1999] were obtained. A scapular SSM was used to predict the premorbid glenoid shape for each scapula. The scapula and humerus from each patient were automatically segmented and exported as 3D object files along with the scapular SSM from a pre-operative planning software. Each scapula and a copy of its corresponding SSM were aligned using the coracoid, lateral edge of the acromion, inferior glenoid tubercule, scapular notch, and the trigonum spinae. Points were then digitized on both the pathologic humeral and glenoid surfaces and were used in an iterative closest point (ICP) algorithm in MATLAB (MathWorks, Natick, MA, USA) to align the humerus with the glenoid surface. A Boolean subtraction was then performed between the scapular SSM and the humerus to create a virtual erosion in the scapular SSM that matched the erosion orientation of the pathologic glenoid. This led to the development of three distinct glenoid models for each patient: premorbid, pathologic, and virtually eroded (Fig. 1). The glenoid surface area from each model was then determined using 3-Matic (Materialise, Leuven, Belgium). Figure 1. (A) Premorbid glenoid model, (B) pathologic glenoid model, and (C) virtually eroded glenoid model. The average glenoid surface area for the pathologic scapular models was 70% greater compared to the premorbid glenoid models (P < 0 .001). Furthermore, the surface area of the virtual glenoid erosions was 6.4% lower on average compared to the premorbid glenoid surface area (P=0.361). The larger surface area values observed in the pathologic glenoid cavities suggests that sufficient bone remodelling exists at the periphery of the glenoid bone in patients exhibiting A2 type glenohumeral arthritis. This is further supported by the large difference in glenoid surface area between the pathologic and virtually eroded glenoid cavities as the virtually eroded models only considered humeral anatomy when creating the erosion. For any figures or tables, please contact the authors directly

Osteoarthritis (OA) is a chronic degenerative joint disease with cartilage degeneration, subchondral bone sclerosis, synovial inflammation and osteophyte formation. Sensory nerves play an important role in bone metabolism and in the progression of inflammation. This study explored the effects of capsaicin-induced sensory nerve denervation on OA progression in mice. This study was approved by the Institutional Animal Care and Use Committee. OA was induced via destabilization of the medial meniscus (DMM). Sensory denervation was induced by subcutaneous injection of capsaicin (90mg/kg) one week prior to DMM. One week after capsaicin injection, sensory denervation in the tibia was confirmed by immunofluorescent staining with calcitonin gene-related peptide (CGRP)-specific antibodies. Four weeks after DMM, micro-CT scans, histological analysis and RT-PCR tests were performed to evaluate OA progression. Statistical analysis was performed using SPSS 13. P values of less than 0.05 were considered statistically significant. Subcutaneous injection of capsaicin successfully induced tibial sensory denervation (n=3), which aggravated OA by increasing subchondral bone resorption. The Osteoarthritis Research Society International (OARSI) score of the capsaicin+DMM group (n=8) (11.81±2.92) was significantly higher (P=0.003) than the score of the vehicle+DMM group (n=8) (8.31±1.80). The BV/TV of the tibial subchondral bone in the capsaicin+DMM group (n=8) was 55.67%±3.08, which was significantly lower (P < 0 .001) than in the vehicle+DMM group (n=8) (86.22%±1.92). In addition, the level of expression of somatostatin in the capsaicin+DMM group (n=8) was lower than in the vehicle+DMM group (n=8) (P=0.007). Capsaicin-induced sensory denervation increased tibial subchondral bone resorption, reduced the expression of somatostatin and eventually exacerbated the existing cartilage degeneration in mice. Despite capsaicin is often used clinically to relieve OA pain, its safety is still controversial according to the OARSI guidelines for the non-surgical management of knee osteoarthritis. The findings of our study suggest that application of capsaicin, although effective in relieving pain, may accelerate the progression of existing OA

Introduction. Hip resurfacing arthroplasty has been surgical options in younger and more active patients with osteoarthritis (OA) and osteonecrosis (ON) of the femoral head. Although excellent midterm results of this procedure have been reported, there is a concern about postoperative impingement between the preserved femoral neck and the acetabular component. There were few reports about kinematics after hip resurfacing. Therefore, the purpose of this study was to investigate the postoperative motion analysis after hip resurfacing using a noble dynamic flat-panel detector (FPD) system by which clear sequential images were obtained with low dose radiation exposure. Materials and methods. 11 patients (mean age: 47.8 ± 7.4), 15 hips were included in this study. There were ten men and one woman. The preoperative diagnoses were ON of the femoral head in 10 hips, OA in 3 hips, and others in 2 hips. Mean postoperative follow-up period was 25.1 ± 21.6 months. Femoral anteversion, cup inclination and cup anteversion were measured on computed tomography and plain radiograph. Impingement signs such as the reactive osteophyte formation and divot around the femoral neck were also investigated on the anteroposterior (AP) and lateral radiographs. Sequential images of active and passive flexion motion in 45-degrees semilateral position, and active abduction motion in a supine position were obtained using a noble dynamic FPD system. Results. Mean femoral anteversion was 13.2° ± 9.1° and mean cup inclination and anteversion were 35.4° ± 2.3° and 6.8° ± 3.9°, respectively. The reactive osteophyte formation apeared in 1 hip (6.7%) on AP radiograph and 4 hips (26.7%) on lateral radiograph, and divot sign was observed in 1 hip (6.7%) on each radiographs. The location of the impingement signs were mostly observed at the anteroinferior portion of the femoral neck. In motion analysis, impingement between the femoral neck and the acetabular component was detected in 12 hips (80.0%) in flexion motion and 2 hips (13.3%) in abduction motion (Figure). There were no findings of the subluxation between the acetabular and femoral component after the impingement, but cooperative motion of lumber and pelvic flexion was occurred. None of the patients who had a impingement signs on plain radiographs and motion analysis had any symptoms and pain during hip motion. Discussion and conclusion. Postoperative motion analysis is a noble and useful technique and that can detect various findings which could not be detected by the routine static radiographs. Also, postoperative kinematics after hip resurfacing remains unknown and we investigated it in detail using a noble dynamic FPD system. The present study indicated that impingement between the preserved femoral neck and the acetabular component and consequent cooperative motion of lumber and pelvic flexion were similar to the physiological motion of the nomal hip joint. No sign of the subluxation between the component proved the good stability of the resurfacing articulation. Proprioception of the preserved femoral neck can be related to this unique kinematics

Flexion contractures are a common finding in an end-stage arthritic knee, occurring in up to 60% of patients undergoing total knee arthroplasty. Fixed flexion deformities may result from posterior capsular scarring, osteophyte formation, and bony impingement. It is essential to correct this deformity at the time of total knee arthroplasty, as a residual flexion contracture will result in joint overload and abnormal gait mechanics. This may translate to a slower walking velocity, shorter stride length, and pain. This presentation will discuss a systematic way of dealing with flexion contractures to ensure that the total knee arthroplasty will achieve full extension. The surgical technique for treating fixed flexion deformity about the knee includes release of the posterior cruciate ligament, posterior capsular release, adequate distal femoral bone resection, and removal of osteophytes. Postoperatively, attention must be divided between obtaining maximal flexion and full extension. Should a flexion contracture be noted upon the postoperative visit, additional measures should be taken to address it

Flexion contractures are a common finding in an end-stage arthritic knee, occurring in up to 60% of patients undergoing total knee arthroplasty. Fixed flexion deformities may result from posterior capsular scarring, osteophyte formation, and bony impingement. It is essential to correct this deformity at the time of total knee arthroplasty, as a residual flexion contracture will result in joint overload and abnormal gait mechanics. This may translate to a slower walking velocity, shorter stride length, and pain. This presentation will discuss a systematic way of dealing with flexion contractures to ensure that the total knee arthroplasty will achieve full extension. The surgical technique for treating fixed flexion deformity about the knee includes release of the posterior cruciate ligament, posterior capsular release, adequate distal femoral bone resection, and removal of osteophytes. Post-operatively, attention must be divided between obtaining maximal flexion and full extension. Should a flexion contracture be noted upon the post-operative visit, additional measures should be taken to address it

Introduction. The first carpometacarpal (CMC) joint is the second most common joint of the hand affected by degenerative osteoarthritis (OA). 1. Laxity of ligamentous stabilizers that attach the first metacarpal bone (MC1) and the trapezium bone (TZ), notably the volar anterior oblique ligament (AOL), has been associated with cartilage wear, joint space narrowing, osteophyte formation, and dorsal-radial CMC subluxation. 2. In addition, the proximal-volar end of the MC1 has a bony prominence known as the palmar lip (PL) that adds conformity to this double-saddle joint, and is thought to be a supplemental dorsal stabilizer. Currently, no study has looked at the changes to the 3D shape and relative positions of these structures with OA. Methods. CT scans of patients with clinically diagnosed CMC OA (n=11, mean age 73 [60–97], 8 females) and CT scans of ‘normal’ patients with no documented history of CMC OA (n=11, mean age 37 [20–51], 6 females) were obtained with the hand in a prone position. 3D reconstructions of the MC1 and TZ bones were created, and each assigned a coordinate system. 3. The long axis of the MC1 and the proximal-distal axis of the TZ were established, and the location where they intersected the CMC articular surface was defined as their articular center points, X and O, respectively (Figure 1). Using the TZ as a fixed reference, we calculated the relative position of X in the dorsal-ventral and radial-ulnar directions. A two sample t-test was performed to compare the normal and OA groups. In addition, the distal position of the PL relative to X was recorded. Results. The dorsal position of the MC1 relative to the TZ was significantly greater (p=0.002) in the OA group compared with the normal group, with mean dorsal positions of 7.1 and 3.2mm, respectively (Figure 2). The distal position of the PL relative to X was also significantly greater (p=0.001) in the OA group when compared with the normal group, with mean positions of 5.8 and 1.9mm, respectively (Figure 3). Discussion. Dorsal migration of the MC1 in the OA group would suggest a compromised AOL, known to be elongated or absent intraoperatively. Without a sufficient AOL, the PL was positioned more distally in the OA group, as the load on the PL during extension activities could possibly exceed cartilage strength resulting in subchondral bone remodeling and further joint degeneration. We did not observe radial migration of the MC1 bone possibly due to the presence of bony osteophytes that can reduce abduction-adduction function in OA patients. 4. The relationship discovered between OA and changes to bone morphology and relative bone positions of the CMC joint may provide further insight into the natural progression of this disease

Introduction. The purpose of this retrospective study was to review the outcome of THA in the treatment of bilateral hip ankylosis of different causes; surgical, septic or spontaneous. Methods & Material. 20 THA procedures in 10 patients were included in the study, 5 males and 5 females all had bilateral fusion. Previous pathologies included: ankylosing spondylitis, AVN, septic arthritis and surgical arthrodesis. Flexion deformity ranged (10°-45°). Shortening as compared to normal anatomy was up to 6 cm and leg length discrepancy (LLD) ranged from 1 cm to 2.5 cm. Most unified X-ray finding was massive osteophytes formation with 3 patients showing severe narrowing of the femoral canal. Operative time averaged 147 minutes (70–210) and lateral approach was used in all patients, anesthesia was general with only 3 undergoing spinal anesthesia. Results. Serious complications were reported and were related to the correction of LLD; 1 incidence of sciatic nerve injury that recovered in one year, and another incidence of femoral nerve injury (sensory > motor) that recovered within 3 months, and one case of incomplete correction of LLD. At 5 years follow up (minimum 6 month), there is no loosening or revision. Discussion. The conversion of bilateral fused hip joints to THA is a very rewarding surgery but with higher risk of complications

INTRODUCTION. In total hip arthroplasty, preoperative planning is almost indispensable. Moreover, 3-dimensional preoperative planning became popular recently. Anteversion management is one of the most important factors in preoperative planning to prevent dislocation and to obtain better function. In arthritic hip patients osteophytes are often seen on both femoral head and acetabulum. Especially on femoral head, osteophytes are often seen at posterior side and its surface creates smooth round contour that assumes new joint surface. (Fig. 1). We can imagine new femoral head center tracing that new joint surface. OBJECTIVES. In the present study, the posterior osteophytes are compared in osteoarthritic patients and other patients. MATERIALS & METHODS. Anteversion and new anteversion which was reduced by osteophyte formation were assessed in 28 hip CAT scans, (22 arthritic hips, 6 avascular necrotic hips). RESULTS. Only in arthritic patients, osteophytes on posterior side were observed. The anteversion was 33.7+/− 13.0 degree in arthritic patients, which was reduce to 29.7+/−13.1 degree. The mean difference was 4.0+/−4.7 degree reduction. In AVN patients the mean anteversion was 21.4 +/− 9.40 in AVN patients. No reduction was observed in AVN patients. DISCUSSION. Osteophytes are often created to make the biomechanical situation better. This phenomenon is possiblly explained that those posterior osteophytes have been formed for proper reduction of excessive anteversion

Post-traumatic avascular necrosis of the femoral head usually occurs after hip dislocation and femoral neck fracture. Recently along the development of hip arthroscopy, early stage of avascular necrosis of the femoral head can be treated rthroscopically. We hereby present two cases of post-traumatic avascular necrosis patients treated with hip arthroscopy. Case 1. Twenty one year old female patient came to the hospital because of fall from height of 3 floors. Left acetabular fracture, both superior pubic rami fractures and severely displaced left femoral neck fracture were identified at the emergency department (Fig. 1-A). She underwent surgery at the injury day. After the repair of ruptured urinary bladder, internal fixation of the femoral neck was done. Four cannulated screws with washers were inserted for displaced femoral neck fracture, consistent with garden stage IV (Fig. 1-B). Skeletal traction of ipsilateral lower extremity was applied four weeks after the surgery for acetabular fracture. She visited us for painful limitation of motion on left hip at eight months postoperatively. Plain radiograph showed collapse of femoral head and osteophyte formation which were caused by post-traumatic avascular necrosis (Fig. 1-C,D). Femoral head was perforated by a screw. She was planned to remove the screw and resect the osteophyte arthroscopically. On arthroscopic examination, severe synovitis and folded, collapsed femoral cartilage were identified (Fig. 1-E). Screws were removed and osteophyte were also resected (Fig. 1-F). We filled the cavity caused by the screws with allogenic strut graft for structural support. After the surgery, pain was relieved and she came back to her active daily living and for six months, no other complication nor further collapse were identified postoperatively. Case 2. Fourty year old male patient was admitted to the hospital for fall from height about fifteen feet from the ground. Left femoral neck fracture was identified on the emergency department. Previously he had underwent intramedullary nailing for the femoral shaft fracture about five years ago. Urgent internal fixation with four cannulated screws was done on the day of injury. The fixation was unsatisfactory because previously inserted intramedullary nail hindered the proper trajectory of screws. Furthermore, direction of cephalad interlocking holes of the nail were not consistent with the anteversion of femoral neck, we could not place the screws through the nail. Four months after the index surgery, collapse of femoral head and loosening of screws have occurred. MRI showed the collapse of femoral head and posttraumatic avascular necrosis. Prominent bony beak of femoral neck were identified and he complained difficulty and pain on his hip during abduction. We left two screws for secure fixation and resected the bony beak using arthroscopic burr. After the surgery, he felt free from the pain on abduction of hip. Discussion. Even though collapse of the femoral head is identified, early intervention by the arthroscopy could minimize pain or delay the progression of arthritic change. Authors think that it might be helpful for the young adult patients in terms of pain relief and potential delay of the total hip arthroplasty

Introduction. Coronal plane deformity can pose difficulties with balancing in Total Ankle Replacement (TAR). Current reports outline improved outcomes in the presence of varus deformity. Soft tissue balancing techniques are well described, but are limited by no link to eitiology and pathoanatomy of the deformity. Method. A prospective review of all the TAR by the senior author was performed to identify cases of pre-operative varus greater than 10°. A chart review was performed to identify aetiology, intraoperative findings, and operative techniques to achieve a balanced TAR. X-rays were examined to measure deformity and amount of correction. Volumetric rendering and segmentalisation was performed on pre- and post-CTs to identify anatomical defects, osteophyte formation, rotational and translational changes of the hindfoot joints. Results. Between January 2002 and January 2009 there were thirty-five cases from two hundred and thirty cases with varus deformity greater than 10°, with an average 17° varus angle (range 10° to 30°). Multiple sprains and instability over several years was seen in 62% of patients. Clinically, increasing varus was associated with cavovarus foot position. Incongruent deformities had intact tibial plafond. Congruent deformities had tibial defects in the anteromedial tibial plafond and associated anterolateral tibial ostephyte. Increasing deformity often had lateral fibula osteophytes and ossicles between fibula osteophyte and anterolateral talar body. In more severe cases, 3D analysis showed the talus was anteriorly displaced and internally rotated. Post operative alignment improved from 17° to 1.5°. Conclusion. Understanding the pathoanatomy of the arthritic ankle with coronal plane deformity can help plan the surgical techniques required to correct this often challenging surgical reconstruction

Treatment for osteoarthritis (OA) has traditionally focused on joint replacement for end-stage disease. An increasing number of surgical and pharmaceutical strategies for disease prevention have now been proposed. However, these require the ability to identify OA at a stage when it is potentially reversible, and detect small changes in cartilage structure and function to enable treatment efficacy to be evaluated within an acceptable timeframe. This has not been possible using conventional imaging techniques but recent advances in musculoskeletal imaging have been significant. In this review we discuss the role of different imaging modalities in the diagnosis of the earliest changes of OA. The increasing number of MRI sequences that are able to non-invasively detect biochemical changes in cartilage that precede structural damage may offer a great advance in the diagnosis and treatment of this debilitating condition.

Cite this article: Bone Joint J 2013;95-B:738–46.