Background. Adequate rotation of femoral component in total knee arthroplasty(TKR) is mandatory for preventing numerous adverse sequelae. The transepicondylar axis has been a well-accepted reference for femoral component rotation in the measured resection technique. In this technique, measured resection is performed referenced off the tibial cut - perpendicular to the tibial mechanical axis with the knee in 90 ° of flexion. However, to the best of our knowledge, it is not known whether this technique apply well to a knee with tibia vara. This study evaluates the reliability of the transepicondylar axis as a rotational landmark in knees with tibia vara. Methods. We selected 101 osteoarthritis knees in 84 symptomatic patients(mean age: 69.24 ± 5.68) with proximal tibia vara (Group A). Group A was compared with 150 osteoarthritic knees without tibia vara in 122 symptomatic patients (mean age: 69.51 ± 6.01) (Group B). The guide line for selection of all these knees were based on the degree of tibia vara angle (TVA) which was formed by line perpendicular to epiphysis and by anatomical axis of the tibia - all measured in radiographs of the entire lower limb.