Introduction: Limb salvage through a total femur (TOFEM) prosthesis is a rare procedure. The infection rate is high due to the large implant surface, a long OR-time and often severely compromised soft tissues. In case of infection the one stage procedure is the way of revision to avoid impairing instability for the patient.

Material + Methods: Between 1996 and 2005 46 one stage exchanges were performed in 37 patients. 23 patients were available for review in 2006. 13 had died, 1 could not be located. The infection-free periods, subjective satisfaction with the procedure and clinical outcome were evaluated. The average follow-up time (FU) was 46 months (8/104). Male/female ratio 10/27, average age 66 yrs. (30/87). The average number of revisions before the TOFEM was 5 (1/11).

Indication for a TOFEM was fracture in 43%, bone loss in 51% and others in 6 %. Infection occurred at primary intervention in 32%, in connection with revisions in 18% or delayed in 49%.

Results: 16 Patients were cured in a one step procedure. 10 Patients underwent further revisions. Two or more exchanges were carried out in 6 cases with success. Patient’s satisfaction rate was 55%. 13 were valued unsatisfied. 8 exarticulations became necessary later and 5 Patients died in the course of the treatment. 2 of those were exarticulated before.

Conclusion: One stage exchange is a promising procedure avoiding loss of the limb. A high complication rate exists and secondary exarticulation may still become necessary.

Summary: The infectious complication in total femur prosthesesis presents a severe problem. A one stage revision offers another good chance for limb salvage, but morbidity and mortality risks are high.