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Bone & Joint Research
Vol. 12, Issue 4 | Pages 245 - 255
3 Apr 2023
Ryu S So J Ha Y Kuh S Chin D Kim K Cho Y Kim K

Aims. To determine the major risk factors for unplanned reoperations (UROs) following corrective surgery for adult spinal deformity (ASD) and their interactions, using machine learning-based prediction algorithms and game theory. Methods. Patients who underwent surgery for ASD, with a minimum of two-year follow-up, were retrospectively reviewed. In total, 210 patients were included and randomly allocated into training (70% of the sample size) and test (the remaining 30%) sets to develop the machine learning algorithm. Risk factors were included in the analysis, along with clinical characteristics and parameters acquired through diagnostic radiology. Results. Overall, 152 patients without and 58 with a history of surgical revision following surgery for ASD were observed; the mean age was 68.9 years (SD 8.7) and 66.9 years (SD 6.6), respectively. On implementing a random forest model, the classification of URO events resulted in a balanced accuracy of 86.8%. Among machine learning-extracted risk factors, URO, proximal junction failure (PJF), and postoperative distance from the posterosuperior corner of C7 and the vertical axis from the centroid of C2 (SVA) were significant upon Kaplan-Meier survival analysis. Conclusion. The major risk factors for URO following surgery for ASD, i.e. postoperative SVA and PJF, and their interactions were identified using a machine learning algorithm and game theory. Clinical benefits will depend on patient risk profiles. Cite this article: Bone Joint Res 2023;12(4):245–255


Bone & Joint Research
Vol. 11, Issue 1 | Pages 8 - 9
7 Jan 2022
Walter N Rupp M Baertl S Ziarko TP Hitzenbichler F Geis S Brochhausen C Alt V




Bone & Joint Open
Vol. 3, Issue 10 | Pages 804 - 814
13 Oct 2022
Grammatopoulos G Laboudie P Fischman D Ojaghi R Finless A Beaulé PE

Aims

The primary aim of this study was to determine the ten-year outcome following surgical treatment for femoroacetabular impingement (FAI). We assessed whether the evolution of practice from open to arthroscopic techniques influenced outcomes and tested whether any patient, radiological, or surgical factors were associated with outcome.

Methods

Prospectively collected data of a consecutive single-surgeon cohort, operated for FAI between January 2005 and January 2015, were retrospectively studied. The cohort comprised 393 hips (365 patients; 71% male (n = 278)), with a mean age of 34.5 years (SD 10.0). Over the study period, techniques evolved from open surgical dislocation (n = 94) to a combined arthroscopy-Hueter technique (HA + Hueter; n = 61) to a pure arthroscopic technique (HA; n = 238). Outcome measures of interest included modes of failures, complications, reoperation, and patient-reported outcome measures (PROMs). Demographic, radiological, and surgical factors were tested for possible association with outcome.


The Bone & Joint Journal
Vol. 105-B, Issue 5 | Pages 474 - 480
1 May 2023
Inclan PM Brophy RH

Anterior cruciate ligament (ACL) graft failure from rupture, attenuation, or malposition may cause recurrent subjective instability and objective laxity, and occurs in 3% to 22% of ACL reconstruction (ACLr) procedures. Revision ACLr is often indicated to restore knee stability, improve knee function, and facilitate return to cutting and pivoting activities. Prior to reconstruction, a thorough clinical and diagnostic evaluation is required to identify factors that may have predisposed an individual to recurrent ACL injury, appreciate concurrent intra-articular pathology, and select the optimal graft for revision reconstruction. Single-stage revision can be successful, although a staged approach may be used when optimal tunnel placement is not possible due to the position and/or widening of previous tunnels. Revision ACLr often involves concomitant procedures such as meniscal/chondral treatment, lateral extra-articular augmentation, and/or osteotomy. Although revision ACLr reliably restores knee stability and function, clinical outcomes and reoperation rates are worse than for primary ACLr.

Cite this article: Bone Joint J 2023;105-B(5):474–480.


The Bone & Joint Journal
Vol. 103-B, Issue 12 | Pages 1754 - 1758
1 Dec 2021
Farrow L Zhong M Ashcroft GP Anderson L Meek RMD

There is increasing popularity in the use of artificial intelligence and machine-learning techniques to provide diagnostic and prognostic models for various aspects of Trauma & Orthopaedic surgery. However, correct interpretation of these models is difficult for those without specific knowledge of computing or health data science methodology. Lack of current reporting standards leads to the potential for significant heterogeneity in the design and quality of published studies. We provide an overview of machine-learning techniques for the lay individual, including key terminology and best practice reporting guidelines.

Cite this article: Bone Joint J 2021;103-B(12):1754–1758.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 500 - 501
1 Nov 2011
Parent S Deschênes S Charron G Beaudoin G Labelle H Miron M Dubois J
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Purpose of the study: Recent studies have shown that the incidence of certain cancers would be due to ionising radiation received during diagnostic radiological explorations. It is thus important to optimise dosimetry. In this context, slot scanners have demonstrated potential for generating images with a quality comparable with conventional systems but with a considerable reduction in dose. We wanted to verify this proposition. Material and method: Radiographs were obtained in 50 scoliosis patients (posteroanterior and lateral incidences) using the slot scanner (EOS, Biospace) and with a conventional machine (FCR-7501S, Fuji). A dosimeter was placed on the patient after each exam. Phantoms were used to adjust radiographic parameters for each system in order to obtain comparable quality images. Patient images were then acquired ad the dose calculated at several entry points. These measures were used to compare skin radiation and to initialise a Monte-Carlo simulation calculating the effective dose. Two orthopaedic surgeons and two radiologists then evaluated the visibility of the structures of interest using a standard check list. They read the images in random order and were blinded to all information concerning the patient and the system used to acquire the images. Visibility was noted on a non-parametric scale with 4 levels. Wilcoxon’s test was used to compare the visibility scores. Results: Mean radiation of the skin in the thoracoab-dominal region varied from 0.11 to 0.30 mGy (effective dose 0.057 mSv) for the EOS and 0.73 to 2.47 mGy (effective dose 0.460 mSv) for the FCR-7501S. EOS provided significantly superior visibility for all structures (frontal view, p< 0.006), lateral view p< 0.04) except for the posterior arch of the lumbar vertebrae in the lateral view for which visibility was superior for FCR-7501S (p< 0.003). Discussion: Using the slot scanner, the patients received 6 to 9 times less radiation to the skin for the thoracoab-dominal region and an 8-fold reduction in effective dose than with the conventional system. In addition, the doses presented in the literature for the same exam are much higher than reported for EOS. Conclusion: The EOS slot scanner offers image quality which is globally superior to conventional systems while considerably reducing radiation dose


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 268 - 268
1 May 2006
Gaffey A Wellings R
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Pre-operative planning for limb deformity correction involves detailed imaging of the lower limb to define the level, magnitude and direction of deformity. This is then used to plan the correction by defining the centre of rotational alignment (CORA). The method as described by Paley and Hertzenberg involves the use of orthogonal radiographs of the lower limbs using long cassettes (130 cm) taken from a distance of 305 cm to minimize magnification. This method requires special equipment, trained radiographers and multiple doses of radiation even when each radiograph was perfectly positioned first time every time. We present a work in progress replacing the radiographs with a “virtual 3D” CT dataset of the lower limb which we hope will improve the ability to pre-operatively plan deformity correction, but at a lower cost in terms of skill, equipment and dose. Whole limb CT is too costly in terms of time and radiation dose for this to be suitable. New multislice CT systems allow a single coherent study to include segments of unscanned data. Thus it is possible to run a single series through a lower limb to include the articular surfaces, but excluding the diaphyseal segments (gaps). This reduces the radiation exposure to the patient. Such data when entered into suitable DICOM image manipulation software allows the Radiologist or Surgeon to measure and assess the deformity with great precision. Such software is available on the diagnostic radiology workstations but is also available for personal computers, allowing the Surgeon to perform preoperative planning in a numerical modeling setting. Allowing the elements of length, rotation, translation and angulation of the deformity to be measured and corrective surgery tested on the mathematical model. We have compared the measurements taken from a deformity model using this new CT approach and compared it to standard radiographs and found that the above method is no less accurate. Rotational deformities are easier to estimate. However the advantage of our method is that the dataset can be manipulated to determine other technical aspects of deformity correction such as calculating the mounting parameters of the Talyor Spatial Frame. We present worked examples of the methodology showing how this technique improves deformity appraisal


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 348 - 348
1 Sep 2005
Hunt D Ji B
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Introduction and Aims: A number of x-ray appearances have been identified as indicative of discoid menisci. None are reliable or statistically significant. The purpose of this paper is to identify a reliable radiographic sign, diagnostic of the discoid lateral meniscus. Method: The anteroposterior view radiographs of 14 knees in 13 patients with arthroscopically proven discoid meniscus were studied. Ages ranged from 11 to 26, with a mean age of 18.4 ± 4.84 years, right to left ratio 9/5, male to female ratio 8/5. Fifteen normal knees in 14 people were used as a control group, age from 11 to 30, mean age 16.20 ± 6.41, right to left ratio 8/7, male to female ratio 6/8. The parameters measured were: Lateral Joint Space (LJS); Height of the Lateral Tibial Spine (LTS); change of the Medial Tibial Spine (MTS); Height of Fibular Head (HFH); changes of the Edge of the Lateral Tibial Plateau (ELTP), cupping of the lateral tibial plateau, and squaring of the lateral femoral condyle. Results: There was no significant difference between the two groups in LJS, height of LTS, cupping of the lateral tibial plateau, and squaring off of the lateral femoral condyle. There was a difference between the two groups in HFH which was statistically significant at an absolute value of p = 0.033, but not significant in normalised value p = 0.056. The medial tibial spine was sharpened in three patients. There were 12 positive changes on ELTP out of 14 patients (85.71%) in the discoid group, while only one positive of 15 (6.67%) in the normal group, and the difference between the two groups was statistically significant at p< 0.01. The diagnosis parameters were Sensitivity (Se) = 85.71%, Specificity (Sp) = 93.33%, Positive predictive value (PV+) = 92.31%, Negative predictive value (PV−) = 87.50%, Correct rate (ñ) = 89.66%. The typical change on the edge of lateral tibial plateau is sharpening and/or formation of a spur. Conclusion: Sharpening with spur formation on the edge of lateral tibial plateau is a diagnostic radiological sign of a discoid lateral meniscus


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 50 - 50
1 Sep 2012
Roche A Selvaratnam V Mukhopadhaya S Unnikrishnan N Abiddin Z Narayan B Giotakis N Aniq H Nayagam S
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Introduction. The treatment of chronic osteomyelitis involves a debridement of affected non-viable tissue and the use of antibiotics. Where surgery leaves a cavity, dead space management is practised with antibiotic impregnated cement. These depots of local antibiotics are variable in elution properties and need removal. We review the use of bioabsorbable synthetic calcium sulphate as a carrier of gentamicin and as an adjunct in treating intramedullary osteomyelitis. Methods. A retrospective review of cases treated consecutively from 2006 to 2010 was undertaken. Variables recorded included aetiology, previous interventions, diagnostic criteria, radiological features, serology and microbiology. The Cierney-Mader system was used to classify. Treatment involved removal of implants (if any), intramedullary debridement and local resection (if needed), lavage and instillation of the gentamicin carrier, supplemented with systemic antibiotics. Follow-up involved a survival analysis to time to recurrence, clinical and functional assessment (AOFAS-Ankle/IOWA knee/Oxford Hip) and general health outcome (SF36). Results. There were 31 patients (22 male, 9 female). The mean age was 47 years (20–67). Twenty-five cases were post-surgery (6 open fractures) and 6 were haematogenous in origin. The median duration of osteomyelitis was 1.6yrs. The bones affected were 42% femur, 45% tibia, 3% radius and 10% humerus. 11 cases had diffuse as well as intramedullary involvement. 9 cases underwent segment resection and bone transport. We identified Staph. Aureus in 16 and Coag. Neg. Staph. in 6 cases. The median follow-up was 1.7 years (0.5–5.6). The median scores attained were: AOFAS-78, DASH-32, IOWA-71, Oxford-32. There were two recurrences. Discussion. Dead space management of intramedullary infections is difficult. We describe a method for delivery of local antibiotics and provide early evidence to its efficacy. The treatment success to date is 93%. Conclusion. Bioabsorbable carriers of antibiotics are efficacious adjuncts to surgical treatment of intramedullary osteomyelitis


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIV | Pages 17 - 17
1 Jul 2012
Roche A Selvaratnam V Mukhopadhaya S Unnikrishnan N Abiddin Z Narayan B Giotakis N Aniq H Nayagam S
Full Access

The treatment of chronic osteomyelitis involves a debridement of affected non-viable tissue and the use of antibiotics. Where surgery leaves a cavity, dead space management is practised with antibiotic impregnated cement. These depots of local antibiotics are variable in elution properties and need removal. We review the use of bioabsorbable synthetic calcium sulphate as a carrier of gentamicin and as an adjunct in treating intramedullary osteomyelitis. A retrospective review of cases treated consecutively from 2006 to 2010 in the Royal Liverpool University Hospital was undertaken. Variables recorded included aetiology, previous interventions, diagnostic criteria, radiological features, serology and microbiology. The Cierney-Mader system was used to classify. Treatment involved removal of implants (if any), intramedullary debridement and local resection (if needed), lavage and instillation of the gentamicin carrier, supplemented with systemic antibiotics. Follow-up involved a survival analysis to time to recurrence, clinical and functional assessment (AOFAS-Ankle/IOWA knee/Oxford Hip) and general health outcome (SF36). There were 31 patients (22 male, 9 female). The mean age was 47 years (20-67). Twenty-five cases were post-surgery (6 open fractures) and 6 were haematogenous in origin. The median duration of osteomyelitis was 1.6yrs. The bones affected were 42% femur, 45% tibia, 3% radius and 10% humerus. 11 cases had diffuse as well as intramedullary involvement. 9 cases underwent segment resection and bone transport. We identified Staphylococcus Aureus in 16 and Coagulase Negative Staphylococcus in 6 cases. The median follow-up was 1.7 years (0.5-5.6). The median scores attained were: AOFAS-78, DASH-32, IOWA-71, Oxford-32. There were two recurrences. Dead space management of intramedullary infections is difficult. We describe a method for delivery of local antibiotics and provide early evidence to its efficacy. The treatment success to date is 93%. Bioabsorbable carriers of antibiotics are efficacious adjuncts to surgical treatment of intramedullary osteomyelitis


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 233 - 233
1 Nov 2002
Anil A Dhami I Kumar S Nadkarni B Arora G Mathur N
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The diagnosis of painful heel syndrome is quite common in any busy orthopaedics OPD. Though neoplasm and infections are not uncommon in calcaneum, the surgeon does not suspect infection unless there is an obvious history of punctured wound or constitutional symptoms. As such till date there is no series of large number of cases of calcaneal tuberculosis. We present our experience with 39 cases of calcaneal tuberculosis which include 2 cases of simultaneous bilateral symmetric involvement and 13 cases of tubercular lesion at the site of the attachment of Tendoachilles and Plantar Fascia. A classification of calcaneal tuberculosis is proposed. Material & Methods: (n=39) age 6–60 years; male: female – 20:19; duration of symptoms – 2 weeks to 8 years; “Heel up” sign present in 19 cases; X-ray showed erosive lesion at the site of Tendoachilles attachment (enthesitic type lesion) – 8 cases; erosive lesion at the site of Plantar Fascia attachment – 5 cases; Intraosseous lytic lesion(s) without subtalar joint involvment – 23 cases; subtalar joint involvemnet – 3 cases. FNAC was positive in 17 cases and core biopsy revealed tubercular material in 12 cases. All cases except one were treated conservatively. Discussion: The diagnosis and treatment of calcaneal tuberculosis are often delayed because the surgeon is unaware and signs and symptoms of calcaneal osteomyelitis are less dramatic than seen in osteomyelitis of long bones. The diagnostic and radiological features will be discussed


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 2 - 3
1 Mar 2005
Watmough P Canty S Higgins G Paul A
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In contrast to bony metastases, soft tissue metastases from carcinoma are rare. We reviewed all referrals to our Sarcoma Unit over an eight-year period, and found an incidence of soft tissue metastases from carcinoma of 1.4%. The most common mode of presentation was a painless soft tissue lump in a patient with an occult primary. Lung and kidney were the most frequent primary sources. Overall, prognosis was poor, with a mean survival of 9.4 months. Renal tumours however had a much better prognosis that other types of tumours. Treatment should be individualised according to the underlying disease and the prognosis. Although much rarer than primary soft tissue sarcomas, soft tissue metastases from carcinoma should remain a differential diagnosis in any patient presenting with a suspicious soft tissue lump. Introduction: Carcinoma most commonly metastasises via the lymphatic system firstly to the regional lymph nodes and then into the general circulation. Dependent upon the primary site of tumour, metastases from carcinoma commonly occur to the lungs, liver and bone. Distant metastases to the soft tissues are rare. There are few published case series (. 1. ,. 2. ) – the majority of the literature containing only case reports. We report a series of 10 cases of soft tissue metastases from carcinoma, collected from retrospective review of the case notes of consecutive patients referred over a eight year period to our Sarcoma Unit with a soft tissue lump, suspicious of a sarcoma. Patients and Methods: We retrospectively reviewed the case notes of consecutive patients over a eight year period (April 1995 – April 2003) referred to our Unit with a soft tissue lump, suspicious of a sarcoma. All patients underwent magnetic resonance (MR) scanning, and then trucut or open biopsy of the lesion. Dependent on the histological and MR findings, patients then underwent computer tomography (CT) of the chest and ultrasound examination of the abdomen. Included in this series were all patients with a histologically proven, soft tissue (skeletal muscle or subcutaneous tissue) metastatic carcinomatous deposit. Demographic, diagnostic, clinical, radiological and treatment data was collected on all patients. Results: Of the 702 referrals to our Unit over the eight-year period with a soft tissue lump suspicious of a sarcoma, 10 cases proved to be soft tissue metastases from carcinomas (incidence 1.4%). Data for the 10 patients comprising the series is shown in Table 1. Eight of the patients were male, two were female. The mean age at presentation was 68 years (range 39–85 years). Two patients presented with a painful lump, and in the other eight patients the lump was asymptomatic. The involved sites included the thigh in four cases, the arm in three cases, the back, buttock and axilla one each.In nine cases, the soft tissue lump was the presenting symptom of an occult primary carcinoma, whilst in one case (Case 4); the patient had a history of previous excision of a hypernephroma. The sources of primary carcinoma were small cell carcinoma of the lung in 4 cases, renal clear cell carcinoma in 3 cases, large bowel adenocarcinoma in 1 case, prostate 1 case, and in 1 case the primary site was unknown. All but one patient (Case 6) underwent radiotherapy or chemotherapy or both. Case 6 presented with a soft tissue lump over the shoulder, which on biopsy was found to be metastatic adenocarcinoma of large bowel origin. CT scan of the head confirmed multiple brain metastases. He declined any treatment and died within 2 months of presentation. In total, nine of the ten patients have died of their disease. The mean duration from diagnosis of soft tissue metastasis to death was 9.4 months (range 2–31 months). The duration of survival was significantly better for metastatic carcinoma of the kidney (23 months) compared to the other carcinomas (7 months). Discussion: The most commonly reported primary carcinomas to result in soft tissue metastases are those of the lung, kidney and colon (. 1. –. 3. ), contrasting with those carcinomas which commonly metastasise to bone such as prostate, breast and thyroid which only very rarely metastasise to the soft tissues. Damron and Heiner (. 1. ) who reported the largest series to date however had no cases where the patients primary site of carcinoma was of renal or colon origin and suggested that these cases were over-represented in the literature. Our series differs from their findings, concurring instead with the other published literature. Histologically, the most common diagnosis is adenocarcinoma, though many have been reported (. 1. –. 3. ). Soft tissue metastases from carcinoma are rare, which again contrasts to bony metastases from carcinoma. Tolia and Whitmore (. 4. ) reviewed 586 patients with renal cell carcinoma, and whilst a quarter had evidence of distant metastases at presentation, no patient had soft tissue metastases. Chandler et al (. 5. ) reported on 726 patients who died following metastatic renal carcinoma; only 3 patients had soft tissue metastases, all of which were only found at autopsy. Our series, which reviewed all patients referred to our Unit over a eight year period with a soft tissue lump initially suspicious of a sarcoma, found an overall incidence of 1.4%. Damron and Heiner (. 1. ) reported that the most common mode of presentation was a painful soft tissue lump. In our series however, the majority were painless. Whilst for most, the lump is the first sign of an occult malignancy, renal cell carcinomas tend to be different, often presenting as a solitary soft tissue deposit a few months to up to 16 years after the initial diagnosis of renal cell carcinoma has been made (. 1. ,. 2. ). Our series agreed with these findings; only in 1 case (Case 4) was there evidence of previously documented carcinoma prior to presentation with the soft tissue lump. All patients in our series underwent pre-operative MR scans, the appearances of which were not diagnostic of metastases, though highly suggestive of malignancy. Subsequently patients underwent either Tru-cut or open biopsy which gave the definitive diagnosis. As part of the pre-operative work-up, all patients had a CT of the chest and abdominal ultrasound scanning. Rao et al (. 6. ) reported 5 cases of soft tissue metastases from primary sarcoma, concluding that metastases in these cases were seen as late events and survival was generally poor. In our series of soft tissue metastases from carcinoma, we also found that prognosis was poor (averaging 9.4 months), especially when the primary carcinoma was lung, though the prognosis, if the primary was renal carcinoma was less bleak. Conclusions: Although rare, soft tissue metastases from carcinoma should remain a differential diagnosis in any patient presenting with a suspicious soft tissue lump. Whilst the MR scan appearances were suggestive of malignancy, they were not diagnostic of metastases. Tru-cut or open biopsy was reliable in confirming the diagnosis of carcinoma and helpful in the detection of the possible origin of the primary. The most common primary sites were lung, kidney and bowel


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 12 | Pages 1557 - 1566
1 Dec 2006
Khanduja V Villar RN

This review describes the development of arthroscopy of the hip over the past 15 years with reference to patient assessment and selection, the technique, the conditions for which it is likely to prove useful, the contraindications and complications related to the procedure and, finally, to discuss possible developments in the future.