INTRODUCTION. Analysis of retrieved ceramic components have shown areas of localized ‘stripe wear’, which have been attributed to joint laxity and/or impingement resulting in subluxation of the head, causing wear on the edge of the cup. Studies have been conducted into the effects of mild subluxation, however few in vitro tests have looked at severe subluxation. The aim of this study was to develop a more clinically relevant subluxation protocol. MATERIALS & METHODS. Seven (Subluxation n=4; standard test n=3) of 36mm Biolox Forte (R3, Smith & Nephew) ceramic devices were tested for 0.5m cycles (mc). Two of the subluxed joints were further tested to 1 Mc. The devices were subjected to subluxation under standard testing conditions. The flex/ext was 30° and 15° respectively, with internal/external rotation of ±10°. The force was Paul type stance phase loading with a maximum load of 3 kN, and a standard ISO swing phase load of 0.3 kN at 1 Hz. The test was conducted on a ProSim hip joint wear simulator (SimSol, UK). The simulator is equipped with a novel mechanism to achieve translation of the head, to achieve subluxation. During the ISO swing phase load of 0.3kN, a controlled lateral force required for the translation of the head is applied by a cam mechanism, head retraction then occurs during heel strike. The lubricant used was new born calf serum diluted with de-ionised water to achieve average protein concentration of 20 g/l, with 0.2 wt % concentration NaN3, and changed every 250k cycles. Measurements have been taken at 0.5 & 1 mc stages. RESULTS. Linear wear measurements conducted on the subluxed joints resulted in stripe wear similar to that reported in vivo. Average length, width and depth dimensions were 25.34±1.96 mm, 8±1.60 mm and 16.95±3.87 μm (± 95% CL) respectively. Linear wear at 0.5 Mc for standard joints, were undistinguishable from the original profile. Gravimetrically, weight loss was undetectable for joints tested under standard conditions. The volume loss of the joints under subluxation was 1.9± 0.7 mm3 at 0.5 mc. Two joints tested to 1mc generated an average volume loss of 3.1±2.3 mm3. The stripe wear length, width and depth at 1 Mc were 25.30±3.33mm, 8±3.92mm and 35±17.07 μm respectiveley. DISCUSSION. The current study presents test results of a hip joint simulator with a novel subluxation mechanism to simulate severe and clinically relevant hip joint. Past techniques have had to reduce the swing phase load to achieve stripe wear patches of varying size and depth. The subluxed joints produced significantly higher volumetric wear than the standard joints. Dimensional measurements in terms of length, width and depth of wear patches of subluxed joints generated similar results to that which have been observed following retrieval analysis. Tests that can simulate different types of activity in hip joint simulators will help to improve the design and understanding of implant behaviour in vivo