The aim of this study was to measure the effect of hospital case-volume on the survival of revision total knee arthroplasty (RTKA). A retrospective analysis of Scottish Arthroplasty Project data was performed. The primary outcome was RTKA survival at ten years. The primary explanatory variable was annual hospital case-volume. Kaplan-Meier survival curves were plotted with 95% confidence intervals (CI) to determine the lifespan of RTKA. Multivariable Cox proportional hazards were used to estimate relative revision risks over time. From 1998 to 2019, 8894 patients underwent RTKA surgery in Scotland (median age 70 years, median follow-up 6.2 years, 4789 (53.5%) females; 718 (8.8%) for infection). Of these patients, 957 (10.8%) underwent a second revision procedure on their knee. Male sex, younger age at index revision, and positive infection status were associated with need for re-revision. The ten-year survival estimate for RTKA was 87.3% (95%CI 86.5–88.1). Adjusting for gender, age, surgeon volume and infection status, increasing hospital case-volume was significantly associated with lower risk of re-revision (Hazard Ratio 0.78 (0.64–0.94, p<0.001)). The risk of re-revision steadily declined in centres performing >20 cases per year: relative risk reduction 16% with >20 cases; 22% with >30 cases; and 28% with >40 cases. The majority of RTKA in Scotland survive up to ten years. Increasing yearly hospital case-volume above 20 cases is independently associated with a significant risk reduction of re-revision. Development of high-volume tertiary centres may lead to an improvement in the overall survival of RTKA