Fractures of the clavicle are relatively common, occurring mostly in younger patients and have historically been managed non-operatively. Recent studies have shown an advantage to surgical reduction and stabilisation of clavicle fractures with significant displacement. Currently, fracture displacement is measured using simple anterior-posterior two-dimensional x-rays of the clavicle. Since displacement can occur in all three-dimensions, however, evaluation of the amount displacement can be difficult and inaccurate. The purpose of this study was to determine the view that provides the most accurate assessment. Nine CT scans of acute displaced clavicle fractures were analysed with AmiraDEV5.2.2 Imaging software. Measurements for degrees of shortening and fracture displacement of the fracture clavicle were taken. Using a segmentation and manipulation module (ITK toolkit), five digitally reconstructed radiographs (DRRs) mimicking antero-posterior x-rays were created for every CT, with each differing by projection angle (ranging from 20° upwards tilt to 20° downwards tilt). Measurements were taken on each DRR using landmarks of entire clavicle length, distance from vertebrae to fracture (medial fragment length), distance from fracture to acromium (lateral fragment length), and horizontal shortening, and then compared to the true measurement obtained from the original CT. For all 9 samples, after comparing the measurements of clavicle fracture displacement in each 2D image, we found that an AP view with a 20° downward tilt yielded displacement measurements closest to the 3D (“gold standard”) measurements. The results agree with previous data collected from cadaveric specimens using physical X-ray film images. DDRs enable creation of multiple standard AP radiographs from which accurate tilt can be measured. The large deviation in measurements on different DRR projections motivates consideration of standardising X-ray projections. A uniform procedure would allow one to correctly evaluate the displacement of clavicular fractures if fracture displacement information is to be utilized in motivating surgical decision-making

Evaluate precisely and reproducibly tridimensional positioning of bone tunnels in anterior cruciate ligament reconstructions (ACL). To propose biplanar stereoradiographic imaging as a new reference in tridimensional evaluation of ACL reconstruction (ACLR). Comparing knee 3D models issued from EOStm low-irradiation biplanar X-Ray with those issued from computed tomography (CT-Scan) high definition images will allow a bone morphological description of a previously unseen precision. We carried out the transfer of 3D models from EOStm X-Ray images obtained from 10 patients in the same reference frame with models issued from CT-Scan. Two evaluators reconstructed both pre-operative and post-operative knees, using two different stereoradiographic projections, for a total of 144 knee 3D models from EOStm. A surface analysis by distance mapping allowed us to know the differences or errors between the homologous points of the EOStm and CT reconstructions, the latter being our “bronze-standard”. At the femur, we obtained a mean (95% confidence level) error of 1.5 mm (1.3–1.6) between the EOStm models compared to the Arthro-CT segmentations when using AP-LAT incidences, compared to 1 mm (1.0 – 1.1) with oblique projections. For the tunnels placement analysis, the total radius difference between EOStm and Arthro-CT's femoral tunnel apertures was 0.8 mm (0.4–1.2) in AP-LAT and 0.6 mm (0.0–1.2) in oblique views. These femoral apertures positioning on EOStm models were within 4.3 mm (3.0–5.7) of their homologues on CT-Scan models, 4.6 mm (3.5–5.6) with the oblique views. Furthermore, 9.3o (7.2–11.4) of difference in direction between femoral tunnels from EOStm models and CT reconstructions is obtained with AP-LAT projections, 8.3o (6.6–10) with obliques views. Measures of these parameters were also performed at the tibia. According to the intra and inter-reproducibility analysis of our knee 3D models, EOStm biplanar X-Ray images prove to be fast, efficient and precise in the design of ACLR 3D models with respect to CT-Scan. Our results also propose the recourse of oblique stereoradiographic projections for the realization of knee 3D models. These models will be subjects of further analysis and will allow us eventually to propose a new frame of reference guiding the positioning of the tunnels in the ACLR

Liner exchange and bone grafting are commonly used in cases of wear and osteolysis around well- fixed acetabular components in revision total hip arthroplasty. However, in total knee revision, liner exchange is a more rare option. In a multicenter study, we evaluated 22 TKAs that were revised with liner exchange and bone grafting for wear and osteolysis. All knees were well-fixed and well-aligned, and all components were modular tibial components. Osteolytic areas averaged 21.1cm2 and 7.6cm2 on AP projections of the femur and tibia, respectively, and averaged 21.6cm2 and 5.7cm2 on lateral projections of the femur and tibia, respectively, with the largest area being 54cm2 on a single projection. Follow up was minimum 2 years and average 40 months. No knees were revised and radiographically, all osteolytic lesions showed evidence of complete or partial graft incorporation. In addition, there was no radiographic evidence of loosening at final follow up. The Mayo Clinic evaluated 56 isolated tibial insert exchange revisions at their institution. Cases of loosening, infection, knee stiffness, or extensor mechanism problems were excluded. At minimum 2-year follow up (average 4.6 years), 14 knees (25%) required re-revision. Baker et al. evaluated 45 total knees undergoing isolated tibial insert exchange. At minimum 2 years, 4 knees (9%) required revision. Significant improvement was seen in clinical outcomes questionnaires, but only 58% had clinical successful global WOMAC scores. In summary, isolated liner exchange in the revision total knee setting has variable results. It can be successful but it is indeed a rare option and should be limited to cases were the total knee arthroplasty is both well-fixed and well-aligned

Liner exchange and bone grafting are commonly used in cases of wear and osteolysis around well fixed acetabular components in revision total hip arthroplasty. However, in total knee revision, liner exchange is a more rare option. In a multicenter study, we evaluated 22 TKAs that were revised with liner exchange and bone grafting for wear and osteolysis. All knees were well fixed and well aligned, and all components were modular tibial components. Osteolytic areas averaged 21.1 cm2 and 7.6 cm2 on AP projections of the femur and tibia, respectively, and averaged 21.6 cm2 and 5.7 cm2 on lateral projections of the femur and tibia, respectively, with the largest area being 54 cm2 on a single projection. Follow up was minimum 2 years and average 40 months. No knees were revised and radiographically, all osteolytic lesions showed evidence of complete or partial graft incorporation. In addition, there was no radiographic evidence of loosening at final follow up. The Mayo Clinic evaluated 56 isolated tibial insert exchange revisions at their institution. Cases of loosening, infection, knee stiffness, or extensor mechanism problems were excluded. At minimum 2 year follow up (average 4.6 years), 14 knees (25%) required re-revision. Baker et al evaluated 45 total knees undergoing isolated tibial insert exchange. At minimum 2 years, 4 knees (9%) required revision. Significant improvement was seen in clinical outcomes questionnaires, but only 58% had clinical successful global WOMAC scores. In summary, isolated liner exchange in the revision total knee setting has variable results. It can be successful but it is indeed a rare option and should be limited to cases where the total knee arthroplasty is both well fixed and well aligned

Problem. Total hip replacement (THA) is among the most common and highest total spend elective operations in the United States. However, up to 7% of patients have 90-day complications after surgery, most frequently joint dislocation that is related to poor acetabular component positioning. These complications lead to patient morbidity and mortality, as well as significant cost to the health system. As such, surgeons and hospitals value navigation technology, but existing solutions including robotics and optical navigation are costly, time-consuming, and complex to learn, resulting in limited uptake globally. Solution. Augmented reality represents a navigation solution that is rapid, accurate, intuitive, easy to learn, and does not require large and costly equipment in the operating room. In addition to providing cutting edge technology to specialty orthopedic centers, augmented reality is a very attractive solution for lower volume and smaller operative settings such as ambulatory surgery centers that cannot justify purchases of large capital equipment navigation systems. Product. HipInsight™ is an augmented reality solution for navigation of the acetabular component in THA. HipInsight is a navigation solution that includes preoperative, cloud based surgical planning based on patient imaging and surgeon preference of implants as well as intraoperative guidance for placement of the acetabular component. Once the patient specific surgical plan is generated on the cloud-based planning system, holograms showing the optimal planned position of the acetabular component are exported in holographic format to a Microsoft HoloLens 2™, which the surgeon wears during placement of the acetabular component in total hip arthroplasty. The pelvis is registered using the HipXpert™ mechanical registration device, which takes 2–3 minutes to dock in the operating room. The surgeon then is able to view the patient's anatomy and optimal placement of the acetabular component under the skin in augmented reality. The surgeon then aligns the real cup impactor with the augmented reality projection of the cup impactor resulting in precise placement of the cup. Timescales. HipInsight was FDA cleared on January 28, 2021 for intraoperative use for placement of the acetabular component in total hip arthroplasty. The first case was performed in February 2021, and the product was launched to a select group of orthopedic surgeons in March 2021. Funding. HipInsight has been self-funded to date, and is beginning to engage in discussions to raise capital for a rapidly scaling commercial launch

Introduction. The most common method for accurate kinematic analysis of the knee arthroplasty uses bi-planar fluoroscopy and model-based RSA. The main challenge is to have access to reverse-engineered CAD models of the implant components, if not provided by the company, making this method impractical for a clinical study involving many types or sizes of implants. An alternative could be to reconstruct the 3D primitive features of the implant, such as cylindrical pegs, flat surfaces and circular boundaries, based on their 2D projections. This method was applied by Kaptein et al. (2006) for hip implants. However, despite its broad potential, it has not yet been applied for studying TKA kinematics. This study develops a methodology for feature-based RSA of TKA and investigates the range of accuracies in comparison to model-based RSA. Methods. Joint-3D software was developed in the MATLAB programming language to segment and fit elementary 2D features such as circles, lines, and ellipses to the edges of the parts on the radiographs (Figure 1). The software has the capability to reconstruct the 3D location and orientation of the components based on their 2D projections. To test the accuracy of the system a standard primary knee replacement system (Zimmer NexGen) was implanted on bone replica models, and positioned at 0° to 120° flexion at 30° intervals, simulating a lunge activity. For each pose, a multi-planar radiography system developed in our lab (Amiri et al., 2011) was used to take a sagittal and a 15° distally rotated radiograph (Figure 2a). Figure 1 shows the features C, L, and E segmented on the tibia and femur. The 3D reconstruction is performed based on a number of functions: Functions ‘f’ and ‘g’ reconstruct a 3D point or line based on their 2D projections. Function ‘h’ finds the plane containing the 3D circular edge based on its two projection ellipses. Function ‘i’ finds the 3D location of a line based on one projection line, and a known 3D vector normal to the solution 3D line. Based on these, the coordinate systems of the components were reconstructed (Figure 2b):. Femur_Origin=f(C1A,C1B);. Femur_Anteroposterior=g(L1A, L1B);. Femur_Proximodistal=g(L2A,L2B);. Femur_Mediolateral=i(L,C1A–C1B),{L=L1: if flexion<45°; L=L2: if flexion>45°};. E_3D=h(E1A,E1B);. Tibia_Origin=f(E1A_Centre,E1B_Centre);. Tibia_Anteroposterior=g(L3A,L3B);. Tibia_Mediolateral=cross(E_3D, Tibia_Anteroposterior);. Tibia_Proximodistal=cross(Tibia_Anteroposterior, Tibia_Mediolateral). To determine the errors, model-based RSA measures were used as the reference using the reverse-engineered models of the components in JointTrack software (University of Florida). Results. The overall accuracies in terms of bias (the mean error) and precision (standard deviation of the errors) are shown in Figure 3. The bias was within 0.5–1 mm and 0.9–1.2°, and the calculated precision was in the range of 0.4–0.6 mm and 0.7–1.0°. The overall accuracy was 0.8±0.6 mm and 1±0.7°. Discussion. The very good accuracies obtained show the practicality of the methodology. The methodology can be easily worked out for any type of implant based on the primitive geometric features at the bone-implant interface. This method can be extremely useful in a large clinical study by eliminating the need for having the 3D models of many types and sizes of the implant available

Pedicle screw fixation is a technically demanding procedure with potential difficulties and reoperation rates are currently on the order of 11%. The most common intraoperative practice for position assessment of pedicle screws is biplanar fluoroscopic imaging that is limited to two- dimensions and is associated to low accuracies. We have previously introduced a full-dimensional position assessment framework based on registering intraoperative X-rays to preoperative volumetric images with sufficient accuracies. However, the framework requires a semi-manual process of pedicle screw segmentation and the intraoperative X-rays have to be taken from defined positions in space in order to avoid pedicle screws' head occlusion. This motivated us to develop advancements to the system to achieve higher levels of automation in the hope of higher clinical feasibility. In this study, we developed an automatic segmentation and X-ray adequacy assessment protocol. An artificial neural network was trained on a dataset that included a number of digitally reconstructed radiographs representing pedicle screw projections from different points of view. This model was able to segment the projection of any pedicle screw given an X-ray as its input with accuracy of 93% of the pixels. Once the pedicle screw was segmented, a number of descriptive geometric features were extracted from the isolated blob. These segmented images were manually labels as ‘adequate’ or ‘not adequate’ depending on the visibility of the screw axis. The extracted features along with their corresponding labels were used to train a decision tree model that could classify each X-ray based on its adequacy with accuracies on the order of 95%. In conclusion, we presented here a robust, fast and automated pedicle screw segmentation process, combined with an accurate and automatic algorithm for classifying views of pedicle screws as adequate or not. These tools represent a useful step towards full automation of our pedicle screw positioning assessment system

Background. Artificial total knee designs have revolutionized over time, yet 20% of the population still report dissatisfaction. The standard implants fail to replicate native knee kinematic functionality due to mismatch of condylar surfaces and non-anatomically placed implantation. (Daggett et al 2016; Saigo et al 2017). It is essential that the implant surface matches the native knee to prevent Instability and soft tissue impingement. Our goal is to use computational modeling to determine the ideal shapes and orientations of anatomically-shaped components and test the accuracy of fit of component surfaces. Methods. One hundred MRI scans of knees with early osteoarthritis were obtained from the NIH Osteoarthritis Initiative, converted into 3D meshes, and aligned via an anatomic coordinate system algorithm. Geomagic Design X software was used to determine the average anterior-posterior (AP) length. Each knee was then scaled in three dimensions to match the average AP length. Geomagic's least-squares algorithm was used to create an average surface model. This method was validated by generating a statistical shaped model using principal component analysis (PCA) to compare to the least square's method. The averaged knee surface was used to design component system sizing schemes of 1, 3, 5, and 7 (fig 1). A further fifty arthritic knees were modeled to test the accuracy of fit for all component sizing schemes. Standard deviation maps were created using Geomagic to analyze the error of fit of the implant surface compared to the native femur surface. Results. The average shape model derived from Principal Component Analysis had a discrepancy of 0.01mm and a standard deviation of 0.05mm when compared to Geomagic least squares. The bearing surfaces showed a very close fit within both models with minimal errors at the sides of the epicondylar line (fig 2). The surface components were lined up posteriorly and distally on the 50 femurs. Statistical Analysis of the mesh deviation maps between the femoral condylar surface and the components showed a decrease in deviation with a larger number of sizes reducing from 1.5 mm for a 1-size system to 0.88 mm for a 7-size system (table 1). The femoral components of a 5 or 7-size system showed the best fit less than 1mm. The main mismatch was on the superior patella flange, with maximum projection or undercut of 2 millimeters. Discussion and Conclusion. The study showed an approach to total knee design and technique for a more accurate reproduction of a normal knee. A 5 to 7 size system was sufficient, but with two widths for each size to avoid overhang. Components based on the average anatomic shapes were an accurate fit on the bearing surfaces, but surgery to 1-millimeter accuracy was needed. The results showed that an accurate match of the femoral bearing surfaces could be achieved to better than 1 millimeter if the component geometry was based on that of the average femur. For any figures or tables, please contact the authors directly

Introduction. Studies show that cup malpositioning using conventional techniques occurs in 50 to 74% of cases defined. Assessment of the utility of improved methods of placing acetabular components depends upon the accuracy of the method of measuring component positioning postoperatively. The current study reports on our preliminary experience assessing the accuracy of EOS images and application specific software to assess cup orientation as compared to CT. Methods. Eighteen patients with eighteen unilateral THA had pre-operative EOS images were obtained for preoperative assessment of leg-length difference and standing pelvic tilt. All of these patients also had preoperative CT imaging for surgical navigation of cup placement. This allows us to compare cup orientation as measured by CT to cup orientation as measured using the EOS images. Application specific software modules were developed to measure cup orientation using both CT and EOS images (HipSextant Research Application 1.0.13 Surgical Planning Associates Inc., Boston, Massachusetts). Using CT, cup orientation was determined by identifying Anterior Pelvic Plane coordinate system landmarks on a 3D surface model. A multiplanar reconstruction module allows for creation of a plane parallel with the opening plane of the acetabulum and subsequent calculation of plane orientation in the AP Plane coordinate space according to Murray's definitions of operative anteversion and operative inclination. Using EOS DICOM images, spatial information from the images were used to reconstruct the fan beam projection model. Each image pair is positioned inside this projection model. Anterior Pelvic Plane coordinate points are digitized on each image and back-projected to the fan beam source. Corresponding beams are then used to compute the 3D intersection points defining the 3D position and orientation of the Anterior Pelvic Plane. Ellipses with adjustable radii were then used to define the cup border in each EOS image. By respecting the fan beam projection model, 3D planes defining the projected normal of the ellipse in each image are computed. 3D implant normal was estimated by determining 3D plane intersection lines for each image pair. Implant center points are defined by using the back-projected and intersected ellipse center beams in the image pairs (Figure 1). Results. The results are shown in Figure 2. The mean anteversion error was −0.9 degrees (SD 4.1, range −6.9 to 10.3). The mean inclination error was 1.8 (SD 2.1, range −2.9 to 8.6). All three cups with errors greater than 7 degrees were in cups with 40 or more degrees of anteversion. Discussion and Conclusion. The current study, while very preliminary, demonstrates the potential that EOS images can be used to measure cup orientation with a reasonable degree of accuracy. Accurate determination of cup orientation appears to be more challenging in cups with higher anteversion

Introduction. Navigated freehand cutting (NFC) technology simplifies bone cutting in laboratory trials by directly navigating implants and power tools [1]. Experiments showed that NFC bone cutting was faster than with conventional jigs. However, most delays occurred at the start of each cut [2]. Therefore, we further reduced starting times and gained more accuracy with a NaviPen and a ‘smart’ NaviPrinter [3]. There were used to physically mark a line on the bone surface indicating where each cut should start. (Fig. 1). Further gains are targeted with our introduction of the On-Tool Marker (OTM); a touch-less laser marking technology as a standalone device or mounted on the cutting instrument (e.g. on the saw). The OTM points the desired cut by projecting a laser image on the bone. That image (usually a line or cross) changes dynamically, so that for any given cut the line projection remains stationary on the bone regardless of the relative location of the device. Materials & Methods. The OTM is a standalone wireless module composed of three main parts: a small laser projector, electronics for control and communication (WiFi), and a tracking frame. It is navigated in real-time with a Polaris tracker. Software routines on a proprietary NFC system compute its relative position to the target and dynamically re-calculate the image parameters. Such parameters are sent to the OTM for processing, image generation, and projection (Fig. 2). Bandwidth and data integrity were evaluated through bench tests. To assess accuracy of the projection, a target planar cut was defined on a flat surface (a line drawn on grid paper pasted to a navigated board), and the NFC system was fed with this geometrical information. The OTM was moved within a volume of ∼50cm in diameter (distance to the target plane from 5cm to 50cm), and at various angles up to +/− 80° (in roll, pitch and yaw). The projected line should coincide with the target line on paper regardless of the relative positioning of the OTM. Errors (target vs. projected) were measured on the grid paper. Results. Well-defined lines were projected at a rate of 17fps. Projected lines remained within +/− 2 mm from the target (average ∼0mm). Errors, largely caused by a lag in the images, were unperceivable after a fraction of a second if OTM remained still. Among different colors tested, green was the most suitable, based on brightness and visibility (Fig. 3). Discussion and Conclusion. A ‘smart’ navigated laser marker was successfully created and tested. The limited refresh speed and lag was not much of a concern, as common use would not require fast motion. However, further work will focus on improving these, and devise solutions for projection on non-planar bone models. OTM would speed the surgery more as it saves the time to use the NaviPen or the NaviPrinter. We estimate this can reach 2–3 minutes based on some preliminary experiments we conducted and not reported here. Finally, OTM can help reduce the number of instruments in surgery even further (less inventory, less sterilization, less cost and less worries)

The design of every post-surgical knee arthroplasty study begins with the question “How soon after surgery should we assess the patients?”. The consensus, based primarily upon clinical rating systems, is that patients' scores reach a plateau roughly one year after surgery, and that observations performed at that time should be indicative of the long-term behavior of the joint. This is satisfactory for long-term studies of clinical performance. However, when new devices are introduced there is a need to determine as quickly as possible if the device performs as designed. Waiting a year or more after surgery to characterize a device's performance may place additional patients at risk of receiving an inferior design, or may delay widespread availability of a superior design. The goal of this study was to assess knee arthroplasty patients at 6–12 weeks, 6 months and 1 year after surgery to determine if their tibiofemoral kinematics changed during functional activities. A total of 13 patients (7 female) were recruited from an ongoing clinical study to participate in this IRB-approved sub-study. All subjects received fixed-bearing, cemented, posterior-cruciate-retaining total knee arthroplasty of the same design from a single surgeon. Subjects averaged 69 years, 169cm tall, and 28 BMI. Subjects were studied at 6–12 weeks, at 6 months and at 12 months post-surgery, when they showed an average clinical flexion of 106°, 113° and 115°, respectively. Subjects' knees were observed using pulsed-flat-panel-fluoroscopy during three activities: lunging to maximum flexion with their foot placed on a 20cm step, kneeling to maximum flexion on a padded bench, and step-up/down on a 20cm step without progression of the contralateral limb. Model-image registration was used to register 3D geometric models of the implants with their radiographic projections based upon measured projection parameters. 3D knee kinematics were derived from the registered models, including joint angles and the antero-posterior translation of the medial and lateral condyles relative to the tibial baseplate. There were no statistically significant changes in knee kinematics between the 6–12 week and 6 month, and 6-month and 12-month visits during the kneel and lunge activities (Table 1). Similarly, there were no pair-wise differences in tibial rotation or condylar translation during the dynamic step activity at any flexion angle (Figure 1). Traditional thinking suggests studies of knee mechanics should be performed at least one year after surgery to make observations that are predictive of long-term joint function. In three different functional activities, we could not demonstrate significant changes in knee kinematics between 6–12 weeks and 6 months, nor between 6 months and 12 months. If these results can be confirmed in a larger subject cohort, and for a range of TKA designs, then functional follow-up studies of novel knee arthroplasty designs might be justified as early as 6–12 weeks after surgery, making it possible to accelerate confirmation devices are performing in patients as designed. For any figures or tables, please contact the authors directly

Up to 20 percent of patients remain dissatisfied after primary total knee arthroplasty (TKA) surgery. Understanding the reasons for dissatisfaction post TKA may allow for better patient selection and optimized treatment for those who remain dissatisfied. The association between function, mobility and satisfaction are not well understood. The purpose of this study was to investigate the association between post-TKA satisfaction and i) pre-operative, ii) post-operative, and iii) change in knee joint function during gait. Thirty-one patients scheduled to receive primary TKA for knee osteoarthritis (OA) diagnosis were recruited and visited the Dynamics of Human Motion laboratory for instrumented walking gait analysis (using a synchronized NDI Optotrak motion capture system and AMTI force platforms in the walkway) at two time points, first within the week prior to their surgery, and second at approximately one year after surgery. At their post-operative visit, patients were asked to indicate their satisfaction with their knee prosthesis on a scale from zero to 100, with zero being totally unsatisfied and 100 being completely satisfied. Knee joint mechanics during gait at both time points were characterized by discriminant scores, the projection of their three-dimensional knee angles and moments during gait onto an existing discriminant model that was created to optimize separation of severe knee OA and healthy asymptomatic gait patterns. This discriminant model was created using data from 73 healthy participants and 73 with severe knee OA, and includes the magnitude and pattern features (captured with principal component analysis) of the knee adduction and flexion moment, and the magnitude of the knee flexion angle during gait. Larger discriminant scores indicate improved function toward healthy patterns, and smaller scores indicate more severe function. Associations between post-operative satisfaction and pre, post and change in discriminant scores were examined using Pearson correlation analyses. We also examined associations between satisfaction and pre-operative BMI, EQ5D and Oxford 12 scores, as well as changes in these scores from pre to post-TKA. Discriminant scores representing knee joint function during gait significantly improved on average after surgery (P =0.05). While overall knee joint function improved after primary TKA surgery, the amount of improvement in function was not reflected in post-operative patient satisfaction. However, the pre-operative function of the patient was negatively associated with satisfaction, indicating that patients with higher pre-operative function are overall less satisfied with their TKA surgery, regardless of any functional improvement due to the surgery. Interestingly, the only significant association with post-operative satisfaction was knee joint function, and the relationship between function and patient satisfaction following TKA appears to relate only to the baseline functional state of the patient, and not with functional improvement. This suggests that dissatisfaction post-surgery is more likely reflecting the unmet expectations of a higher functioning patient, and has implications for the need for improved understanding of pre-operative patient functional variability in TKA triage and expectation management

INTRODUCTION. An accelerometer-based portable navigation system (KneeAlign2, OrthAlign Inc., Aliso Viejo, CA) is expected to improve mechanical axis and component alignment compared to conventional instrumentation in total knee arthroplasty (TKA). However, past reports have evaluated its accuracy using only radiographic measurements. The purpose of this study was to analyze the accuracy of the KneeAlign2 system with radiography and more detailed three-dimensional (3D) CT. METHODS. We targeted 22 patients (24 knees) with severe osteoarthritis who underwent primary TKA using the KneeAlign2 system. Cemented, fixed-bearing, cruciate-retaining prostheses were implanted in all patients. We used postoperative standing-position full-length radiographic evaluation of the lower limbs to measure the hip-knee-ankle angle (HKA), frontal femoral component angle (FFC), and frontal tibial component angle (FTC). However, lower limb rotation and knee flexion could affect radiographic measurement of HKA and the component positioning angle. We used 3D bone models reconstructed from pre- and postoperative CT images to precisely analyze the 3D component positioning. For a 3D matching bone model made from these models, a 2D projection of the pre- and postoperative component positioning planes was made, and the projection angle was measured as angle error compared to the preoperative planned position (Figure 1). Average surgery time and total blood loss on postoperative day 7 were also recorded. RESULTS. There were 24 knees available for analysis. Mean HKA was 0.1° ± 2.2 varus; 16.7% of knees had coronal outliers exceeding 3°. Mean FFC was 0.9° ± 1.9 varus; 29.2% of femoral components were placed with coronal outliers exceeding 2°. Mean FTC was 1.2° ± 1.6 valgus; 20.8% of tibial components were placed with coronal outliers exceeding 2°. In 3D-CT evaluation, mean femoral coronal and sagittal alignment were 1.2° ± 1.7 varus (outliers exceeding ±2°: 37.5%) and 0.8° ± 2.4 flexion (outliers exceeding ±2°: 20.8%), respectively. Mean tibial coronal and sagittal alignment were 1.1° ± 1.4 valgus (outliers exceeding ±2°: 33.3%) and 0.1° ± 1.6 flexion (outliers exceeding ±2°: 20.8%), respectively. Average surgical time was 96 ± 7.7 minutes, and blood loss was 400 g ± 113 on postoperative day 7. CONCLUSIONS. With radiographic and 3D-CT evaluation, the mean angle error values for the femoral and tibial components were less than 2° in the coronal plane, and less than 1° in the sagittal plane. KneeAlign2 is highly accurate in positioning the femoral and tibial components in TKA. For figures/tables, please contact authors directly.

Perthes disease is a childhood disorder often resulting in femoral head deformity. Categorical/dichotomous outcomes of deformity are typical clinically, however quantitative, continuous measures, such as Sphericity Deviation Score (SDS), are critical for studying interventions. SDS uses radiographs in two planes to quantify femoral head deformity. Limitations of SDS may include non-orthogonal planes and lost details due to projections. We applied this method in 3D, with specific objectives to: 1. Develop SDS-like sphericity measures from 3D data 2. Obtain 2D and 3D sphericity for normal and Perthes hips 3. Compare slice-based (3D) and projection-based (2D) sphericity CT images of 16 normal (8 subjects) and 5 Perthes hips (4 subjects) were segmented to create 3D hip models. Ethics board approval was obtained for this study. SDS consists of roundness error (RE) in two planes and ellipsoid deformation (ED) between planes. We implemented a modified SDS which was applied to (a) orthogonal projections simulating radiographs (sagittal/coronal; 2D-mSDS), and (b) largest radii slices (sagittal/coronal; 3D-mSDS). Mean 2D-mSDS was higher for Perthes (27.2 (SD 11.4)) than normal (11.9 (SD 4.1)). Mean 3D-mSDS showed similar trends, but was higher than 2D (Perthes 33.6 (SD 5.3), normals 17.0 (SD 3.1)). Unlike 2D-mSDS, 3D-mSDS showed no overlap between groups. For Perthes hips, 2D-mSDS was consistent with SDS. For normal hips, 2D-mSDS was higher than expected (similar to Stulberg II). Projection-based (2D) measures may produce lower mSDS due to spatial averaging. Slice-based (3D) measures may better distinguish between normal and Perthes shapes, which may better differentiate effectiveness of treatments

Bone remodeling effects is a significant issue in predicting long term stability of hip arthroplasty. It has been frequently observed around the femoral components especially with the implantation of prosthesis stem. Presence of the stiffer materials into the femur has altering the stress distribution and induces changes in the architecture of the bone. Phenomenon of bone resorption and bone thickening are the common reaction in total hip arthroplasty (THA) which leading to stem loosening and instability. The objectives of this study are (i) to develop inhomogeneous model of lower limbs with hip osteoarthritis and THA and (ii) to predict the bone resorption behavior of lower limbs for both cases. Biomechanical evaluations of lower limbs are established using the finite element method in predicting bone remodeling process. Lower limbs CT-based data of 79 years old female with hip osteoarthritis (OA) are used in constructing three dimensional inhomogenous models. The FE model of lower limbs was consisted of sacrum, left and right ilium and both femur shaft. Bond between cartilage, acetabulum and femoral head, sacrum and ilium were assumed to be rigidly connected. The inhomogeneous material properties of the bone are determined from the Hounsfield unit of the CT image using commercial biomedical software. A load case of 60kg body weight was considered and fixed at the distal cut of femoral shaft. For THA lower limbs model, the left femur which suffering for hip OA was cut off and implanted with prosthesis stem. THA implant is designed to be Titanium alloy and Alumina for stem and femoral ball, respectively. Distribution of young modulus of cross-sectional inhomogeneous model is presented in Fig. 2 while model of THA lower limbs also shown in Fig. 2. Higher values of young modulus at the outer part indicate hard or cortical bone. Prediction of bone resorption is discussed with the respect of bone mineral density (BMD). Changes in BMD at initial age to 5 years projection were simulated for hip OA and THA lower limbs models. The results show different pattern of stress distribution and bone mineral density between hip OA lower limbs and THA lower limbs. Stress is defined to be dominant at prosthesis stem while femur experienced less stress and leading to bone resorption. Projection for 5 years follow up shows that the density around the greater tronchanter appears to decrease significantly

The management of the dysplastic hip represents a clinical and a technical challenge to the paediatric orthopaedic surgeon. There is a great deal of variation in the degree and direction of acetabular dysplasia. Preoperative planning in the dysplastic hip is still largely based on plain radiographs. However, these plain films are a 2D projection of a 3D structure and measurement is prone to inaccuracy as a result. Hip arthrography is used in an attempt to analyse the 3D morphology of the hip. However, this still employs a 2D projection of a 3D structure and in addition has the risk of general anaesthesia and infection. Geometrical analysis based on multiplanar imaging with CT scans has been shown to reduce analysis variability. We present a system for morphological analysis and preoperative of the paediatric hip using this model. Our system can be used to determine the most appropriate osteotomy based on morphology. This system should increase the accuracy of preoperative planning and reduce the need for arthrography

In order to achieve a true AP and lateral radiograph of the wrist, there must be no movement at the radio-ulnar joint. Projections taken with only pronation and supination at the wrist provide two views of the radius but a single view of the ulna. True radiographs are achieved by rotating the humerus through 90 degrees and extending at the elbow between the two views. Our aim was to look at whether true lateral and AP radiographs are taken by our radiology department. Between April 2009 to November 2010, we identified all patients with ulna shortening osteotomies. This was because the plate and screws placed only in ulna making it easy to identify if two projections of the ulna have been achieved. Radiograph at first follow up were reviewed using PACS. Of the 29 patients identified, 5 patients were excluded. Only 6 out of 24 patients had TRUE wrist projections. Most radiographs taken were inadequate and this has to be communicated with the radiology department. Two different views are needed to accurately comment on radiographs. Patients have to be sent back to radiology department. This causes an increase in clinic time, radiation to the patient and inconvenience

Accurate reconstruction of the knee pose from two X-Ray images will allow the study pre-operative kinematics (for custom prosthesis design) and the post-operative evaluation of the intervention. We used a SSM of the distal femur, based on 24 MRI datasets, from which the mean model and its modes of variation were defined. On the SSM, N landmarks in predefined positions were defined. The user identifies the same landmarks on two X-ray projections. Back-projecting the X-ray from the identified landmarks pixel to the corresponding source, each landmark position in the 3D space is reconstructed and the mean model pose initialised with a corresponding points registration. The silhouette of the SSM is projected on each X-ray image, which is automatically segmented in order to define the bone contours. With a Robust Point Matching algorithm based on Thin Plate Splines the projected silhouette points are deformed to better approximate the contour. For each contour point, the associated silhouette point is computed. We back-projected the ray from each contour point to the source and find on each ray the point with minimum distance to the silhouette. The cost function is the squared sum of the distances for both images. After a first optimisation of the pose, we perform a shape optimisation to find the correct weights for the SSM. To evaluate our algorithm, we used two Digitally Reconstructed Radiographs (DRR) created as projections at 90° from a CT dataset. The CT based model was reconstructed and the landmarks were defined on it with a rigid registration of the SSM. In order to validate the robustness of our reconstruction method, a random uniform noise distribution (0–50 mm on each direction) was added on each landmark. The reconstruction accuracy was measured as the distance between each reconstructed landmark and the ground truth defined on the CT. Results show that the population of the errors for the noise levels from 0 to 30 is similar: only the population with 50 mm noise is significantly different from the results obtained with other noise levels. We can conclude that with a noise level below 50 mm the algorithm is able to return the correct pose of the femur, while with higher noise the initial distribution of the landmarks in the 3D space prevents the correct outcome of the algorithm. The user should select the landmarks within a range of 50 mm on the 3D representation, that is half the dimension of the bounding box containing the model. We can assume that in the real case it will be more difficult to select the proper position of the landmarks, but our method proved to be robust even with misplaced landmarks

Background. Under- or oversizing of either component of a total knee implant can lead to early component loosening, instability, soft tissue irritation or overstuffing of joint gaps. All of these complications may cause postoperative persistent pain or stiffness. While survival of primary TKA's is excellent, recent studies show that patient satisfaction is worse. Up to 20% of the patients are not satisfied with the outcome as and residual pain is still a frequent occurrence. The goal of this study was therefore to evaluate if the sizing of the femoral component, as measured on a 3D-reconstructed projection, is related to patient reported outcome measures. From our prospectively collected TKA outcome database, all patients with a preoperative CT and a postoperative X-ray of their operated knee were included in this study. Of these 43 patients, 26 (60,5%) were women and 17 (39,5%) were men. The mean age (+/−SD) was 74,6 +/− 9 years. Methods. CT scans were acquired. All patients underwent TKA surgery in a single institution by one surgical team using the same bi- cruciate substituting total knee (Journey II BCS, Smith&Nephew, Memphis, USA). Using a recently released X-ray module in Mimics (Materialise NV, Leuven, Belgium), this module allows to align the post-operative bi-planar x-rays with the 3D- reconstructed pre-operative distal femur and to determine the 3D position of the bone and implant models using the CAD- file of the implant. This new technique was validated at our department and was found to have a sub-degree, sub-millimeter accuracy. Eleven zones of interest were defined. On the medial and the lateral condyle, the extension, mid-flexion and deep flexion facet were determined. Corresponding trochlear zones were defined and two zones were defined to evaluate the mediolateral width. In order to compare different sizes, elastic deforming mesh matching algorithms were implemented to transfer the selected surfaces from one implant to another. The orthogonal distances from the implant to the nearest bone were calculated. Positive values represent a protruding (oversized) femoral component, negative values an undersized femoral component. The figure shows the marked zones on the femoral implant. The KOOS subscores and KSS Satisfaction subscore were evaluated. Results. Two-step cluster analysis based on the clinically relevant zones on both medial (zone 12, 14 and 17) and lateral (zone 2, 5 and 9) femoral condyle of the implant, led to the formation of two clusters. Cluster 1 contained 23 patients with, in general, an undersized femoral component (negative values) whilst cluster 2 contained 20 patients with in general an oversized femoral component (positive values). (see graph) No significant differences were found between both clusters regarding demographics. Regarding PROM data, a significant difference was found for KOOS Symptoms (p=0.037) and a KOOS Pain (p=0.05). Other PROMs are not significantly different between both clusters. Conclusion. Our data shows that undersizing the femoral component results in less postoperative pain and symptoms. The clinical consequence of this study is that in case of in between femoral component sizes, the smallest size should be chosen to diminish the occurrence of postoperative pain and symptoms

Introduction. Literature describes pelvic rotation on lateral X rays from standing to sitting position. EOS full body lateral images provide additional information about the global posture. The projection of the vertical line from C7 (C7 VL) is used to evaluate the spine balance. C7 VL can also measure pelvic sagittal translation (PST) by its horizontal distance to the hip center (HC). This study evaluates the impact of a THA implantation on pelvic rotation and sagittal translation. Materials and Method. Lumbo-pelvic parameters of 120 patients have been retrospectively assessed pre and post- operatively on both standing and sitting acquisitions (primary unilateral THA without complication). PST is zero when C7VL goes through the center of the femoral heads and positive when C7VL is posterior to the hips' center (negative if anterior). Three subgroups were defined according to pelvic incidence (PI): low PI <45°, 45°<normal PI<65° or high PI>65°. Results. Pre-operatively PST standing was −0.9 cm (SD 4.5; [−15.1 to 7.2]) and PST sitting was 1.3cm (SD 3.3; [−7.7 to 11.8]). The overall mean change from standing to sitting was 2.2 cm ([−7.2 to 17.4]) (p<0.05). Post-operatively PST standing was 0.2 cm (SD 4.7; [−17 to 8.1]) and PST sitting was 1.4cm (SD 3.5; [−7.3 to 10.4]). The overall mean change from standing to sitting was 1.2 cm ([−14.2 to 22.4]) (p<0.05). In low PI group pre and post-operatively, PST increased significantly from standing to sitting (p<0.05; with HC going anterior to C7VL). When comparing pre and post operative changes, standing PST significantly increased (p=0.001). Pre to postoperative PST variation (sitting-standing) decreased significantly (p=0,01). In normal PI group pre-operatively, PST increased from standing to sitting (p=0.004). When comparing pre and postoperative changes, PST increased (p=0.006). Pre to postoperative PST variation (sitting-standing) decreased significantly (p=0,04). In high PI group pre and post operatively, PST increased from standing to sitting (p=0.034) while there are no significant changes from pre to post-operative status in standing and in sitting. Discussion. Anteroposterior pelvic tilt is not the only adaptation strategy for postural changes from standing to sitting positions. Anteroposterior pelvic translation (quantified by PST) is an important adaptation mechanism for postural changes. Comparison of pre and post-operative values of PST points out the importance of pelvic translation for low and standard PI patients after THA. The anteroposterior translation appears to change significantly in different functional positions pre and post operatively. This is an important variable to consider when assessing the patients' posture change or investigating the causes of the hip dislocation after total hip arthroplasty or spinal fusion. Conclusion. Pelvic translation must be considered as a significant mechanism of adaptation after THA. Further studies are needed to study the impact on subluxation or dislocation