Femoroacetabular impingement (FAI) – enlarged, aspherical femoral head deformity (cam-type) or retroversion/overcoverage of the acetabulum (pincer-type) – is a leading cause for early hip osteoarthritis. Although anteverting/reverse periacetabular osteotomy (PAO) to address FAI aims to preserve the native hip and restore joint function, it is still unclear how it affects joint mobility and stability. This in vitro cadaveric study examined the effects of surgical anteverting PAO on range of motion and capsular mechanics in hips with acetabular retroversion. Twelve cadaveric hips (n = 12, m:f = 9:3; age = 41 ± 9 years; BMI = 23 ± 4 kg/m2) were included in this study. Each hip was CT imaged and indicated acetabular retroversion (i.e., crossover sign, posterior wall sign, ischial wall sign, retroversion index > 20%, axial plane acetabular version < 15°); and showed no other abnormalities on CT data. Each hip was denuded to the bone-and-capsule and mounted onto a 6-DOF robot tester (TX90, Stäubli), equipped with a universal force-torque sensor (Omega85, ATI). The robot positioned each hip in five sagittal angles: Extension, Neutral 0°, Flexion 30°, Flexion 60°, Flexion 90°; and performed hip internal-external rotations and abduction-adduction motions to 5 Nm in each position. After the intact stage was tested, each hip underwent an anteverting PAO, anteverting the acetabulum and securing the fragment with long bone screws. The capsular ligaments were preserved during the surgery and each hip was retested postoperatively in the robot. Postoperative CT imaging confirmed that the acetabular fragment was properly positioned with adequate version and head coverage. Paired sample t-tests compared the differences in range of motion before and after PAO (CI = 95%; SPSS v.24, IBM). Preoperatively, the intact hips with acetabular retroversion demonstrated constrained internal-external rotations and abduction-adduction motions. The PAO reoriented the acetabular fragment and medialized the hip joint centre, which tightened the iliofemoral ligament and slackenend the pubofemoral ligament. Postoperatively, internal rotation increased in the deep hip flexion positions of Flexion 60° (∆IR = +7°, p = 0.001) and Flexion 90° (∆IR = +8°, p = 0.001); while also demonstrating marginal decreases in external rotation in all positions. In addition, adduction increased in the deep flexion positions of Flexion 60° (∆ADD = +11°, p = 0.002) and Flexion 90° (∆ADD = +12°, p = 0.001); but also showed marginal increases in abduction in all positions. The anteverting PAO restored anterosuperior acetabular clearance and increased internal rotation (28–33%) and adduction motions (29–31%) in deep hip flexion. Restricted movements and positive impingement tests typically experienced in these positions with acetabular retroversion are associated with clinical symptoms of FAI (i.e., FADIR). However, PAO altered capsular tensions by further tightening the anterolateral hip capsule which resulted in a limited external rotation and a stiffer and tighter hip. Capsular tightness may still be secondary to acetabular retroversion, thus capsular management may be warranted for larger corrections or rotational osteotomies. In efforts to optimize surgical management and clinical outcomes, anteverting PAO is a viable option to address FAI due to acetabular retroversion or overcoverage

The Bernese periacetabular osteotomy (PAO) described by Ganz, et al. is a commonly used surgical intervention in hip dysplasia. PAO is being performed more frequently and is a viable alternative to hip arthroplasty for younger and more physically active patients. The procedure is challenging because pelvic anatomy is prohibitive to visibility and open access and requires four X-ray guided blind cuts around the acetabulum to free it from the hemi-pelvis. The crucial step is the re-orientation of the freed acetabulum to correct the inadequate coverage of the femoral head by idealy rotating the freed acetabular fragment. Diagnosis and the decision for surgical intervention is currently based upon patient symptoms, use of two-dimensional (2D) radiographic measurements, and the intrinsic experience of the surgeon. With the advent of new technologies allowing three-dimensional reconstructions of hip anatomy, previous two-dimensional X-ray definitions have created much debate in standardizing numerical representations of hip dysplasia. Recent work done by groups such as Arminger et al. have combined and expanded two-dimensional measurements such as Center-Edge (CE) angle of Wiberg, Vertical-Center-Anterior margin (VCA) angle, Acetabular Anteversion (AcetAV) and applied them to three-dimensional CT rendering of hip anatomy. Further, variability in pelvic tilt is a confounding factor and has further impeded measurement translatability. Computer assisted surgery (CAS) and navigation also called image-guided surgery (IGS) has been used in clinical cases of PAO with mixed results. The first appearing study of CAS/IGS in PAO was conducted by Langlotz, et. al 1997 and reported no clinical benefit to using CAS/IGS. However, they did conclude that the use of CAS/IGS is undoubtedly useful for surgeons starting this technically demanding procedure. This is supported by a more recent study done by Hsieh, et. al 2006 who conducted a two year randomised study of CAS/IGS in PAO and concluded its feasibility to facilitate PAO, but there was not an additional benefit when conventional PAO is done by an experienced surgeon. A study done by Peters, et. Al 2006 studying the learning curve necessary to become proficient at PAO found that “The occurrence of complications demonstrates a substantial learning curve” and thus makes a compelling argument for the use of CAS/IGS. A major obstacle to navigation and CAS/IGS revolves around consistency, intra-operative time and ease of use. Custom made guides and implants may help circumvent these limitations. The use of CAS/CAM in developing custom made guides has been proven very successful in areas of oral maxillofacial surgery, hip arthroplasty, and knee replacement surgeries. Additionally, a significant study in the development of rapid prototyping guides in the treatment of dysplastic hip joints was done by Radermacher et. al 1998. They describe a process of using CAS/CAM within the operational theatre using a desktop planning station and a manufacturing unit to develop what they termed as “templates” to carry out a triple osteotomy. Our group is evaluating and developing strategies in PAO using CAS/IGS and more recently using CAS and computer aided modeling (CAM) to develop custom made guides for acetabular positioning. Our first study (Burch et al.) focused on CAS/IGS in PAO using cadavers and yielded small mean cut (1.97± 0.73mm) and CE angle (4.9± 6.0) errors. Our recent study used full sized high-resolution foam pelvis models (Sawbones. ®. , Vashon, Washington) and used CAS/IGS to carry out the pelvic cuts and CAS/CAM to develop a acetabular positioning guide (APG) by rapid prototyping. The CAS/IGS pelvic cuts results were good (mean error of 3.18 mm ± 1.35) and support our and other studies done using CAS/IGS in PAO. The APG yielded high accuracy and was analysed using four angles with an overall mean angular error of 1.81 (0.55. 0. )and individual angulation was as follows: CE 0.83° ± 0.53, S-AC 0.28° ± 0.19, AcetAV 0.41° ± 0.37, and VCA 0.68° ± 0.27. To our knowledge this is the first developed APG for PAO. The APG we developed was to demonstrate the concept of using a positioning guide to obtain accurate rotation of the acetabular fragment. For a clinical application a refined and sleeker design would be required. Further, because working space within the pelvis is extraordinary constrained, once fitted the APG would need to remain and serve as an implantable cage capable of holding bone graft. A potential material is polyetheretherketone (PEEK). Customised PEEK implants and cages have been established in the literature and is a potential option for PAO. The benefits of an implant not only serve to constrain the acetabular fragment in the ideal position based upon the pre-operative plan, but may also provide the structural support for rotations not other wise possible. Though CAS/IGS is a proven viable option, we envision a potentially simpler method for PAO, the use of a cut guide and an acetabular positioning implant. Using customized guides and implants could potentially circumvent the need for specialised intra-operative equipment and the associated learning curves, by providing guides that incorporate the pre-operational plan within the guide, constraining the surgeon to the desired outcome

It has been reported that 60-85% of patients who undergo PAO have concomitant intraarticular pathology that cannot be addressed with PAO alone. Currently, there are limited diagnostic tools to determine which patients would benefit from hip arthroscopy at the time of PAO to address intra-articular pathology. This study aims to see if preoperative PROMs scores measured by IHOT-33 scores have predictive value in whether intra-articular pathology is addressed during PAO + scope. The secondary aim is to see how often surgeons at high-volume hip preservation centers address intra-articular pathology if a scope is performed during the same anesthesia event. A randomized, prospective Multicenter trial was performed on patients who underwent PAO and hip arthroscopy to treat hip dysplasia from 2019 to 2020. Preoperative PROMs and intraoperative findings and procedures were recorded and analyzed. A total of 75 patients, 84% Female, and 16% male, with an average age of 27 years old, were included in the study. Patients were randomized to have PAO alone 34 patients vs. PAO + arthroscopy 41 patients during the same anesthesia event. The procedures performed, including types of labral procedures and chondroplasty procedures, were recorded. Additionally, a two-sided student T-test was used to evaluate the difference in means of preoperative IHOT score among patients for whom a labral procedure was performed versus no labral procedure. A total of 82% of patients had an intra-articular procedure performed at the time of hip arthroscopy. 68% of patients who had PAO + arthroscopy had a labral procedure performed. The most common labral procedure was a labral refixation which was performed in 78% of patients who had a labral procedure performed. Femoral head-neck junction chondroplasty was performed in 51% of patients who had an intra-articular procedure performed. The mean IHOT score was 29.3 in patients who had a labral procedure performed and 33.63 in those who did not have a labral procedure performed P- value=0.24. Our findings demonstrate preoperative IHOT-33 scores were not predictive in determining whether intra-articular labral pathology was addressed at the time of surgery. Additionally, we found that if labral pathology was addressed, labral refixation was the most common repair performed. This study also provides valuable information on what procedures high-volume hip preservation centers are performing when performing PAO + arthroscopy

Abstract. Introduction. Recurrent groin pain following periacetabular osteotomy (PAO) is a challenging problem. The purpose of our study was to evaluate the position and dynamics of the psoas tendon as a potential cause for recurrent groin pain following PAO. Methods. Patients with recurrent groin pain following PAO were identified from a single surgeon series. A total of 13 patients with 18 hips (4.7%) out of a 386 PAO, had recurrent groin pain. Muscle path of the psoas tendon was accurately represented using 3D models from CT data were created with Mimics software. A validated discrete element model using rigid body springs was used to predict psoas tendon movement during hip circumduction and walking. Results. Five out of the 18 hips did not show any malformations at the osteotomy site. Thirteen hips (72%) showed malformation secondary to callus at the superior pubic ramus. These were classified into: osteophytes at the osteotomy site, hypertrophic callus or non-union and malunion at the osteotomy. Mean minimal distance of the psoas tendon to osteophytes was found to be 6.24 mm (n=6) and to the osteotomy site was 14.18 mm (n=18). Conclusions. Recurrent groin pain after PAO needs a thorough assessment. One need to have a high suspicion of psoas issues as a cause. 3D CT scan may be necessary to identify causes related to healing of the pubic osteotomy. Dynamic ultrasound of the psoas psoas tendon may help in evaluating for psoas impingement as a cause of recurrent groin pain in these cases

The influence of patient age on functional outcomes after periacetabular osteotomy (PAO) for acetabular dysplasia remains unclear, with previous studies utilising scores developed for older, arthritic patients. The purpose of this study is to assess the influence of patient age on International Hip Outcome Tool (iHOT-12) scores, two years after PAO. Eighty-six patients (72 female, 14 male; mean age 26.9 years) who underwent PAO by a single surgeon and had completed a minimum of two years follow up were identified. Patients were categorised into three groups according to age at the time of surgery: adolescent (11–20 years; n=29), young adult (21–30 years; n=29), and mature (≥31 years; n=28). The three groups were compared with respect to baseline variables and functional outcomes (iHOT-12, EQ-5D quality of life score, University of California Los Angeles (UCLA) activity score, pain visual analogue score (VAS)). Multivariate regression was undertaken to assess for independent predictors of two-year iHOT-12 score. The adolescent group demonstrated a lower BMI (p=0.004) while the mature group had a greater American Society of Anaesthesiology (ASA) score (p=0.049). There were otherwise no significant differences in baseline variables between the three groups (all p>0.05). The three groups demonstrated significant post-operative improvements across all functional outcome measures. There were no significant differences in two-year iHOT-12, EQ-5D, UCLA score or pain VAS between the three groups (all p>0.05). Regression modelling found that patient age at the time of surgery did not have an independent effect on two-year iHOT-12 score (p=0.878). We found that patient age at the time of surgery did not influence functional outcomes two years after PAO. Our results suggest that patient age should not be considered in isolation as an indication or contraindication for PAO

Higher levels of socioeconomic deprivation have been associated with worse health outcomes. The influence of socioeconomic deprivation on patients undergoing periacetabular osteotomy (PAO) has not previously been investigated. A total of 217 patients (171 female, 46 male; median age 23.4 years) who underwent PAO by a single surgeon were identified. Patients were categorised into three groups according to their New Zealand Deprivation (NZDep) Index: minimal deprivation (NZDep Index 1–3, n=89), moderate deprivation (NZDep Index 4–6, n=94), and maximal deprivation (NZDep Index 7–10, n=34). The three groups were compared with respect to baseline variables, surgical details, complications, and pre-operative and two-year post-operative functional scores (including International Hip Outcome Tool (iHOT-12), EQ-5D quality of life score, and University of California Los Angeles (UCLA) activity score). Multivariate regression was undertaken to assess for the effect of NZDep Index on patient outcomes. Patients in the maximal deprivation group were more likely to be Māori (p<0.001) and have surgery in a public rather than a private hospital (p=0.004), while the minimal deprivation group demonstrated a lower BMI (p=0.005). There were otherwise no other significant differences in baseline variables, surgical details, complications, nor pre-operative or two-year post-operative functional scores between the three groups (all p>0.05). Multivariate analysis identified a higher NZDep Index to be independently predictive of a lower pre-operative UCLA activity score (p=0.014) and a higher two-year iHOT-12 score (p<0.001). Our results demonstrate an inequality in access to PAO, with patients exposed to higher levels of socioeconomic deprivation under-represented in our study population. When provided access to PAO, these vulnerable patients achieve significant functional improvement at least as great as patients with less socioeconomic deprivation. Initiatives to improve access to hip preservation care in socioeconomically deprived populations appear warranted

Introduction. We perform PAO via a modified Smith-Petersen approach. The purpose of this study was to investigate the result of PAO via a modified Smith-Petersen approach at a minimum 10-years' follow-up. Methods. We retrospectively reviewed 209 hips in 179 patients with acetabular dysplasia who underwent PAO with a modified Smith-Petersen approach from August 1995 to April 2010. Exclusion criteria were as follows: under 10 year follow-up, incomplete clinical or radiographic data. Harris hip score (HHS) was investigated preoperatively, at the time of most improvement and at the final follow-up for clinical evaluation. Tönnis classification was investigated preoperatively and at the final follow-up for evaluation of osteoarthritis. Center edge (CE) angle and acetabular roof obliquity (ARO) were investigated preoperatively, postoperatively and at the final-follow up for radiographic evaluation. Tönnis classification and radiographic parameters were investigated on anterior-posterior radiographs. Patients of conversion of PAO to total hip arthroplasty (THA) were investigated for preparing Kaplan Myer survival analysis. The Wilcoxon signed-rank test was used to compare changes in HHS and radiographic parameters between the preoperative and the postoperative values. Statistical significance was defined a priori as p < 0.05. Results. Eighty-seven hips in 79 patients (44.1%) were included in this study. 100 patients were excluded from this study. The average age of the patients at the time of surgery was 39 years (rang, 15 to 65 years) and the mean follow-up period was 12 years and 2 months (range, 10 years to 18 years and 3 months). The mean HHS improved from 74 points (range, 38 to 98 points) preoperatively to 95 points (range, 62 to 100 points) at the time of most improvement (p < 0.01) and decrease slightly to 89 points (range, 32 to 100 points) at final follow-up. Tönnis classification was as follows: grade 0 was 4 hips preoperatively and 2 hips at the final follow-up, grade 1 was 55 hips preoperatively and 50 hips at the final follow-up, grade 2 was 25 hips preoperatively and 24 hips at the final follow-up, grade 3 was 3 hips preoperatively and 11 hips at the final follow-up. The mean CE angle improved from 5° (range, −19 to 24°) preoperatively to 30° (range, 2 to 56°) postoperatively (p < 0.01) and increased 38° (range, 12 to 68°) at final follow-up. The mean ARO improved from 24° (range, 6° to 45°) preoperatively to 6° (range, −14° to 48°) postoperatively (p < 0.01) and increased to 12° (range, −24 to 45°) at final follow-up. THA was performed on 5 hips in 5 patients (5.7%) after PAO. The mean duration between PAO and THA was 9 years and 6 months (range, 1 year and 4 months to 15 years 4 months). Ten-year survival rate was 97 % with conversion THA as the end point. Discussion & Conclusion. Clinical data and radiographic parameter were improved in patients who underwent PAO satisfactory. PAO was instrumental as time-saving surgical treatment of symptomatic acetabular dysplasia or slightly osteoarthritis because of 97% survival rate at 10 years

Purpose. Periacetabular osteotomy (PAO) is a versatile acetabular reorienting procedure that is most commonly used to provide greater femoral head coverage in adolescent hip dysplasia. However, PAO can also be used to reorient the acetabulum in the opposite direction to treat femoroacetabular impingement (FAI) due to acetabular over-coverage. We describe the indications, surgical technique, and early results of reverse PAO to reduce femoral head coverage in symptomatic hips with FAI due to acetabular over-coverage. Methods. IRB approval was obtained to retrospectively review cases of symptomatic acetabular over-coverage treated with reverse PAO and that had a minimum of two years follow-up. All hips had atypical intraoperative positioning of the acetabular fragment to uncover the lateral and anterior aspects of the femoral head, with or without anteverting the acetabulum. Prospectively collected pre- and post-operative demographics, WOMAC scores, Modified Harris Hip Score (MHHS), and radiographic measurements consisting of the lateral center edge angle (LCEA), Tönnis angle (TA), and anterior center edge angle (ACEA) were compared using student's t-test. Results. Between 2004 and 2015, 31 hips (18 left, 13 right) in 26 patients (18 female, 8 male) met the inclusion criteria. Average age at the time of surgery was 19.4 years. Average length of follow-up was 30.4 months. After reverse PAO, femoral head coverage significantly decreased (LCEA 41.7° to 35.3°, p<.001; TA −7.4° to −3.7°, p<.01; ACEA 44.0° to 35.3°, p<.0001). Patients experienced improved post-operative pain, with decreases in WOMAC pain score (from 8.8 to 4.2, p<.001) and WOMAC stiffness score (from 3.5 to 1.9, p<.001). Patients also experienced improvements in function and quality of life with improvements in WOMAC function score (from 24.8 to 10.0, p<.001) and MHHS (from 60.8 to 83.2, p<.0001). Conclusion. Reverse PAO is a technically challenging procedure that provides clinical and radiographic improvement in patients with symptomatic FAI due to acetabular over-coverage. Significance. Reverse PAO is an especially useful and appropriate alternative to arthroscopic acetabular rim-trim in complex FAI pathomorphologies

During a periacetabular osteotomy (PAO), intra-operative assessment of correction of acetabular parameters is typically performed using fluoroscopy of the hip, a technique that has not been shown to produce predictable measurements. Furthermore, paralysing agents are used in order to facilitate dissection and fragment mobilization. The effect of paralysing agents on spino-pelvic posture is yet to be investigated. This study aims to: 1. Compare the reliability of intra-operative x-rays versus hip fluoroscopy in the assessment of acetabular fragment correction and 2. Evaluate the effect of changes in spino-pelvic alignment on the assessment of acetabular correction. An IRB approved, retrospective review of all patients who underwent a PAO at our institution between 2006–2018 was performed. Patient demographic data was collected and all available imaging studies were retrieved. Patients were excluded if there was no available to review intra-operative AP pelvis x-ray or intra-operative fluoroscopic PA image of the hip. Using a validated hip analysis software (Hip2Norm), the lateral center edge angle (LCEA) and acetabular index (AI) of plain radiographs were measured. The sacro-femoral-pubic angle (SFP), along with the LCEA and AI of the fluoroscopic image were measured using ImageJ. A oneway ANOVA was used to detect differences between measured parameters in the intra-operative x-ray, the post-operative x-ray and the fluoroscopic image. A total of 93 patients were identified. 26 patients were excluded due to missing data. The mean LCEA in the post-operative, intra-operative, and fluoroscopic groups were as follows: 33.67° (range 5.3° to 52.4°), 30.71°(range 9° to 55.6°), and 29.23°(range 12.4° to 51.4°) respectively. The mean AI in the post-operative, intra-operative, and fluoroscopic groups were as follows: −0.65° (range −18.10° to 27.30°), 0.35°(range −16.10° to 17.20°), and 5.54°(range −11.66° to 27.83°) respectively. When comparing intra-operative to post-operative plain radiographs, there was no statistically significant difference in AI (ΔAI −1±1.29° p=0.71) or LCEA (ΔLCEA 2.95±1.38° p=0.09). When comparing fluoroscopy to post-operative plain radiographs, there was a statistically significant difference in AI (ΔAI −6.21±1.29° p < 0 .0001) as well as LCEA (ΔLCEA 4.44±1.38° p < 0 .0001). Statistical analysis revealed no influence of demographics (age, BMI, gender), on acetabular correction parameters. The mean SPF angles measured from intra-operative and post-operative x-rays were 69.32±5.11° and 70.45±5.52°. There was a statistically significant difference between these 2 measurements with a ΔSFP of 1.03° (p < 0 .0001). The results of our study show that the use of intra-operative x-ray for the assessment of LCEA and AI is more reliable than fluoroscopic images. Further, we found a difference in SFP angle, which offers an indirect assessment of pelvic tilt, between the intra-operative and the post-operative plain x-rays. This suggests that there are changes in pelvic tilt during the surgery, which can be attributed to either patient positioning or changes in spino-pelvic posture secondary to the paralysing agents used by the anesthetists. The use of intra-operative x-rays as well as the effect of paralysing agents on spino-pelvic alignment should be considered by surgeons performing PAO's

Over the past fifteen years hip preservation surgery has rapidly evolved. Improved understanding of the pathomechanics and associated intra-articular degeneration of both hip instability and femoroacetabular impingement have led to improved surgical indications, refined surgical techniques and more effective joint preservation surgical procedures. The periacetabular osteotomy (PAO) was initially introduced by Ganz and colleagues and has become the preferred treatment in North America for pre-arthritic, symptomatic acetabular dysplasia. Both hip arthroscopy and safe surgical dislocation of the hip have been popularised for the treatment of symptomatic femoroacetabular impingement disorders. Hip arthroscopy is effective for focal and\or accessible impingement lesions while the surgical dislocation approach is reserved for nonfocal disease patterns as seen in complex FAI, and residual Perthes and SCFE deformities. Femoroacetabular impingement from major acetabular retroversion can be managed with the PAO if there is coexistent posterosuperior acetabular insufficiency. Short- to mid-term results of these procedures are generally good to excellent for most patients and the complication rates associated with these procedures are very acceptable. Long-term outcomes are best known for the PAO. Several recent studies have documented survivorship rates of 65–90% at 10–20-year follow-up. Certain factors are associated with long-term success including minimal pre-operative radiographic OA, early symptoms, accurate acetabular correction, and younger age. These data strongly suggest that the PAO can defer THA to an older age for most patients while completely avoiding arthroplasty may only be possible in select patients with excellent congruency, no secondary OA and an ideal surgical correction

Developmental dysplasia of the hip (DDH) is relatively a common condition that can lead to early arthritis of the hip. Although total hip arthroplasty is the surgical treatment of choice for these patients with end stage arthritis, some patients afflicted with DDH may present early. Acetabular osteotomy, in particular Bernese or periacetabular osteotomy (PAO as described by Professor Ganz and Jeff Mast back in 1980s) may be an option with patients with symptomatic DDH who have joint space available. PAO has many advantages. First, it is performed through a single incision (modified Smith Peterson approach) without breaching the abductor mechanism. The periacetabular fragment has, hence, excellent blood supply and avascular necrosis of the acetabular portion is not an issue. In addition, the osteotomy is so versatile allowing for great mobility of the fragment to obtain coverage even in the worst of circumstances. The osteotomy does not affect the posterior column and hence allows for earlier weight bearing. Most joint preservation surgeons in North America and Europe prefer PAO to other types of osteotomy. The indications for PAO are a patient with symptomatic DDH who has good joint space and a congruent joint. The congruency of the joint is usually determined by the abduction views (obtained at 30 degrees abduction and neutral rotation). Although the joint space may be measured on plain radiographs, in recent years some centers have been utilising cross sectional imaging, such as dGEMERIC for evaluation of the articular cartilage, which has been shown to be a good predictor of outcome for PAO

Introduction. Several reports demonstrated the overcoverage of the anterior acetabulum. Anterior CE angle over 46°may be a probable risk factor for pincer FAI syndrome after a rotational acetabular osteotomy. In addition, a highly anteverted femoral neck, reported as a risk factor for posterior impingement, has been found in DDH patients. These findings indicate proper acetabular reorientation is essential to avoid anterior or posterior impingement after periacetabular osteotomy (PAO). The aim of this study was to evaluate the relationship between acetabular three-dimensional (3D) alignment reorientation and clinical range of motion (ROM) after periacetabular osteotomy (PAO). Methods. A total of 53 patients who underwent curved PAO (CPO) for DDH from January 2014 to April 2017 were selected. Three (5.7%) of them were lost to follow-up. Therefore, the data from 58 hips, contributed by 50 patients (44 women and 6 men), were included in the analysis. Pre- and postoperative computed tomography (CT) scans from the pelvis to the knee joint were performed and transferred to a 3D template software (Zed Hip; Lexi, Tokyo, Japan). The pelvic plane axis was defined according to the functional pelvic plane. The pre- and postoperative lateral and anterior 3D center-edge (CE) angles were measured on the coronal and sagittal views through the center of the femoral head. The pre- and postoperative 3D center-edge (CE) angles and femoral anteversion were measured and compared with clinical outcomes, including postoperative ROM. Results. The radiographical outcomes of our study are demonstrated in Figure 1. The mean values of pre- and postoperative lateral CE angles were 12.6º±8.7 and 30.2º±9.7, respectively (p<0.001), and mean pre- and postoperative anterior CE angles were 42.4º±15.3 and 63.9º±12.1, respectively (p<0.001). Both CE angles were significantly improved. The correlation between pre- and postoperative acetabular coverage and postoperative ROM was evaluated. Postoperative abduction and internal rotation ROM were significantly associated with postoperative lateral CE angles (abduction; p < 0.001, internal rotation; p = 0.028); flexion and internal rotation ROM was significantly associated with postoperative anterior CE angles (flexion; p < 0.001, internal rotation; p = 0.028). Femoral anteversion was negatively correlated with postoperative abduction (p = 0.017) and external rotation (p = 0.047) ROM (Table 1). Postoperative abduction ROM was strongly positively correlated with femoral anteversion, whereas postoperative external rotation was strongly negatively correlated (Table 2). The total anteversion was strongly correlated with pre- or postoperative ROMs during flexion and internal rotation ROM (Table 2). Conclusion. Postoperativeanterior acetabular coverage may affect internal rotation ROM more than the lateral coverage. Therefore, the direction of acetabular reorientation should be carefully determined according to 3D alignment during PAO. For any figures or tables, please contact the authors directly

INTRODUCTION. The efficacy of tranexamic acid (TXA) to reduce blood loss in various surgical procedures has been proven. However, there is little data about the effect of TXA on blood loss, rate of blood transfusion and thromboembolic events during periacetabular osteotomy (PAO). The reduction of blood loss during PAO promotes postoperative mobilization and reduces the risk of complications, associated with blood transfusions. The aim of the following study was to determine, if TXA can reduce both blood loss and the rate of blood transfusions. In addition we analyzed whether TXA was associated with an increased risk of thromboembolic events. METHODS. A consecutive series of 96 PAO procedures was reviewed to compare the groups immediately prior to and following the routine implementation of TXA. The TXA group received a continuous infusion of TXA with a rate of 10mg/kg/h. The outcome was blood transfusion rate, total blood loss, length of hospital stay, and thromboembolic events. RESULTS. The rate of autogenic and allogeneic blood transfusion decreased from 62.5% to 12.5% (p<0.001) between the non-TXA and TXA group. The average blood loss (1.9 l ± 0.9 vs. 1.5 l ± 0.7, p <0.01) was significantly reduced in the patients receiving TXA. No cases of postoperative thromboembolic events were identified in either group. The hospital stay was reduced from 10 days to 9 days in the TXA group. DISCUSSION AND CONCLUSION. The utilization of TXA reduced the transfusion rate and blood loss after PAO, without additional adverse effects such as an increased rate of thromboembolic events

Introduction. The goal of this work is to develop a system for three-dimensional tracking of the acetabular fragment during periacetabular osteotomy (PAO) using x-ray images. For PAO, the proposed x-ray image-based navigation provides geometrical and biomechanical assessment of the acetabular fragment, which is unavailable in the conventional procedure, without disrupting surgical workflow or requiring tracking devices. Methods. The proposed system combines preoperative planning with intraoperative tracking and near real-time automated assessment of the fragment geometry (radiographic angles) and biomechanics (contact pressure distribution over the acetabular surface). During PAO, eight fiducial beads are attached to the patient after incision and prior to performing osteotomy. Four of the beads attach to the iliac wing above the expected superior osteotomy (these are termed confidence points), and four attach on the expected fragment (denoted fragment points). At least two x-ray images are obtained before and after osteotomy. In each set of images, image processing routines segment the fiducials and triangulate the 2D fiducial projections in 3D space. A paired-point registration between the confidence points triangulated from the two x-ray image sets aligns the imaging frames. We measured the transformation between the fragment points with respect to the confidence points to quantify the motion of the acetabular fragment. Applying an image-based 2D-3D registration to the measured acetabular transformation localises the reoriented acetabular fragment with respect to an anatomical coordinate system. We present the surgeon with visualisation and automatic estimations of radiographic angles and biomechanics of the reoriented acetabular fragment. We conducted an experiment to evaluate feasibility and accuracy of the proposed system using a high density pelvic sawbone. Stainless steel beads were glued to the sawbone as fiducials. X-ray images were selected from cone-beam CT (CBCT) scans with an encoded motorised C-arm. Fiducial segmentation from reconstructed volumes of the CBCT scans provided a ground truth for the experiment. Results. We used four images spaced at 45° to perform the 2D/3D registration. The measured fragment transformation errors in translation and rotation about a fixed axis when compared to the CBCT-computed transformation were 0.37°, 0.34mm for the x-ray image based approach (with 3 images spaced at 20°) and 1.49°, 4.39mm for the optical tracker. Conclusion. We developed and evaluated x-ray image-based navigation to track the acetabular fragment in 3D Cartesian space during PAO. Capturing the fragment transformation allows automated algorithms to assess the biomechanics and geometry of the realigned acetabulum that are unavailable in 2D. The error between the measured positions of the beads and the triangulated positions is attributed to three main sources: 1) fiducial segmentation error; 2) geometric calibration error; and 3) localisation of fiducials in volumetric reconstructions of the CBCT scans. These small reported errors suggest the procedure is a viable approach for conducting x-ray image-based navigation of PAO

Purpose. To validate a small, easy to use and cost-effective augmented marker-based hybrid navigation system for peri-acetabular osteotomy [PAO] surgery. Methods. A cadaver study including 3 pelvises (6 hip joints) undergoing navigated PAO was performed. Inclination and anteversion of two navigation systems for PAO were compared during acetabular reorientation. The hybrid system consists of a tracking unit which is placed on the patient's pelvis and an augmented marker which is attached to the patient's acetabular fragment. The tracking unit sends a video stream of the augmented marker to the host computer. Simultaneously, the augmented marker sends orientation output from an integrated inertial measurement unit (IMU) to the host computer. The host computer then computes the pose of the augmented marker and uses it (if visible) to compute acetabular orientation. If the marker is not visible, the output from the IMU is used to update the orientation. The second system served as ground truth and is a previously developed and validated optical tracking-based navigation system. Results. Mean absolute difference for inclination and anteversion (N = 360) was 1.34 degrees and 1.21 degrees, respectively. The measurements from our system show a very strong correlation to the ground-truth optical tracking-based navigation system for both inclination and anteversion (0.9809 / 0.9711). Conclusion. In this work, we successfully demonstrated the feasibility of our system to measure inclination and anteversion during acetabular reorientation

90% of young patients that develop DJD of the hip have an underlying structural problem, most frequently hip dysplasia. The structural problem results in decreased contact area, increased contact stresses about the anterior and lateral acetabulum and femoral head and results in labral pathology, early cartilage damage and if left untreated leads to end stage hip arthritis. Despite the optimism of alternative bearing surfaces and highly cross linked polyethylene, THA should still be discouraged in young patients. Many patients with symptomatic hip dysplasia in the absence of arthritis will benefit from joint preservation. The goal of treatment should be restoration of anatomy as close to normal as possible. The Bernese PAO is the preferred technique in many centres in North America and Europe because of its balance between minimal exposure, complications, and ability to provide optimal correction. The ideal patient for a PAO is young, has no arthritis, is not obese (BMI <30) and has poorly covered femoral head where congruency is possible. A PAO has advantages over other osteotomies and include: . 1). Performed through one incision without violation of the abductors. 2). Pelvic ring and an outlet, are not disrupted. 3). Posterior column is preserved. 4). Allow multidirectional correction. 5). Can perform capsulotomy to assess the labrum and check for impingement. The results of the osteotomy have been encouraging with up to 60% survivorship free from total hip arthroplasty at 20 years. Most studies show improvement in pain and function, improvement in radiographic coverage of the femoral head with no improvement in range of motion. Treatment should be individualised to each patient based on radiographic findings, age and cartilage status and restoration of anatomy as close to normal as possible should be the ideal treatment, most commonly in the form of a periacetabular osteotomy

Background. Periacetabular osteotomy (PAO) is an effective treatment method for early or mild osteoarthritis caused by developmental dysplasia of the hip. Since the procedure is performed from late eighties of the past century it is still a very demanding procedure performed only by high skilled surgeons in high volume orthopaedic centres. The idea was to develop a custom-made surgical tool to improve the accuracy of the two osteotomies of the iliac bone and help us to avoid inadvertent intraarticular osteotomy of the acetabulum. Methods. Firstly CT scans of pelvises of two cadavers were performed. The DICOM format files were up-loaded into EBS software (Ekliptik d.o.o., Ljubljana, Slovenia), application for preoperative planning, constructing and designing different templates, where the three-dimensional (3D) model of each pelvis was created. On the virtual pelvis models the PAO lines on each of four acetabuls were placed and virtual PAOs were performed [Fig. 1]. For the execution of the two iliac bone osteotomies the osteotome or saw guiding jigs were virtually created and exported in STL format in ProJet 3500 HDPlus printer which created custom made jigs made from VisiJet Crystal biocompatible plastic material (3D systems, Rock Hill, South Carolina, USA) for each of the four acetabula. The next step was the surgery on aforementioned cadavers. Extended Smith-Petrson approach was performed on each of four cadaveric hips and Bernese PAOs were performed using custom-made jigs. After performing the acetabular correction the cadavers were carefully dissected to study any possible posterior column damage or damage of the acetabular wall. None of them were damaged and the osteotomies were performed according to the virtual plan. Next step was the real procedure on 47-years old female patient with bilateral acetabular dysplasia. The procedure was executed on right side using the extended Smith-Peterson approach. Preoperatively native X-ray of both hips and the CT scan of pelvis were performed. According the CT scan (DICOM format) the virtual 3D model of the pelvis was created and virtual osteotomy lines were decided and production of the appropriate jig was manufactured in the same manner as for the cadavers [Fig. 2]. Preoperative and postoperative centre-edge (CE) angles were measured. Results. Preoperatively the patient had a Tönnis grade I osteoarthritis of the right hip. The preoperative CE angle was 19.1° and the postoperative CE angle is 36.7° [Fig. 3] which indicates good improvement in coverage of the femoral head. Patient had an uneventful postoperative course, with no neuro-vascular damage. The intraoperative blood loss was 250 ml and the patient was discharged from hospital on seventh postoperative day, walking with crutches loading 15 kg. Conclusion. Custom-made jig for iliac bone osteotomy in PAO procedures is a helpful tool, which improves accuracy of the osteotomy lines, safety of the patient and considerably reduces surgical time. We are planning to create also jigs for screw placement and the device to verify intraoperatively the level of PAO correction

Introduction. Acetabular retroversion is an accepted cause of Pincer-type femoroacetabular impingement. There is increasing evidence that acetabular retroversion is rather a rotational abnormality of the pelvis than an overgrowth of the acetabular wall or even a dysplasia of the posterior wall. Initially, patients with a retroverted acetabulum were treated with an open rim trimming through a surgical hip dislocation (SHD) based on the early understanding of the pathomorphology. Theoretically, the reduction of the anterior wall can decrease the already small joint contact area in retroverted hips to a critical size. Based on the most recent literature, anteverting periacetabular osteotomy (PAO) seems to be the more appropriate surgical treatment. With this technique, the anterior impingement conflict can be treated efficiently without compromising the joint contact area. However, it is unknown whether this theoretical advantage in turn results in better mid term results of treatment. Objectives. We asked if anteverting PAO results in better clinical and radiographical mid term results compared to rim trimming through a surgical hip dislocation. Methods. We performed a retrospective comparative study based on 257 hips (221 patients) with symptomatic femoroacetabular impingement due to acetabular retroversion. Acetabular retroversion was defined by a cross-over sign, a posterior wall sign, and a positive ischial spine sign. We then formed two matched groups consisting of 73 hips undergoing open acetabular rim trimming and 54 hips with an anteverting periacetabular osteotomy. Patients with incomplete radiographic documentation, previous surgery, and hip dysplasia (LCE < 20°) were excluded. Some patients were excluded due to a matching process (Fig. 1). Patients were generally followed clinically and radiographically after two, five and ten years. A Kaplan-Meier survivorship analysis was performed using the following endpoints: a low clinical score, radiographic progression of osteoarthritis, and/or the conversion to total hip arthroplasty. The Log Rank Score was used to compare the two survivorship curves. Results. Patients undergoing anteverting PAO for acetabular retroversion had a significantly increased survivorship (82%, 95% confidence interval, 72–91%) at seven years in comparison to open surgical rim trimming (63%, 95%CI, 49–76%, p<0.0001). The two survivorship curves are comparable for the first four years with a substantial drop for the rim trimming group after year five (Fig. 2). Conclusion. This study proofs for the first time that the theoretical advantages of anteverting periacetabular osteotomy in hips with symptomatic acetabular retroversion results in an increased survivorship at mid term follow-up in comparison to open rim trimming. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Hip dysplasia has traditionally been classified based on the lateral centre edge angle (LCEA). A recent meta-analysis demonstrated no definite consensus and a significant heterogeneity in LCEA values used in various studies to define hip dysplasia and borderline dysplasia. To overcome the shortcomings of classifying hip dysplasia based on just LCEA, a comprehensive classification for adult acetabular dysplasia (CCAD) was proposed to classify symptomatic hips into three discrete prototypical patterns of hip instability, lateral/global, anterior, or posterior. The purpose of this study was to assess the reliability of this recently published CCAD. One thirty four consecutive hips that underwent a PAO were categorized using a validated software (Hip2Norm) into four categories of normal, lateral/global, anterior or psosterior. Based on the prevalence of individual dysplasia and using KappaSize R package version 1.1, seventy four cases were necessary for reliability analysis: 44 dysplastic and 30 normal hips were randomly selected. Six blinded fellowship trained raters were then provided with the classification system and they looked at the x-rays (74 images) at two separate time points (minimum two weeks apart) to classify the hips using standard PACS measurements. Thereafter, a consensus meeting was held where a simplified flow diagram was devised before a third reading by four raters using a separate set of 74 radiographs took place. Intra-rater results per surgeon between Time 1 and Time 2 showed substantial to almost perfect agreement amongst the raters. With respect to inter-rater reliability, at time 1 and time 2, there was substantial agreement overall between all surgeons (kappa of 0.619 for time 1 and 0,623 for time 2). Posterior and anterior rating categories had moderate and fair agreement at time 1 and time 2, respectively. At time 3, overall reliability (kappa of 0.687) and posterior and anterior rating improved from Time 1 and Time 2. The comprehensive classification system provides a reliable way to identify three categories of acetabular dysplasia that are well-aligned with surgical management. The term borderline dysplasia should no longer be used

There are three major diagnoses that have been associated with early hip degeneration and subsequent hip replacement in young patients: FAI, hip dysplasia and hip osteonecrosis. I will focus mainly on the first two. Both conditions, if diagnosed early in the symptomatic patient, can be surgically treated in order to try to prevent further hip degeneration. But, what is the natural history of these disorders?. Our recent paper published this year described the natural history of hip dysplasia in a group of patients with a contralateral THA. At an average of 20 years, 70% of hips that were diagnosed at Tönnis Grade 0, had progression in degenerative changes with 23% requiring a THA at 20 years. Once the hip degeneration progressed to Tönnis 1, then 60% of hips progressed and required a THA. This natural history study demonstrates that degeneration of a dysplastic hip will occur in over 2/3 of the hips despite the limitations of activity imposed by a contralateral THA. In this same study, we were unable to detect a significant difference in progression between FAI hips and those categorised as normal. FAI damage has been commonly considered to be “motion-induced” and as such, the limitations imposed by the THA, might have limited the progression in hip damage. Needless to say, progression was seen in about half of the hips at 10 years, but very few required a THA at final follow-up. We have recently presented data on a group of young asymptomatic teenagers with FAI. At 5 years of follow-up, the group of patients with limited ROM in flexion and internal rotation, cam deformity and increased alpha angles, depicting a more severe form of disease, showed MRI evidence of progression in hip damage and worst clinical scores than a control group. This data supports our initial impressions that FAI may truly lead to irreversible hip damage. Is surgery always the option? I indicate surgery when the patient is symptomatic and has a correctable structural problem that has failed non-operative management. The data suggests that few patients improve with physical therapy, but activity modification may be an option in patients with FAI as the hip damage is mainly activity related. This may not be the case with hip dysplasia. For hip dysplasia, my current recommendations are in the form of a periacetabular osteotomy (PAO) to correct the structural problem. The procedure leads to improvement in pain as it takes care of the 4 pain generators in the dysplastic hip: the labrum, cartilage, abductors, and resultant instability. The labrum and cartilage are off-loaded with the PAO, the instability is improved by providing containment and the abductor pain is improved by improving the hip mechanics by medializing the acetabulum. I perform a hip arthroscopy prior to the PAO in the majority to treat the labrum and to perform a head neck junction osteochondroplasty, if needed. Correction of the dysplasia to a more normal hip, will improve the outcome of these hips in the long-term. For FAI, arthroscopy has become the best option for management and today is considered the gold standard. A careful review of the imaging is important prior to surgical decision making as patient selection and surgical correction is key. Poor outcomes have been seen in patients with advanced degenerative changes (joint space narrowing, femoral head damage) or in patients with incomplete correction of the deformity. Open surgical correction is an option in cases where deformity precludes an arthroscopic treatment alone