Joint load reduction is effective for alleviating OA pain. Treatment options for joint unloading include braces and HTO, both of which may be impractical for patients. The purpose of the present study was to examine the biomechanical rationale of a practical, partial unloading implant (KineSpring® System, Moximed) for knee OA.

Device durability was tested by cyclically loading bone-implant constructs through simulated use for at least 10 million cycles. Joint load reduction with the implant was quantified by measuring changes in medial and lateral knee compartment loads generated by cadaver knees in simulated gait. Safety of the device was tested by 3, 6, and 12 month follow-up of implants in an in vivo ovine model. Surgical technique and device safety and efficacy were assessed in human clinical studies.

The unloader device survived over 15 million cycles of simulated use without failure. In the simulated gait cadaver model, the unloading device significantly reduced medial compartment (29 ± 13 lbs, p<0.05) and overall knee joint loads during the stance phase of gait testing but did not significantly increase lateral compartment loading. Chronic ovine implants demonstrated good tolerance of the implant with normal wound healing and secure device fixation. Clinical experience (n=49) demonstrated uneventful device implantation. Unlike HTO, the implantation technique for the unloader does not alter joint alignment. This surgical technique avoids removal of bone, ligament, and cartilage, thus preserving future primary arthroplasty, if required. Early-term clinical experience also demonstrates good outcomes for patients, the earliest of whom are beyond 2.6 years with the implant.

This unloading device offers a practical and attractive treatment option for patients with medial knee OA: load reduction without load transfer, durability, preservation of downstream treatment options, safety, and early-term efficacy.

Opening wedge high tibial osteotomy (OWHTO) is a treatment option for medial compartment osteoarthritis of the knee in the young active adult. Limited evidence exists in the literature regarding return to activities following OWHTO.

We performed a retrospective study of local patients who underwent OWHTO from 2005 – 2012 assessing post-operative return to sporting function. Patients with additional knee pathology, surgery or alternative issues affecting activity were excluded.

110 patients met inclusion criteria, 75 were successfully contacted.

Mean improvement in pain score = 4.8/10 (95%CI 4.2 to 5.4, p<0.01). Mean pre-operative KOS-SAS score = 0.5/2, mean post-operative KOS-SAS score = 1.1/2, mean change in KOS-SAS score following OWHTO = 0.6 (95% CI 0.5 to 0.7, p<0.01). Mean pre-morbid Tegner score = 5.9/10, pre-operative = 2.7/10, post-operative = 4.2/10. Mean change in Tegner score following OWHTO = 1.5 (95% CI 1 to 1.9, p<0.01). Following OWHTO 25% of patients achieved pre-morbid Tegner scores. Patient BMI, age, type of implant or graft used had no significant effect on outcome.

OWHTO can temporarily improve pain, activity and sporting levels in young patients with isolated medial compartment knee OA. Return to pre-morbid activity levels and even high level sports function is possible although not the norm.

Several attempts have been made to treat medial compartment OA of the knee with mobile spacers. All have met with dismal failure. This presentation explores the history of attempts to treat OA in the younger knee with mobile spacers and explains why they were all doomed to fail. Sources of information for this presentation include the published peer reviewed literature, publically available documents, and an insiders view of some of the failed attempts to solve the problem of medial compartment OA with mobile spacers. All attempts to treat medial compartment OA of the knee with mobile spacers have failed. The unispacer has been a failure with a 60% revision rate at three years. The ABS intercushion had a 100% revision rate at one year and in many cases caused permanent damage to the host knees. The Salucartilage spacer was implanted in one patient only and failed within 48 hours. Mobile spacers do not work, are never likely to work, and are not indicated for the treatment of medial compartment osteoarthritis of the knee

Osteoarthritis (OA) is the fastest growing global health problem, with a total joint replacement being the only effective treatment for patients with end stage OA. Many groups are examining the use of bone marrow or adipose derived mesenchymal stem cells (MSCs) to repair cartilage, or modulate inflammation to promote healing, however, little efficacy in promoting cartilage repair, or reducing patient symptoms over temporary treatments such as micro-fracture has been observed. There is a growing body of literature demonstrating that MSCs derived from the synovial lining of the joint are superior in terms of chondrogenic differentiation and while improvements in clinical outcome measures have been observed with synovial MSCs, results from clinical studies are still highly variable. Based on our results, we believe this variability in clinical studies with MSCs results in part from the isolation, expansion and re-injection of distinct MSCs subtypes in normal vs. OA tissues, each with differing regenerating potential. However, it remains unknown if this heterogeneity is natural (e.g. multiple MSC subtypes present) or if MSCs are influenced by factors in vivo (disease state/stage). Therefore, in this study, we undertook an ‘omics’ screening approach on MSCs from normal and OA knee synovial tissue. Specifically, we characterized their global proteome and genomic expression patterns to determine if multiple MSC from normal and OA joints are distinct at the protein/gene expression level and/if so, what proteins/genes are differentially expressed between MSCs derived from normal and OA synovial tissue. Synovium tissue was collected from OA patients undergoing joint replacement and normal cadaveric knees. The in vitro adipogenic, chondrogenic and osteogenic differentiation potential of the MSCs was analyzed via qPCR and histology. Fully characterized MSC populations where then analyzed through an unbiased shotgun proteomics, and microarray analysis. Synovial MSCs isolated from both OA and normal knees demonstrated similar multipotent differentiation capacity. Likewise, both OA and normal MSCs display the typical MSCs cell surface marker profile in vitro (CD90+, CD44+, CD73+, CD105+). Using shotgun proteomics, 7720 unique peptides corresponding to 2183 proteins were identified and quantified between normal and OA MSCs. Of these 2183 proteins, 994 were equally expressed in normal and OA, MSCs, 324 were upregulated in OA MSCs (with 50 proteins exclusively expressed in OA MSCs), 630 proteins were upregulated in normal MSCs (with 16 proteins exclusively expressed in normal MSCs). Microarray analysis of normal and OA MSCs demonstrated a similar result in where, 967 genes were differentially expressed between normal and OA MSCs, with 423 genes upregulated in OA, and 544 genes upregulated in normal MSCs. In this project, we have demonstrated that although normal and OA synovial derived MSCs demonstrate similar multipotent differentiation potential and cell surface markers expression, these cells demonstrated significant differences at the molecular level (protein and gene expression). Further research is required to determine if these differences influence functional differences in vitro and/or in vivo and what drives this dramatic change in the regulatory pathways within normal vs. OA synovial MSCs

There are a number of different non-operative management options for patients with a painful knee secondary to osteoarthritis (OA). In 2013 the American Academy of Orthopaedic Surgeons developed an evidence-based clinical practice guideline addressing treatment of osteoarthritis of the knee. Strength of recommendations were designated as strong, moderate and inconclusive. Strong recommendations included: self-management program, NSAIDs or tramadol and no acupuncture, no glucosamine and chondroitin sulfate and no hyaluronic acid. The “No” recommendations for hyaluronic acid and glucosamine and chondroitin sulfate were quite controversial because orthopaedic surgeons argued that some of their patients benefited from these treatments. Moderate strength recommendations included weight loss, lateral wedge insoles and needle lavage. The evidence-based data was inconclusive with respect to valgus force unloading brace, manual physical therapy, acetaminophen, opioids and pain patches. The effectiveness of corticosteroid and platelet rich plasma (PRP) injections were also inconclusive. Unloader braces are available to decrease pressure on the involved compartment. There is data showing that these braces can be effective for some patients. However, there are concerns with patient compliance because of poor fit and discomfort. These braces seemed to be tolerated best when used for sports activities in patients with medial compartment arthritis. Oral anti-inflammatory agents are effective in relieving pain and are a good first line agent for patients with OA. There is significant interest in the use of PRP injections for management of patients with knee OA particularly when patients have already received a steroid and/or a hyaluronic acid injection. To date there are no appropriately powered multi-centered randomised trials demonstrating that PRP is effective in decreasing pain and function in knee OA. However, there are some studies that suggest PRP can be helpful for patients with OA. Further studies to determine the indications for PRP injections are necessary. PRP injections are not covered by insurance in the United States. In summary, the management of patients with painful OA of the knee needs to be individualised based on patient symptoms and expectations. Non-operative management can be effective in limiting pain and enhancing function

Are there any patho-anatomical features that might predispose to primary knee OA? We investigated the 3D geometry of the load bearing zones of both distal femur and proximal tibias, in varus, straight and valgus knees. We then correlated these findings with the location of wear patches measured intra-operatively. Patients presenting with knee pain were recruited following ethics approval and consent. Hips, knees and ankles were CT-ed. Straight and Rosenburg weight bearing X-Rays were obtained. Excluded were: Ahlbäck grade “>1”, previous fractures, bone surgery, deformities, and any known secondary causes of OA. 72 knees were eligible. 3D models were constructed using Mimics (Materialise Inc, Belgium) and femurs oriented to a standard reference frame. Femoral condyle Extension Facets (EF) were outlined with the aid of gaussian curvature analysis, then best-fit spheres attached to the Extension, as well as Flexion Facets(FF). Resected tibial plateaus from surgery were collected and photographed, and Matlab combined the average tibia plateau wear pattern. Of the 72 knees (N=72), the mean age was 58, SD=11. 38 were male and 34 female. The average hip-knee-ankle (HKA) angle was 1° varus (SD=4°). Knees were assigned into three groups: valgus, straight or varus based on HKA angle. Root Mean Square (RMS) errors of the medial and lateral extension spheres were 0.4mm and 0.2mm respectively. EF sphere radii measurements were validated with Bland-Altman Plots showing good intra- and interobserver reliability (+/− 1.96 SD). The radii (mm) of the extension spheres were standardised to the medial FF sphere. Radii for the standardised medial EF sphere were as follows; Valgus (M=44.74mm, SD=7.89, n=11), Straight (M=44.63mm, SD=7.23, n=38), Varus (M=50.46mm, SD=8.14, n=23). Ratios of the Medial: Lateral EF Spheres were calculated for the three groups: Valgus (M=1.35, SD=.25, n=11), Straight (M=1.38, SD=.23, n=38), Varus (M=1.6, SD=.38, n=23). Data was analysed with a MANOVA, ANOVA and Fisher's pairwise LSD in SPSS ver 22, reducing the chance of type 1 error. The varus knees extension facets were significantly flatter with a larger radius than the straight or valgus group (p=0.004 and p=0.033) respectively. In the axial view, the medial extension facet centers appear to overlie the tibial wear patch exactly, commonly in the antero-medial aspect of the medial tibial plateau. For the first time, we have characterised the extension facets of the femoral condyles reliably. Varus knees have a flatter medial EF even before the onset of bony attrition. A flatter EF might lead to menisci extrusion in full extension, and early menisci failure. In addition, the spherical centre of the EF exactly overlies the wear patch on the antero-medial portion of the tibia plateau, suggesting that a flatter medial extension facet may be causally related to the generation of early primary OA in varus knees

Introduction. CMS is now publicly reporting 30-day readmission rates following total joint replacement (TJR) by hospital and is planning the collection of patient-reported function and pain after TJR. Nationally, 5% of patients are readmitted to the hospital after TJR for both medical and orthopedic-related issues. However, the relationship between readmission and functional gain and pain relief after TJR has not been evaluated. Methods. Clinical data on 2990 CMS patients from over 150 surgeons practicing in 22 US states who elected primary unilateral TJR in 2011–2012 were identified. Measures include pre-operative demographics, BMI, medical and musculoskeletal comorbidities, pain and function (KOOS/HOOS; SF36) and 6 month post-TJR pain and function. Data were merged with CMS claims to verify 30-day readmissions. Descriptive statistics and multivariate models adjusted for covariates and clustering within site were performed. Results. Overall 4.7% of patients were readmitted; 2.0% due to limb related diagnoses. Readmitted patients had significantly greater number of medical comorbidities; more severe OA in non-operated knees and hips; were more likely to smoke; and have poorer pre-TJR function (all p<0.05). After TJR, a greater proportion of readmitted patients had poor global function (PCS<30= 14% vs. 8%; p<0.008) but knee/hip function was similar in both groups. Joint pain improvement did not differ by readmit status. Conclusion. In this national representative cohort of CMS patients, patients readmitted within 30 days after TJR had poorer global function but similar joint specific function as non-readmitted patients. Readmitted patients also had significantly more medical comorbidities, more severe osteoarthritis in non-operated knees and hips; were more likely to smoke; and have poorer pre-TJR function. The overall rate of FORCE-TJR CMS patients readmitted within 30 days (4.7%) is consistent with national CMS analyses (5%). Of interest, in our cohort, readmitted patients had poorer global function after surgery, but similar joint specific (hip/knee) function compared to patients who were not readmitted. They also had poorer pre-THR function, and more severe OA in other joints, which may contribute to their overall lower global function scores. As CMS moves to use PROs in its bundled payment, these data support the importance of hip/knee-specific PRO measures to assess THR outcomes in quality of care programs and CMS reporting programs

Purpose. The purpose of this study is to evaluate stiff knees which have a preoperative arc of motion (AOM) < 65 degrees and maximum flexion < 90 degrees under anesthesia for primary TKA. Material and Methods. We prospectively evaluated 25 knees, 20 patients, the follow up period was 5±3 years, OA 13, RA 10 and traumatic OA 2 knees. All case were medial para-patella approaches and snip was added in one knee operation, 23 PS-type and 2 constrain-type TKAs. Results. Preoperative and postoperative FTA were 185.3±8.4 and 174.2±2.8 degrees, α95.5±3.0, β88.6±2.1, γ4.1±2.9, σ83.8±3.0, CTA1.4±1.9 degrees. Soft tissue releases were performed in Clayton stage I 9, II 14 and III 2 knees, and additional resection for the posterior capsule 11, vastus intermedius 2 and ITT 4 knees and lateral release 4 knees. Additional bone cuts were performed in 19 knees including femur 14 knees and tibia 12 knees. Component gaps (20/30/40lb) of medial and lateral were 9.8±0.8/10.8±2.9/12.2±1.9 mm and 11.0±2.1/12.6±2.5/13.6±2.8 mm at 0 degrees, they were 11.4±2.8/13.5±3.6/15.8±4.1 mm and 12.5±2.7/15.1±3.8 /18.0±4.2 mm at 90 degrees. (Figure1) MCL avulsion was in 3 knees. AOMs in preoperative, perioperative, 1-year later and final observation were 45.0±16.5, 110.4±15.5, 110.8±18.4 and 113.4±18.2 degrees. (Figure2) Flexions were72.5±17.7, 104.0±14.0, 104.0±14.0 and 106.5±14.4 degrees. Extensions were −28.3±10.5, −6.0±7.5, −6.0±7.0 and −6.9±7.8 degrees. There were no statistical differences between perioperative and final AOM, flexion and extension, and between OA and RA. Discussion. AOM improved and remained after the surgeries. We evaluated soft tissue release and component gaps in 25 stiff knees when preoperative arc of motion (AOM) was < 65 degrees and maximum flexion < 90 degrees under anesthesia for primary TKA. There were no statistical differences between perioperative and final AOM, flexion and extension, and between OA and RA. For any figures or tables, please contact the authors directly

Introduction. The deformity in osteoarthritis (OA) of the knee has been evaluated mainly in the frontal plane two dimensional X-ray using femorotibial angle. Although the presence of underlying rotational deformity in the varus knee and coexisting hip abnormality in the valgus knee have been suggested, three dimensional (3D) deformities in the varus and valgus knee were still unknown. We evaluated the 3D deformities of the varus and valgus knee using 3D bone models. Methods. Preoperative computed tomography (CT) scans of twenty seven OA knees (fifteen varus and twelve valgus) undergoing total knee arthroplasty were assessed in this study. CT scans of each patient's femur and tibia, with a 2 mm interval, obtained before surgery. We created the 3D digital model of the femur and tibia using visualization and modeling software developed in our institution. The femoral coordinate system was calculated by the 3D mechanical axis and clinical transepicondylar axis and the tibial coordinate system was calculated by the 3D mechanical axis and Akagi's line. The 3D deformities of the knee were determined by the relative position of the femorotibial coordinate system, and described by the tibial position relative to the femur. The anteversion of the femoral neck were calculated to evaluate the relationship between the valgus knee and hip region. Results. The 3D deformities of the varus knee were 12.1±5.5°varus (5.4 to 22.6°), 6.8±6.3°flexion (1.7 to 21.7°) and 6.5±6.1 °external rotation (−1.2 to 23.2°). The flexion and external rotational deformities were larger in knees with increased varus deformities. The 3D deformities of the valgus knee were 10.2±4.2°valgus (0.6 to 15.0°), 9.5±8.8°flexion (−5.2 to 23.7°) and 2.3±7.3°external rotation (−9.4 to 16.1°). Although there were no tendency about the 3D deformities in the valgus knee, the anteversion of the femoral neck in the valgus knees was 31.9°compared with 10.8°in the varus knees. Conclusion. The varus deformity in OA of the knee is associated with significant flexion and external rotational deformity. In contrast, the valgus deformity has a biomechanical background originating from the anteversion of the femoral neck

Objective. We performed total knee arthroplasty (TKA) without patella resurfacing in patients with osteoarthritis (OA) of the knee. The purpose of the present study was to evaluate the clinical results and the appropriateness TKA without patella resurfacing. Methods. A total of 61 patients (61 affected knees) who had undergone a Low Contact Stress mobile − bearing knee arthroplasty (LCS− TKA) (Depuy, Warsaw, IN. USA) 10 years or more before the present study were enrolled. The LCS− TKAs did not include patella resurfacing. The patients' mean age was 77.7 ± 6.1 years (range: 59−94 years). The mean follow-up period was 121 ± 2.4 months (range: 120−129 months). The clinical evaluation used the scoring system for OA of the knees issued by the Japanese Orthopaedic Association (JOA score). We defined patellofemoral (PF) pain, crepitation, patellar clunk syndrome, spin-out, and reoperation as complications. We also used X-Ray imaging to measure the component angle, patella height, lateral shift ratio, tilting angle, femorotibial angle, posterior condylar offset and joint line, and evaluated the localization of sclerotic changes in the patella. All of the LCS− TKAs were performed by one surgeon using the midvastus approach. During the operation, the osteophyte around the patella was resected, and the osteophyte on the articular surface was shaped using a bone saw. For statistical analysis we performed Mann-Whitney's U test and adopted a significance level of P<5%. Results. The average JOA score improved significantly from 46.2 ± 10.4 before the LCS− TKA to 82.6 ± 6.1 after the LCS− TKAs (P = 0.0002). No cases of patellar clunk syndrome or spin-out. occurred. Revision surgery was performed for two cases, one involved an infection, and the other involved a patella fracture. Postoperative PF pain was found in 6 patients (6 affected knees) at the final evaluation. However, in these patients, the pain was less severe than it had been preoperatively, and revision surgery for PF pain was needed or performed. The postoperative radiological evaluation was favorable on the whole. The localization of sclerotic changes in the patella on X-ray were in 32 cases around tip of the patella, on the other no remarkable change were in 29 cases. Conclusion. The clinical and radiological evaluations of the patella non−resurfacing mobile bearing total knee arthroplasty was favorable overall. Treatment of the patella in total knee arthroplasty remains controversial. We suggest that the patella in LCS−TKAs does not always need to be resurfaced

Conservative management of osteoarthritis is boring, boring, boring! After all, we are surgeons. We operate, we cut! We all know that to retain respectability we have to go through the motions of ‘conservative management’, just so that we don't appear too anxious to apply a ‘real’ solution to the problem. However, the statistics are overwhelming. An estimated 43 million Americans have ‘arthritis’, but only 400,000 are coming forward each year for TKR. That means that in one way or another 42,600,000 are being treated conservatively. Most of those are self treating by self medication, use of external support, but mostly by decreasing their activities to a level where they can tolerate symptoms. They come to us when these measures stop working. We know what to do. 1. Weight loss – patients don't do it, 2. Physical therapy – very limited effectiveness 3. NSAIDS – patients have already tried OTC NSAIDS and have heard scary stories about therapeutic NSAIDS, 4. Hyaluronans – expensive, labour intensive, modest effectiveness, 5. Glucosamine/Chondroitin – might work, won't hurt, mixed evidence, 6. SAM-e, MSM – limited evidence – who knows?. What's on the horizon? Could OA of the knee go the way of RA, i.e. dramatically disappear from the population seeking TKR? It could happen. Electrical stimulation – it does good things for chondrocytes, circulation, suppresses destructive enzymes and in controlled studies reduces symptoms and improves function, deferring TKR. Cell therapy – possibly an effective solution to early cartilage lesions in the knee

Aims. A new therapy, based on the intra-articular injection of autologous conditioned serum (ACS), is used in several European countries for osteoarthritis (OA) treatment. ACS is generated by incubating venous blood with medical grade glass beads. Peripheral blood leukocytes produce elevated amounts of endogenous anti-inflammatory cytokines such as interleukin-1 receptor antagonist (IL-1Ra) and growth factors that are recovered in the serum(1). ACS has been shown to improve the clinical lameness in horses significantly to enhance the healing of muscle injuries in animal models, and in human athletes. In the present study, the efficacy and safety of ACS was compared to intra-articular hyaluronan (HA), and saline in patients with confirmed knee OA. Methods. In a prospective, randomised, patient- and observer-blind trial with three parallel groups, 376 patients with knee OA were included in an intention to treat (ITT-) analysis. Efficacy was assessed by patient-administered outcome instruments (WOMAC, VAS, SF-8, GPA) after 7, 13 and 26 weeks (blinded) and Two-years (non-blinded). The frequency and severity of adverse events were used as safety parameters. Results. In all treatment groups, intra-articular injections produced a significant reduction in WOMAC-scores and weight-bearing pain (VAS). However, responses to ACS were stronger. The superiority of ACS and either HA or saline was statistically significant for all outcome measures and time points. No significant differences between HA treatment and saline injections (p>0.05, at all time points and outcome measures) were recorded. Frequency of adverse advents (AE) was comparable in the ACS- and the saline-group (p>0.05). Conclusion. The results demonstrate that ACS is effective, long-lasting and well tolerated in the management of chronic, idiopathic OA of the knee. So far, the efficacy of ACS is defined through improvement in clinical signs and symptoms, particularly pain. It remains to be determined whether they are disease-modifying, chondroprotective, or even chondroregenerative, sequelae

Introduction. Unicompartmental knee arthroplasty (UKA) is a successful procedure for medial compartment osteoarthritis (OA). Recent studies using the same implant report a revision rate of 2.9%. Other centers have reported revision rates as high as 10.3%. The purpose of this study was to retrospectively review the clinical results of Oxford Phase 3 UKA's performed in the setting of isolated medial compartment OA and to compare our results to the previous mid-term studies. Our secondary goal was to determine reasons for revision and evaluate selected independent predictors of failure. Methods. A retrospective review of 465 Oxford Phase 3 medial UKA's performed on 386 patients (222 female; 164 male) with isolated medial compartment OA. The average age at surgery was 69.5 years (40–88). Outcome measures included: Knee Society Scores(KSS), Oxford Knee Scores(OKS), SF-12, WOMAC, revision rates, and patient satisfaction. We evaluated independently predictors of failure including: gender, body mass index(BMI), number of previous surgeries, implant sizes, cement technique (simultaneous vs staged), cement type. Revision rates based upon the polyethylene thickness (defined as thin 3–4 mm; medium 5–6 mm; thick 7–9 mm). The need for stems and augments and the degree of constraint required at revision to a total knee arthroplasty (TKA) were evaluated. Results. At a mean follow-up of 60.7 months (11–114) OKS improved from 21 to 37 points (p<.05). Latest SF-12 score was 43.8 points (16.8–64.7 points; SD, 10.5) and WOMAC was 80 points (23–100 points; SD, 18). The overall revision rate was 6.9% (32/465 knees). Mean time to revision in 25 knees was 34.5 months (7–96), and revision was most commonly performed for lateral compartment OA (10). Eight knees were revised for tibial loosening, femoral loosening (6), and PCL failure (1). Revision implants included posterior stabilized in 13 knees (52%), cruciate retaining in 9 knees (36%), and cruciate substituting/dished in 3 knees (12%). Five revisions (20%) required tibial augments and 2(8%) had cemented tibial stems. The mean revision polyethylene thickness was 12 mm (range, 9–19 mm) and one knee required a constrained polyethylene. Three knees are pending revision to TKA. Four knees underwent poly exchange for bearing dislocation and 3 knees had further arthroscopic procedures. Eighty-four percent of the patella were resurfaced at revision. Three quarters (76%) of the patients were extremely or very satisfied with their surgery. Over 90% would have had their surgeries again. Gender, BMI, number of previous surgeries, femoral or tibial sizing, poly thickness, cementing technique or type did not predict revision, the need for constraint, or the need for stems or augments. Conclusion. Our revision rate of 6.9% was comparable to other midterm studies from independent centers but not as low as recently reported results from Oxford. Progression to lateral compartment OA was the most common reason for revision. We could not find any independent predictors of failures in this group of 465 knees

Background. More and more patients with end-stage knee OA are treated with total knee replacements (TKR). A modern TKR (Persona PS system, Zimmer Inc.) was designed with the hope to improve fit by providing additional sizing options on the femur and tibia. To date, there is very little information regarding the knee strength and knee mechanics during gait after the TKR. Furthermore, as a great percentage of knee OA patients have OA limited in one knee compartment and in the patellofemoral joint, a bi-compartmental knee replacement (BKR) (iDUO system, ConforMIS Inc.) was designed to treat OA at these affected areas. The BKR re-creates the individual's knee shape while correcting for any deformity. In addition, the BKR procedure results in less bone loss and retains the cruciate ligaments. To date, the influence of the BKR on knee strength and knee mechanics remains unknown. The purpose of the study was to evaluate knee strength and mechanics during level walking after the TKR and BKR surgeries. Methods. Twelve healthy control participants (age=57±6 yr.; mass=82±11 kg; height=175±11 cm), eight patients (age=63±10 yr.; mass=87±20 kg; height=166±8 cm) with ten BKR systems (post-op time = 17±9 mo.), and nine patients (age=65±9 yr.; mass=90±35 kg; Height=169±12 cm) with twelve TKR systems (post-op time = 14±5 mo.) participated in the study. In a laboratory setting, maximal isometric knee strength was evaluated. Motion capture and 3D kinematic and kinetic analyses were conducted for level walking. One way ANOVA was used to determine differences among the BKR, TKR, and the healthy control knees. Findings. The TKR knee extensor strength was 34% and 20% less than that of the control limb (p<0.05) and the BKR limb (p=0.07), respectively. The TKR limb had less knee extensor moment during walking than both the control limb (40% less) and the BKR limb (24% less) (p<0.05). The TKR knee displayed smaller internal rotation at stance than that of the control knee (60% less) and the BKR knee (50% less) (p<0.05). Both the control and BKR groups walked at a faster pace (24% and 17% faster, respectively) than the TKR group (p<0.05). No differences were found for peak knee abduction and abduction moment among the TKR, BKR, and control limbs during walking (p0.05). Interpretations. BKR patients saw their knee extensor strength returned to a normal level and were able to produce the same level of knee extensor moment of the healthy control limbs during walking. The TKR patients still experienced knee strength deficit after one year post-surgery. Both the TKR and BKR groups exhibited similar frontal plane mechanics when compared to the control limbs during walking. However, BKR patients were able to walk significantly faster than their TKR counterparts, at speeds similar to the control subjects. Patients with OA limited in the medial/lateral compartment and the patellofemoral joint may consider the BKR procedure for better knee strength recovery and functional outcomes. Acknowledgement. Funding source: ConforMIS Inc

Valgus knee unloader braces are often prescribed as treatment for knee osteoarthritis (OA). These braces are designed to redistribute the loading in the knee, thereby reducing medial contact forces. Patient response to bracing is variable; some patients experience improvements in joint loading, pain, and function, others see little to no effect. We hypothesised that patients who experienced beneficial response to the brace, measured by reductions in medial contact force, could be predicted based on static and dynamic measures. Participants completed a WOMAC questionnaire and walked overground with and without an OA Assist knee brace in a motion capture lab. Eighteen patients with medial compartment OA (8 female, 53.8±7.0 years, BMI 30.3±4.1, median Kellgren-Lawrence grade 4 (range 1–4)) were evaluated. The abduction moment applied by the brace was estimated by multiplying brace deflection by the pre-determined brace stiffness. A generic musculoskeletal model was scaled for each participant based on standing full length radiographs and anatomical markers. Inverse kinematics, inverse dynamics, residual reduction, and muscle analysis were completed in OpenSim 3.2. A static optimisation was then performed to estimate muscle forces and then tibiofemoral contact forces were calculated. Brace effectiveness was defined by the difference in the first peak of the medial contact force between braced and unbraced conditions. Principal component analysis was performed on the hip, knee, and ankle angles and moments from the unbraced walking condition to extract the principal component (PC) scores for these variables. A linear regression procedure was used to determine which variables related to brace effectiveness. Potential regressors included: hip-knee-ankle angle and medial joint space measured radiographically; KL grade; mass; WOMAC scores; unbraced walking speed; and the first two principal component scores for each of the unbraced hip, knee, and ankle joint angles and moments. KL grade, walking speed, and hip adduction moment PC1, which represented the magnitude of the first peak were all found to be correlated with change in medial contact force. The brace was more successful in reducing medial contact force in subjects with higher KL grades, faster self-selected walking speeds, and larger peak external hip adduction moments. The R2 value for the overall regression model was 0.78. The best predictor of brace effectiveness was the hip adduction moment, indicating the need to consider dynamic measures. Participants who had hip adduction moments and walking speeds similar to those of their healthy counterparts saw a greater reduction in medial contact force. Thus, those who responded to bracing had more severe OA as measured by the KL grade but had not experienced changes in their hip adduction moment due to OA. The results of this study suggest that there is potential for an objective criterion for valgus knee brace use to be established

Introduction. Deformity of knee joint causes deviation of mechanical axis in the coronal plane, and the mechanical axis deviation also could adversely affect biomechanics of the ankle joint as well as the knee joint. Particularly, most of the patients undergoing total knee arthroplasty (TKA) have significant preoperative varus malalignment which would be corrected after TKA, the patients also may have significant changes of ankle joint characteristics after the surgery. This study aimed 1) to examine the prevalence of coexisting ankle osteoarthritis (OA) in the patients undergoing TKA due to varus knee OA and to determine whether the patients with coexisting ankle OA have more varus malalignment, and 2) to evaluate the changes of radiographic parameters for ankle joint before and 4 years after TKA. Methods. We evaluated 153 knees in 86 patients with varus knee OA who underwent primary TKA. With use of standing whole-limb anteroposterior radiographs and ankle radiographs before and 4 years after TKRA, we assessed prevalence of coexisting ankle OA in the patients before TKA and analyzed the changes of four radiographic parameters before and after TKA including 1) the mechanical tibiofemoral angle (negative value = varus), 2) the ankle joint orientation relative to the ground (positive value = sloping down laterally), 3) ankle joint space, and 4) medial clear space. Results. Of the 153 knees, 59 (39%) had radiographic ankle OA. The knees with ankle OA had significantly more varus mechanical tibiofemoral angle preoperatively than those without ankle OA (− 11.9° vs. − 9.3° on average, respectively; P = 0.003). Compared to the preoperative condition, the ankle joint orientation relative to the ground significantly changed after TKA (from 9.0° to 4.8° on average, P<0.001) while ankle joint space and medial clear space did not. Conclusions. Our study revealed that coexisting ankle OA would be common in patients with varus knee OA, particularly in patients with more varus malalignment. TKA also significantly changes the ankle joint orientation relative to the ground which shows more parallel to the ground. However, its effect on ankle joint space and medial clear space seems to be minimal upto 4 years after TKA. Our findings warrant consideration in preoperative evaluations of ankle OA in varus knee OA patients undergoing TKA, and further studies should evaluate prospectively the clinical implications of radiographic change of the ankle joint after TKA

Introduction:. This is a case report of a 78 year old male who underwent outpatient mini-incision medial UKA using the haptic robotic guidance. The patient subsequently suffered a traumatic lateral meniscus tear and underwent a lateral compartment UKA with the same robotic system instead of converting to a total knee replacement at one year post op and is now 2 years post op on the lateral side as well. Methods:. The patient is a 74 year old male with a BMI of 27, suffering from OA of the right knee. He had a previous TKA on his left side by another surgeon that was followed with a lateral release by still another surgeon with fair to good satisfaction currently; however he did not want another TKA. He had multiple aspirations and injections of corticosteroids for arthritic effusions on his right knee that were moderate to severe and painful. On 7/6/2010 he underwent a right medial UKA using with robotic guidance. The patient had a subsequent injury to his lateral meniscus causing pain for which multiple options were discussed with the patient. The informed patient chose to have a lateral compartment arthroplasty. On 6/21/2011 a lateral compartment UKA was performed on the same patient's right knee through a second mini-lateral incision again using robotic guidance. Results:. The patient is now 35 months after his right medial UKA and 24 months after his right lateral UKA. His function is excellent, his range of motion is excellent at 0–135° compared to 120° pre-operatively, his satisfaction is excellent and he has no self-reported limitations with his right knee. Conclusions:. The complexity of patient-specific planning, the ability to adjust that plan intra-operatively to optimize kinematics and the safety of implementing this plan using haptically guided robotic bone resection provides many advantages in partial knee arthroplasty. In the case presented here, a post-operative lateral meniscal injury subsequent to medial UKA in the same knee was treated with a lateral UKA. Accurate placement of the components and balancing the knee with the existing medial UKA provided by the robotic platform was critical to the excellent post-operative outcomes