Introduction. To meet the demands of younger more active patients more robust pre-clinical wear testing methods are required, in order to simulate a wider range of activities. A new electromechanical simulator (Simulation Solutions, UK) with a greater range of motion, a driven abduction/adduction axis and improved input kinematic following has been developed to meet these requirements, as well as requirements of the relevant international standards. This study investigated the wear of a fixed bearing total knee replacement using this new electromechanical knee simulator, comparing with previous data from a pneumatic simulator. Materials/Methods. The wear of six Sigma CR fixed bearing TKRs (DePuy, UK) with curved moderately cross-linked polyethylene inserts (XLK) was determined in pneumatic and electromechanical Prosim knee simulators (Simulation Solutions, UK). Standard gait displacement controlled kinematics were used, with a maximum anterior-posterior displacement of either 10mm (high) or 5mm (intermediate) [1]. The output profiles from the simulators were obtained and compared to the demand input profiles. The lubricant used was 25% new-born calf serum and wear determined gravimetrically. Statistical analysis was performed using the one-way ANOVA with 95% confidence interval and significance was taken at p<0.05. Results. The electromechanical and pneumatic knee simulators both achieved the demanded maximum axial load although the pneumatic simulator did not achieve the initial peak on heel strike. The maximum delivered AP displacements from the electromechanical knee simulator were 2.8 (3.5mm input) and 9.6 (10mm input) [mm] compared to 1.7 and 9.2 [mm] from the pneumatic simulator during the stance and the swing phases respectively. The corresponding values for the IE rotation angle were ±4.9 (5 degrees input) and ±4.1 [degrees] from the electromechanical and pneumatic simulators respectively (both stance and swing phases) (Figure 1). The electromechanical knee simulator produced a mean wear rate of 2.7 ±0.9mm3/MC (mean ± 95% CI) under intermediate kinematics, compared to 2.6 ±0.9mm3/MC from the pneumatic simulator (p=0.99). The corresponding mean wear rates under high kinematics were 5.6 ± 2.3 and 6.7 ±1.5 [mm3/MC] from the electromechanical and pneumatic knee simulators respectively (p=0.59). Discussion. The wear rates from the electromechanical and pneumatic knee simulators were not significantly different. However, the output kinematic profiles followed the input kinematic profiles more closely on the electromechanical simulator than the pneumatic simulator. This electromechanical knee simulator can be used for a wider range of conditions, including high-flexion, due to it's improved capability and performance over the pneumatic simulators. Conclusion. The electromechanical knee simulator showed improved performance and capability compared to the pneumatic knee simulator, and can therefore meet higher current and future testing demands. The wear trends, from the two simulators, were however not significantly different under standard gait conditions. Acknowledgements. This research work was supported by EPSRC, Innovate UK and BBSRC [IKC Medical Technologies], the Leeds Centre of Excellence in Medical Engineering, WELMEC, funded by the Wellcome Trust and EPSRC, WT088908/Z/09/Z and the Leeds Musculoskeletal Biomedical Research Unit (LMBRU), funded by
The aim of this study was to develop and evaluate machine-learning-based computerized adaptive tests (CATs) for the Oxford Hip Score (OHS), Oxford Knee Score (OKS), Oxford Shoulder Score (OSS), and the Oxford Elbow Score (OES) and its subscales. We developed CAT algorithms for the OHS, OKS, OSS, overall OES, and each of the OES subscales, using responses to the full-length questionnaires and a machine-learning technique called regression tree learning. The algorithms were evaluated through a series of simulation studies, in which they aimed to predict respondents’ full-length questionnaire scores from only a selection of their item responses. In each case, the total number of items used by the CAT algorithm was recorded and CAT scores were compared to full-length questionnaire scores by mean, SD, score distribution plots, Pearson’s correlation coefficient, intraclass correlation (ICC), and the Bland-Altman method. Differences between CAT scores and full-length questionnaire scores were contextualized through comparison to the instruments’ minimal clinically important difference (MCID).Aims
Methods
Introduction. Patella femoral joint bearings in total knee replacements have shown low wear (3.1 mm. 3. /MC) under standard gait simulator conditions. 1. However, the wear in retrieval studies have shown large variations between 1.3 to 45.2 mm. 3. /year. 2. Previous in vitro studies on the tibial femoral joint have shown wear is dependent on design, materials and kinematics. 3. . The aim of this study was to investigate the influence of the design (geometry) and shape on the wear rate of patella femoral joints in total knee replacements. Materials and Methods. The Leeds/Prosim knee simulator was used to investigate the wear of two types of commercially available patellae. The PFC Sigma cobalt chrome femoral component was coupled with 2 types of patellae buttons: round and oval dome. The UHMWPE was the same for the both types – GUR1020 GVF (gamma irradiated in vacuum and foiled packed). 25% bovine serum was used as the lubricant. The test were carried out at three conditions – high medial lateral (ML) rotations (<4°) and uncontrolled ML displacement (<4 mm), low ML rotation (<1°) and uncontrolled ML displacement (<4 mm); the physiological gait cycle; and low ML rotation and controlled ML displacement (<1.5 mm). In this abstract the two designs were tested in physiological gait condition (Figure 1). Patella ML displacement and tilt were passively controlled and measured after every 300,000 cycles. A ligament resisting force equivalent to 10 N4 was applied on the lateral side of the patella to avoid patella slip. Five samples of each design were tested for 3 million cycles at a cycle rate of 1 Hz. The wear volume was obtained gravimetrically every million cycles and presented with 95% confidence limits. Statistical significance was taken at p<0.05. Results and Discussions. The wear rate of PFC sigma round dome patella was higher (8.63 ± 3.44 mm. 3. /million cycles) compared to the PFC sigma oval dome patella (6.28 ± 3.89 mm. 3. /million cycles) (Figure 2). However, no significant difference in the wear rates was found between the two shapes (P=0.2). The low area of contact of oval dome patella (31.2% of total surface area) as compared to round dome patella (39.9%) led to low wear. 5. . The wear volume and the patellar tilt were positively correlated for oval dome and round dome patella, R. 2. > 0.9 (Figure 3). Increase in the patellar tilt resulted increase in sliding distance in perpendicular direction of polymer orientation. This led to higher wear volume. Conclusions. Wear rate decreased with change of patella shape from round dome to oval dome although not significantly. Increase in the patellar tilt resulted in increase in the wear volume. Acknowledgement. This research was supported in part by the DePuy and EPSRC. In addition, it was partially funded through WELMEC, a Centre of Excellence in Medical Engineering funded by the Wellcome Trust, under grant number WT 088908/Z/09/Z and additionally supported by the
