We evaluated the efficacy of Escherichia
coli-derived recombinant human bone morphogenetic protein-2
(E-BMP-2) in a mini-pig model of spinal anterior interbody fusion.
A total of 14 male mini-pigs underwent three-level anterior lumbar
interbody fusion using polyether etherketone (PEEK) cages containing
porous hydroxyapatite (HA). Four groups of cages were prepared:
1) control (n = 10 segments); 2) 50 μg E-BMP-2 (n = 9); 3) 200 μg
E-BMP-2 (n = 10); and 4) 800 μg E-BMP-2 (n = 9). At eight weeks
after surgery the mini-pigs were killed and the specimens were evaluated
by gross inspection and manual palpation, radiological evaluation
including plain radiographs and
Aims. Anchorage of pedicle screw rod instrumentation in the elderly spine with poor bone quality remains challenging. Our study aims to evaluate how the screw bone anchorage is affected by screw design, bone quality, loading conditions, and cementing techniques. Methods. Micro-finite element (µFE) models were created from