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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 133 - 133
1 Jul 2020
Hardesty C Janas M
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A growing number of children are being implanted with magnetically controlled growing rods. Some also have baclofen pumps, a device that delivers a neuromodulating medication using a magnet. There has been no previous testing to determine if the External Remote Controller (ERC) would stall the baclofen pump during magnetic rod lengthening, a potentially life-threatening event. Two baclofen pumps, 20 mL and 40 mL, were placed in varying proximity to the ERC while the magnetic field was generated. The speed (dose) of the baclofen pump, the distance from the ERC, the length of time the ERC was run, the position of the pump in relationship to the magnetic field, and the presence or absence of a stall were recorded. To stall a baclofen pump, the ERC needed to be running continuously for at least 30 mm of lengthening (about 3 minutes). The pump would not stall if it was more than 1 cm away from the ERC, even if the ERC generated a field for 3 minutes. The speed of the pump did not affect the instance of a motor stall. The pump was more likely to stall if it was positioned in front of or behind the magnetic field, as opposed to the center of the field. Baclofen pumps are always more than 1 cm away from the magnetic rods when both are implanted in a child. The typical lengthening interval is under 10 mm, much less than what was required to stall a baclofen pump. The ERC is highly unlikely to stall a baclofen pump during a magnetic rod lengthening, making a life-threatening event almost impossible


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_10 | Pages 9 - 9
1 Oct 2022
Klim S Madl T Habisch H Amerstorfer F Stradner M Hauer G Leithner A Glehr M
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Aim. The aim of this study was to investigate the metabolomic profile of synovial fluid in periprosthetic joint infection (PJI) cases regarding a possible diagnostic approach. Also, further information about the metabolic composition of synovial fluid in PJI may point to future diagnostic and therapeutic approaches. Method. Patients with a clinical suspicion of a prosthesis infection who underwent a joint puncture in our outpatient department or ward were included. After sample preparation, the nuclear magnetic resonance (NMR) experiments were performed at 310 K on an AVANCE™ NeoBruker Ultrashield 600 MHz spectrometer. Bruker Topspin version 4.0.2 was used for NMR data acquisition. The spectra for all samples were automatically processed (exponential line broadening of 0.3 Hz), phased, and referenced using TSP at 0.0 ppm. In total, 37 metabolites were analysed using a volume of 200 µl per synovial sample. The PJI and aseptic cases were assigned according to the EBJIS criteria. Results. In total, 76 samples were included in the final analysis with 48 PJI cases and 28 aseptic cases. Five measured metabolites have shown an area under the curve (AUC) over 0.8, with Taurine (AUC 0.8558, p<0.0001) and Glutamine (AUC 0.8333, p<0.0001) showing the best diagnostic performance. When combining two metabolites, the AUC indicated even higher diagnostic performance: Glucose/Glycogen (AUC 0.9073, p<0.0001), Taurine/Mannose (AUC 0.9073, p<0.0001), Mannose/Glycogen (AUC 0.8992, p<0.0001) and Taurine/Glucose (AUC 0.8956, p<0.0001). Conclusions. While NMR as a method in PJI diagnostics is currently not broadly available for daily clinical work, our results indicate that certain synovial metabolites and their combinations can be used for PJI diagnosis


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 209 - 209
1 Sep 2012
Vittorio O Parchi P Raffa V Cuschieri A Lisanti M
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MSCs (mesenchymal stem cells) are bone marrow-derived cells capable of replication and differentiation in-vitro into several tissues including bone, cartilage, stroma, fat, muscle and tendon. MSCs can be isolated by relatively simple procedures and then expanded without losing the ability to differentiate into multiple lineages. As such, these cells have immense clinical potential in regenerative medicine and in orthopaedics for repair or replacement of damaged tissues. In this work we investigated the interaction between magnetic carbon nanotubes (CNTs) and MSCs and their ability to guide these cells injected intravenously in living mice by using an external magnetic field. CNTs did not affect cell viability and their ability to differentiate. Both the CNTs and the magnetic field did not alter cell growth rate, phenotype and cytoskeletal conformation. CNTs, when exposed to magnetic fields, are able to shepherd MSCs towards the magnetic source in vitro. Moreover, the application of a magnetic field alters the biodistribution of CNT-labelled MSCs after intravenous injection into rats. We demonstrated that CNTs hold the potential for use as nano-devices to improve therapeutic protocols for transplantation and homing of stem cells in vivo. This could pave the way for the development of new strategies for manipulation/guidance of MSCs in regenerative medicine and cell transplantation for the treatment of many orthopaedic diseases


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 165 - 165
1 Dec 2013
Russo A Panseri S Shelyakova T Sandri M Ortolani A Meikle S Lacey J Tampieri A Dediu V Santin M Marcacci M
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Introduction. Diaphyseal bone defect represents a significant problem for orthopaedic surgeons and patients. Bone is a complex tissue whose structure and function depend strictly on ultrastructural organization of its components: cells, organic (extracellular matrix, ECM) and inorganic components. The purpose of this study was to evaluate bone regeneration in a critical diaphyseal defect treated by implantation of a magnetic scaffold fixed by hybrid system (magnetic and mechanical), supplied through nanoparticle-magnetic (MNP) functionalized with Vascular Endothelial-Growth-Factor-(VEGF) and magnetic-guiding. Methods. A critical long bone defect was created in 8 sheep metatarsus diaphysis: it was 20.0 mm in length; the medullary canal was reamed till 8.00 mm of inner diameter. Then a 8.00 mm diameter magnetic rod was fitted into proximal medullary canal (10 mm in length). After that a scaffold made of Hydroxyapatite (outer diameter 17.00 mm) that incorporates magnetite (HA/Mgn 90/10) was implanted to fill critical long bone defect. A magnetic rod (6.00 mm diameter) was firmly incorporated at proximal side into the scaffold. Both magnets had 10 mm length. To give stability to the complex bone-scaffold-bone a plate was used as a bridge; it was fixed proximally by 2 screws and distally by 3 screws. Scaffolds biocompatibility was previously assessed in vitro using human osteoblast-like cells. Magnetic forces through scaffold were calculated by finite element software (COMSOL Multiphysics, AC/DC Model). One week after surgery, magnetic nanoparticles functionalized with VEGF were injected at the mid portion of the scaffold using a cutaneous marker positioned during surgery as reference point in 4 sheep; other sheep were used as control group. After sixteen weeks, sheep were sacrificed to analyze metatarsi. Macroscopical, radiological and microCT examinations were performed. Results. Samples obtained didn't show any inflammatory tissue around the scaffold and revealed bone tissue formation inside pores of the scaffolds and we could see also complete coverage of the scaffolds. Formation of new bone tissue was more evident at magnetized bone-scaffold interface. X-rays showed a good integration of the scaffold with a good healing process of critical bone defect: new cortical bone formation seemed to be present, recreating continuity of metatarsus diaphysis. No signs of scaffold mobilization was showed (Fig. 1). All these datas were confirmed by the microCT: new bone formation inside the scaffolds was evident, in particular at proximal bone-scaffold interface, where permanent magnet were present (Fig. 2). These preliminary results lead our research to exploiting magnetic forces to stimulate bone formation, as attested in both in vitro and in vivo models and to improve fixation at bone scaffold interface, as calculated by finite element software, and moreover to guide targeted drug delivery without functionalized magnetic nanoparticles dissemination in all body


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_5 | Pages 40 - 40
1 Apr 2022
Hafez M Nicolaou N Dixon S Obasohan P Giles S Madan S Fernandes J Offiah A
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Introduction. Motorised intramedullary lengthening nails are considered more expensive than external fixators for limb lengthening. This research aims to compare the cost of femoral lengthening in children using the PRECICE magnetic lengthening nail with external fixation. Materials and Methods. Patients: Retrospective analysis of 50 children who underwent femoral lengthening. One group included patients who were treated with PRECICE lengthening nails, the other group included patients who had lengthening with external fixation. Each group included 25 patients aged between 11–17 years. The patients in both groups were matched for age. Cost analysis was performed following micro-costing and analysis of the used resources during the different phases of the treatments. Results. : Each group's mean patient age was 14.7 years. Lengthening nails were associated with longer operative times compared to external fixators, both for implantation and removal surgery (P-value 0.007 and <0.0001 respectively). Length of stay following the implantation surgery, frequency of radiographs, frequency of outpatient department appointments were all more favourable with lengthening nails. The overall cost of lengthening nails was £1393 more than external fixators, although this difference was not statistically significant (P-value 0.088). Conclusions. The cost of femoral lengthening with lengthening nails was not significantly higher than the external fixators’ cost. Further research to review the effectiveness of the devices and the quality of life during the lengthening process is crucial for robust health economic evaluation


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_3 | Pages 60 - 60
1 Mar 2021
Jodoin M Rouleau D Provost C Bellemare A Sandman E Leduc S De Beaumont L
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Acute pain is one of the most common symptoms shared among patients who have suffered from an orthopedic trauma such as an isolated upper limb fracture (IULF). Development of interventions with limited side effects aiming to prevent the installation of chronic pain is critical as persistent pain is associated with an increased risk of opioid dependence, medical complications, staggering financial burdens and diminished quality of life. Theta burst stimulation (TBS), a non-invasive magnetic brain stimulation technique with minimal side effects, has shown promising results in patients experiencing various types of chronic pain conditions as it precisely targets brain regions involved in pain processing. Surprisingly, its impact on acute pain has never been investigated. This study aims to assess longitudinal effects of a 10-day continuous TBS (cTBS) protocol applied in the acute phase of an IULF on key functional outcomes. Patients with an IULF aged between 18 to 60 years old were recruited within 7 days post-accident at a Level I Trauma Center. Exclusion criteria included a history of brain injury, neurological disorders, musculoskeletal complications, and open fractures. In order to assess longitudinal changes, questionnaires measuring intensity and characteristics of pain (Numerical Rating Scale, NRS; McGill Pain Questionnaire, MPQ) as well as functional disability (DASH) were completed by all patients at three time points, namely prior to the start of the TBS program as well as 72 hours and 3 months post-intervention. Patients were randomly attributed to the active TBS protocol (active group) or to the placebo protocol (sham group). The stimulation site for each participant corresponded to the contralateral motor cortex of the injured arm. Fifty patients were recruited (female: 24; age: 40.38 years old), of which 25 were in the active group and 25 were in the sham group. Both groups were equivalent based on age, sex, type of injury, and surgical procedures (p>0.05). The intervention protocol was introduced on average 6.18 days post-accident. In comparison to the sham group, the active group showed a significant decrease in pain intensity (NRS) at 72h (F=6.02; p=0.02) and 3-month (F=6.37; p=0.02) post-intervention. No group difference was found early-on (72h post) in regard to pain characteristics (MPQ; F=3.90; p=0.06) and functional disabilities (DASH; F=0.48; p= 0.49). At three-month post-intervention, the active group showed statistically significant improvement on the MPQ (F=5.02; p=0.04) and the DASH (F=5.88; p=0.02) compared to the placebo group. No complications related to the treatment were reported. Results from this study show that patients who underwent active cTBS reported less pain and better functional states shortly after the end of the TBS protocol compared to sham patients and treatment effects were maintained at three months post-intervention. Given that acute pain intensity is an excellent predictor of chronic pain development, this safe technique available in numerous centers in Canada may help prevent chronic pain development when administered during the acute post-injury phase. Future studies should continue to investigate mechanisms involved to optimize this technique among the orthopedic trauma population and to reduce opioid consumption


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_11 | Pages 1 - 1
1 Nov 2022
Patel R
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Abstract

Aims

The aim of this study was to evaluate the indications for patients presenting with knee pain undergoing magnetic resonance imaging of the knee prior to referral to the orthopaedic department and to ascertain whether plain radiograph imagining would be more beneficial prior to an MRI scan.

Method

A retrospective review of all referrals received by the hospital over a 6-month period was performed. Patients with knee pain that underwent an MRI scan were classified into two age groups, under 50 years and over 50 years old. Patients having undergone Magnetic resonance imaging (MRI) prior to referral were identified, and findings of the scan were recorded. These patients were reviewed further to see if a plain radiograph had been completed prior to or after the MRI.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 28 - 28
1 Feb 2012
Kumar V Panagopoulos A Triantafyllopoulos J Fitzgerald S van Niekerk L
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Aim. The aim of this study was to compare the diagnostic accuracy of the Magnetic Resonance Imaging with that of Stress views of the ankle in testing the integrity of the lateral ankle ligaments. Arthroscopic diagnosis was used as the gold standard. Methods. This was a prospective study involving 45 patients who had previous trauma to the ankle and reported symptoms of ankle instability. Our patients were recreational athletes or military patients. These patients had MRI evaluation prior to arthroscopic evaluation and treatment of the ankle. The diagnosis regarding the integrity of the Calcaneofibular ligament (CFL) and the Anterior Talo-fibular ligament (ATFL), as obtained from the MRI was compared against the assessment of integrity from the stress views. These were compared against the assessment made by direct visualisation of the ligaments during arthroscopy. The sensitivity, specificity, negative (NPV) and positive predictive values (PPV) and accuracy were then calculated. Results. The sensitivity and specificity of the MRI and the stress views were poor for diagnosis of ATFL tears. However, the stress views had better sensitivity (93.7%) and specificity (96.5%), for the CFL, as compared with those of the Magnetic Resonance scans (sensitivity 50% and specificity of 86.2%). There was a difference between the diagnostic accuracy of the two methods of investigation with respect to integrity of the CFL but not of that of the ATFL. The PPV and the NPV for the ATFL was comparable using the MRI and the stress radiographs, the stress radiographs had a better predictive values for the calcaneo-fibular ligament, PPV of 93.7% and NPV of 96.5%. Conclusion. The results of this study suggest that routine pre-operative Magnetic Resonance Imaging is not beneficial or cost effective in diagnosing lateral ligament


The Bone & Joint Journal
Vol. 105-B, Issue 1 | Pages 88 - 96
1 Jan 2023
Vogt B Rupp C Gosheger G Eveslage M Laufer A Toporowski G Roedl R Frommer A

Aims

Distraction osteogenesis with intramedullary lengthening devices has undergone rapid development in the past decade with implant enhancement. In this first single-centre matched-pair analysis we focus on the comparison of treatment with the PRECICE and STRYDE intramedullary lengthening devices and aim to clarify any clinical and radiological differences.

Methods

A single-centre 2:1 matched-pair retrospective analysis of 42 patients treated with the STRYDE and 82 patients treated with the PRECICE nail between May 2013 and November 2020 was conducted. Clinical and lengthening parameters were compared while focusing radiological assessment on osseous alterations related to the nail’s telescopic junction and locking bolts at four different stages.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 35 - 35
1 Mar 2013
Nicholson J Waiter G Lawrie D Ashcroft G
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Dupuytrens disease is a fibrosing condition of the palmar aponeurosis and its extensions within the digits. Normal fascial fibres running longitudinally in the subcutaneous tissues of the palm become thickened and form the characteristic nodules and cords pathognomonic of Dupuytrens disease. A wide variety of surgical interventions exist, of these the partial fasciectomy remains the most conventional and widely used technique. Minimally invasive surgical treatments such as needle fasciotomy are, however, becoming increasingly popular. Dupuytrens disease remains a challenging condition to treat as recurrence is universally found with all surgical interventions. Although recurrence may be related to the severity of the disease, there are currently no research tools other than clinical examination to examine changes in the diseased tissue postoperatively and predict likelihood of long-term success. Magnetic Resonance Imaging (MRI) may be of value for the study of Dupuytren disease, at present its use has been greatly underexplored. We wished to carry out a pilot study in order to examine the possibility of using 3.0 Tesla MRI to study Dupuytren tissue and then furthermore to examine the potential changes post-operatively following percutaneous fasciotomy. Five patients set to undergo percutaneous needle fasciotomy were recruited and consented for the study. All patients underwent MRI scanning of the affected hand pre-operatively and at two weeks post-operatively. Scanning was carried out in the 3.0 Tesla research MRI scanner at Aberdeen Royal Infirmary. Patients were placed prone in the MRI scanner with the hand outstretched above the head in the so-called “Superman” position. A specially designed wrist and hand coil was used. Under the expertise of radiographers and physicists, image capture encompassed four novel scanning sequences in order to make a volumetric three-dimensional image sample of the affected hand. MIPAV software (Bethesda, Maryland) was used for image analysis. Scanning revealed well defined anatomy. The Dupuytren cord arose from the palmar aponeurosis tissue which is deep to the palmar skin and subcutaneous tissue. It was distinctly different to deep structures such as the flexor tendons and intrinsic hand muscles which appeared with a uniform low and high signal respectively. The Dupuytren tissue had a heterogeneous signal on both T1 and T2 images. On T1 the tissue signal appeared high to intermediate, similar to that of bone and muscle, but low areas of signal were observed diffusely in an irregular fashion throughout. On T2 the tissue had a low signal throughout with some focal areas of high signal. Dupuytren tissue was mapped using MIPAV software for pre- and post-operative comparisons. Signal intensity, surface area and volume of the cords and fasciotomy sites were explored. Our initial results suggest MRI can be used to study Dupuytren tissue. Such a research tool may be of use to study the natural history of Dupuytren disease and furthermore, the response to medical and surgical interventions


Introduction. It is widely accepted that computer navigation more reliably restores neutral mechanical alignment than conventional instrumentation in total knee arthroplasty (TKA) surgery. Recently, magnetic resonance (MR) based instrumentation has been introduced to the market with a rapid growth in usage. However, a paucity of comparative data still exists on the precision of magnetic resonance (MR) based instruments in achieving acceptable lower limb alignment when compared to other validated techniques. In this analysis, we compare the radiographic outcomes of 3 techniques to achieve satisfactory prosthetic alignment by 2 surgeons using the same prosthesis and surgical technique. Methods. A series of 180 patients who had undergone TKA surgery were included in this study. Two fellowship-trained knee surgeons performed all surgeries using the same cemented, posterior stabilized implants (NexGen, Zimmer, Warsaw, In). Patients were stratified in to 3 groups according to the technique used to align the knee; 1. Conventional Intra-medullary Instrumentation, 2. Computer Navigation (Orthosoft), and 3. MR-based guides (Zimmer PSI). All patients underwent a post-operative CT Perth Protocol to assess coronal, sagittal and rotational alignment of the femoral and tibial implants. A radiographer who was blinded to the alignment technique used performed all radiographic measurements. Outliers were defined at a deviation of more than 3 degrees from the mechanical axis in all planes of motion. Results. The radiographic outcome measures will be presented to highlight the significant differences between 3 groups. In addition, the early surgical experience with the introduction of MR based instruments will be reviewed along with the early problems encountered from tibial sagittal alignment that became apparent with time. Conclusion. The rapid introduction of MR based instruments in to the market by several prosthetic companies has occurred without adequate pre-release analysis. This study will allow surgeons to make an informed decision on whether to use this technology based on validated radiographic measures, when compared to both conventional alignment techniques and computer navigation


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_9 | Pages 8 - 8
1 Feb 2013
Raymond A McCann P Sarangi P
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Glenohumeral arthritis is associated with eccentric posterior glenoid wear and subsequent retroversion. Total shoulder arthroplasty provides a reliable and robust solution for this pattern of arthritis but success may be tempered by malposition of the glenoid component, resulting in pain, functional impairment, prosthetic loosening and ultimately failure. Correction of glenoid retroversion through anterior eccentric reaming, prior to glenoid component implantation, is performed to restore normal joint biomechanics and maximise implant longevity. The aim of this study was to assess whether magnetic resonance imaging (MRI) or plain axillary radiography (XR) most accurately assessed glenoid version and hence provided the optimal modality for pre-operative templating. Glenoid version was assessed in pre-operative shoulder MRIs and axillary radiographs (XR) by two independent observers in forty-eight consecutive patients undergoing total shoulder arthroplasty. The mean glenoid version measured on magnetic resonance imaging was −14.3 degrees and −21.6 degrees on axillary radiographs (mean difference −7.36, p=<0.001). Glenoid retroversion was overestimated in 73% of XRs. Intra-observer and inter-observer reliability coefficients for MRI were 0.96 and 0.9 respectively. Intra-observer and inter-observer reliability coefficients for XR were 0.8 and 0.71 respectively. Axillary radiographs significantly overestimate glenoid retroversion and are less precise than shoulder magnetic resonance, which provides excellent intra- and inter-observer reliability. MRI is a useful pre-operative osseous imaging modality for total shoulder arthroplasty as it offers a more precise method of determining glenoid version, in addition to the standard assessment rotator cuff integrity


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 144 - 144
1 May 2012
T. R R. M J. M C. A
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Introduction. In degenerative lumbar spine, it seems possible that foraminal stenosis is over-diagnosed as axial scanning is not performed in the plane of the exiting nerve root. We carried out a two-part study to determine the true incidence of foraminal stenosis. Patients and Methods. Initially we performed a retrospective analysis of radiology reports of conventional Magnetic Resonance Imaging in 100 cases of definite spinal stenosis to determine the incidence of reported ‘foraminal stenosis’. Subsiquently we performed a prospective study of MRI including fine slice T2 and T2 STIR coronal sequences in 100 patients with suspected stenosis. Three surgeons and one radiologist independently compared the diagnoses on conventional axial and sagittal sequences with the coronal scans. Results. The retrospective analysis found that ‘foraminal stenosis’ was reported by radiologists in 46% using conventional axial and sagittal sequences. In the prospective study of 100 patients suspected of having stenosis, spinal stenosis was reported in 40; degenerative spondylolisthesis in 14; posterolateral disc herniation in 14; normal report in 13; far lateral disc herniation in 7; isthmic (lytic) spondylolisthesis in 6; and degenerative scoliosis in 6. Conventional sequences diagnosed lateral recess stenosis reliably, but also suggested foraminal stenosis in 43%. However, coronal sequences clearly showed no foraminal nerve compression at all. In degenerative spondylolisthesis conventional scans suggested foraminal stenosis in 10 of 14 cases. Coronal imaging again showed no foraminal stenosis. Excellent correlation was found in normal spines and in disc herniation. Foraminal nerve compression was confirmed by conventional and coronal imaging only in isthmic spondylolisthesis, degenerative scoliosis and far lateral disc herniation. Conclusion. The addition of coronal MRI proves that foraminal stenosis is over-diagnosed. True foraminal stenosis definitely exists in isthmic spondylolisthesis, degenerative scoliosis and far lateral disc herniation, but we question its existence in spinal stenosis and degenerative spondylolisthesis


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 34 - 34
1 Sep 2012
Segar A French G
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The use of peritumoral oedema on magnetic resonance (MR) imaging to predict soft tissue tumour grade is controversial. The clinical significance of oedema visualised on MR scans is poorly defined in the literature. We undertook this study to ascertain a diagnostic relationship between peritumoral oedema surrounding soft tissue sarcomas and the histological grade of the tumour. One hundred and ten consecutive soft tissue tumours were extracted from the New Zealand Bone and Soft Tissue Tumour Registry. Key inclusion criteria were tumours deep to fascia, measuring more than 5cm in any dimension. Both benign and malignant sarcomas were included. MR scans and histology were reviewed, separately and in random order by a single author. Histology was graded as benign, low or high grade (based on the American Joint Committee on Cancer grading system). Peritumoral oedema was defined as the increased signal intensity, on T2 or STIR images, immediately surrounding a discrete lesion. It was measured on two or more planes with the largest value used in diagnostic calculations. Oedema greater than or equal to 20mm was defined as a positive test result. Twenty five random scans were double read to ensure inter-observer reliability. Data was obtained for 83 tumours, 36 benign and 47 malignant (34 high grade and 13 low grade). The tumours in all groups were matched for size. The mean peritumoral oedema was 10.5mm for benign tumours, 20.6mm for low grade sarcomas (p<0.1), 28.1mm for high grade tumours (p<0.01) and 26.1mm if all malignant tumours were included as a single group (p<0.01). Using peritumoral oedema as a diagnostic test for tumour grade resulted in a specificity of 72%. The highest diagnostic ability was found when comparing benign to high grade tumours which yielded sensitivity of 59% and a positive likelihood ratio of 2.1. This data suggests a high false negative rate and that the test adds little to the diagnostic process. To our knowledge this is the first study which assesses the diagnostic accuracy of peritumoral oedema to predict the histological grade of soft tissue sarcomas. Our results show a statistically significant difference, in surrounding peritumoral oedema, exists when comparing benign to high grade sarcomas and to all malignant tumours. This relationship is not apparent for low grade tumours. As a diagnostic test, using only peritumoral oedema to predict histological grade is unreliable


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 191 - 191
1 Jun 2012
Rahim MR
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MRI has been little utilised in the post-operative assessment of joint replacement due to the problem of artifact. With modern machines and sequencing, artifact can be minimised in small joints with titanium prostheses. Twenty four consecutive patients implanted with a Buechel-Pappas Total Ankle Replacement underwent MRI examination at an average of 583 days post surgery to determine its usefulness as an adjunct to x-ray and bone scan in assessing prosthetic integrity and the source of post-operative symptoms.

The purpose of the study was to evaluate the use of modified MRI techniques in the assessment of bone-implant interface, soft tissue changes, bone oedema and extent of osteolysis in setting of total ankle joint replacement and propose a descriptive classification to document the changes.

We found MRI was extremely useful in identifying abnormalities in structures apart from the prosthesis such as occult degeneration in the subtalar joint and ligament pathology. Despite the new techniques, artifact remains a problem when assessing the bone prosthesis interface although adjacent bone oedema is well seen.

MRI has a role in the identification of pathology in the tissues surrounding a TAJR especially with unexplained pain in an otherwise well functioning prosthesis. It's role in the assessment of prosthetic integrity remains qualitative but further work will be required to correlate MRI findings with clinical examination.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_5 | Pages 23 - 23
1 Feb 2016
Al-Attar N Venne G Easteal R Kunz M
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Osteophytes are bony spurs on normal bone that develop as an adaptive reparative process due to excessive stress at/near a joint. As osteophytes develop from normal bone, they are not always well depicted in common imaging techniques (e.g. CT, MRI). This creates a challenge for preoperative planning and image-guided surgical methods that are commonly incorporated in the clinical routine of orthopaedic surgery.

The study examined the accuracy of osteophyte detection in clinical CT and MRI scans of varying types of joints.

The investigation was performed on fresh-frozen ex-vivo human resected joints identified as having a high potential for presentation of osteophytes. The specimens underwent varying imaging protocols for CT scanning and clinical protocols for MRI. After dissection of the joint, the specimens were subjected to structured 3D light scanning to establish a reference model of the anatomy. Scans from the imaging protocols were segmented and their 3D models were co-registered to the light scanner models. The quality of the osteophyte images were evaluated by determining the Root Mean Square (RMS) error between the segmented osteophyte models and the light scan model.

The mean RMS errors for CT and MRI scanning were 1.169mm and 1.419mm, respectively. Comparing the different CT parameters, significance was achieved with scanning at 120kVp and 1.25mm slice thickness to depict osteophytes; significance was also apparent at a lower voltage (100kVp).

Preliminary results demonstrate that osteophyte detection may be dependent on the degree of calcification of the osteophyte. They also illustrate that while some imaging parameters were more favourable than others, a more accurate osteophyte depiction may result from the combination of both MRI and CT scanning.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 155 - 155
1 Dec 2013
Park C Ranawat A Chang A Khamaisy S Pearle A
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Introduction:

Unicompartmental knee arthroplasty (UKA) is a well established method for treatment of single compartment arthritis. However, a subset of patients still present with continued pain after their procedure in the setting of a normal radiographic examination. We propose the use of magnetic resonance imaging (MRI) as a useful modality in determining the etiology of symptoms in symptomatic unicompartmental knee arthroplasties.

Materials & Methods:

An IRB-approved retrospective analysis of 300 consecutive unicompartmental knee arthroplasties between 2008–2010 found 28 cases symptomatic for continued pain. Magnetic resonance imaging was performed with a 1.5 T Surface Coil unit after clinical and radiographic assessment. MRI evaluation included assessment for osteoarthritis, synovitis, osteolysis, and loosening. Validated questionnaires including PAQ, WOMAC and UCLA Activity Score were used for clinical assessment


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 62 - 62
1 Mar 2012
Auplish S Wilson D
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Aim

This study aims to determine the value of MRI in children with hip pain which remained unexplained following routine investigations including ultrasound examination.

Materials and methods

Retrospective review of clinical notes and MRI findings in all children who received and MRI scan for undiagnosed hip pain over three years.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_9 | Pages 13 - 13
1 May 2016
Manalo J Patel A Goyal N Fitz D Talati R Stulberg S
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Introduction

Current techniques in total knee arthroplasty aim to restore the coronal mechanical axis to neutral. Preoperative planning has historically been based on long-leg standing films (LLSF) which allow surgeons to plan bony resection and soft tissue releases. However, LSSF can be prone to error if malrotated. Recently, patient-specific guides (PSG) utilizing supine magnetic resonance imaging (sMRI) have become an accepted technique for preoperative planning. In this study we sought to compare the degree of coronal deformity using LLSF and sMRI.

Methods

Two hundred thirty knees underwent planning for total knee arthroplasty with sMRI and LLSF. Coronal plane deformity was determined based on the femoral-tibial angle (FTA) as defined by the angle formed between a line from the center of the femoral head to the intercondylar notch and a line from the middle of the tibial spines to the middle of the ankle joint. Mechanical axis values from the sMRI were compared with values obtained from LLSF


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 45 - 45
1 Feb 2012
Ghosh S Deshmukh S Charity R
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There is a difference of opinion regarding the usefulness of MR Imaging as a diagnostic tool for triangular fibrocartilage complex (TFCC) tears in the wrist. Our aim was to determine the accuracy of direct magnetic resonance arthrography (MRA) in the diagnosis of triangular fibrocartilage complex (TFCC) tears of the wrist in a district general hospital setting.

In a retrospective review of 21 patients who presented with complains of wrist pain and following a clinical examination, all had direct MR arthrography of the wrist in our hospital in a 1.5Tesla scanner. All had a diagnostic arthroscopy within 2-4 months of the MR scan. All patients had chronic ulnar sided wrist pain, although only two had a definite history of trauma. The findings of each diagnostic method were compared, with arthroscopy considered the gold standard.

Twenty-one patients were studied (10 male: 11 female), mean age 42 years (range 27-71) years). Seventeen TFCC tears were diagnosed on arthroscopy. For the diagnosis of TFCC tears MRA had a sensitivity, specificity and accuracy of 67%.

Our results echoed the opinion of some of the previous investigators with an unacceptable sensitivity or specificity for a diagnostic tool. MR arthrography needs to be further refined as a technique before it can be considered to be accurate enough to replace wrist arthroscopy for the diagnosis of TFCC tears. Other centres have reported better accuracy, using more advanced MRI technology. Until this iswidely available at all levels of healthcare the results of MRI for the diagnosis of TFCC tears should be interpreted with caution.