Abstract. Aim. To identify the difference in infection rates in ankle fracture surgery in Laminar and Non
Introduction. Reducing infection in total joint replacement by using ultra clean air and protective enclosed suits (space suits) has become the standard in many operating theatres without good supporting evidence. This study examined the impact of
Aim. Whether laminar airflow (LAF) in the operating room (OR) is effective for decreasing periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) remains a clinically significant yet controversial issue. This study investigated the association between operating room ventilation systems and the risk of PJI in TJA patients. Method. We performed a retrospective observational study on consecutive patients undergoing primary total knee arthroplasty (TKA) and total hip arthroplasty (THA) from January 2013-September 2017 in two surgical facilities within a single institution, with a minimum 1-year follow-up. All procedures were performed by five board-certified arthroplasty surgeons. The operating rooms at the facilities were equipped with LAF and turbulent ventilation systems, respectively. Patient characteristics were extracted from clinical records. PJI was defined according to Musculoskeletal Infection Society criteria within 1-year of the index arthroplasty. A multivariate logistic regression model was performed to explore the association between LAF and risk of 1-year PJI, and then a sensitivity analysis using propensity score matching (PSM) was performed to further validate the findings. Results. A total of 6,972 patients (2,797 TKA, 4,175 THA) were included. The incidence of PJI within 1 year for patients from the facility without
Adherent cells are known to respond to physical characteristics of their surrounding microenvironment, adapting their cytoskeleton and initiating signaling cascades specific to the type of cue encountered. Scaffolds mimicking native biophysical cues have proven to differentiate stem cells towards tissue-specific lineages and to maintain the phenotype of somatic cells for longer periods of culture time. Although the characteristic anisotropy of tendon tissue is commonly replicated in scaffolds, relevant physical cues such as tendon rigidity or mechanical loading are often neglected. The objective of this study is to use tendons' main extracellular matrix component, collagen type I, to create scaffolds with an anisotropic surface topography and controlled rigidity, in an effort to engineer functional tendon tissue equivalents, with native organization and strength. Porcine collagen type I in solution was treated with one of the following cross-linkers: glutaraldehyde, genipin or 4-arm polyethylene glycol (4SP). The resulting mixture was poured on micro-grooved (2×2×2 μm) or planar polydimethylsiloxane (PDMS) molds and dried in a
Aim. Peri-prosthetic joint infection is a serious and expensive complication of joint arthroplasty. Theatre discipline has infection prevention at its core with multiple studies correlating increased door opening with surgical site infection. The WHO, NICE and Philadelphia Consensus all advocate minimal theatre traffic. The Dutch Health Inspectorate consider >5 door openings per procedure excessive. Method. This prospective observational study over five weeks observed theatre door traffic during hip and knee arthroplasty within the eight
Aims. The worldwide COVID-19 pandemic is directly impacting the field of orthopaedic surgery and traumatology with postponed operations, changed status of planned elective surgeries and acute emergencies in patients with unknown infection status. To this point, Germany's COVID-19 infection numbers and death rate have been lower than those of many other nations. Methods. This article summarizes the current regimen used in the field of orthopaedics in Germany during the COVID-19 pandemic. Internal university clinic guidelines, latest research results, expert consensus, and clinical experiences were combined in this article guideline. Results. Every patient, with and without symptoms, should be screened for COVID-19 before hospital admission. Patients should be assigned to three groups (infection status unknown, confirmed, or negative). Patients with unknown infection status should be considered as infectious. Dependent of the infection status and acuity of the symptoms, patients are assigned to a COVID-19-free or affected zone of the hospital. Isolation, hand hygiene, and personal protective equipment is essential. Hospital personnel directly involved in the care of COVID-19 patients should be tested on a weekly basis independently of the presence of clinical symptoms, staff in the COVID-19-free zone on a biweekly basis. Class 1a operation rooms with
Infection following primary total knee arthroplasty (TKA) is fortunately a relatively uncommon complication with an incidence of approximately 1%. However, because the morbidity and cost of treatment of deep prosthetic TKA infections is so high, effective prevention strategies are key quality improvement initiatives. The cause of post-operative infections are multifactorial and complex but can generally be categorised into 1) host, 2) surgical, and 3) environmental factors. The purpose of this abstract to provide an outline of these factors and their influences on the infection risk following TKA. Patient factors and optimization of modifiable risk factors have been shown to decrease the risk for infection. While the individual contributions of factors such as body mass index (BMI), diabetes, nutritional status, Charlson Comorbidity Index (CCI), and renal disease are unknown, together, they have been shown to influence infection risk. Additionally, Tayton et al. analyzed 64,566 primary TKAs in the New Zealand Joint Registry and found that male gender and prior knee surgery were also independent risk factors of development of PJI 12 months following TKA. Finally, Crowe and colleagues also identified tobacco use and Staphylococcus aureus colonization as modifiable risk factors for minimizing PJI following primary TKA. Timely administration of prophylactic antibiotics prior and after surgery has been shown to be the most effective strategy to reduce infection risk. The optimal prophylaxis regimen for all patients is unknown and in certain situations, administration of Vancomycin in additional to a conventional cephalosporin may be beneficial. However, universal administration of Vancomycin has not been shown to decrease the incidence of surgical site infections and could actually increase the risk for renal failure. Conversely, addition of antibiotics to cement during primary TKA has not been shown to reduce long term infection risk. The use of dilute betadine lavage has been shown by some authors to be beneficial. Finally, good surgical technique, proper soft tissue handling, and meticulous wound closure are all critical factors influencing the risk for infectious complications following TKA. Environmental factors have also been shown to affect infection rates following TKA. While the use of
Infection following primary total knee arthroplasty (TKA) is fortunately a relatively uncommon complication with an incidence of approximately 1%. However, because the morbidity and cost of treatment of deep prosthetic TKA infections is so high, effective prevention strategies are key quality improvement initiatives. The cause of post-operative infections are multifactorial and complex but can generally be categorised into 1) host, 2) surgical, and 3) environmental factors. The purpose of this abstract is to provide an outline of these factors and their influences on the infection risk following TKA. Patient factors and optimization of modifiable risk factors have been shown to decrease the risk for infection. While the individual contributions of factors such as body mass index (BMI), diabetes, nutritional status, Charlson Comorbidity Index (CCI), and renal disease are unknown, together, they have been shown to influence infection risk. Additionally, Tayton et al. analyzed 64,566 primary TKAs in the New Zealand Joint Registry and found that male gender and prior knee surgery were also independent risk factors of development of PJI 12 months following TKA. Finally, Crowe and colleagues also identified tobacco use and Staphylococcus aureus colonization as modifiable risk factors for minimizing PJI following primary TKA. Timely administration of prophylactic antibiotics prior and after surgery has been shown to be the most effective strategy to reduce infection risk. The optimal prophylaxis regimen for all patients is unknown and in certain situations, administration of Vancomycin in additional to a conventional cephalosporin may be beneficial. However, universal administration of Vancomycin has not been shown to decrease the incidence of surgical site infections and could actually increase the risk for renal failure. Conversely, addition of antibiotics to cement during primary TKA has not been shown to reduce long term infection risk. The use of dilute betadine lavage has been shown by some authors to be beneficial. Finally, good surgical technique, proper soft tissue handling, and meticulous wound closure are all critical factors influencing the risk for infectious complications following TKA. Environmental factors have also been shown to affect infection rates following TKA. While the use of
The aim of the New Zealand National Shoulder Arthroplasty Register is to evaluate the provision of shoulder arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all shoulder replacements performed in New Zealand. An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete the Oxford Shoulder Score and comment on post-operative complications. Data from 686 consecutive primary and 44 revision shoulder arthroplasties were prospectively collected from January 2000 until December 2003. 82 surgeons performed shoulder arthroplasty during the study period but only 9 performed on average more than 5 per year. Their results at 6 months were statistically superior to those provided by other surgeons. Amongst all diagnoses, osteoarthritis scored significantly better than the rest and for this condition total shoulder replacement scored higher than hemiarthroplasty. 15 different prostheses were used, many of them too infrequently. There was no difference in outcome amongst the 5 most commonly used prostheses. The number of complications reported by patients and the revision rate within the study period was low. No benefit was observed in the use of
Introduction. Infection is disastrous in arthroplasty surgery and requires multidisciplinary treatment and debilitating revision surgery. Between 80-90% of bacterial wound contaminants originate from colony forming units (CFUs) present in operating room air, originating from bacteria shed by personnel present in the operating environment. Steps to reduce bacterial shedding should reduce wound contamination. These steps include the use of unidirectional laminar airflow systems and the introduction of theatre attire modelled on this principle (e.g. total body exhaust suits). Our unit introduced the use of the Stryker Sterishield Personal Protection System helmet used with
Introduction. We report the results of a prospective study of 1349 patients undergoing 1509 total knee replacements, identifying factors increasing the risk of infection. Methods. Data were collected prospectively between October 1998 and February 2002 by a dedicated audit nurse. Pre-operative demographic and medical details were recorded. Operative and post-operative complications were noted. The definitions of surgical-site infection were based on a modification of those published by the Centre for Disease Control (CDC) in 1992. A superficial wound infection had a purulent discharge or positive culture of organisms from aseptically-aspirated fluid, tissue, or from a swab. Deep infection was counted as an infection that required a secondary procedure. Patients were seen at 6, 18 and 36 months post-operatively in a dedicated knee audit clinic and infection details recorded. The association between infection and other factors was tested by chi-squared or Mann-Whitney tests for categorised or quantitative factors respectively. Results. 18 patients (1.2% of all total knee replacements) had deep infection and a further 49 suffered a superficial infection. We found no correlation between risk of infection and age, sex, BMI, ASA grade, tourniquet time, lateral release, surgeon, transfusion or the need for catheterisation in the early post-operative period. Diabetic patients had an increased odds ratio for deep and superficial infection, but these results did not reach statistical significance. Only 3 of the 49 superficial infections went onto develop a deep infection at an average of 21 months after surgery. Conclusion. Using modern orthopaedic surgical techniques including
Purpose. Surgical complications are common and frequently preventable. The introduction of the WHO Surgical Safety Checklist has improved surgical outcomes. WHO guidelines reduce, but do not prevent errors. Successful arthroplasty surgery requires strict infection control measures. We observed a single surgical team to see if errors caused by operating room personnel were covered by the WHO Checklist. Method. Two independent observers studied compliance of WHO Checklists and operating room etiquette, for one surgical team. All operating room personnel were observed during thirteen arthroplasties (hips and knees) from induction to recovery. All Personnel were blinded to the purpose of this study. Data was categorised into errors with WHO checklists and operating room etiquette. Results. 120 errors were observed in thirteen cases, none of these errors affected patient outcome and they were all corrected promptly. 113 (94%) were operating room etiquette errors and 7 (6%) were WHO checklist errors. Types of operating room etiquette errors which occurred were 32%
Aim. To test the hypothesis that surface skin swabs taken after skin preparation with alcoholic povidone iodine (APVPI) would not grow bacteria, whereas full thickness biopsies taken from the line of surgical incision would grow bacteria. Method. Informed consent was obtained from 44 patients undergoing primary hip (n=13) and knee (n=31) arthroplasty. Each received antimicrobial prophylaxis before skin preparation with APVPI under
In 1823 J. White excised the head. In 1887 a German surgeon replaced the head with ivory. Interposition arthroplasties were common after WW1. Short-stemmed head replacing prosthesis were developed after WW2. Moores and Thompson designed a more stable intramedullary stem. Acetabular erosion was troublesome—and so replacing both surfaces started in the late 1950s using Teflon cup and metal femur. Unfortunately, these quickly became loose due to wear or sepsis. In 1960, Charnley used a polyethylene cup and stainless-steel femur and fixed both with dental cement. This ‘low friction arthroplast’ became a routine procedure after 1961. In the 1970s there were many ‘Charnley look-alike’ prosthesis with similar problems of poly-wear, granulomas and cysts causing bone loss, loosening, breakages and infection. Resurfacing with two thin shells was developed to reduce the foreign material, the bone resection and the cement used. Unfortunately, neck fractures, avascular necrosis and excessive wear of the poly shell were common. Despite operating theatres with
Aim. The purpose of this study was to compare the presence of P.acnes on the skin after topical pre-operative application with benzoyl peroxide (BPO) to chlorhexidine soap (CHS) and whether this also affected skin recolonization after surgical preparation and draping. Method. Forty volunteers – twenty-four men and sixteen women were randomized to pre-operative topical treatment at home with either CHS or BPO in the area of a delto-pectoral approach of their left shoulder. The right served as a control. Five skin swabs were taken in a standardized manner on different occasions: before and after topical treatment, after surgical skin preparation and sterile draping and 120 minutes after draping. A fifth sample was taken on the contralateral untreated side as a control when the patient was draped. The draping took place in an operating room with
Aim. The aim of this study was to validate the information on operating room ventilation reported to the Norwegian Arthroplasty Register (NAR) and to assess the influence of this ventilation on the risk of revision due to infection after primary total hip arthroplasty (THA). Method. Current and previous ventilation systems were evaluated together with the hospitals head engineer in 40 orthopaedic hospitals. The ventilation system of each operating room was assessed and confirmed as either conventional ventilation, vertical laminar airflow (LAF) or horizontal LAF. We then identified cases of first revision due to deep infection after primary THA and the type of ventilation system reported to the NAR in the period 1987–2014. The association between revision due to infection and operating room ventilation was estimated by relative risks (RR) in a Cox regression model. Results. 103370 primary THAs and 971 (0.9%) first revisions due to deep infection were reported. 51% of the primary THAs were performed in a room with vertical LAF, 44% in a room with conventional ventilation and 5% in a room with horizontal LAF. There was a mean misreporting rate of approximately 12%. There was similar risk of revision due to infection after THA performed in operating rooms with vertical
The aim of this study was to validate the information on operating room ventilation reported to the Norwegian Arthroplasty Register (NAR). We then wanted to assess the influence of operating room ventilation on the rate of revision due to infection after primary THA performed in operating rooms with conventional ventilation, “greenhouse”–ventilation and Laminar Airflow ventilation (LAF). We identified cases of THA revisions due to deep infection and the type of ventilation system reported to the NAR from the primary THA. We included 5 orthopaedic units reporting 17947 primary THAs and 136 (0.8%) revisions due to infection during the 28 year inclusion period from 1987 to 2014. The hospitals were visited and the current and previous ventilation systems were evaluated together with the hospitals head engineer, and the factual ventilation on the specific operating rooms was thereby assessed. The association between revision due to infection and operating room ventilation was estimated by calculating relative risks (RR) in a Cox regression model. 73% of the primary THAs were performed in a room with LAF, in contrast to the reported 80 % of LAF. There was similar risk of revision due to infection after THA performed in operating rooms with
Postoperative sepsis is a costly and potentially devastating problem in total joint arthroplasty. Airborne bacteria and other viable microorganisms shed from surgical staff are a source of deep prosthetic infection, and the density of airborne bacteria is correlated with the rate of postoperative joint sepsis in total joint arthroplasty surgery. Previous studies have also reported a positive relationship between the density of nonviable airborne particulate and viable CFU counts, both airborne and in the surgical wound, during surgery. The purpose of this study was to determine the extent to which a system that delivers a small field of local, directed HEPA-filtered air flow over the surgical field reduces airborne particulate and airborne bacteria during total hip arthroplasty. A minimum of 8 subjects per group provided 80% power (a = 0.05) to detect a =75% difference in bacterial density between groups. All patients who consented to undergo primary total hip arthroplasty were eligible. Thirty-six patients were prospectively randomized into three groups: directed air flow, air flow system present but turned off (sham), and control (standard) conditions. Airborne particulate and bacteria were continuously collected in consecutive 10 minute intervals within 5 cm of the surgical wound using an air sampling device. Data were analyzed using a generalized linear model for repeated measures. Particulate counts and bacterial density at the surgical site were 80% lower on average in the directed air flow group compared to the other two groups (p<0.001) (Figure 1). Density of particulate >10 μm in diameter was strongly related to bacterial density at the surgical site (p<0.001), as was staff count (p<0.001) and bacterial density at a control site that was remote from the surgical field (p<0.001). The directed air flow system's effectiveness in reducing bacteria appears to be related to its ability to reduce particulate that may carry and allow proliferation of bacteria. The directed air flow system is relatively simple to use and does not appear to hinder the function of the surgeon or operating room staff, impede access to the surgical site, or interfere with the surgical procedure. The directed air flow system can be used in any operating room environment to provide clean air equivalent to a properly-used, well-functioning
COVID-19 has changed the practice of orthopaedics across the globe. The medical workforce has dealt with this outbreak with varying strategies and adaptations, which are relevant to its field and to the region. As one of the ‘hotspots’ in the UK , the surgical branch of trauma and orthopaedics need strategies to adapt to the ever-changing landscape of COVID-19. Adapting to the crisis locally involved five operational elements: 1) triaging and workflow of orthopaedic patients; 2) operation theatre feasibility and functioning; 3) conservation of human resources and management of workforce in the department; 4) speciality training and progression; and 5) developing an exit strategy to resume elective work. Two hospitals under our trust were redesignated based on the treatment of COVID-19 patients. Registrar/consultant led telehealth reviews were carried out for early postoperative patients. Workflows for the management of outpatient care and inpatient care were created. We looked into the development of a dedicated operating space to perform the emergency orthopaedic surgeries without symptoms of COVID-19. Between March 23 and April 23, 2020, we have surgically treated 133 patients across both our hospitals in our trust. This mainly included hip fractures and fractures/infection affecting the hand.Aims
Methods