Femoroacetabular impingement (FAI) is a significant cause of osteoarthritis in young active individuals but the pathophysiology remains unclear. Increasing mechanistic studies point toward an inflammatory component in OA. This study aimed to characterise inflammatory cell subtypes in FAI by exploring the phenotype and quantification of inflammatory cells in FAI versus OA samples. Ten samples of labrum were obtained from patients with FAI (confirmed pathology) during open osteochondroplasty or hip arthroscopy. Control samples of labrum were collected from five patients with osteoarthritis undergoing total hip arthroplasty. Labral biopsies were evaluated immunohistochemically by quantifying the presence of macrophages (CD68 and CD202), T cells (CD3), mast cells (mast cell tryptase) and vascular endothelium (CD34). Labral biopsies obtained from patients with FAI exhibited significantly greater macrophage, mast cell and vascular endothelium expression compared to control samples. The most significant difference was noted in macrophage expression (p<0.01). Further sub typing of macrophages in FAI using CD202 tissue marker revealed and M2 phenotype suggesting that these cells are involved in a regenerate versus a degenerate process. There was a modest but significant correlation between mast cells and CD34 expression (r=0.4, p<0.05) in FAI samples. We provide evidence for an inflammatory cell infiltrate in femoroacetabular impingement. In particular, we demonstrate significant infiltration of mast cells and macrophages suggesting a role for innate immune pathways in the events that mediate hip impingement. Further mechanistic studies to evaluate the net contribution and hence therapeutic utility of these cellular lineages and their downstream processes may reveal novel therapeutic approaches to the management of early hip impingement

Surgical dislocation of the hip in the treatment of acetabular fractures allows the femoral head to be safely displaced from the acetabulum. This permits full intra-articular acetabular and femoral inspection for the evaluation and potential treatment of cartilage lesions of the labrum and femoral head, reduction of the fracture under direct vision and avoidance of intra-articular penetration with hardware. We report 60 patients with selected types of acetabular fracture who were treated using this approach. Six were lost to follow-up and the remaining 54 were available for clinical and radiological review at a mean follow-up of 4.4 years (2 to 9). Substantial damage to the intra-articular cartilage was found in the anteromedial portion of the femoral head and the posterosuperior aspect of the acetabulum. Labral lesions were predominantly seen in the posterior acetabular area. Anatomical reduction was achieved in 50 hips (93%) which was considerably higher than that seen in previous reports. There were no cases of avascular necrosis. Four patients subsequently required total hip replacement. Good or excellent results were achieved in 44 hips (81.5%). The cumulative eight-year survivorship was 89.0% (95% confidence interval 84.5 to 94.1). Significant predictors of poor outcome were involvement of the acetabular dome and lesions of the femoral cartilage greater than grade 2. The functional mid-term results were better than those of previous reports. Surgical dislocation of the hip allows accurate reduction and a predictable mid-term outcome in the management of these difficult injuries without the risk of the development of avascular necrosis

Introduction. Ectopic ossification (EO) at the acetabular rim has been suggested to be associated with pincer impingement and to lead to ossification of the labrum. However, this has never been substantiated with histological, radiographic and MRI findings in large cohorts of patients. We hypothesized that it is more a bone apposition of the acetabular rim and that it occurs more frequently in coxa profunda (CP) hips. Materials and Methods. In the first part, a cohort of 20 hips with this suspected ectopic rim ossification (EO) pattern were identified. The radiographic features that could be associated with this ossification pattern were described and evaluated by a histologic examination of intra-operative samples taken from the rim trimming. In the second part, we assessed the prevalence of this ectopic ossification process in a cohort of 203 patients treated for FAI. Results. Histologic examination revealed that new acetabular bone formation was either overgrowing the non-ossified labrum or moving it away from the native rim. Radiologically, this was associated with an “indentation sign” and/or a “double line sign”. There were no specimens that had shown any evidence of labral ossification. EO was found in 26 hips (18%) of the second cohort. Twenty of 26 hips (77%) with EO had CP morphology and 29% of CP hips had EO signs. In contrast, only 6 non-profunda hips (8%) were associated with EO. There was a high correlation between XR and MRI findings as >80% of XR findings were confirmed on MRI. Sixty-nine hips had CP morphology. The double line sign (N = 13), the indentation sign (N = 12) and a prominent lateral rim (N = 11) were found. Hips with an EO pattern were found in patients that were significantly older than those without EO (p = 0.01). The acetabular characteristics of the EO groups were not significantly different from the CP hips without EO. The femoral characteristics were significantly different between groups with lower neck shaft angles (128° vs 134°;p = 0,0002) and shorter femoral necks lengths (62mm vs 65mm; p = 0,04)) in the EO group. The mean Tonnis classification was not significantly different (p = 0,18). In addition, the mean acetabular cartilage degeneration status was not different between both groups (p = 0,9). Rim trimming down to the native acetabular bone was done in all cases either by arthroscopy (N = 40) or open surgical dislocation (N = 17). Discussion. Ectopic ossification of the acetabular rim predominantly occurs in CP and is associated with specific anatomic features of the proximal femur. This type of impingement seems to be different and less aggressive than other described impingement processes. The double line sign and indentation sign are highly indicative for this EO process and are indicative for a longstanding impingement problem. Trimming of the acetabular rim should be conducted

Purpose. The purpose of this retrospective study was to investigate the acetabular morphology of pincer impingement hips in order to better understand damage pattern in these patients. We compared MRI measurements made at different postions from anterior to posterior on the acetbulum in patients with pure pincer type FAI to those made in patients with pure cam-type to collect parameters that may be useful in the diagnosis and classification of pincer impingement. Material and Methods. From an initial consecutive retrospective population of 1022 patients that underwent MRI with clinical impingement signs 78 hips which were selected with as clear cam (n=57) or pincer (n=21) impingement on plain radiographics. On these MR Imaging was performed with a 1.5-Tesla system. For analysis, a lateral angle of overcoverage on coronal MRI (MR_LCE), the MR extrusion index and the alpha angle (after Nötzli) were used. In addition to these the gamma angle, the acetabular depth and the angle of lateral acetabular overcoverage were described clock-wise on 7 radial slides from anterior to posterior. These were compared between the cam and pincer population using students-t-test. Measurements were obtained by two observers and inter-observer variability was assessed. Results. The acetabular depth showed in all 7 positions significant smaller values for pincer-type in comparison to cam-type impingement. Highest difference was found is superior-posterior position. The acetabular angle is also significant smaller for pincer than for cam in all radial positions. Highest difference of the acetabular angle is located in superior (pincer −102.93°/cam 109.62°) and anterior-superior position (pincer 102.48°/cam 108.77 °). The gamma angle showed significant differences in all radial positions except anterior position. The highest difference is located in superior-posterior position (pincer 86.18 °/cam 08.77°). The mean MR extrusion index was significant lower for pincer type (12.73%) compared to cam-type patients (17.76%) (p=0.004). LCE angle and extrusion index on MRI displayed a Person correlation coefficient of 0.920. The correlation of the acetabular depth and angle was 0.638. Conclusion. There are several morphological differences between pincer and cam acetabuli: They are significantly deeper in all radial positions than cam hips. They tend to have greater retroversion and have smaller gamma angles. Our results suggest that the superior-posterior quadrant displays greater coverage in pincer hips than cam hips, and therefore damage to the labrum and cartilage surface may extend further into the posterior portion of the acetabulum in pincer hips than in cam hips

Aims

The aims of this study were to determine the cumulative ten-year survivorship of hips treated for acetabular fractures using surgical hip dislocation and to identify factors predictive of an unfavourable outcome.