Aims

To assess the feasibility of a randomized controlled trial (RCT) that compares three treatments for acetabular fractures in older patients: surgical fixation, surgical fixation and hip arthroplasty (fix-and-replace), and non-surgical treatment.

The arcOGEN study identified the 9q33.1 locus as associated with hip osteoarthritis (OA) in females. TRIM32 lies within this locus and may have biological relevance to OA; it encodes a protein with E3 ubiquitin ligase activity. Sanger sequencing of TRIM32 in the youngest 500 female patients with hip OA from the arcOGEN study identified genetic polymorphisms in the proximal promoter, and 3'untranslated region of TRIM32 that are disproportionately represented in female patients with hip OA compared to the control population. Reduced expression of TRIM32 was identified in femoral head articular chondrocytes from patients with hip OA compared to control patients. Trim32 knockout resulted in increased aggrecanolysis in murine femoral head explants. Murine chondrocytes deficient in Trim32 exhibited increased expression of mature chondrocyte markers following anabolic cytokine stimulation, and increased expression of hypertrophic chondrocyte markers following catabolic cytokine stimulation. Trim32 knockout mice demonstrated increased cartilage degradation and tibial subchondral bone changes after surgically-induced knee joint instability. Increased cartilage degradation and medial knee subchondral bone changes were also identified in aged Trim32 knockout mice. These results further implicate TRIM32 in the genetic predisposition to OA, and indicate a role for TRIM32 in the joint degeneration evident in OA. These results support the further study of TRIM32 in the pathophysiology of OA and development of novel therapeutic strategies to manage OA

Aims

Acetabular fractures in older adults lead to a high risk of mortality and morbidity. However, only limited data have been published documenting functional outcomes in such patients. The aims of this study were to describe outcomes in patients aged 60 years and older with operatively managed acetabular fractures, and to establish predictors of conversion to total hip arthroplasty (THA).

Introduction. Since the introduction of 3rd generation Metal-on-Metal-Hip-Resurfacing-Arthroplasty (MoMHRA), thousands of such prostheses have been implanted worldwide in younger patients with end-stage hip osteoarthritis. However, no independent centre has reported their medium-to-long term outcome. The aim of this study is to report the ten year survival and outcome of the Birmingham Hip Resurfacing (BHR), the most commonly used MoMHRA worldwide. Methods. Since 1999, 648 BHRs were implanted in 555 patients, the majority of which were male (326). The mean age at surgery was 52.1years (range: 17–82), with primary OA as most common indication (85%). Mean follow up was 7.1years (range: 1–11). The Oxford Hip Score (OHS) and UCLA questionnaires were sent to all patients. Implant survival was established, with revision as the end point. Sub-analysis was performed by gender, femoral component size (small: <45mm, standard: 46–52, large: >53mm) and age at surgery (young:<50yrs, old:>50yrs). Results. Preliminary results show that survival and clinical outcome were better in men than women (p=0.013) and in patients with large and standard components compared to small (p=0.005). In women the survival and clinical outcome were worse in the young than the old (p=0.049). In men there was no difference in survival or clinical outcome between the young and old (p=0.106). In young men the 10-year survival was 95%, the mean OHS was 45 and the mean UCLA score was 8.1. Conclusion. The results of resurfacing are good in men. They perform particularly well in the young and highly active men who tend to have problems with conventional hip replacements

Introduction. Our classic outcome scores increasingly fail to distinguish interventions or to reflect rising patient demands. Scores are subjective, have a low ceiling and score pain rather than function. Objective functional assessment tools for routine clinical use are required. This study validates inertial sensor motion analysis (IMA) by differentiating patients with knee versus hip osteoarthritis in a block-step test. Methods. Step up and down from a block (h=20cm, 3 repetitions) loading the affected (A) and unaffected (UA) leg was measured in n=59 subjects using a small inertial sensor (3D gyro and accelerometer, m=39g) attached onto the sacrum. Patients indicated for either primary unilateral THA (n=20; m/f=4/6, age=69.4yrs ±9.8) or TKA (n=16;m/f=7/9;age=67.8yrs ±8.2) were compared to healthy controls (n=23;m/f=13/10;age=61.7yrs ±6.2) and between each other to validate the test's capacity for diagnostics and as an outcome measure. The motion parameters derived (semi-) automatically in Matlab for both legs were: front-back (FB-) sway and left-right (LR-) sway (up and down); peak-to-peak accelerations (Acc) during step down. In addition the asymmetry between both legs (ASS) was calculated for each parameter. Group differences were tested (t-test) and the diagnostic value determined by the area under the curve (AUC) of the ROC-curve. Results. During step-up FB-sway was higher for THA (20.4°±4.9) and TKA (21.7°±5.9) patients than for healthy controls (15.5°±3.4, p<0.001). Also asymmetry was higher (THA=20%, TKA=21%, H=11%, p<0.001). Results were similar during step down except for the affected leg of THA patients where FB-sway (THA=16.2°±3.0) was similar to controls but sign. different to TKA patients (22.2±4.4) producing a high diagnostic power (AUC=0.88) to differentiate THA and TKA. LR-sway was also indicative for THA patients being the only subjects showing high asymmetry between the legs (A=14.3°±3.7 vs UA=11.9°±3.1, p<0.001). Acceleration during step-down asymmetric in patients, especially in THA (H<TKA<THA;p<0.05; AUC=0.87). Discussion. The IMA-block-step test could detect pathology specific compensation mechanism: During step-up patients use more FB-sway (+29%) to generate momentum for compensating muscle weakness and decrease joint loading. During step-down, only THA patients showed less FB-sway with their affected leg avoiding the painful hip flexion. Also in THA the LR-sway was higher in the affected than unaffected side due to the typical abductor weakness and resulting Trendelenburg sign. The IMA-block-step test could objectify compensation mechanisms used in OA and showed the power to differentiate between H, TKA and THA. It is low cost and fast to perform (<5min) by non-specialist personnel and thus could be used in clinical routine to supplement questionnaire based outcome scores

Aims

Osteopetrosis (OP) is a rare hereditary disease that causes reduced bone resorption and increased bone density as a result of osteoclastic function defect. Our aim is to review the difficulties, mid-term follow-up results, and literature encountered during the treatment of OP.