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The Bone & Joint Journal
Vol. 101-B, Issue 6_Supple_B | Pages 116 - 122
1 Jun 2019
Whiteside LA Roy ME

Aims

The aims of this study were to assess the exposure and preservation of the abductor mechanism during primary total hip arthroplasty (THA) using the posterior approach, and to evaluate gluteus maximus transfer to restore abductor function of chronically avulsed gluteus medius and minimus.

Patients and Methods

A total of 519 patients (525 hips) underwent primary THA using the posterior approach, between 2009 and 2013. The patients were reviewed preoperatively and at two and five years postoperatively. Three patients had mild acute laceration of the gluteus medius caused by retraction. A total of 54 patients had mild chronic damage to the tendon (not caused by exposure), which was repaired with sutures through drill holes in the greater trochanter. A total of 41 patients had severe damage with major avulsion of the gluteus medius and minimus muscles, which was repaired with sutures through bone and a gluteus maximus flap transfer to the greater trochanter.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 30 - 30
1 Oct 2019
Antoniou J Gomes SK Zukor D Huk O Bergeron S Robbins SM
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Introduction. Gluteus medius is disrupted during lateral approach total hip arthroplasty (THA) which may impact its function and ability to control the pelvis. The objective was to compare gluteus medius activation and joint mechanics associated with a Trendelenburg sign (pelvic drop, trunk lean) during gait and hip abductor strength between patients that underwent lateral or posterior THA approaches one year post-surgery and healthy adults. Methods. Participants that underwent primary THA for hip osteoarthritis using lateral (n=21) or posterior (n=21) approaches, and healthy adults (n=21) were recruited for this cross-sectional study. Participants completed five walking trials. Surface electromyography captured gluteus medius activation. A 3-dimensional optical motion capture system measured frontal plane pelvic obliquity and lateral trunk lean angles. Participants performed maximum voluntary isometric contractions (MVIC) on a dynamometer to measure hip abductor torque. Characteristics from gait waveforms were identified using principal component analysis, and participant waveforms were scored against these characteristics to produce principal component scores. One-way analysis of variance and effect sizes (d) compared gait principal component scores and isometric hip abductor torque between groups. Results. Lateral THA group had statistically significant higher gluteus medius PC-scores indicating higher overall amplitudes during gait (p<0.01, d=0.97) and prolonged midstance activation (p=0.01, d=0.95) compared to the healthy group (Figure). There were no statistically significant (p>0.05) differences in pelvis or trunk angles. Isometric hip abductor torque was significantly (p=0.03, d=0.74) lower in the lateral THA than healthy group. There were no statistically significant differences between THA groups (d=0.27–0.50). Conclusions. Although the lateral THA group had lower abductor torque, there were no Trendelenburg signs during gait. Elevated gluteus medius activation in this group was a compensation for the weakness, and the muscle produced sufficient force to control the pelvis. Also, 1 year post-THA there were no statistically significant gait differences between lateral and posterior approaches. For any tables or figures, please contact the authors directly


Bone & Joint Open
Vol. 3, Issue 4 | Pages 340 - 347
22 Apr 2022
Winkler T Costa ML Ofir R Parolini O Geissler S Volk H Eder C

Aims

The aim of the HIPGEN consortium is to develop the first cell therapy product for hip fracture patients using PLacental-eXpanded (PLX-PAD) stromal cells.

Methods

HIPGEN is a multicentre, multinational, randomized, double-blind, placebo-controlled trial. A total of 240 patients aged 60 to 90 years with low-energy femoral neck fractures (FNF) will be allocated to two arms and receive an intramuscular injection of either 150 × 106 PLX-PAD cells or placebo into the medial gluteal muscle after direct lateral implantation of total or hemi hip arthroplasty. Patients will be followed for two years. The primary endpoint is the Short Physical Performance Battery (SPPB) at week 26. Secondary and exploratory endpoints include morphological parameters (lean body mass), functional parameters (abduction and handgrip strength, symmetry in gait, weightbearing), all-cause mortality rate and patient-reported outcome measures (Lower Limb Measure, EuroQol five-dimension questionnaire). Immunological biomarker and in vitro studies will be performed to analyze the PLX-PAD mechanism of action. A sample size of 240 subjects was calculated providing 88% power for the detection of a 1 SPPB point treatment effect for a two-sided test with an α level of 5%.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 9 | Pages 1203 - 1209
1 Sep 2005
Mattsson P Alberts A Dahlberg G Sohlman M Hyldahl HC Larsson S

We undertook a multicentre, prospective study of a series of 112 unstable trochanteric fractures in order to evaluate if internal fixation with a sliding screw device combined with augmentation using a calcium phosphate degradable cement (Norian SRS) could improve the clinical, functional and radiological outcome when compared with fractures treated with a sliding screw device alone. Pain, activities of daily living, health status (SF-36), the strength of the hip abductor muscles and radiological outcome were analysed.

Six weeks after surgery, the patients in the augmented group had significantly lower global and functional pain scores (p < 0.003), less pain after walking 50 feet (p < 0.01), and a better return to the activities of daily living (p < 0.05). At follow-up at six weeks and six months, those in the augmented group showed a significant improvement compared with the control group in the SF-36 score. No other significant differences were found between the groups. We conclude that augmentation with calcium phosphate cement in unstable trochanteric fractures provides a modest reduction in pain and a slight improvement in the quality of life during the course of healing when compared with conventional fixation with a sliding screw device alone.