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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 59 - 59
1 Dec 2019
MULTIDRUG- AND EXTENSIVELY DRUG-RESISTANT GRAM-NEGATIVE OSTEOSYNTHESIS-ASSOCIATED OSTEOMYELITIS OF THE LOWER EXTREMITIES: A MULTICENTRE INTERNATIONAL STUDY (on behalf of the ESGIAI)
Giannitsioti E Salles M Mavrogenis A Rodríguez-Pardo D Pigrau C Ribera A Ariza J Toro DD Nguyen S Senneville E Bonnet E Chan M Pasticci MB Petersdorf S Soriano A Benito N Connell NO García AB Skaliczki G Tattevin P Tufan ZK Pantazis N Megaloikonomos PD Papagelopoulos P Papadopoulos A
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Aim

Gram negative bacteria (GNB) are emerging pathogens in chronic post-traumatic osteomyelitis. However, data on multi-drug (MDR) and extensively drug resistant (XDR) GNB are sparse.

Methods

A multi-centre epidemiological study was performed in 10 countries by members of the ESGIAI (ESCMID Study Group on Implant Associated Infections). Osteosynthesis-associated osteomyelitis (OAO) of the lower extremities and MDR/XDR GNB were defined according to international guidelines. Data from 2000 to 2015 on demographics, clinical features, microbiology, surgical treatment and antimicrobial therapy were retrospectively analyzed. Cure was assessed after the end of treatment as the absence of any sign relevant to OAO. Factors associated with cure were evaluated by regression analysis.

Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 91 - 91
1 Dec 2018
PROSTHETIC JOINT INFECTION BY MULTIDRUG- AND EXTENSIVELY DRUG-RESISTANT GRAM-NEGATIVE BACTERIA: A MULTICENTRE COHORT STUDY
Papadopoulos A Ribera A Mavrogenis A Rodríguez-Pardo D Bonnet E Salles M del Toro MD Nguyen S García AB Skaliczki G Soriano A Benito N Petersdorf S Pasticci MB Tattevin P Tufan ZK Chan M Connell NO Pantazis N Pigrau C Megaloikonomos PD Senneville E Ariza J Papagelopoulos P Giannitsioti E
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Aim

Data on Prosthetic joint infection (PJI) caused by multi-drug resistant (MDR) or XDR (extensively drug resistant) Gram negative bacteria (GNB) are limited. Treatment options are also restricted. We conducted a multi-national, multi-center assessment of clinical data and factors of outcome for these infections.

Method

PJI were defined upon international guidelines. Data from 2000–2015 on demographics, clinical features, microbiology, surgical treatment and antimicrobial therapy was collected retrospectively. Factors associated with treatment success were evaluated by logistic regression analysis.

Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 170 - 171
1 Mar 2009
RADIOLOGICAL AND CLINICAL ASSESSMENT OF BONE REMODELING AFTER IMPACTION BONE GRAFTING IN REVISION HIP ARTHROPLASTY. PRELIMINARY RESULTS OF A PROSPECTIVE STUDY
Skaliczki G Zahár Á Somogyi P Makra M Kovács D Lakatos J
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Aim of the study: Impaction bone grafting is examined and published by numerous authors in the literature, however possible correlation between bone remodeling at the site of revision hip arthroplasty and bone turnover markers is not well known yet.

Materials and method: 22 patients undergoing revision hip arthroplasty with impaction bone grafting were enrolled in a prospective study. Bone turnover markers and bone mineral density (DXA) were measured preoperatively. WOMAC and Harris Hip Score (HHS) were evaluated pre- and postoperatively. During a one-year-period the same tests were performed after 6 weeks, 3 months, 6 months, 12 months respectively. The data were analyzed using logistic regression.

Results: Significant bone remodeling was observed at the site of revision hip arthroplasty at the 6 month follow up. WOMAC and HHS improved significantly after surgery. One deep wound infection occurred due to MRSE, removal of the prosthesis was performed.

Conclusion: Cancellous bone grafting secures primary stability for the hip implants, and after a period of 12 months proper bone remodeling is achieved.