Canals are the preferential sites for failure in cortical bone and their architecture is able to dictate the mechanical behaviour of the bone: smaller and branched canals generate a high volume of bone failure even at low apparent tissue strain. Osteogenesis imperfecta (OI), or brittle bone disease, is caused by mutations in the collagen genes and results in skeletal fragility. We recently showed that a mouse model of osteogenesis imperfecta (Summary
Introduction
