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Bone & Joint Research
Vol. 9, Issue 11 | Pages 789 - 797
2 Nov 2020
Seco-Calvo J Sánchez-Herráez S Casis L Valdivia A Perez-Urzelai I Gil J Echevarría E

Aims

To analyze the potential role of synovial fluid peptidase activity as a measure of disease burden and predictive biomarker of progression in knee osteoarthritis (KOA).

Methods

A cross-sectional study of 39 patients (women 71.8%, men 28.2%; mean age of 72.03 years (SD 1.15) with advanced KOA (Ahlbäck grade ≥ 3 and clinical indications for arthrocentesis) recruited through the (Orthopaedic Department at the Complejo Asistencial Universitario de León, Spain (CAULE)), measuring synovial fluid levels of puromycin-sensitive aminopeptidase (PSA), neutral aminopeptidase (NAP), aminopeptidase B (APB), prolyl endopeptidase (PEP), aspartate aminopeptidase (ASP), glutamyl aminopeptidase (GLU) and pyroglutamyl aminopeptidase (PGAP).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 92 - 92
1 May 2011
Noriega-Fernandez A Hernandez-Vaquero D Suarez-Vazquez A Sandoval-Garcia M Perez-Coto I
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Introduction: Computer assisted-surgery (CAS) brings in a great precision to the alignment of the components and the axis of the extremity in total knee arthroplasty (TKA). On the other hand, even though the MIS technique exerts a lesser aesthetic impact, favours the faster recovery of the patient and preserves the soft parts better, it can also lead to mistakes in the alignment of the implant due to the deficient visualization. Adding CAS to MIS may solve this potential complication.

Objective: To compare the alignment of the components with regard to the mechanical axis in four TKA groups (standard surgery, MIS surgery, standard surgery with CAS, and MIS with CAS).

Materials and Methods: Prospective and randomized study. 100 patients with Alhbäck degree III primary degenerative osteoarthritis of the knee and less than 10° of varus-valgus were included. The patients were randomly distributed in 4 groups of 25 patients each, and the same surgeons performed the surgery. Two CT surviews were performed on every patient, one preoperatively and one during the immediate postoperative period, including hip and ankle, where the femoral, tibial and femoro-tibial axis measurements were carried out.

Results: Mean age was 71.63 years (SD 6.68); 81 % of patients were women. Preoperative mean varus was of 7.57° (SD 1.10). No significant differences were found in the femoro-tibial alignment nor in the components with regard to the mechanical femoral axis between the four groups (Table 1). Nevertheless, significant differences in favour of the MIS-CAS technique group for the alignment of the tibial component with regard to the mechanical tibial axis were found.

Conclusions: The MIS technique allows for a well-aligned TKA implantation. Nevertheless, when CAS is coupled with this technique, the alignment of the tibial component is improved. It is possible for the association of MIS and CAS to become a true advance in TKA implantation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 321 - 321
1 May 2009
Escobar D Murillo AD Perez I Bartolome E
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Introduction and purpose: Kienböck’s disease was described by R. Kienbock in 1910. From that date onwards, multiple surgical techniques for its treatment have been described. Amongst these techniques is the one we have used: a radial osteotomy with Nakamura effect; this is a radial osteotomy with a wedge-shaped base and minimum dorsal width with subsequent osteoclasia carried out distally to the distal radioulnar joint to prevent any alterations in joint congruence. The aim of this study is to assess the results of this technique and compare them with those described in the literature using other surgical techniques.

Materials and methods: We selected patients with Kien-böck’s disease stage II and IIIA that underwent surgery using the technique described and we subsequently assessed clinical and radiological parameters both pre and postoperatively.

Results: Of the 17 patients diagnosed with Kienböck’s disease in our department, only 11 were operated using the technique described above. In these patients it was possible to see that a greater number had their dominant arm affected, there was a greater percentage of ulnar plus variants, the radial inclination angle was higher and the main symptom was pain. At this time, having undergone surgery, the patients are stable both clinically and radiologically, with the exception of 1 case that required rescue surgery. Satisfactory union was seen in 100% of cases after osteotomy.

Conclusions: During the initial stages, surgical treatment is preferable, and osteotomies are the techniques most frequently used. Radial osteotomy with Nakamura effect is a technique with excellent results, comparable to those seen with other techniques applied used during the initial stage.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 213 - 213
1 Mar 2003
Villanueva-Lopez F Psychoyios V Esteo-Perez I Zambiakis E Villegas-Rodriguez F
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Introduction: Various surgical techniques existed for the treatment of three and four part proximal humeral fractures with variable outcomes. The aim of this study is to present a technique using small materials, to preserve all the biologic principles of fracture fixation, in the treatment of these challenging injuries.

Material: We perform a study taking as inclusion criteria: 3 and 4 parts proximal, closed, humeral fractures, treated surgically by open reduction and a modular biological internal fixation.

Surgical technique: Through a standard deltopectoral approach the fragments reduced, taking care to preserve the periosteum and manipulate meticulously the soft tissues. All the fractures were fixed with a combined system of Kirschner wires inserted to the proximal fragments, connected by “bone clips” forming a modular construction and fixed to the main distal fragment by AO screws.

Results: 24 patients complied with the inclusion criteria and were followed up a mean of 18 months. All patients achieved a satisfactory result except a fracture-dislocation that developed AVN and was revised into a shoulder arthroplasty and two demented elderly patients with metalware failure that were also revised.

Conclusion: In this first series of non-selected cases the outcome of fracture consolidation is promising. Although this technique is in its embryonary phase of development and the functional results are currently been assessed, the radiological outcomes suggest that the technique described is a valid alternative to the treatment of these fractures if we indicate an osteosynthesis method that combines biology and stability.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 213 - 214
1 Mar 2003
Villanueva-Lopez F Psychoyios V Ramos-Salguero J Zambiakis E Esteo-Perez I
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Introduction: Pelvic ring injuries represent a complex injury pattern and sometimes have significant consequences. The aim of this retrospective study is to delineate the indications of surgical treatment with emphasis in the anatomic reconstruction.

Materials and Methods: 85 patients with pelvic ring fracture with or without acetabular fracture reviewed retrospectively. The average patient age was 34 years. Operative treatment was provided to 26 patients. Six isolated acetabular fractures were treated by ORIF. Twenty pelvic ring fractures were treated, by anterior Ex-Fix in five cases, Ex-Fix plus sacroiliac screws in three, anterior reconstruction plate plus sacroiliac screws in two, anterior plate plus sacral bars in three. The remaining seven patients with an additional acetabular fracture treated with anterior plate for the pelvis and plates for the acetabulum.

Results: All the acetabular fractures were anatomically reduced. All fractures consolidated and no patient has developed hip AVN or post-traumatic arthritis. Brooker’s grade III ossifications complicated two patients. Partial neurological deficit of sciatic nerve was seen in three cases of acetabular fractures that improved spontaneously. A case of vertical shearing sacral fracture through the foramina presented with lumbosacral plexus paresis that recovered near normal function in 6 months. Deep infection complicated a case that subsided at 2 weeks on antibiotics and serial surgical debridement.

Conclusions: The strict application on rational criteria and an exquisite surgical technique caring of the soft tissues produce satisfactory outcome of these injuries. The above-described surgical treatment shortens the hospital stay and allows early physiotherapy to restore function.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 234 - 234
1 Mar 2003
Villanueva-Lopez F Psychoyios V Esteo-Perez I Zambiakis E
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Introduction: Management of supracondylar fractures above a TKR is a difficult problem, aggravated by the increasing number of arthroplasties carried out and the increase of the ageing population. The aim of this paper is to determine the limb function after treatment of these fractures.

Materials and Methods: We performed a retrospective study of the outcome of the treatment of suprandylar fractures above an ipsilateral TKR. All fractures were classified according to the Lewis & Rorabeck System. Conservative treatment was provided to eight fractures. Osteosynthesis using a Dynamic Condylar Screw (DCS) was performed to five patients. The largest group of twenty patients was treated with a retrograde supracondylar nail. Three patients underwent a revision surgery.

Results: Four out of eight fractures treated conservatively had a satisfactory outcome. All patients treated with a DCS achieved a satisfactory result. Seventy five percent of patients treated with a supracondylar nail gained adequate functional and anatomical result. Revision surgery was satisfactory in all cases.

Conclusion: The above-described fractures are still not very frequent, but represent a high risk of important complications, with potentially disastrous consequences. For those reasons and the poor bone stock in the elderly its management is controversial. The challenge for the surgeon is to achieve the goals of consolidation of the fracture, preservation of a painless TKR, and, restoration of the previous functional status. A complex group of factors, such as fracture pattern, implant status, bone quality and general condition of the patient, need to be assessed.