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The Bone & Joint Journal
Vol. 102-B, Issue 12 | Pages 1752 - 1759
1 Dec 2020
Tsuda Y Tsoi K Stevenson JD Laitinen M Ferguson PC Wunder JS Griffin AM van de Sande MAJ van Praag V Leithner A Fujiwara T Yasunaga H Matsui H Parry MC Jeys LM

Aims

Our aim was to develop and validate nomograms that would predict the cumulative incidence of sarcoma-specific death (CISSD) and disease progression (CIDP) in patients with localized high-grade primary central and dedifferentiated chondrosarcoma.

Methods

The study population consisted of 391 patients from two international sarcoma centres (development cohort) who had undergone definitive surgery for a localized high-grade (histological grade II or III) conventional primary central chondrosarcoma or dedifferentiated chondrosarcoma. Disease progression captured the first event of either metastasis or local recurrence. An independent cohort of 221 patients from three additional hospitals was used for external validation. Two nomograms were internally and externally validated for discrimination (c-index) and calibration plot.


The Bone & Joint Journal
Vol. 98-B, Issue 8 | Pages 1138 - 1144
1 Aug 2016
Albergo JI Gaston CL Laitinen M Darbyshire A Jeys LM Sumathi V Parry M Peake D Carter SR Tillman R Abudu AT Grimer RJ

Aims

The purpose of this study was to review a large cohort of patients and further assess the correlation between the histological response to chemotherapy in patients with Ewing’s sarcoma with the overall (OS) and event-free survival (EFS).

Patients and Methods

All patients treated for Ewing’s sarcoma between 1980 and 2012 were reviewed. Of these, 293 patients without metastases at the time of diagnosis and treated with chemotherapy and surgery were included. Patients were grouped according to the percentage of necrosis after chemotherapy: Group I: 0% to 50%, Group II: 51% to 99% and Group III: 100%.


The Bone & Joint Journal
Vol. 98-B, Issue 4 | Pages 555 - 563
1 Apr 2016
Parry MC Laitinen M Albergo J Jeys L Carter S Gaston CL Sumathi V Grimer RJ

Aims

Osteosarcoma of the pelvis is a particularly difficult tumour to treat as it often presents late, may be of considerable size and/or associated with metastases when it presents, and is frequently chondroid in origin and resistant to chemotherapy.

The aim of this study was to review our experience of managing this group of patients and to identify features predictive of a poor outcome.

Patients and Methods

Between 1983 and 2014, 121 patients, (74 females and 47 males) were treated at a single hospital: 74 (61.2%) patients had a primary osteosarcoma and 47 (38.8%) had an osteosarcoma which was secondary either to Paget’s disease (22; 18.2%) or to previous pelvic irradiation (25; 20.7%).

The mean age of those with a primary osteosarcoma was 29.3 years (nine to 76) and their mean follow-up 2.9 years (0 to 29). The mean age of those with a secondary sarcoma was 61.9 years (15 to 85) and their mean follow-up was one year (0 to 14).

A total of 22 patients with a primary sarcoma (52.4%) and 20 of those with a secondary sarcoma (47.6%) had metastases at the time of presentation.


The Bone & Joint Journal
Vol. 97-B, Issue 12 | Pages 1698 - 1703
1 Dec 2015
Laitinen M Parry M Albergo JI Jeys L Abudu A Carter S Sumathi V Grimer R

The aim of this study was to evaluate the prognostic and therapeutic factors which influence the oncological outcome of parosteal osteosarcoma.

A total of 80 patients with a primary parosteal osteosarcoma were included in this retrospective study. There were 51 females and 29 males with a mean age of 29.9 years (11 to 78).

The mean follow-up was 11.2 years (1 to 40). Overall survival was 91.8% at five years and 87.8% at ten years. Local recurrence occurred in 14 (17.5%) patients and was associated with intralesional surgery and a large volume of tumour. On histological examination, 80% of the local recurrences were dedifferentiated high-grade tumours. A total of 12 (14.8%) patients developed pulmonary metastases, of whom half had either a dedifferentiated tumour or a local recurrence. Female gender and young age were good prognostic factors. Local recurrence was a poor prognostic factor for survival. Medullary involvement or the use of chemotherapy had no impact on survival.

The main goal in treating a parosteal osteosarcoma must be to achieve a wide surgical margin, as inadequate margins are associated with local recurrence. Local recurrence has a significant negative effect on survival, as 80% of the local recurrences are high-grade dedifferentiated tumours, and half of these patients develop metastases.

The role of chemotherapy in the treatment of parosteal osteosarcoma is not as obvious as it is in the treatment of conventional osteosarcoma. The mainstay of treatment is wide local excision.

Cite this article: Bone Joint J 2015;97-B:1698–1703.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 256 - 257
1 Mar 2004
Hirn M Laitinen M Aho A
Full Access

Aims: The aim of this study was to evaluate the long-term results of osteoarticular allografts operated during the years 1973–1992. Materials: 33 osteoarticular allograft operations were performed because of malignant (14) and benign tumors (19). The mean follow-up time was 15 years. Eight patients were excluded because of death (5) and amputation (3). Results: 25 (76%) of the grafts survived more than 10 years. 18 were whole-joint grafts and 7 hemi-joint grafts. 13 grafts situated in proximal tibia, 11 in distal femur and one in distal tibia. So far three cases have been converted to arthroplasty and two to arthrodesis. 20 grafts are still functioning. 19 of them are excellent or good according to Mankin score. Whole-joint and hemi-joint allografts were clinically equally good. Clear degeneration is seen in every joint and during the time the range of motion tends to decrease because of osteoarthrosis but clinically the patients were surprising painless. Conclusions: The operation is demanding and may cause a large variety of complications, for instance infection, non-union, fatigue fracture, nerve palsy and joint instability. On the other hand, the graft may provide weight-bearing bone that will incorporate biologically into the host skeleton and function almost as a normal joint for years. As prosthesis solutions have also problems and tend to fail with time, osteoarticular allografts should be taken to serious consideration when the first operation method is chosen.