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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 370 - 370
1 Jul 2011
Kanakaris N Mallina R Stavlas P Kontakis G Giannoudis P
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Anterior wall and/or column acetabular fractures (AW/ C) have a low incidence rate. Paucity of information exists regarding the clinical results of these fractures. We present our experience in treating AW/C at a tertiary referral centre.

Between Jan-2002 and Dec-2007, 200 consecutive patients were treated in our institution with displaced acetabular fractures. All AW/C fractures according to the Letournel classification were included in the study. All patients underwent plain radiography and CT investigations. Retrospective analysis of the medical notes and radiographs was performed for type of associated injuries, operative technique, peri-operative complications. Radiological assessment of fracture healing was determined by Matta’s criteria and functional hip scores were assessed using Merle-d’-Aubigne scoring. The mean follow up was 44.5 months (28–64).

15 patients (10 males) met the inclusion criteria (mean age 55.5 years). Four had associated anterior dislocation. Associated injuries included pneumothorax, splenic rupture, tibial and distal radius fractures. Five were treated by percutaneous methods, 8 with plate-screw fixation, and 2 with circlage wire, (10 ilioinguinal approaches). Mean time-to-surgery was 14 days(10–21 days). The average operative time for the percutaneous group was 75min vs. 190min in the orif group. Mean postoperative-in-patient-stay was 4 days(3–7 days), and 21 days(14–37 days). One patient developed chest infection post-operatively, two loss of sensation over the distribution of lateral cutaneous nerve. None of them developed incisional hernia, deep venous thrombosis and pulmonary embolism. At the last follow-up radiological outcome was excellent in 11 and good in 4 patients; clinical outcome was excellent in 12 and good in 3 patients, and none of the patients has developed heterotopic calcification or early osteoarthritis.

Our results on management of these fractures are comparable to the early results reported by Letournel. Operative treatment for the rare anterior wall and anterior column fractures yields a favourable outcome resulting in early mobilization with limited patient morbidity


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 362 - 362
1 Jul 2011
Giannoudis P Kanakaris N Tzioupis C Nikolaou V Kontakis G
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To evaluate the effectiveness of Pulsed-Lavage and of Versajet-hydrosurgery in removing two Staphylococcus aureus strains from porcine tissue and graphite powder from simulated fractures.

Overnight broth cultures (NCTC-6571) and S.aureus strains were diluted to yield inocula containing 1x103c. f.u. ml-1. Initially 8 porcine legs were used; porcine tissues were inoculated with 10ml of either of the two S.aureus strains. Control tissues were inoculated with PBS. All inoculated samples were irrigated with 300ml of saline using the pulsed-lavage system or using the Versajet. 10ml of each of the following were plated out in triplicate:

inoculum pre-incubation

inoculum post-incubation,

each left over inoculum following removal of tissue and dilutions of 10-1 and 10-2 and

Wash from all samples.

Eight additional porcine legs were used where 2 incisions were made down to bone in a cross-hatch pattern. 1g of graphite powder was infiltrated into each fracture site to simulate a contaminated open fracture. Each fracture site was irrigated with 500ml saline through pulsed-lavage or Versajet.

The average microbiological reduction using Pulsed-Lavage or Versajet was 2% and 15% respectively. The clinical S.aureus strain was more adherent than the laboratory strain. The Versajet maintained a 12–16% reduction of S.aureus, whereas pulsed-lavage did not reduce contamination. The number of graphite particles was significantly reduced with the use of the Versajet system compared with the pulsed-lavage.

Versajet system was more effective in removal of foreign particles and more effectively reduced the micro-biological load of both examined S.aureus strains in a porcine model. Further studies are indicated to evaluate the efficacy of this system in clinical practice


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 22 - 22
1 Jan 2011
Nikolaou V Kanakaris N Efstathopoulos N Kontakis G Giannoudis P
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In order to assess the effect of osteoporosis on healing time we retrospectively reviewed the files of 165 patients with femoral shaft fractures that were treated in our service by locked, intramedullary nailing. Patients were divided in two age groups; Group A (study group) consisted of patients over 65 years old with radiological evidence of osteoporosis and group B (control group) of patients between 18 and 40 years old with no signs of osteoporosis.

Sixty-six out of 165 patients fulfilled the inclusion criteria for this study. Patients with open fractures, pathological fractures, revision surgery, severe brain injuries, prolonged ITU stay and severe co morbidities were excluded. Twenty-nine patients were classified in group A and 37 in group B. All patients had been assigned the Injury Severity Score (ISS) and had been followed-up clinically and radiographically until fracture union.

In all patients the Singh Index Score for osteoporosis was assigned. In all group A patients Singh score 4 or less was assigned, suggesting the presence of installed osteoporosis, whereas group B patients were assigned with Sighn score 5 or 6. Fracture healing was significantly different between the groups.

Fractures of Group A healed in 19.38±5.9 weeks (12–30) and in group B 16.19±5.07 weeks (10–28) (P=0.02) Fracture healing of nailed femoral diaphyseal fractures significantly delays in older osteoporotic patients. Further studies are mandatory to clarify the exact impact of osteoporosis in the whole healing process and the possible future therapeutic strategies.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 3 | Pages 294 - 303
1 Mar 2009
Lindner T Kanakaris NK Marx B Cockbain A Kontakis G Giannoudis PV

Failure of fixation is a common problem in the treatment of osteoporotic fractures around the hip. The reinforcement of bone stock or of fixation of the implant may be a solution. Our study assesses the existing evidence for the use of bone substitutes in the management of these fractures in osteoporotic patients. Relevant publications were retrieved through Medline research and further scrutinised. Of 411 studies identified, 22 met the inclusion criteria, comprising 12 experimental and ten clinical reports. The clinical studies were evaluated with regard to their level of evidence. Only four were prospective and randomised.

Polymethylmethacrylate and calcium-phosphate cements increased the primary stability of the implant-bone construct in all experimental and clinical studies, although there was considerable variation in the design of the studies. In randomised, controlled studies, augmentation of intracapsular fractures of the neck of the femur with calcium-phosphate cement was associated with poor long-term results. There was a lack of data on the long-term outcome for trochanteric fractures. Because there were only a few, randomised, controlled studies, there is currently poor evidence for the use of bone cement in the treatment of fractures of the hip.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 11 | Pages 1407 - 1413
1 Nov 2008
Kontakis G Koutras C Tosounidis T Giannoudis P

We performed a comprehensive systematic review of the literature to examine the role of hemiarthroplasty in the early management of fractures of the proximal humerus. In all, 16 studies dealing with 810 hemiarthroplasties in 808 patients with a mean age of 67.7 years (22 to 91) and a mean follow-up of 3.7 years (0.66 to 14) met the inclusion criteria. Most of the fractures were four-part fractures or fracture-dislocations.

Several types of prosthesis were used. Early passive movement on the day after surgery and active movement after union of the tuberosities at about six weeks was described in most cases. The mean active anterior elevation was to 105.7° (10° to 180°) and the mean abduction to 92.4° (15° to 170°). The incidence of superficial and deep infection was 1.55% and 0.64%, respectively. Complications related to the fixation and healing of the tuberosities were observed in 86 of 771 cases (11.15%). The estimated incidence of heterotopic ossification was 8.8% and that of proximal migration of the humeral head 6.8%. The mean Constant score was 56.63 (11 to 98). At the final follow-up, no pain or only mild pain was experienced by most patients, but marked limitation of function persisted.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 1 | Pages 1 - 6
1 Jan 2008
Papadokostakis G Kontakis G Giannoudis P Hadjipavlou A

We have compared the outcomes of the use of external fixation devices for spanning or sparing the ankle joint in the treatment of fractures of the tibial plafond, focusing on the complications and the rates of healing. We have devised a scoring system for the quality of reporting of clinical outcomes, to determine the reliability of the results.

We conducted a search of publications in English between 1990 and 2006 using the Pubmed search engine. The key words used were pilon, pylon, plafond fractures, external fixation. A total of 15 articles, which included 465 fractures, were eligible for final evaluation.

There were no statistically significant differences between spanning and sparing fixation systems regarding the rates of infection, nonunion, and the time to union. Patients treated with spanning frames had significantly greater incidence of malunion compared with patients treated with sparing frames. In both groups, the outcome reporting score was very low; 60% of reports involving infection, nonunion or malunion scored 0 points.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 2 | Pages 278 - 279
1 Feb 2006
Kontakis G


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 312 - 312
1 Mar 2004
Joseph C Kontakis G Katonis P Stergiopoulos K Hadjipavlou A
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Aims: In this study we assessed the results of the hemi-arthroplasty for shoulder fractures in patients with a follow-up 2 to 7 years. Methods: Twenty six patients (20 women and 6 men, mean age 64.7±8.2 years [range 41 to 78 years]), with a fracture of the upper humerus requiring hemiarthroplasty, were followed-up 2–7 years after surgery. Ten Coþeld, nine Global and seven Aequalis prosthesis were implanted, all cemented. All the procedures were performed 0–17 days after the injury (mean 5.5±4.6 days). The clinical outcome was assessed using the Constant-Murley scale. Results: The mean score, at their last follow up, was 70.4±16.4% (39–96%). The mean ßexion of the arm was 150û (30û–175û), the mean abduction was 145û (30û–170û), the mean external rotation was 30û (10û–45û) and the internal rotation corresponded with a position of the dorsum of the hand at the L3 vertebrae. The patients in our series achieved the optimum clinical result during the þrst 6 months after the operation. No statistical signiþcant improvement occurred after this period. Six months after the injury 20 out of the 26 patients (76.9%) had the same activity level as they had prior to the fracture. At their last follow up eighteen patients (69.2%) had no any pain and 7 (27%) patients had some mild pain at the end of their daily activities and 1 patient (3.8%) had pain even with mild activities. Conclusions: Shoulder hemiarthroplasty seems to be a worthwhile procedure in modern orthopaedic surgeonsñ armamentarium, giving predictable results presuming careful selection of the patients, restoration of the individual anatomy of the shoulder and aggressive rehabilitation program during the þrst 6 months after surgery.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 324 - 324
1 Mar 2004
Joseph C Kontakis G Katonis P Maris T Voloudaki A Hadjipavlou A
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Aims: The objective of this study was to assess whether anatomical placement of the prosthesis, in shoulder hemi-arthroplasty for fracture of the humeral head, is important to the clinical outcome. Methods: Sixteen patients, with a fracture of the upper humerus treated with hemi-arthroplasty, were followed-up 45.7±15.1 (20–72) months after surgery. The results were assessed using the Constant-Murley scale. The mean score was 75.8±15.7% (54–96%). At the time of their last follow up they underwent CT of the fractured and sound humerus, in order to be measured differences in humeral length and retroversion using special software. Correlation between these differences and the clinical outcome, as it was measured with the Constant-Murley scale, was performed. Results: The mean difference in retroversion was 8.7 degrees and the mean difference in length was 0.65cm, between fractured and sound humerus in our patients. We have achieved a very good þnal outcome (Constant score more than 71%) in patients with difference in retroversion less than 10 degrees and difference in length less then 14mm, between fractured and sound humerus. Conclusions: Restoration of the humeral length and retroversion is very important in shoulder hemiarthroplasty for fracture of the humeral head. Only small differences from the optimum length are well tolerated while only big differences from the optimum retroversion are likely to affect signiþcantly the clinical outcome. We attribute the very good clinical outcome in our series to the quality of the anatomical reconstruction that was performed despite the fact that our sample is small and we cannot have powerful statistics.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 370 - 371
1 Mar 2004
Hadjipavlou A Gaitanis I Crow W Lander P Katonis P Kontakis G
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Purpose: To describe the percutaneous transpedicular biopsy technique as a novel way of approaching lesion of the thoracic and lumbar spine, to determine the amount of bone retrievable through the pedicle and its diagnostic yield. Material and Methods: Seventy-nine patients underwent 84 biopsies. Seventy-seven procedures were performed with ßuoroscopic guidance arid seven with CT guidance. Seventy-one biopsies underwent under local anesthesia and ten under general anesthesia. Age range of patient was from 3 to 81 years. Results: Adequate specimens for correct diagnosis were obtained in 80 of the 84 patients with the following diagnoses. Pyogenic spondylodiscitis 31, tuberculosis 4, coccidiomycosis 2, echinococcus cyst 1, blastomycosis 1, brucella 4, primary neoplasm 7, metastatic neoplasms 16, osteoporotic fractures 8, osseous repair for insufþciency fractures 5, Pagetñs disease 1. The 4 negative biopsies subsequently proven to be Ç false negative È and were related to faulty biopsy techniques. Conclusion: Pitfalls can be avoided when adhering to the details of our technique. These pitfalls can occur while retrieving the instrumentation without simultaneous withdrawal of the guiding pin; crushing pathological soft tissue against sclerotic or normal bone; or when encountering a sclerotic lesion distal to normal bone without using a sequential type of biopsy specimen-retrieval technique. Any type of bleeding is controllable. The approach is a safe, efþcacious and cost effective and avoids so the problems such low diagnostic yield nerve root injury, pneumothorax and hematoma encountered with conventional needle technique