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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 62 - 62
1 Jul 2014
INTRA-ARTICULAR DECORIN DOES NOT REDUCE CONTRACTURES, BUT DOES INFLUENCE THE FIBROSIS GENETIC EXPRESSION PROFILE IN A RABBIT MODEL OF JOINT CONTRACTURE
Abdel M Morrey M Barlowv J Grill D Kolbert C An K Steinmann S Morrey B Sanchez-Sotelo J
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Summary

Based upon genetic analysis, decorin is an exciting pharmacologic agent of potential anti-fibrogenic effect on arthrofibrosis in our animal model.

Introduction

While the pathophysiology of arthrofibrosis is not fully understood, some anti-fibrotic molecules such as decorin could potentially be used for the prevention or treatment of joint stiffness. The goal of this study was to determine whether intra-articular administration of decorin influences the expression of genes involved in the fibrotic cascade ultimately leading to less contracture in an animal model.