Surgeons sometimes encounter moderate or severe varus deformed osteoarthritic cases in which medial substantial release including semimembranosus is compelled to appropriately balance soft tissues in total knee arthroplasty (TKA). However, medial stability after TKA is important for acquisition of proper knee kinematics to lead to medial pivot motion during knee flexion. The purpose of the present study is to prove the hypothesis that step by step medial release, especially semimembranosus release, reduces medial stability in cruciate-retaining (CR) total knee arthroplasty (TKA). Twenty CR TKAs were performed in patients with moderate varus-type osteoarthritis (10° < varus deformity <20°) using the tibia first technique guided by a navigation system (Orthopilot). During the process of medial release, knee kinematics including tibial internal rotation and anterior translation during knee flexion were assessed using the navigation system at 3 points; (1) after anterior cruciate ligament resection (pre-release), (2) medial tibial and femoral osteophyte removal and release of minimum deep layer of medial collateral ligament (minimum release) and (3) release of semimembranosus (semimembranosus release). In addition, the kinematics after all prostheses implantation (semimembranosus release group) were assessed and compared with those assessed in another 20 patients in which only minimum release was performed (minimum release group).Purpose
Methods
Patients planning to undergo total knee arthroplasty (TKA), especially in Asian and Middle Eastern countries, usually expect to be able to perform activities requiring knee flexion such as sitting cross-legged or kneeling with ease after the surgery. Postoperative range of motion (ROM) can be affected by multiple factors such as the patient's gender, age, preoperative ROM, diagnosis, the surgeon's technique, the pre- and post-operative rehabilitation program, and the design of the prosthesis. Among these, the choice of the prosthesis depends on the surgeon's preference. As a result, several trials and studies have been conducted to improve postoperative ROM by modifying prosthesis design. The present study aimed to examine the results of TKA with the NexGen LPS-Flex system (Zimmer, Warsaw, Indiana), which is one of several high-flexion total knee prostheses that were designed to achieve a wide ROM for osteoarthritis in the valgus knee. A total of 27 primary TKAs in 26 osteoarthritis patients with valgus knee deformities (femorotibial angle (FTA) ≤ 170°) were performed using the NexGen LPS-Flex fixed prosthesis between July 2003 and December 2011. The patients included 2 men (7.7%, 2 knees) and 24 women (92.3%, 25 knees) with a mean age of 72.6 years (range, 59 to 83 years) at the time of the surgery. The mean duration of follow-up after surgery was 50.1 months (range, 24 to 126 months). Knee Society Knee Score (KSKS), Knee Society Function Score (KSFS), maximum flexion angle, maximum extension angle, and radiological femorotibial angle (FTA) were evaluated pre- and post-operatively. The mean preoperative KSKS and KSFS were 42.6 points (SD 7.5) and 41.1 points (SD 8.6), respectively, which improved after surgery to 82.2 points (SD 8.2) and 80.9 points (SD 7.6), respectively (P < 0.01). The maximum flexion angle improved from 109.1° (SD 23.1) to 117.3° (SD 12.4) postoperatively, but it did not reach statistical significance (P = 0.097). The preoperative maximum extension angle improved from −9.7° (SD 10.8) to −3.6° (SD 4.9) postoperatively (p < 0.05). The mean radiological FTA was 166.4° (SD 4.2; range: 155° − 170°) preoperatively and 172.4° (SD 2.7; range: 168° − 178°) at the final follow-up, and the difference was statistically significant (P < 0.01). None of the patients had undergone revision surgery by the final follow-up. As a conclusion, the results of the present study showed that the use of NexGen LPS-Flex implant in TKA for knee osteoarthritis with valgus deformity produced a satisfactory improvement in the clinical and radiological outcomes. Further studies on the outcomes of other prosthesis are needed to determine whether the NexGen LPS-Flex implant is advantageous for osteoarthritis patients with valgus knees who undergo TKA, and further large-scale studies with longer term follow-up are necessary to verify our results.
The axis of the fibula in the sagittal plane are known as a landmark for the extramedullary guide in order to minimize posterior tibial slope measurement error in the conventional total knee arthroplasty (TKA). However, there are few anatomic studies about them. We also wondered if the fibula in the coronal plane could be reliable landmark for the alignment of the tibia. This study was conducted to confirm whether the fibula is reliable landmark in coronal and sagittal plane. We evaluated 60 osteoarthritic knees after TKA using Athena Knee (SoftCube Co, Ltd, Osaka, Japan) 3-D image-matching software. Angle between the axis of the fibula (FA) and the mechanical axis (MA) in the coronal and sagittal plane were measured.Background:
Methods:
In most cases of stable type medial femoral neck fracture and some cases of dislocated medial femoral neck fracture, internal fixation was undertaken. Dual SC Screw (DSCS) System is an internal fixation device which has sliding mechanism and preventing mechanism of back out of the screw. The purpose of this study is to evaluate the results and complication of medial femoral neck fracture treated with DSCS. Fifty two patients operated for fractures of the medial femoral neck with DSCS were identified as the study population. All patients followed up at least 2years. Outcome measures included the period of bone union, revision surgery, operating times and clinical symptoms and complication.Introduction
Methods
Failures in fracture healing are mainly caused by a lack of neovascularization. We have previously demonstrated that G-CSF-mobilized peripheral blood (GM-PB) CD34+ cells, an endothelial progenitor enriched cell population, contributed to fracture healing via vasculogenesis and osteogenesis. We postulated the hypothesis that local transplantation of culture expanded bone marrow (cEx-BM) CD34+ cells could exhibit therapeutic potential for fracture healing. BM CD34+ cells were cultured in specific medium with 5 growth factors for 1week. A reproducible model of femoral fracture was created in nude rats with periosteum cauterization, which leads to nonunion at 8 weeks post-fracture. Rats received local administration of the following cells or PBS alone(1)cEx-BM, (2)BM, (3)GM-PB CD34+ cells or (4)PBS.Introduction
Materials
CXC chemokine receptor 4 (CXCR4) is a specific receptor for stromal-derived-factor 1 (SDF-1). SDF-1/CXCR4 interaction contributes to the regulation of endotherial progenitor cell (EPC) recruitment in ischemic tissues. The purpose of this study is to investigate the mechanistic function of CXCR4 on EPCs for bone fracture healing. We made CXCR4 gene knockout mice using the Cre/loxP system. A reproducible model of femoral fracture was created in both Tie2-Cre CXCR4 knockout mice (CXCR4KO) and wild type mice (control). To evaluate gain function of the SDF-1/CXCR4 pathway, we set three groups of the SDF-1 intraperitoneally injected group, wild type group, and SDF-1 injected CXCR4 KO group.Introduction
Materials and methods
Plate fixations have been recommended for dislocated clavicle fractures. However, existing plates are inadequate for morphological compatibility with the clavicle. The aim of this study is to measure the anatomical shape of the clavicle and to compare the radiographical and clinical outcomes of our tree-dimensional (3D) reconstruction plate with conventional straight plate. Chest CT image of 15 patients with normal clavicle were analyzed. Their clavicles were reconstructed and measured their anatomical variables. A hospital-based case-control study was conducted, including a consecutive series of 52 patients with displaced midshaft clavicle fractures. 3D reconstruction plate was used for 26 patients and another 26 patients were treated with conventional straight plate. Outcome measures included the period of bone union, revision surgery, operating times and clinical symptoms using DASH score.Introduction
Methods
The therapeutic potential of hematopoietic stem cells for fracture healing has been demonstrated with mechanistic insight of vasculogenesis and osteogenesis enhancement. Lnk has recently been proved an essential inhibitory signaling molecule in SCF-c-Kit signaling pathway for stem cell self-renewal demonstrating enhanced hematopoietic and osteogenic reconstitution in Lnk-deficient mice. We investigated the hypothesis that down regulation of Lnk enhances regenerative response via vasculogenesis and osteogenesis in fracture healing. A reproducible model of femoral fracture was created in mice. Immediately after fracture creation, mice received local administration of the following materials with AteloGene, 10μM (1)Lnk siRNA, (2)control siRNA.Introduction
Methods
Thirty-three knees in thirty-three patients who underwent ACLR using four-strand semitendinousus and gracilis tendon in our hospital were included in this study. In 17 knees, we use a fluoroscopic-based navigation system (Vector Vision ACL, BrainLab. Inc.) for positioning of the tunnels (Group 1). In the remaining 16 knees, positioning of the femoral and tibial tunnels was done without navigation (Group 2). In navigation operation, anteroposterior and lateral images of the knee were taken with a fluoroscope and captured into the computer. The optimal target points for bone tunnels were semi-automatically calculated and displayed on the screen. Femoral placement was determined based on the quadrant method. The target for tibial tunnel was set at 43% of tibial plateau AP length. Intraoperatively, positions of the drill guides were decided referring to both navigation image and arthroscopic image. We evaluated Lysholm score, International Knee Documentation Committee (IKDC) subjective score, Lachman test and pivot shift test at 1 year after operation and calculated bone tunnel position on the postoperative lateral x-ray films and expressed them as relative values against total AP length of the Blumensaat's line and of the tibia plateau. Lysholm score, IKDC subjective score, Lachman test and pivot shift test were not significantly differed between the groups. The femoral tunnels were 74.2±3.3% in Group 1 and 71.7±6.0% in Group 2 along and the tibial tunnels were 42.1±1.4% in group 1 and 43.0±4.6% in group 2 along the tibia plateau. Although femur and tibial tunnel positions were not significantly differed between the groups, variation of bone tunnel position was significantly smaller in Group 1, indicating a good reproducibility. One pin tract infection occurred in Group 1. This case successfully treated with debridment and antibiotics containing cement filling. Fluoroscopic navigation system is quite helpful for precise and reproducible creation of both femur and tibial tunnel. The results encourage us to use this system for double-bundle anatomical ACLR. However, a special care must be taken to avoid complication caused by tracker pin placement.
Our purpose was to evaluate the incidence of anterior knee pain after ACL reconstruction and the associated affecting factors. The study assessed 50 ACL reconstructed knees: 29 males and 21 females. The age at surgery was from 14 to 39 years old, with 23.7 years old on the average. The ACL injury was unilateral in all cases, and the normal side was defined as the control. We treated chronic ACL-deficient knees by reconstruction of the ligament through a limited arthrotomy using one-third of the patellar tendon (BTB) with the Kennedy LAD as a graft. Anterior knee pain was classified into 4 group: absent, trace-mild, moderate, and severe. We evaluated the height of the patella, knee extension strength, anterior laxity, leg rotation, Lysholm score, and loss of extension. Anterior laxity and leg rotation were measured by a three-dimensional analyzer. Ten of the fifty knees (20%) had anterior knee pain. Knee extension strength (reconstructed side/control side) was 71.1% in the cases with anterior knee pain and 84.2% in the cases without anterior knee pain. A significant difference was found between these values. Regarding leg rotation, 4 knees showed normal leg rotation (physiological screw home movement) in the cases with anterior knee pain, compared to 31 knees in the cases without anterior knee pain. There was a significant difference in the incidence of anterior knee pain between the cases with normal leg rotation and the cases without. Other factors failed to show any significant correlation. In this study, knee extension strength and leg rotation had a correlation with anterior knee pain.
