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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 73 - 73
1 Mar 2013
Howie D Holubowycz O Neale S Callary S Solomon L
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Introduction

There has been almost universal adoption of highly cross-linked polyethylene as the polyethylene of choice in metal-on-polyethylene articulations in total hip replacement (THR). Although wear of conventional polyethylene has been shown to be related to periprosthetic osteolysis, the relationship between wear of highly cross-linked polyethylene and osteolysis remains uncertain. Our aim was to determine the incidence and volume of periacetabular osteolysis at a minimum of seven years following primary THR with metal on highly cross-linked polyethylene articulations.

Methods

644 patients were enrolled into a randomised controlled trial which examined the effect of articulation size (28 vs 36 mm) on the incidence of dislocation one year following THR. To date, 62 patients (34 patients – 28 mm articulation; 28 patients – 36 mm articulation) have undergone a quantitative computed tomography (CT) scan, with metal artefact reduction protocol, to detect and measure osteolysis at a minimum of seven years following THR. Osteolysis was defined as a localised area of bone loss of at least 1 cm3 that is expansile, with a well-defined sclerotic border, a clear communication between the defect and the joint space and the absence of acetabular cysts. Pre-operative and post-operative plain radiographs were examined to identify the existence of acetabular cysts. Polyethylene wear from one to seven years following THR was also measured, using a computerised edge detection technique (PolyWare Rev 5, Draftware) of analysing standard radiographs.


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Large articulations are increasingly being used to reduce dislocation, the most common early complication following THR. However, potential benefits of large articulations in reducing dislocation have not been proven in a well-controlled clinical trial.

The aim of our randomised controlled trial was to compare the one-year incidence of dislocation between 36 and 28 mm metal on highly cross-linked polyethylene articulations.

Patients were excluded if they had a high risk of dislocation due to, for example, abnormal anatomy, neuromuscular disease, previous infection or dislocation. Eligible patients were stratified according to a number of other factors which may influence dislocation risk, including primary or revision THR and, if primary THR, by surgeon, age, diagnosis, sex and Charnley grade. Patients were randomised intra- operatively to either a 28 or 36 mm articulation. Dislocation incidence was determined using a hip instability questionnaire and a hospital visit questionnaire. A dislocation was diagnosed if there was radiological evidence and reduction by a doctor was required. Six-hundred-and-forty-four patients undergoing primary or revision THR were entered into the study.

Overall, the incidence of dislocation at one year following THR was 5.4% with a 28 mm articulation and 1.3% with a 36 mm articulation (p=.004). Incidence in primary THR patients was 4.4% with a 28 mm articulation, compared to 0.8% with a 36 mm articulation (p=.007). Incidence in revision THR patients was 12.2% and 4.9% with 28 and 36 mm articulations, respectively. For both primary and revision THR patients, sex distribution, age and BMI of patients who dislocated were similar to those of the total samples of primary or revision patients.

This large randomised study unequivocally shows for the first time that, compared to a 28 mm articulation, a 36 mm articulation in THR is efficacious in reducing the incidence of dislocation in the first year following THR.