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The Bone & Joint Journal
Vol. 103-B, Issue 2 | Pages 222 - 233
1 Feb 2021
You D Xu Y Ponich B Ronksley P Skeith L Korley R Carrier M Schneider PS

Aims

Current guidelines recommend surgery within 48 hours among patients presenting with hip fractures; however, optimal surgical timing for patients on oral anticoagulants (OACs) remains unclear. Individual studies are limited by small sample sizes and heterogeneous outcomes. The aim of this study was to conduct a systematic review and meta-analysis to summarize the effect of pre-injury OACs on time-to-surgery (TTS) and all-cause mortality among older adults with hip fracture treated surgically.

Methods

We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 14 October 2019 to identify studies directly comparing outcomes among hip fracture patients receiving direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) prior to hospital admission to hip fracture patients not on OACs. Random effects meta-analyses were used to pool all outcomes (TTS, in-hospital mortality, and 30-day mortality).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 554 - 554
1 Nov 2011
Laflamme GY Carrier M Roy L Kim P Leduc S
Full Access

Purpose: To determine if early functional assessment correlates and/or predicts long term function after hemi-arthroplasty for displaced femoral neck fractures.

Method: We evaluated prospectively fifty six (56) patients with Garden-type III and IV femoral neck fractures in a Level 1 trauma center with a minimum of two years follow-up. Validated functional measures including Lower Extremity Measure (LEM) and Timed Up and Go (TUG) were used. Score progression was recorded and analyzed in relation to patient baseline data.

Results: The regression analysis between TUG times at three months and the mean LEM scores at two years follow-up showed a good correlation (R2=0.659). Further analysis determined that patients with TUG times of less than twenty (20) seconds at six weeks of follow-up had a mean LEM score significantly higher at both one year (81.5 vs 56.2; p< 0.001) and two years follow-up (77.1 vs 41.8; p< 0.001). This difference between mean LEM scores was also noted for the TUG values at three months.

Conclusion: The TUG test is an early clinical indicator of future function. Innovative clinical approaches such as the one demonstrated in this study to anticipate future function will contribute to increasing efficiency in the overall management of this growing patient population.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 531 - 532
1 Oct 2010
Vendittoli P Carrier M Ganapathi M Lavigne M
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Background: Moore et al. recently described five radiological signs (absence of radiolucent line, zone 2 osteo-penia, superolateral buttress, inferomedial buttress and radial trabeculae) for predicting osseointegration of porous coated uncemented acetabular components in the long term. The positive predictive value for a stable fixation was 96.9% when three or more signs were present. 83% of the cups with one or no signs were unstable.

Aim: To evaluate the prevalence of these signs in clinically well functioning uncemented acetabular components in the short term and to evaluate whether there is a difference acetabular components with different modulus of elasticity.

Materials and methods: The preoperative, immediate postoperative and the latest (minimum 2 years) radiographs of 196 hip replacements with 2 different acetabular components: a 2.9 mm, thin, flexible, macro textured titanium component (Allofit, Zimmer) and a 4 mm thick, stiff, titanium plasma sprayed chrome-cobalt component (Durom, Zimmer) were reviewed by two independent observers searching for the five osseointegration signs. The observers also looked for conventional signs of loosening including: continuous radiolucency of more than 2 mm, component migration of more than 3 mm, component rotation, or the presence of broken screws.

Results: 95 Allofit components and 101 Durom components were available for evaluation. None of the hips were considered loose according to conventional criteria and were well functioning. Out of the new osseointegration signs, at least one sign was present in 100 % of the cases, two signs or more in 30%, three signs or more in 5% and four signs in 1%. There was no difference between the two types of cups. In addition, superolateral buttress and zone 2 osteopenia were also present in preoperative/immediate postoperative radiographs in 8% and 4% of respectively.

Conclusion: Apart from absence of radiolucency, very few of the five osseointegration signs were present at short term follow-up of two very different well functioning uncemented acetabular components designs. We conclude they are not useful in evaluation of unce-mented acetabular components at a follow up of 2–5 years. Further study at mid-term follow-up might reveal whether the bony adaptive changes occur with time.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 254 - 254
1 May 2009
Carrier M Laflamme Y Roy L
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The primary objective of this study was to report the progression of functional status over time after hemiarthroplasty surgery for displaced femoral neck fractures in one hundred patients. One of the secondary outcomes was to determine factors predictive of bad outcome (age, co-morbidities, type of anesthesia, surgical approach, etc). Another secondary objective was to determine if early functional assessment correlates and/or predicts long term function. Finally, our group was compared to a normal control group database.

A hundred patients treated with hemiarthroplasty for Garden-type III and IV femoral neck fractures were evaluated prospectively using validated functional outcome measures. Baseline data and preoperative functional level was determined for all patients. Functional recovery was evaluated using the Lower Extremity Measure (LEM) and the Time Up and Go (TUG). Clinical outcome was equally measured using the Harris Hip Score and SF-36 (Short-Form 36). Follow-up was done at one and a half, three, six, nine, twelve and twenty-four months.

Preliminary results show that this study group is comparable to the group used in Jaglal et al.’s original study of the Lower Extremity Measurement score. LEM scores at one year follow-up are significantly lower than pre-operative scores. TUG scores at three months follow-up were significantly lower in the female sub-group in comparison to normal controls.

This study of patients undergoing hemiarthroplasty for femoral neck fractures demonstrates the significant post operative functional repercussions as shown by the deterioration of scores of functional outcome measures used. Predicting functional outcomes based on pre-operative patient baseline data and function is relevant in that it could potentially impact decision to operate and determination of surgical procedure of choice.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 254 - 254
1 May 2009
Roy L Carrier M Laflamme Y
Full Access

This study is a prospective randomised clinical trial which primary objective was to demonstrate the safety and efficacy of a single posterior mini-incision approach compared to a standard posterior approach for hemiarthroplasty in acute femoral neck fractures.

Fifty-five patients have been randomised: twenty-four patients in the mini-incision surgery group (MIS) and thirty-one patients in the standard incision group (STD). The mini-incision was defined as less than 8cm. Data were collected preoperatively and at four days, three and six weeks, three, six, twelve, and twenty-four months postoperatively. The Jaglal Lower Extremity Measurement (LEM) and the Time Up and Go (TUG) where evaluated. Secondary endpoints of pain, function, and quality of life where assessed by the components of the Harris hip Score and SF-36. Radiograghic outcomes where also evaluated.

The demographic data where similar between the two groups for age, gender, weight, type of anaesthesia used, pre-operative haemoglobin and preoperative comorbidities. There was no significant difference for operative time, blood losses, 72h postoperative haemoglobin and the need for transfusion therapy between the two groups. Also, there was no difference between the groups for post-operative morphine use and pain evaluation with the Visual Analog Scale. The functional assessment using the LEM, TUG, Harris Hip score and SF-36 scores did not demonstrate any statistically significant difference between mini and standard incision.

This study demonstrates that the clinical and functional outcomes measured are similar between the two groups, thus limiting the potential benefits of MIS in hip fracture patients.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 168 - 169
1 Mar 2009
Roy L Laflamme Y Carrier M
Full Access

In the recent years, the concept of minimally invasive surgery has invaded the orthopaedic field and literature on the subject is spawning. Mini-incision surgery for total hip arthroplasty has been studied without a clear consensus on the efficacy, safety and advantage of that innovative technique. To our knowledge, the efficacy and safety of mini-incisions in hip fracture surgery has not been studied.

This study is a prospective clinical randomized trial which primary objective was to demonstrate the safety and efficacy of a single posterior mini-incision approach compared to a standard posterior approach for hemiarthroplasty in acute femoral neck fractures. The mini-incision was defined as less than 8 cm. To date, 45 patients have been randomized between the two surgery groups has follows: 22 patients in the mini-incision surgery group (MIS) and 23 patients in the standard incision group (STD). Data were collected preoperatively as well as 4 days, 3 and 6 weeks, 3, 6, 12, and 24 months postoperatively. The following validated disease-specific outcome instruments where used: the Jaglal Lower Extremity Measurement (LEM) and the Time Up and Go (TUG). Secondary endpoints of pain, function, and quality of life where assessed by the components of the Harris hip Score and SF-36. Radiograghic outcomes where also evaluated as well as the rates of all reported complications and adverse events during the two years follow-up.

The demographic data where similar between the 2 groups for age, gender, weight, type of anaesthesia used, pre-operative haemoglobin and preoperative comorbidities. There was no significant difference for operative time, blood losses, 72h postoperative haemoglobin and the need for transfusion therapy between the 2 groups. Also, there was no difference between the groups for post-operative morphine use and pain evaluation with the Visual Analog Scale. The functional assessment using the LEM, TUG, Harris Hip score and SF-36 scores did not demonstrate any statistically significant difference between mini and standard incision.

This study demonstrates that the clinical and functional outcomes measured are similar between the two groups, thus limiting the potential benefits of MIS in hip fracture patients.