Aims. There is little information regarding the risk of a patient developing
Objectives. We used the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) to investigate the risk of revision due to
Objectives.
Objectives.
Aims.
Aims. Fungal
Aims. The aim of this study was to evaluate the performance of metagenomic next-generation sequencing (mNGS) in detecting pathogens from synovial fluid of
Aims. Positive cultures are not uncommon in cases of revision total
knee and hip arthroplasty (TKA and THA) for presumed aseptic causes.
The purpose of this study was to assess the incidence of positive
intra-operative cultures in presumed aseptic revision of TKA and
THA, and to determine whether the presence of intra-operative positive cultures
results in inferior survival in such cases. Patients and Methods. A retrospective cohort study was assembled with 679 patients
undergoing revision knee (340 cases) or hip arthroplasty (339 cases)
for presumed aseptic causes. For all patients three or more separate
intra-operative cultures were obtained. Patients were diagnosed
with a previously unsuspected
Aims. In 2013, we introduced a specialized, centralized, and interdisciplinary team in our institution that applied a standardized diagnostic and treatment algorithm for the management of
Aims.
Aims. This pilot study tested the performance of a rapid assay for diagnosing
Aims. The increasing infection burden after total hip arthroplasty (THA) has seen a rise in the use of two-stage exchange arthroplasty and the use of increasingly powerful antibiotics at the time of this procedure. As a result, there has been an increase in the number of failed two-stage revisions during the past decade. The aim of this study was to clarify the outcome of repeat two-stage revision THA following a failed two-stage exchange due to recurrent
Objectives. The optimal protocol for antibiotic loading in the articulating cement spacers for the treatment of
Objectives. The optimal protocol for antibiotic loading in the articulating cement spacers for the treatment of
Aims. Biopsy of the periprosthetic tissue is an important diagnostic tool for
Aims. In the absence of an identified organism, single-stage revision is contraindicated in
Aims. This study aimed to explore whether serum combined with synovial interleukin-6 (IL-6) measurement can improve the accuracy of
Aims. The aim of this study was to evaluate the diagnostic accuracy of the synovial alpha-defensin enzyme-linked immunosorbent assay (ELISA) for the diagnosis of
Aims. Failure of irrigation and debridement (I&D) for
Aims. Preoperative diagnosis is important for revision surgery after
Aims. The aim of this study was to establish the diagnostic accuracy
of culture of joint aspirate with and without saline injection-reaspiration. Patients and Methods. This is a retrospective analysis of 580 hip and knee aspirations
in patients who were deemed to have a moderate to high risk of infection,
and who subsequently proceeded to revision arthroplasty over a period
of 12 years. It was carried out at a large quaternary referral centre
where preoperative aspiration is routine. Results. Fluid was aspirated primarily in 313 (54%) cases and after saline
injection-reaspiration of a ‘dry tap’ in 267 (46%) cases. Overall
sensitivity and specificity of the diagnostic aspirate were 84%
(78% to 89%) and 85% (81% to 88%), respectively. Sensitivity and
specificity of saline injection-reaspiration after ‘dry tap’ were
87% (79% to 92%) and 79% (72% to 84%) compared with 81% (71% to
88%) and 90% (85% to 93%) for direct aspiration. Conclusion. Preoperative joint aspiration and culture is a sensitive and
specific test for the confirmation of diagnosis in patients at a
moderate to high risk of
Aims. The aim of this study was to determine the prevalence and characteristics of C-reactive protein (CRP)-negative
Aim. Prosthetic joint replacement is more commonly done in the elderly group of patients due to an increase pathology related to joint degeneration that comes with age. In this age group is also more frequent having underling condition that may predispose to a
Aim. Culture negative (CN)
Aims. Two-stage exchange arthroplasty is the most common definitive treatment for
Aims. This study aimed to evaluate calprotectin in synovial fluid for diagnosing chronic
Introduction. A proportion of patients with hip and knee
Aim.
Introduction. Gram-negative
Aims. To investigate the experience and emotional impact of
Introduction. The burden of
Gram-negative
Aim.
Aim. To provide proof of concept in an in vivo animal model for the prevention of
The management of
Background. Treatment of staphylococcal
Listeria monocytogenes is usually thought of as a bacterial pathogen that causes invasive disease including meningitis and bacteraemia in susceptible hosts. It remains a rare cause of bone and joint infection; there is therefore potential for clinical and laboratory delay in diagnosis and for uncertainty over optimal management. We describe our experience of two such cases of L. monocytogenes
Background. In the UK, over 160,000 total joint replacements are performed annually. About 1% of patients subsequently develop a deep bacterial infection and, if untreated, this can result in severe pain, disability, and death. Costs to the NHS are substantial. The INFORM (Infection Orthopaedic Management) programme aims to address gaps in knowledge relating to treatment of deep
Aims.
Aims. Current treatments of
INTRODUCTION. Deep infection is a potentially catastrophic complication of joint replacement surgery. Early intervention in suspected
This study aimed to identify the success rate of debridement, antibiotics and implant retention (DAIR) for
Aims. The aim of this study was to compare the results of 16S/28S rRNA sequencing with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and synovial fluid analysis in the diagnosis of
Introduction. The infection rate after total joint arthroplasty (TJA) has been shown to be 1–2% in multiple series and registry data. Irrigation, debridement, and polyethylene exchange (IDPE) is a common first line treatment in many cases of acute
Aim. The aim of this study was to gain insight into the in vivo expression of virulence and metabolic genes of Staphylococcus aureus in a
The infection rate after total joint arthroplasty (TJA) has been shown to be 1–2% in multiple series and registry data. Irrigation, debridement, and polyethylene exchange (IDPE) is a common first line treatment in many cases of acute
Introduction. In the last couple of years, several synovial biomarkers have been introduced in the diagnostic algorithm for a