Aims. The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA). Patients and Methods. A pragmatic, single centre, two arm parallel group, patient blinded, randomised controlled trial was undertaken. All patients due for TKA were eligible. Exclusion criteria included contraindications to the medications involved in the study and patients with a neurological abnormality of the lower limb. Patients received either a femoral nerve block with 75 mg of 0.25% levobupivacaine hydrochloride around the nerve, or periarticular infiltration with 150 mg of 0.25% levobupivacaine hydrochloride, 10 mg morphine sulphate, 30 mg ketorolac trometamol and 0.25 mg of adrenaline all diluted with 0.9% saline to make a volume of 150 ml. Results. A total of 264 patients were recruited and data from 230 (88%) were available for the primary analysis. Intention-to-treat analysis of the primary outcome measure of a visual analogue score for pain on the first post-operative day, prior to physiotherapy, was similar in both groups. The mean difference was -0.7 (95% confidence interval (CI) -5.9 to 4.5; p = 0.834). The periarticular group used less morphine in the first post-operative day compared with the femoral nerve block group (74%, 95% CI 55 to 99). The femoral nerve block group reported 39 adverse events, of which 27 were serious, in 31 patients and the periarticular group reported 51 adverse events, of which 38 were serious, in 42 patients up to six weeks post-operatively. None of the adverse events were directly attributed to either of the interventions under investigation. Conclusion . Periarticular infiltration is a viable and safe alternative to femoral nerve block for the early post-operative relief of pain following TKA. Cite this article: Bone Joint J 2017;99-B:904–11

Objective: The aim of this prospective observational study was to evaluate the feasibility of performing ACL reconstruction with femoral nerve block as a day-case procedure, implement the necessary changes and audit the outcomes following instigation of a day-case protocol. Methods: From November 2005 to April 2006 all patients undergoing ACL reconstruction were entered into a day-case feasibility study. Any issues preventing day-case discharge were identified, and in November 2006 changes were implemented to address these. Since then all ACL reconstruction patients have been treated as day-cases using femoral nerve blocks. Patients are discharged if safe, and contacted 1 and 7 days postoperatively to detect any problems and to assess patient satisfaction. Patients undergoing ACL reconstruction with femoral nerve block in the independent sector, by the same surgeon but without a strict protocol were used as a comparison group. Results: 18 patients have followed the day-case pathway, 15 (83%) being discharged as day-cases. The other cases had afternoon surgery delaying discharge. Only 25% (3/12) patients treated in the independent sector were discharged on the day of surgery. All patients had good working femoral nerve blocks, were able to mobilise safely with crutches and reported no adverse effects from their blocks at follow-up phone calls. All reported good analgesia at home and high satisfaction with being a day-case. Conclusions: With appropriate education of patients and staff, and following a day-case protocol, ACL reconstruction with femoral nerve block is a safe day-case procedure with high patient satisfaction

Femoral nerve block is a reliable and effective method of providing anaesthesia and analgesia in the peri-operative period but there remains a small but serious risk of neurological complication. We aimed to determine incidence and outcome of neurological complications following femoral nerve block in patients who had major knee surgery. During the period January 2003 to August 2008, medical records of all patients undergoing knee surgery by Dr Myles Coolican and Dr David Parker, who had been administered femoral block for peri-operative analgesia, were evaluated. Patients with a neurological complication were invited take part in the study. A detailed physical examination including sensory responses, motor response and reflexes in both limbs was performed by an independent orthopaedic surgeon. Subjective outcome and pain specific questionnaires as well as clinical measurements were also collected. Out of 1393 patients administered with femoral nerve block anaesthesia during this period, 28 subjects (M:F= 5:23) were identified on the basis of persistent symptoms (more than three months) of femoral nerve dysfunction. All the patients had sensory dysfunction in the autonomous zone of femoral nerve sensory distribution. The incidence of neurological complications was 2.01%. One patient was deceased of unrelated causes and five patients declined to participate in the study. 14 patients out of the 22 have been examined so far. Nine cases had a one shot nerve block and five had continuous peripheral nerve block catheter. Areas of hypoesthesia/anaesthesia involving femoral nerve distribution occurred in 7 subjects and hyperaesthesia/paresthesia occurred in four. One subject had a combination of hypoesthesia and hyperesthesia in different areas of the femoral nerve distribution. Three subjects had bilateral symptoms following bilateral simultaneous nerve blocks. Dysesthesias in the affected dermatomes were found in seven cases and paresthesias were found in eight cases. Douleur Neuropathique en 4 questions (DN4) score of ï. 3. 4 was found in all the patients (average value: 5.55). The average scores for tingling, pins and needles and burning sensation (in a scale from 0 to 10) are 3.8, 3.1 and 2.9 respectively. The incidence of persistent neurological complication after femoral nerve block in our series is much higher compared to the reported incidence in the contemporary literature (Auroy Y. et al. Major complications of regional anesthesia in France: Anesthesiology 2002; 97:1274 80). The symptoms significantly influence the quality of life in the affected cases and question the value of the femoral nerve block in knee surgery

Objective: The aim of this prospective observational study was to evaluate the feasibility of performing ACL reconstruction with femoral nerve block as a day-case procedure, implement this change and audit our outcomes. Methods: From November 2005 to April 2006 all patients undergoing ACL reconstruction were entered into a day-case feasibility study. Any issues preventing day-case discharge were identified, and in November 2006 changes were implemented to address these. Since then all ACL reconstruction patients have been treated as day-cases using femoral nerve blocks. Patients are discharged if safe, and contacted 1 and 7 days postoperatively to detect any problems and to assess patient satisfaction. Results: 23 patients have followed the day-case pathway, 15 being discharged as day-cases. The other cases had afternoon surgery delaying discharge or surgery in the independent sector where the protocol was not enforced. All patients had good working femoral nerve blocks, were able to mobilise safely and easily with crutches and reported no adverse effects from their blocks at follow-up phone calls. All reported good analgesia at home and high satisfaction with being a day-case. Conclusions – With appropriate education of patients and staff, ACL reconstruction with femoral nerve block is a safe day-case procedure with high patient satisfaction

We randomised 50 patients with extracapsular fractures of the femoral neck to receive either a bupivacaine femoral nerve block or systemic analgesia alone. A femoral nerve block was found to be an easy and effective procedure which significantly reduced perioperative analgesic requirements and postoperative morbidity

Objectives. The goal of this retrospective study was to compare two different processes of pain control after total knee arthroplasty (TKA): local anesthesia versus femoral nerve block. The tested hypothesis was that the patient's ability to be discharged was obtained sooner with the local anesthesia process. Methods. 110 patients consecutively operated on for TKA by a single surgeon without any selection criterion were included. The study group included 58 patients operated on under general anesthesia with infiltration of the surgical field with local anesthesia. The control group included 52 patients operated on under general anesthesia and continuous femoral nerve block. In the study group, 200 ml of ropivacaïne 5% were injected into the surgical field, and an intra-articular catheter was left to allow continuous infusion of ropivacaïne (20 ml/h during 24 hours). The control group was treated by a femoral nerve block with ropivacaïne during 24 hours. Discharge was considered allowed when the patient was able to walk independently, go upstairs and downstairs independently, when the knee flexed over 90° and if the subjective pain assessment (VAS) was under 3/10. Results. Discharge allowance was obtained sooner (mean 2 days) in the study group (p<0.01). 40 patients of the study group (69%) and 2 patients of the control group (4%) were able to stand up on the day of implantation (p<0.001). Deambulation was possible at D1 in the study group and D2 in the control group (p<0.001). Gait was possible at D4 in the study group and D6 in the control group (p<0.05). Discharge was possible 2 days earlier in the study group (p<0.01). Active quadriceps function was recovered 2 days earlier in the study group (p<0.001). Knee flexion exceeded 90° 2 days earlier in the study group (p<0.001). There was a faster decrease of the pain VAS in the study group, but the total consumption of analgesic was not different in the two groups. The complication rate was not different in the two groups. Conclusion. The process using local anesthesia may allow a better pain control after TKA, and consequently a faster rehabilitation and an earlier discharge

We performed a randomized feasibility trial to examine the impact of preoperative femoral nerve block (FNB) on elderly patients with hip fractures, including those with mild to moderate cognitive impairment. We evaluated the impact of preoperative FNB on the following outcomes within 5 days of surgical fixation: 1. Pain levels, 2. Total narcotic consumption, 3. Postoperative mobilization. Randomized allocation of 73 patients in a 2:1 intervention:control ratio. To allow comparison between the 2 groups as well as sub- analysis of the intervention group to examine treatment fidelity (i.e. the ability to deliver the intervention as planned). Inclusion criteria: Patient age≥ 65 years admitted with a low energy hip fracture, ambulatory preinjury, Mini Mental State Exam MMSE score≥13 (moderate dementia), Able to provide direct or proxy consent. Exclusion criteria: Admission ≥ 30 hours after injury, prior regular use of opiates. Potential participants were identified and either participants or proxy respondents provided signed informed consent. Participants allocated to the intervention group received a FNB administered by the UAH acute pain service (APS) within 20 hours of admission to hospital in addition to the usual care. Participants in the control group received usual care. Participants were followed for 5 days postoperatively with daily assessment of pain, narcotic consumption, delirium and mobility. Main outcome measure: (1) Pain at rest and activity (2) Preoperative and postoperative opioid consumption, (3) Mobilization in POD#1. Overall, 73 participants were enrolled (23 Control: 50 FNB). The FNB group was slightly older (mean [SD] 80.1 [8.7] vs. 76.2 [9.2], p=0.09) and had more males (21 [42%] vs. 5 [22%], p=0.09) than the Control group. The mean MMSE score for both groups was >24 (p=0.35 for group comparison), suggesting minimal cognitive impairment of participants. The FNB group reported significantly less pain at rest and activity than the control group over time (p < 0 .001 for both). Opioid consumption were non-significantly higher and more variable in the control group preoperatively (Median [25, 75 quartile] 10.6 [0, 398] vs 7.5 [0, 125], p=0.26) and postoperatively (13.1 [0, 950] vs 10 [0, 260], p=0.31). 41 (85%) of FNB participants mobilized on day 1 vs. 16 (73%) of control participants (p=0.21). Preoperative FNB significantly reduced pain. Opioid consumption was not significantly different, but more variable in the control group. Although not significant, more FNB patients successfully mobilized on day 1 postoperatively. Participants with cognitive impairment were not enrolled due to difficulty in obtaining proxy consent. A definitive randomized trial would be feasible and add valuable information about pain management following hip fracture

Introduction: Inadequate control of postoperative pain after total knee arthroplasty (TKA) has been associated with a poor functional recovery. This study investigated whether the addition of a single injection femoral nerve block (FNB) to continuous epidural analgesia (EA) provides improved pain control, lowered side effects, and a further acceleration in achievement of rehabilitation goals. Material and methods: Eighty patients undergoing TKA and receiving EA with 18 ml of 0.5% marcaine were randomized whether to receive or not a single dose of FNB. A nerve stimulator and 30 ml of 0.375% marcaine with 5 μg/ml of epinephrine were used to perform FNB prior to surgery. Post-operative continuous EA was self-administered by the patient adding bolus (up to 4bolus/hour) to the basal infusion rate of 2 ml/hour of 0.175% marcaine. Standardized post-operative rehabilitation protocol were followed for both groups. Therapists and clinicians were blinded to treatment group. Overall narcotic consumption, bolus dosing, and side effects were recorded. Outcomes measurements included postoperative strength and sensation, range of motion and progression, pain score (VAS), achievements of functional milestones and length of stay. Results: Femoral nerve block group had significantly lower pain scores and lower epidural consumption in comparison to the group without block (p< 0.01). Range-of-motion was significantly greater through post-operative day three in the FNB group (p< 0.04). There was a consistent trend toward improved achievements in rehabilitation milestones after FNB. Decreased quadriceps strength was noted in 33% of the FNB patients on post-operative day one compared to 10% of the patients with isolated EA. Discussion: We found significant improvements both in terms of analgesia and in functional parameters adding a FNB to continuous EA following TKA. Combination of the two techniques has a sound basis for preventing severe post-operative pain after TKA

Background:. Total knee replacement (TKR) is a frequent and effective surgery for knee osteoarthritis. Postoperative pain is under concern and can be relieved by different methods, including femoral nerve block (FNB). The efficacy of FNB on pain relief was associated with the absence of clinical impact when measured with the range of motion (ROM). Recent studies suggest that the quadriceps strength is the best indicator of functional recovery after TKR. The goal of this study is to compare the quadriceps strength recovery after TKR according to the kind of analgesia (patient control analgesia (PCA) with or without FNB) Hypothesis: the FNB delays the QSR at short and mid-term follow-up. Methods:. Prospective randomized trial with single-blind assessment involving 135 patients admitted for TKR in an academic center. Randomization into one of the three following groups: A) Continuous FNB 48h + PCA B) Single-shot FNB and PCA C) PCA alone. Groups were comparable for demographic and surgical data. The FNB was realised and controlled (electric stimulation) by an expert anesthesiologist before the surgery. Follow-up standardised in all groups with blinded assessors. Quadriceps strength measured with a validated dynamometer at 6 weeks, 6 and 12 months. Secondary outcomes included clinical evaluation (ROM, pain, stability) and functional scores (SF-36 v2, WOMAC). Multivariate analysis (Kruskal-Wallis, Mann-Whitney) for main outcomes and Spearman factor for correlation. Sample size calculated for alpha 5% and study power 80%. Results:. 111 patients available for 6 weeks follow-up (A-B-C:40-38-33) and 104 (36-36-32) at 6 and 12 months. Two patients in group B excluded for direct fall in the first postoperative week with extensor mechanism rupture and peri-prosthetic femoral fracture. QSR is significantly decreased in patients with FNB at all times (mean, 95% IC): 6 weeks (A 51.3%, 44.1–58.5; B 62.2%, 55.2–69.2; C 77.4%, 70.7–84.1; p < 0,05), 6 months (A 65.4%, 57.9–72.9; B 82.1%, 74.2–90; C 95.7%, 88.5–102.9; p < 0,05) and 12 months (A 87.8%, 82.1–93.5; B 97.8%, 89–106.6; C 104.8%, 96.1–113.5; p < 0,05). No significant difference between continuous or single-shot FNB. Higher ROM in group C at all times (p 6 weeks = 0,046; p 6 months = 0,159; p 12 months = 0,026). No correlation between ROM and QSR (rho = 0,07; p = 0,23). Better functional results in the group C at all times (p < 0,05), with good correlation to QSR (rho = 0,177; p = 0,032). Slight difference in analgesic effect of FNB (p = 0,14). Conclusion:. Femoral nerve block has a negative influence on QSR at short and mid-term follow-up and delays the rehabilitation after TKR. QSR is actually the most sensitive indicator of functional recovery after TKR and is better related to functional tests than ROM. This can explain the harmlessness of FNB in previous studies. FNB should not yet be recommended for analgesia after TKR

Our study is still in progress. The results mentioned in the abstract are preliminary results. The final results will be provided at the time of presentation. Over the past decade, the widespread availability of high-resolution ultrasonography coupled with advances in regional anaesthesia have popularised peripheral nerve blocks for anterior cruciate ligament reconstructions (ACLRs). The aim of this study is to investigate whether the femoral nerve block (FNB) administered at the time of ACLR has any long-term impact on the quadriceps strength as compared to patients who did not receive a FNB. This is a retrospective study. Four hundred charts of patients who underwent ACLR at our institution and had subsequent Biodex testing (an isokinetic rehabilitation test that provides objective information about muscle strength deficits and imbalances of the operated leg compared to the non-operated leg) from 2004 to 2015 were reviewed. Patients who had prior ipsilateral knee surgery, multi-ligament knee injury or at extreme ages were excluded from the study. The following baseline patient characteristics was recorded for each reviewed chart: age, sex, medical comorbidities, the date of the injury, date of the surgery, surgery technical notes and associated procedures, the surgeon, the hospital were the patient was operated, the Biodex test date and the Biodex test results. Data extraction assessed any association between the ACLR patients' who received FNB with the results of the Biodex test after completing the rehabilitation protocol. Descriptive statistics were used to compare the type of anaesthesia, mode of pain control and the results of the Biodex tests between patients grouped by the mode of anaesthesia used at the time of surgery (FNB versus no FNB). A multivariate regression model then compared quadriceps strength (inferred by Biodex test results) between groups while controlling for baseline differences between groups. Fifty five percent of the ACLR patients received FNB compared to 45% that did not receive FNB over the last 11 years of performing ACLRs (2004–2015) at our institute. Fifty percent of the patients that received FNB failed to achieve more than or equal to 80% quadriceps strength (compared to the contralateral non-operated leg) at 6 months on Biodex test. On the other hand, only 20% of the non-FNB group failed to achieve more than or equal to 80% quadriceps strength. This study lead us to think that ACLR patients that received FNB are significantly weaker in quadriceps strength at 6 months post ACLR in comparison to non-FNB ACLR patients. This finding subsequently might affect the time needed to return to sports and might indicate a considerable clinical consequence of the FNB on ACL-reconstruction patients

Background. Total knee arthroplasty is associated with early postoperative pain. Appropriate pain management is important to facilitate postoperative rehabilitation and positive functional outcomes. This study compares outcomes in TKA with three techniques; local infiltration analgesia, single shot femoral nerve block and intrathecal morphine. Methods. Forty-five patients undergoing elective primary Total Knee Arthroplasty (TKA) with were randomized into one of three groups in a double blind proof of concept study. Study arm 1 received local infiltration analgesia ropivacaine intra-operatively, an elastomeric device of ropivacaine for 24 hours post-op. Study arm 2 received a femoral nerve block of ropivacaine with placebo local infiltration analgesia and placebo intrathecal morphine. Study arm 3 received intrathecal morphine, placebo femoral nerve block and placebo local infiltration analgesia. All patients received standardized pre-operative, intraoperative and Post-operative analgesic medication. Participants were mobilized at 4 hrs, 24hrs and 48 hrs post operation. Range of Motion, Visual Analogue Scale (VAS) pain intensity scores and two minute walk test and Timed Up and Go test were performed. Postoperative use of analgesic drugs was recorded. Knee Society Score (KSS), Oxford Knee Score and Knee Injury and Osteoarthritis Outcome Score (KOOS) were completed at preoperative and 6 weeks post op. Results. Assessment of the efficacy of analgesia will be conducted using VAS pain scores collected preoperatively, 0–24hrs and 24–48 hours postoperatively between the three randomized groups. Frequency of use of other analgesia and need for PCA will be compared between groups at 0–24hr and 24–48hrs post operatively. The assessment of functional outcomes will be measured between the three groups by comparing the ability to mobilize the first 4 hrs after surgery, maximal flexion and extension, two minute walk test and timed up-and-go preoperatively, on postoperative day 1 and 2 and 6 weeks. Patient reported outcome measures KSS, Oxford Knee score and KOOS will be compared for the three study arms. Conclusion. Results from the study will provide important information for the management of TKA in the hospital setting. The comparison of the three commonly used analgesic techniques and mobilization outcomes are pertinent for physiotherapy and rehabilitation management, anaesthetic specialists, nursing staff, orthopaedic surgeons and patients

Total knee arthroplasty is associated with early postoperative pain. Appropriate pain management is important to facilitate postoperative rehabilitation and positive functional outcomes. This study compares outcomes in TKA with three techniques; local infiltration analgesia, single shot femoral nerve block and intrathecal morphine. Methods. Forty-five patients undergoing elective primary Total Knee Arthroplasty (TKA) with were randomized into one of three groups in a double blind proof of concept study. Study arm 1 received local infiltration analgesia ropivacaine intra-operatively, an elastomeric device of ropivacaine for 24 hours post-op. Study arm 2 received a femoral nerve block of ropivacaine with placebo local infiltration analgesia and placebo intrathecal morphine. Study arm 3 received intrathecal morphine, placebo femoral nerve block and placebo local infiltration analgesia. All patients received standardized pre-operative, intraoperative and Post-operative analgesic medication. Participants were mobilized at 4 hrs, 24hrs and 48 hrs post operation. Range of Motion, Visual Analogue Scale (VAS) pain intensity scores and two minute walk test and Timed Up and Go test were performed. Postoperative use of analgesic drugs was recorded. Knee Society Score (KSS), Oxford Knee Score and Knee Injury and Osteoarthritis Outcome Score (KOOS) were completed at preoperative and 6 weeks post op. Results. Preliminary results of 32 participants convey the positive outcomes after total knee replacement demonstrated by the improvement in Oxford Knee Score and Knee Osteoarthritis Outcome score. There are marked improvements in the 2-minute walk tests at the six week time-point. At day one post-operative only 5 participants were unable to walk. Patient-controlled analgesia was used on 5 occasions on day one, 2 of which continued on day two. Sedation scores were recorded in six participants on day one and 2 on day two. Nausea was reported in 5 cases on day one and 9 on day two. Urinary catheter was needed in 5 cases on day one. Importantly the study remains blinded, therefore an analysis of the three study arms is not available and is therefore currently difficult to report on the statistical significance. There will be further assessment of the efficacy of analgesia using VAS pain scores, analgesia consumption and side effects collected preoperatively, 0–24hrs and 24–48 hours postoperatively between the three randomized groups. The assessment of functional outcomes will be measured between the three groups by comparing the ability to mobilize the first 4 hrs after surgery, maximal flexion and extension, two minute walk test and timed up-and-go preoperatively, on postoperative day 1 and 2 and 6 weeks. Conclusion. Results from the study will provide important information for the management of TKA in the hospital setting. We anticipate completion of all 45 surgeries in the next 2 months. The Blinding codes with be broken thereafter and full data analysis performed. The comparison of the three commonly used analgesic techniques and mobilization outcomes will allow enhanced management of patient's post-operative pain with earlier discharge from hospital an lower complication rates

Purpose. To evaluate the effectiveness of post-operative pain management using the intra-operative peri-articular injection(PAI) and/or electromyography (EMG)-guided preoperative femoral nerve block (FNB) in total knee arthroplasty(TKA). Materials and Methods. From March 2013 to February 2014, 90 knees which underwent primary TKA by one surgeon were included in our study. The patients were classified into three groups; a single injection FNB with an EMG guide (Group I, 30 knees), intra-operative PAI (Group II, 30 knees) and both FNB and PAI (Group III, 30 knees). Pain at rest and moving was evaluated by Visual Analogue Scale (VAS) at postoperative 0, 4, 8, 24 and 48 hours. Postoperative range of motion, time to walking, total blood loss, amount of opioid consumption and complications were compared in each group. Results. VAS immediately after surgery was 67.9 in group I, 54.6 in group II and 54.7 in group III. VAS was significantly higher in group I than group II and III (p=0.005), but was not significantly different between group II and III (p>0.05). VAS at postoperative 4 and 8hr showed similar results. VAS at postoperative 24 hr was 49.6 in group I, 56.4 in group II and 46.7 in group III, which was significantly higher in group II than group I and III (p=0.043). After postoperative 48hr, there were no differences in group I, II and III. The total amount of opioid consumption in group III was smaller than that in group I and II (p=0.017). There were no differences in postoperative range of motion, time to walking and total blood loss. There was one case with temporary peroneal nerve palsy in group II and no infection in all cases. Conclusion. PAI was more effective than FNB for early (0∼8hr) postoperative period after TKA. However, PAI showed rebound pain at 24hr after TKA. PAI in combination with FNB could enhance the effect of postoperative pain management from immediate postoperative period to 24hr

Purpose: Continuous femoral nerve block (CFNB) has been revealed to be a safe and effective method to decrease postoperative pain after total knee arthroplasty (TKA). However, optimal duration for CFNB to decrease pain and accelerate rehabilitation program after TKA has not been addressed. We, therefore, compared three groups of patients which had different duration of CFNB (0, 2, and 5days) in this study. Methods: Sixty patients who received primary TKA for osteoarthritis were divided into three groups based on the duration to receive CFNB for 0day, 2days or 5days (twenty patients for each group). Ropivacaine 2mg/mL was given through the femoral nerve catheter using elastomeric infusers (delivering 2ml/hr for each group). Outcomes including visual analog scale (VAS) pain scores and range of motion (ROM) were compared at 1st, 3rd, 6th, 14th and 21th days after surgery. In addition, the postoperative date when patients could walk stably with parallel bar, walker, or T-cane were recorded and compared. Results: At 1st and 3rd day postoperatively, the VAS was significantly better in the CFNB 2 days and CFNB 5 days group than in the CFNB 0 day group (P< 0.05). ROM did not show significant difference among the three groups over postoperative days 1st to 21st (P> 0.05), although groups with the CFNB showed greater ROM at all time points. The CFNB 5 days group obtained stable walking ability with T-cane earlier than other groups (P< 0.05). No patient had any side effect by having CFNB in this study. Discussion: Postoperative use of CFNB reduced pain at first 3days, and shorten the time to acquire stable walking ability after TKA. We conclude that CFNB should be kept for 5days after surgery to decrease pain and accelerate rehabilitation program after TKA

The purpose of this double-blinded prospective study was to evaluate the effectiveness of electromyography (EMG)-guided preoperative femoral nerve block (FNB) for postoperative analgesia in total knee arthroplasty (TKA). Forty knees of primary TKA by one surgeon were included in our study. One doctor performed a single injection FNB with an EMG guide in EMG group (23 knees) and with a blind maneuver in control group (17 knees). The same 10ml of 0.375% ropivacaine was injected in both groups. Same postoperative rehabilitation protocol was applied to all patients. Continuous passive motion was started at postoperative 1st day and weight bearing was started as soon as possible. Intravenous patient-controlled analgesics which contained 30mg of morphine were used until postoperative 72 hours and no additional intravenous, intramuscular or oral analgesics were used. Pain was evaluated by Visual Analogue Scale (VAS) and Postoperative Pain Score (PPS) at postoperative 4, 24, 48 and 72 hours. The amount of opioid consumption and complication were compared between two groups. VAS score was 6.8 in EMG group and 8.0 in control group at postoperative 4 hours, 6.2 and 7.1 at postoperative 24 hours, 5.3 and 5.9 at postoperative 48 hours, and 4.6 and 5.7 at postoperative 72 hours, respectively. PPS was 2.2 in EMG group and 2.2 in control group at postoperative 4 hours, 2.1 and 2.1 at postoperative 24 hours, 1.6 and 1.7 at postoperative 48 hours, and 1.4 and 1.6 at postoperative 72 hours, respectively. The amount of opioid consumption was 6.0mg in EMG group and 7.2mg in control group during postoperative 24 hours, 2.7mg and 3.2mg during postoperative 24–48 hours, and 1.7mg and 3.2mg during postoperative 48–72 hours, respectively. There was no complication in either group. Pain tended to decrease more in EMG group than control group, especially VAS at postoperative 4, 24 and 72 hours (p< 0.05). The demand of opioid was significantly smaller in EMG group during postoperative 24 hours and 48–72 hours (p< 0.05). EMG-guided single FNB before TKA allowed better postoperative pain relief and reduced the demand of pain killer

A prospective randomised study was carried out to compare two methods of pain control following arthroscopically assisted ACL reconstruction. Twenty patients each were randomly recruited to receive either femoral nerve block with 0.5% Bupivicaine or an intra-articular injection with the same. Both groups were prescribed Diclofenac regularly and Coproxamol as required. Visual analogue scores (VAS) were used to assess pain levels preoperatively, four hours postoperatively and on the morning after. The duration between surgery and the first dose of PRN analgesia was recorded, along with the total quantity of analgesia required before discharge. Patients with associated PCL or collateral ligament injuries were excluded beforehand. Both groups were evenly matched for age (t-test p< 0.05). Tourniquet time did not differ significantly between the groups (t-test p:0.24). The VAS pain levels were not significantly different at four hours and the first morning postoperatively in both groups. Femoral block (Ave VAS: 21 & 25) did not confer a significant advantage (t-test p: 0.69, 0.7) over intra-articular injections of Bupivicaine (Ave VAS: 25 & 22). The total quantity of Coproxamol consumed did not vary significantly (p=0.99). There was no correlation between tourniquet time and postoperative pain (r=0.19, 0.08). All but one patient was discharged home on the first postoperative morning. Our study demonstrates that pain levels can be sufficiently controlled by intra-articular infiltration of Bupivicaine coupled with oral analgesia. The level of pain relief achieved could allow this procedure to be increasingly performed in a day surgery setting without the need for femoral block thereby allowing for quicker mobilisation

Purpose: Unicompartmental replacement for medial compartment arthrosis of the knee has become popular with eligible patients because of the shortened recovery time, decreased tissue damage and easier future revision. Contemporary multimodal anesthesia has added the potential to safely perform this as outpatient surgery reducing inpatient bed burden. We describe our initial pilot experience with this approach.

Method: The first 25 patients who fulfilled the criteria developed underwent same day surgery for unicompart-mental arthroplasty for medial (19) or lateral (3) compartment replacement with either the Oxford knee (20) or the Uniglide (2). All patients were treated with an indwelling femoral nerve catheter supplied by Ropivacaine through a constant release pump (Stryker) which was discontinued at 48 hours. Home care support was made available in first 72 hours by way of RN and physiotherapy visits and mandatory use of walker or crutches for the first 48 hours.

Results: Patients in this cohort were universally very satisfied with the model of postop care as described and particularly pleased to avoid a hospital stay. Eighty percent of those who were offered this model chose it. The use of narcotic oral medication was consistently about 50% less than that observed to similar inpatients treated without catheter, and eight patients had complete opioid sparing experience. There were no complications related to the catheter, in particular serious falls or longer term neurologic sequelae. The clinical results were very good and equal to those who were in patients.

Conclusion: Outpatient unicompartmental replacement can be performed safely recognizing the decreased surgical trauma and pain stimuli associated with UKR and a relatively younger and healthier cohort screened for this alternative. These patients are amongst the most satisfied with their perioperative course and all would do the same again if given the chance. Other models of analgesia could be considered, though the catheter does seem to have a large opioid sparing effect that likely contributed to patient well being and satisfaction.

Introduction: Regional anaesthesia is used recently more often in minor and intermediate orthopaedic procedures. This study evaluates regional anaesthesia in knee arthroscopy.

Patients and Method: From September 2002 to February 2003, sixty three patients had knee arthroscopy by regional blockade, (mean age 28, 3 years). Thirty ml Ropivacaine 5% and 10 ml Lidocaine 2% were used to block sciatic and femoral nerve with nerve stimulator help.

Results: They were realized 31 meniscectomies, 8 meniscal repairs, 6 primary ACL reconstructions, 2 ACL revisions, 5 chondroplasties, 6 lateral releases, 2 Fulkerson osteotomies, 4 plica removals, 2 adhesionlysis, 2 localized villonodular synovitis, one total synovectomy and one arthroscopic removal prepatellar bursa. There was no complication concerning the nerve blockade. Two of 8 ACL patients required general anesthesia and one had sedation during the procedure. Sedation also was necessary in three patients with lateral release and two meniscal repairs. The remaining 55 patients were tolerated the arthroscopic procedure without any additional help. All patients hospitalized less than 24 hours except patients with ACL reconstruction. They needed 1, 2 analgesic pills per person. The cost for the anesthetic procedure was 40 euros.

Conclusion: Regional anesthesia has the advantage of avoiding the complications of general anesthesia, is of low cost and well bearable from the majority of patients. It offers prolonged postoperative analgesia and has no complications.

In a randomised controlled pragmatic trial we investigated whether local infiltration analgesia would result in earlier readiness for discharge from hospital after total knee replacement (TKR) than patient-controlled epidural analgesia (PCEA) plus femoral nerve block. A total of 45 patients with a mean age of 65 years (49 to 81) received a local infiltration with a peri-articular injection of bupivacaine, morphine and methylprednisolone, as well as adjuvant analgesics. In 45 PCEA+femoral nerve blockade patients with a mean age of 67 years (50 to 84), analgesia included a bupivacaine nerve block, bupivacaine/hydromorphone PCEA, and adjuvant analgesics. The mean time until ready for discharge was 3.2 days (1 to 14) in the local infiltration group and 3.2 days (1.8 to 7.0) in the PCEA+femoral nerve blockade group. The mean pain scores for patients receiving local infiltration were higher when walking (p = 0.0084), but there were no statistically significant differences at rest. The mean opioid consumption was higher in those receiving local infiltration.

The choice between these two analgesic pathways should not be made on the basis of time to discharge after surgery. Most secondary outcomes were similar, but PCEA+femoral nerve blockade patients had lower pain scores when walking and during continuous passive movement. If PCEA+femoral nerve blockade is not readily available, local infiltration provides similar length of stay and similar pain scores at rest following TKR.

Cite this article: Bone Joint J 2013;95-B:629–35.

Objectives. Effective analgesia after total knee arthroplasty (TKA) improves patient satisfaction, mobility and expedites discharge. This study assessed whether continuous femoral nerve infusion (CFNI) was superior to a single-shot femoral nerve block in primary TKA surgery completed under subarachnoid blockade including morphine. Methods. We performed an adequately powered, prospective, randomised, placebo-controlled trial comparing CFNI of 0.125% bupivacaine versus normal saline following a single-shot femoral nerve block and subarachnoid anaesthesia with intrathecal morphine for primary TKA. Patients were randomised to either treatment (CFNI 0 ml to 10 ml/h 0.125% bupivacaine) or placebo (CFNI 0 ml to 10 ml/h normal saline). Both groups received a single-shot femoral nerve block (0.25% 20 ml bupivacaine) prior to placement of femoral nerve catheter and subarachnoid anaesthesia with intrathecal morphine. All patients had a standardised analgesic protocol. The primary end point was post-operative visual analogue scale (VAS) pain score over 72 hours post-surgery. Secondary outcomes were morphine equivalent dose, range of movement, side effects, and length of stay. Results. A total of 86 patients were recruited. Treatment and placebo groups were comparable. No significant difference was found in VAS pain scores, total morphine equivalent requirements, side effects, range of movement, motor block, or length of hospital stay. Conclusion. No significant advantage was found for CFNI over a single-shot femoral block and subarachnoid anaesthesia after TKA. Cite this article: Bone Joint Res 2015;4:11–16

Regional anaesthesia is integral to best practice analgesia for patients with neck of femur fractures (NOFFs). These patients are generally frail and are vulnerable to side effects of opioid analgesia. Femoral nerve block (FNB) or fascia-iliaca block (FIB) can reduce opioid requirement. Literature supports good efficacy for extra-capsular NOFFs however it is acknowledged to be suboptimal for intracapsular fractures. We present a novel technique, using point of care ultrasound guidance to perform hip ultrasound guided haematoma (HUSH) aspiration, and injection of local anaesthetic (block) for intracapsular NOFFs. This a case control series. A consecutive series of cognitively intact patients, with an isolated intra-capsular NOFF, received a HUSH block using 10mls of 0.75% Ropivicaine. Haematoma was aspirated and volume recorded. This was performed in addition to standard NOFF pathway analgesia that includes a FIB and multimodal analgesia including opioids. Visual Analogue Scale (VAS)pain scores at rest and on movement were recorded pre and post procedure as well as combined morphine equivalent units administered post HUSH block. The control arm was a retrospective group of similar patients who followed the routine care pathway including a FIB. VAS pain scores from observation charts and usage of morphine equivalent units were calculated. Ten patients consented to receive HUSH blocks and we included thirty-eight patients in our control series. The HUSH block group showed mean VAS pain score of 4.2/10 at rest and 8.6 on movement prior to block. In the time after the block, VAS pain scores reduced to 1.5 at rest (p=0.007) and 3.1 on movement (p=0.0001) with a mean total morphine equivalent use of 8.75mg. This is significantly different from the control group's mean VAS pain at rest score 6.9 (p=0.0001) and 24.1mg total morphine equivalent (p=0.07). HUSH Block in addition to fascia iliaca block appears to significantly better pain relief in intracapsular neck of femur fracture patients when compared to fascia iliaca block alone. We believe it is relatively easy to perform with readily available ultrasound scanners in emergency departments

Background and objectives: Total knee replacement (TKR) produces severe postoperative pain. Peripheral nerve blocks can be used as analgesic adjuncts after TKR. The use of peripheral nerve block has certainly reduced the use of opiates by 50%; however adding the sciatic nerve block to the femoral nerve block is controversial. The aim of this study was to compare femoral and femoral plus sciatic nerve blocks in postoperative pain management of patients undergoing TKR. Materials and Methods: Total of 42 patients were studied. Twenty patients with an average of 75yrs (51–86yrs) received femoral nerve block alone. Twenty-two patients with an average age of 69yrs (53–83yrs) received femoral plus sciatic nerve block. 0.5% Chirocaine was used for nerve blocks. There was no significant difference between two groups in terms of pre-operative pain, pre-operative deformity, ROM and patella replaced. The primary outcome measures used were visual analogue scale (VAS) pain scores at 24 hours, 48 hours and 72 hours after the surgery. The amount of opiate consumption and PCA (patient controlled analgesia) used were also recorded. The secondary outcomes were postoperative nausea and vomiting, straight leg raise, neurological deficit, knee flexion, independent mobility and discharge from the hospital. Results: The results showed significant decrease in the amount of pain in the femoral nerve block group than the combined nerve block patients. Patients who had combined nerve block complained of heaviness in the legs and were slow to mobilise. There was no significant difference in consumption of opiates, use of PCA, nausea and vomiting, independent mobility and the time of discharge from the hospital between the two groups. Conclusion: The addition of sciatic nerve block to the femoral nerve block does not provide any additional benefits in TKR

Aims. The aim of this study was to determine the optimal regimen for the management of pain following total knee arthroplasty (TKA) by comparing the outcomes and cost-effectiveness of different protocols implemented at a large, urban, academic medical centre. Patients and Methods. Between September 2013 and September 2015, we used a series of modifications to our standard regimen for the management of pain after TKA. In May 2014, there was a department-wide transition from protocols focused on femoral nerve blocks (FNB) to periarticular injections of liposomal bupivacaine. In February 2015, patient-controlled analgesia (PCA) was removed from the protocol while continuing liposomal bupivacaine injections. Quality measures and hospital costs were compared between the three protocols. Results. The cohort being treated with PCA-less liposomal bupivacaine injections had a significantly higher percentage of patients who were discharged to their home (p = 0.010) and a significantly shorter length of stay (p < 0.001). Patient-reported Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores relating to pain being “well-controlled” and “overall pain management” also favoured this cohort (p = 0.214 and p = 0.463, respectively), in which cost was significantly lower compared with the other two cohorts (p = 0.005). Conclusion. The replacement of FNBs injections and the removal of PCAs, both of which are known to be associated with high rates of adverse outcomes, and the addition of liposomal bupivacaine periarticular injections to a multimodal pain regimen, led to improvements in many quality measures, HCAHPS pain scores, and cost-effectiveness. Cite this article: Bone Joint J 2018;100-B(1 Supple A):55–61

Introduction. Many determinants of the length of stay (LOS) for primary total knee arthroplasty (TKA) have been described. Multimodal, pre-emptive analgesia, age, walking aid score and stair score are some of them. Single shot peripheral nerve block is a popular method to provide prolonged analgesia in immediate post operative period after TKA. Delayed recovery from the nerve block can delay the rehabilitation programme and subsequently lengthen the LOS when the multi disciplinary team discharge criteria are well defined and standardized. The aim of this study is to calculate the incidence of delayed recovery from the sciatic and femoral nerve block administered in cases of primary TKA and its influence on LOS. Methods. All the patients undergoing primary TKA and receiving forty milliliters of 0.375% of Bupivacaine for sciatic and femoral nerve block since April 2010 till January 2011 have been included in the study. Patients demographics, date and day of operation, time of nerve block, complete recovery from the nerve block post operatively and date of discharge were recorded prospectively. Results. Total 34 patients were included in the study. 24 patients recovered from the effect of peripheral nerve block on the post operative day one and 10 patients recovered on the post operative day two. Mean LOS of patients recovered on post operative day one is 4.8 days and mean LOS of those who recovered on post operative day 2 is 5.6 days. Conclusion. Almost one third of the patients receiving forty milliliters of 0.375% of Bupivacaine for sciatic and femoral nerve block recovered late. Delayed recovery from nerve block seems to increase the duration to achieve the discharge criteria after primary TKA. This information can be used favorably to influence the outcome by altering the concentration and amount of anaesthetic agent used

Background and objectives: Total knee replacement (TKR) produces severe postoperative pain. Peripheral nerve blocks can be used as analgesic adjuncts for TKR, but the efficacy of a sciatic nerve block as an adjunct to a femoral nerve block is controversial. The aim of this study was to compare femoral with femoral and sciatic nerve blocks in postoperative pain management of patients undergoing total knee arthroplasty (TKA). Methods: 42 patients were involved in the study. 20 patients received only a femoral nerve block, consisting of 20ml of 0.5% Chirocaine and 22 patients received femoral and sciatic nerve blocks, consisting of 20ml of 0.375% Chirocaine for the femoral nerve and 10ml of 0.5% Chirocaine for the sciatic nerve. The primary outcome measures used were visual analogue scale (VAS) scores for pain at 24 hours, 48 hours and 72 hours after the surgery, opiates consumption post-operatively and PCA use. The secondary outcomes were post-operative nausea and vomiting, sensory deficit, quadriceps contraction, straight leg raise, knee flexion, independent mobility and discharge from the hospital. Results: The results showed no difference in opiate consumption, PCA use, independent mobility and time of discharge from the hospital between the two groups. Conclusion: The study shows that the addition of a sciatic nerve block to the femoral nerve block does not provide additional benefits

Intra-operative, peri-articular injection of local anaesthesia is an increasingly popular way of controlling pain following total knee replacement. At the same time, the problems associated with allogenic blood transfusion have led to interest in alternative methods for managing blood loss after total knee replacement, including the use of auto-transfusion of fluid from the patient’s surgical drain. It is safe to combine peri-articular infiltration with auto-transfusion from the drain. We performed a randomised clinical trial to compare the concentration of local anaesthetic in the blood and in the fluid collected in the knee drain in patients having either a peri-articular injection or a femoral nerve block. Clinically relevant concentrations of local anaesthetic were found in the fluid from the drains of patients having peri-articular injections (4.92 μg/ml (. sd. 3.151)). However, none of the patients having femoral nerve blockade had detectable levels. None of the patients in either group had clinically relevant concentrations of local anaesthetic in their blood after re-transfusion. The evidence from this study suggests that it is safe to use peri-articular injection in combination with auto-transfusion of blood from peri-articular drains during knee replacement surgery

In a decidedly upper limb themed series of reviews this edition of Cochrane Corner summarises four new and updated reviews published by the Cochrane Bone, Joint and Muscle Trauma Group over the last few months. The tenacious reviewers at the Cochrane collaboration have turned their beady eyes to conservative treatments for shoulder dislocations and clavicle fractures along with evaluation of femoral nerve blocks in knee replacement and how to best manage entrapment injuries in children.

Robust evidence on the effectiveness of peri-operative local anaesthetic infiltration (LAI) is required before it is incorporated into the pain management regimen for patients receiving total knee replacement (TKR). To assess the effectiveness of peri-operative LAI for pain management in patients receiving TKR we conducted a systematic review, fully powered randomised controlled trial (RCT) and economic evaluation. We searched MEDLINE, Embase and Cochrane databases for RCTs of peri-operative LAI in patients receiving TKR. Two reviewers screened abstracts and extracted data. Outcomes were pain, opioid use, mobilisation, hospital stay and complications. Authors were contacted if required. When feasible, we conducted meta-analysis with studies analysed separately if a femoral nerve block (FNB) was provided. In the APEX RCT, we randomised 316 patients awaiting TKR to standard anaesthesia which included FNB, or to the same regimen with additional peri-operative LAI (60mls 0.25% bupivacaine plus adrenaline). Post-operatively, all patients received patient-controlled morphine. The primary outcome was joint pain severity (WOMAC-Pain) at 12 months. Patients and outcome assessors were blinded to allocation. Within APEX, cost-effectiveness was assessed from the health and social-care perspective in relation to quality adjusted life years (QALYs) and WOMAC-Pain at 12-months. Resource use was collected from hospital records and patient questionnaires. In the systematic review, 23 studies including 1,439 patients were identified. Compared with patients receiving no intervention, LAI reduced WOMAC-Pain by standardised mean difference (SMD) −0.40 (95%CI −0.58, −0.22; p<0.001) at 24 hours at rest and by SMD −0.27 (95%CI −0.50, −0.05; p=0.018) at 48 hours during activity. In three studies there was no difference in pain at any time point between randomised groups where all patients received FNB. Patients receiving LAI spent fewer days in hospital, used less opioids and mobilised earlier. Complications were similar between groups. Few studies reported long-term outcomes. In the APEX RCT, pain levels in hospital were broadly similar between groups. Overall opioid use was similar between groups. Time to mobilisation and discharge were largely dependent on local protocols and did not differ between groups. There were no differences in pain outcomes between groups at 12 months. In the economic evaluation, LAI was marginally associated with lower costs. Using the NICE £20,000 per QALY threshold, the incremental net monetary benefit was £264 (95%CI, −£710, £1,238) and the probability of being cost-effective was 62%. Although LAI appeared to have some benefit for reduced pain in hospital after TKR there was no evidence of pain control additional to that provided by femoral nerve block, however it would be cost-effective at the current NICE thresholds

Aims. Adductor canal block (ACB) has emerged as an alternative to femoral nerve block (FNB) for analgesia after total knee arthroplasty (TKA). The optimal duration of maintenance of the ACB is still questionable. The purpose of this study was to compare the analgesic benefits and physiotherapy (PT) outcomes of single-shot ACB to two different regimens of infusion of the continuous ACB, 24-hour and 48-hour infusion. Patients and Methods. This was a prospective, randomized, unblinded study. A total of 159 American Society of Anesthesiologists (ASA) physical status I to III patients scheduled for primary TKA were randomized to one of three study groups. Three patients did not complete the study, leaving 156 patients for final analysis. Group A (n = 53) was the single-shot group (16 female patients and 37 male patients with a mean age of 63.9 years (. sd. 9.6)), group B (n = 51) was the 24-hour infusion group (22 female patients and 29 male patients with a mean age of 66.5 years (. sd. 8.5)), and group C (n = 52) was the 48-hour infusion group (18 female patients and 34 male patients with a mean age of 62.2 years (. sd. 8.7)). Pain scores, opioid requirements, PT test results, and patient-reported outcome instruments were compared between the three groups. Results. The proportion of patients reporting severe pain, defined as a pain score of between 7 and 10, on postoperative day number 2 (POD 2) were 21% for the single-shot group, 14% for the 24-hour block group, and 12% for the 48-hour block group (p = 0.05). Cumulative opioid requirements after 48 hours were similar between the groups. Functional outcomes were similar in all three groups in POD 1 and POD 2. Conclusion. There was no clear benefit of the 24-hour or 48-hour infusions over the single-shot ACB for the primary endpoint of the study. Otherwise, there were marginal benefits for keeping the indwelling catheter for 48 hours in terms of reducing the number of patients with moderate pain and improving the quality of pain management. However, all three groups had similar opioid usage, length of hospital stay, and functional outcomes. Further studies with larger sample sizes are needed to confirm these findings. Cite this article: Bone Joint J 2019;101-B:340–347

Urinary catheterization in the postoperative period is known to increase the risk of deep joint infection following arthroplasty. A number of studies have attempted to elucidate the individual patient factors and surgical procedural factors which predispose patients to postoperative urinary retention. We conducted a retrospective observational study of three hundred patients to specifically determine the effect of the anaesthetic technique on the incidence of urinary retention following elective lower limb arthroplasty. One hundred consecutive patients were surveyed in each of three groups differing by the type of the anaesthetic technique and the drug administered; 1) general anaesthesia with femoral nerve block, 2) spinal anaesthesia with intrathecal fentanyl, and 3) spinal anaesthesia with intrathecal morphine. The incidence of urinary retention requiring catheterisation in male patients receiving intrathecal morphine was 58% compared with 10% and 6% for those who had general anaesthesia with femoral nerve block and intrathecal fentanyl, respectively. This difference was statistically significant (p<0.01). The incidence of urinary retention in females across all groups was =2%. The average residual volume of urine following catheterisation was 750ml (460-1500ml). Our findings show that the use of intrathecal morphine greatly increases the risk of postoperative urinary retention in male patients, whereas no significant increase was found amongst female patients. This risk should be carefully considered when choosing the type of intraoperative anaesthetic/analgesic combination employed in male patients and be rationalised against the intended benefits to the patient

Study Objective: To determine the feasibility of ultrasound-guided femoral nerve blockade performed by orthopaedic trainees. Methods: This was a prospective study involving patients presenting to Acciedent & Emergency with fractured femurs requiring analgesia. Physicians performing the nerve blocks were orthopaedic trainees who had participated in a 1-hour training session. The participants underwent ultrasonography-guided femoral nerve blocks to provide analgesia. Any additional analgesia required was recorded. Subjects rated their pain on a Numerical Pain Rating Scale (NRS) before the nerve block and 30 & 60minutes after the nerve block. The primary outcomes for feasibility were the requirement for additional analgesia following injection and the median reduction in pain on the Numerical Pain Rating Scale after the nerve block. Secondary outcomes for feasibility included the median time for completion of the entire nerve block procedure for each subject (from initiation of ultrasonography to completion of the last injection) and the percentage of participants wishing to have the same procedure for similar injuries in the future. Other secondary outcomes included the percentage of participants with complications during the procedure including nerve and vascular injection. Results: All procedures (100%) were completed without additional anesthesia or analgesia with significant reduction in Numerical Pain Rating Scale. There were no immediate complications. Conclusion: Orthopaedic trainees can perform ultrasound-guided femoral nerve blocks in the emergency department with high patient satisfaction, after minimal training

Wall PDH, Parsons NR, Parsons H, Achten J, Balasubramanian S, Thompson P, Costa ML; P. D. H. Wall on behalf of A. P. Sprowson,† M. L. Costa, PAKA Study Group. A pragmatic randomised controlled trial comparing the efficacy of a femoral nerve block and periarticular infiltration for early pain relief following total knee arthroplasty. Bone Joint J 2017;99-B:904-911

Introduction: Many patients admitted to acute fracture units with femoral neck fractures are frail and elderly, dehydrated and malnourished, often with associated medical conditions. Surgery may be delayed for investigation, prolonged management and inadequate review of their medical problems, leading to clinical deterioration with poor outcome. Local anaesthetic techniques have been described for intracapsular fractures. We describe a technique effective for the treatment of the more difficult extracapsular type. Aims: To provide a safe and effective technique using local anaesthetic and sedation, for the insertion of a dynamic hip screw in high risk elderly patients with extracapsular femoral neck fractures. Method: Fifty elderly patients who sustained an inter-trochanteric fracture of their femoral neck underwent dynamic hip screw insertion under local anaesthetic and sedation. These patients were medically assessed following admission, all were ASA grade 4, had an additional medical condition (recent MI, CVA, chest infection, aortic stenosis) and were deemed unfit for either general or spinal anaesthesia. All patients not fit for traditional anaesthetic methods were assessed for their suitability for operation under LA, consented and placed on the next available theatre list. A femoral nerve block was performed, with the aid of a nerve stimulator for accurate location, in the anaesthetic room; skin and periosteal infiltration was performed using a 22g spinal needle, with caution to include the distribution of the lateral cutaneous nerve. The patient was then placed on the fracture table and mild sedation (Ketamine, Diazemul, 02/N20) was administered, titrated against the patients requirements. The fracture was reduced using traction and internal rotation, and the DHS inserted. Local Anaesthetic:Infiltration; * 20mls O.25% marcaine/1 in 200,000 adrenaline diluted to 40mls with sterile water. (30mls used with 10mls reserved) * 20mls 1% lidocaine diluted in 40mls of sterile water. (10mls used for skin). Local Anaesthetic femoral nerve block; * 10mls 0.25% plain marcaine. The combined amount of local anaesthetic used is well below safe limits recommended by the World Federation of Societies of Anaesthesiologists. Conclusion: This technique is a safe, simple and effective method of allowing high risk, medically unfit patients to undergo surgery. It reduces operative bleeding and postoperative analgesia requirements, no peri-operative deaths occurred and one patient had evidence of post operative tachycardia that settled within 12 hours

Background. The Arthroplasty Pain Experience (APEX) studies are two randomised controlled trials in primary total hip (THR) and knee replacement (TKR) at a large UK orthopaedics centre. APEX investigated the effect of local anaesthetic wound infiltration (LAI), administered before wound closure, in addition to standard analgesia, on pain severity at 12 months. This abstract reports results of the within-trial economic evaluations. Methods. Cost-effectiveness was assessed from the health and social care payer perspective in relation to quality adjusted life years (QALYs). Resource use was collected from hospital records and patient-completed postal questionnaires, and valued using unit cost estimates from local NHS Trust and national tariffs. Missing data were imputed using chained equations. Costs and outcomes were compared per trial arm and plotted in cost-effectiveness planes. The economic results were bootstrapped incremental net monetary benefit statistics (INMB) and cost-effectiveness acceptability curves. One-way deterministic sensitivity analyses explored any methodological uncertainty. Results. In both trials, LAI was cost-saving and more effective than standard care. Using the £20,000 per QALY threshold, in THR, the INMB was £1,125 (95%BCI, £183 to £2,067) and the probability of being cost-effective was over 98%. In TKR, the INMB was £264 (95%BCI, −£710 to £1,238), with only 62% probability of being cost-effective. Considering an NHS perspective only, LAI was no longer dominant in THR, but still highly cost-effective, with an INMB of £961 (95%BCI, £50 to £1,873). Conclusions. Administering LAI is a cost-effective treatment option in THR and TKR surgeries. The evidence is stronger for THR, because of larger QALY gain. In TKR, there is more uncertainty around the economic result, and smaller QALY gains, but results point to LAI being cheaper than standard analgesia, which includes a femoral nerve block. Trial Registration. ISRCTN96095682, 29/04/2010. Funding. NIHR Programme Grant for Applied Research RP-PG-0407-10070

Adductor canal blocks offer an alternative to femoral nerve block for postoperative pain relief in knee arthroplasty. They may reduce the risk of quadriceps weakness, allowing earlier mobilisation of patients postoperatively. However, little is known about the effect of a tourniquet on the distribution of local anaesthetic in the limb. Ultrasound-guided adductor canal blocks were performed on both thighs of five human cadavers. Left and right thighs of each cadaver were randomised to tourniquet or no tourniquet for one hour. Iohexol radio-opaque contrast (Omnipaque 350) was substituted for the local anaesthetic for X-Ray imaging. All limbs underwent periodic flexion and extension during this hour to simulate positioning during surgery. The cadavers were refrozen. Fiducial markers were inserted into the frozen tissue. X-rays were obtained in 4 planes (AP, lateral 45° oblique/medial oblique, lateral). University Research Ethics Approval was obtained and cadavers were all pre-consented for research, imaging and photography according to the Anatomy Act (1984). Analysis of radiographs showed contrast distribution in all thighs to be predominantly on the medial aspect of the thighs. The contrast margins were entire and well circumscribed, strongly suggesting it was largely contained within the aponeurosis of the adductor canal. Tourniquets appeared to push the contrast into a narrower and more distal spread along the length of the thigh compared to a more diffuse spread for those without. Proximal spread towards the femoral triangle was reduced in limbs without tourniquets. The results suggest that contrast material may remain within the adductor canal structures during adductor canal blocks. Tourniquets may cause greater distribution of contrast proximally and distally in the thigh, but this does not appear to be clinically significant. Further studies might include radio-stereo photometric analysis using the fiducial markers in the limbs and in vivo studies to show the effect of haemodynamics on distribution

Peri-articular injections (PAI) have become an important component in many multimodal pain protocols after total knee arthroplasty (TKA). Liposomal bupivacaine has emerged as a highly marketed and touted ingredient for PAI. However, the true efficacy of this material, particularly compared with less expensive PAI “cocktails” such as traditional bupivacaine or ropivacaine, has not been proven to date. Ropivacaine is considered a long-active local analgesic and in combination with epinephrine, ketorolac and clonidine has been shown to be a very effective PAI in a multimodal pain program. Liposomal bupivacaine has been similarly touted as a long-acting PAI. Initial reports provided support for liposomal bupivacaine PAI's providing similar pain relief as epidurals or femoral nerve blocks. The authors of these studies tout comparable pain control with decreased length of stay attributable to avoiding the side effects of epidurals and regional blocks. However, the ultimate clinical issue relates to how liposomal bupivacaine PAI's compares to traditional PAI cocktail ingredients such as bupivacaine and ropivacaine, which also avoid deleterious effects of regional analgesia, and at a much cheaper price point. Fortunately the highest quality research to date, which includes randomised prospective trials and retrospective controlled cohort studies, have reported consistent results. In a retrospective cohort study comparing a traditional ropivacaine and epinephrine versus liposomal bupivacaine PAI demonstrated no difference between the two groups in inpatient pain scores when used in a comprehensive multimodal pain control program. Further, two prospective randomised trials reported no difference in liposomal bupivacaine PAI compared to a traditional PAI of either bupivacaine or ropivacaine, epinephrine, ketorolac and clonidine. Finally, there have been some authors who contend the efficacy of liposomal bupivacaine PAI's is entirely dependent on a meticulous injection technique, however, comparative studies against traditional PAI ingredients with this recommended technique do not exist. In summary, the existing data supports that liposomal bupivacaine is an effective PAI that can be used to provide comparable pain relief to that achieved by regional blocks. However, liposomal bupivacaine has not been shown to provide superior pain relief when compared to traditional ropivacaine or bupivacaine PAI's in multimodal pain protocols after TKA. Further, liposomal bupivacaine is prohibitively priced at approximately six times that of ropivacaine-based PAI cocktails. Therefore, the “game changer” is likely the implementation of peri-articular injections as an essential component of multimodal pain control programs and NOT liposomal bupivacaine

Introduction. Pain control following total knee arthroplasty (TKA) heavily influences timing of mobilization and rehabilitation postoperatively as well as length of hospital stay. Recently, periarticular injection of liposomal bupivacaine (EXPAREL®; Pacira Pharmaceuticals, Inc., San Diego, California) has demonstrated pain relief comparable to femoral nerve block for postoperative analgesia in TKA with earlier mobilization and shortened hospital stay. In order to better explore the use of EXPAREL® in TKA, we standardized the postoperative analgesia to intraoperative periarticular injection of multimodal pain management, which is a recommended postoperative method of pain control in TKA. We studied the effectiveness of periarticular EXPAREL® in TKA postoperative pain control, including impact on early mobilization and length of hospital stay, compared to another local analgesic (Ropivacaine) when both are used as part of a multimodal pain management approach. Methods. We performed a double blind, randomized, controlled, prospective, IRB-approved study that enrolled 96 participants who underwent a unilateral TKA by one surgeon between May 2014 and March 2015. The two randomized groups were as follows: group 1 (control group) was given the standard intra-articular “pain cocktail” injection, consisting of ropivacaine, ketorolac, morphine, and epinephrine mixed with saline into a 100cc preparation and group 2 (study group) was given a similar intra-articular injection consisting of bupivacaine, ketorolac, morphine, and epinephrine mixed with saline into an 80cc preparation as well as an injection of EXPAREL®, 20cc of 1.3% EXPAREL®, to total 100cc. All patients included in the study were determined to be opioid naïve as described by the Food and Drug Administration criteria. Patients were treated with the same postoperative pain management protocol as well as the same post-operative physical therapy program. The consumption of oral and intravenous narcotics at specific time points as well as total use was recorded during hospital stay. We recorded Visual Analog Pain scores, hours to ambulate 100 feet and length of hospital stay (hours). Both the investigator and the patient were blinded as to which group the patient was randomized, making this a double blind study. Results. On a per hour basis, the mean use of narcotics of the two groups differed by only 0.1mg. For total narcotic use during hospital stay, the weighted sum used by patients in the EXPAREL® group, 97.7mg of hydrocodone ±42.84 mg, exceeded the weighted sum, 89.6 mg of hydrocodone ± 58.57 mg, used by patients in the control group. The difference between the two groups was not significant. The means for length of stay differed by only 26 minutes and the difference was not significant. Similarly insignificant, the means for the time to ambulate 100 feet differed by 53 minutes, with the EXPAREL® group actually taking the longer time. The two groups did not differ for Visual Analog Score for pain on day 1 or day 2 post-operatively. Conclusion. When comparing the use of EXPAREL® to another multimodal pain management approach using ropivacaine, there is no difference in post-operative opioid consumption, Visual Analong Scores for pain, amount of time to ambulate or length of hospital stay

Pain control is critical in the management of TKA patients and is crucial to allow for early ambulation and accelerated physical therapy. Currently data suggests that 19% of patients are not satisfied with their results following TKA, and failure to control pain may result in prolonged hospitalization, worse outcomes, and increased patient dissatisfaction. Studies suggest that local analgesics coupled with both pre- and post-operative multimodal pain management may result in improved pain control and increased patient satisfaction. Minimization of opioid use is helpful in decreasing complications, accelerating physical therapy milestones, minimizing length of stay and increasing discharge to home. Femoral nerve blocks (FNB) can reduce pain scores for up to 48 hours post-operatively, but may delay ambulation and result in an increased rate of falls. Periarticular injection (PAI) with local analgesics can provide significant short term relief comparable to FNB and can also facilitate decreased opioid consumption. One commonly used local anesthetic is bupivacaine, but the average half-life of this drug is only 2.7 hours. An alternative to this for PAI during TKA is liposomal bupivacaine (LB). LB is a multivesicular drug designed for rapid absorption, prolonged release of bupivacaine, and analgesia that is maintained for up to 72 hours with a single injection. LB exhibits a bimodal peak of distribution, one immediate associated with extra-liposomal bupivacaine, and a second 10–36 hours later associated with the release of liposomal encapsulated bupivacaine. The safety profile of LB has been investigated and adverse events are similar to standard bupivacaine and demonstrate acceptable tolerability. Multiple studies have demonstrated efficacy of this drug compared to other pain control modalities. LB is highly technique dependent and only one piece of a multimodal pain management protocol. Our study consisted of 1808 consecutive primary TKA patients from Sept 2013 to Sept 2015. Three patient cohorts were compiled by date, from Sept 2013 to May 2014 was cohort 1, consisting of FNB and PCA. Department wide adoption of LB began in May 2014 and became routinely used in all patients undergoing total joint arthroplasty at our institution. Cohort 2 entailed a PCA along with LB injection from May 2014 through Feb 2015. Cohort 3 consisted of LB injection only and was from Feb 2015 through Sept 2015. All patients undergoing TKA were eligible and there were no exclusion criteria as long as the protocols were followed. The standard multi-modal analgesia protocol was provided to all patients in all three cohorts. Prior to entering the operating room, patients received preemptive oral analgesics, consisting of: 200 mg celecoxib, 1000 mg acetaminophen, and 50 mg pregabalin. Intra-operative analgesia was chosen at the discretion of the anesthesiologist and preferentially consisted of spinal anesthesia with general anesthesia as an alternate. For all three cohorts, a peri-incisional analgesic cocktail was injected prior to closure consisting of: 40 cc 0.25% Marcaine, 5 cc of (1 mg/cc) morphine, and 1 cc of (30 mg/cc) ketorolac. Cohorts 1 and 2 received PCA post-operatively for pain control post-operatively with prn oral narcotic administration as well. Cohort 3 did not receive a PCA. The cohort treated without FNB and without a PCA using a multimodal pain management protocol including a short acting periarticular injection and a longer acting periarticular injection with LB, had equivalent pain control, less narcotic use, faster achievement of physical therapy milestones, earlier and more frequent discharge home, less complications and a lower cost of the episode of care

Introduction. Knee osteoarthritis is a leading cause of disability around the world. Traditionally, total knee arthroplasty (TKA) is the gold standard treatment; however, unicompartmental knee arthroplasty (UKA) has emerged as a less-invasive alternative to TKA. Patients with UKAs participate earlier with physical therapy (PT), have decreased complications, and faster discharges (1, 2). As UKA has evolved, so has computer navigation and robotic technology. The Robotic Assisted UKA combines the less invasive approach of the UKA with accurate and reproducible alignment offered by a robotic interface (3)(Figure1). A key part of a patient's satisfaction is perioperative pain control. Femoral nerve blocks (FNB) are commonly performed to provide analgesia, though they cause quadriceps weakness which limits PT (4). An alternative is the adductor canal block (ACB) which provides analgesia while limiting quadriceps weakness (4). The adductor canal is an aponeurotic structure in the middle third of the thigh containing the femoral artery and vein, and several nerves innervating the knee joint including the saphenous nerve, nerve to the vastus medialis, medial femoral cutaneous nerve, posterior branch and occasionally the anterior branch of the obturator nerve (5). In a multi-modal approach with Orthopedic Surgery, Regional Anesthesia, and PT departments, an early goal directed plan of care was developed to study ACB in UKA with a focus on analgesia effectiveness and PT compliance rates. Methods. Following IRB approval, we performed a case series including 29 patients who received a single shot ACB. Primary outcomes were distance walked with PT on postoperative day (POD) 0 and 1 and discharge day. Our secondary outcomes included Visual Analog Scale (VAS) scores in the post-anesthesia care unit (PACU), 8 and 24 hours postoperatively and oral morphine equivalents required for breakthrough pain. Results. All patients received PT prior to discharge. With respect to distance walked, the median distance on POD 0 was 26 feet (IQR 9–66), and on POD 1 was 128 feet (IQR of 80–200), and the median day of discharge was POD 1 (IQR 0–2). In this study, the patients’ median age was 64 (IQR 59–69) and the median BMI was 31 kg/m2 (IQR 22–41). The median VAS score in the PACU was 1 (IQR 0–7). The VAS scores for 8 and 24 hours were 5 (IQR 2–7) and 5 (IQR 2.7–7). Median oral morphine equivalents required for breakthrough pain were 99.5 mg (IQR 67.5–150.5 mg) (Figure 3). Conclusion. This case series supports that a single shot ACB facilitates early PT and hospital discharge in patients post UKA

Background. Continuous epidural anesthesia or femoral nerve block has decreased postoperative pain after total knee arthroplasty to some extent. Although the established efficacy of these pain relief method, some adverse events such as hematoma or muscle weakness are still problematic. Intraoperative local infiltration of analgesia (LIA) has accepted as a promising pain control method after total knee arthroplasty. The safety and efficacy of LIA has been reported, although there are still limited evidence about the effect of LIA on quadriceps function and recovery of range of motion in early post-operative phase. The purpose of this study is to compare the quadriceps function and range of motion after TKA between the LIA with continuous epidural anesthesia and continuous epidural anesthesia alone. Methods. Thirty patients with knee osteoarthritis who underwent primary TKA were included in this study. Patients who took anticoagulants were treated continuous epidural anesthesia alone (n=11) and the other patients were treated with LIA with continuous epidural anesthesia (n=19). A single surgeon at our department performed all surgeries. Surgical procedure and rehabilitation process was identical between two groups. Before the implantation, analgesic drugs consisting of 20 ml of 0.75 % ropivacaine and 6.6 mg of dexamethasone were injected into the peri-articular tissues. In each group, fentanyl continuous epidural patient-controlled analgesia (PCA) was also used during 48-h post-operative period. Knee flexion and extension angle were evaluated before surgery, post-op day 3, 7, 10 and 14. The quadriceps function was evaluated by quadriceps peak torque at 30° and 60° flexion using VIODEX. The peak torque was recorded preoperatively, day 14 and 3 month after surgery. The difference between two groups was analyzed by Mann Whitney U-test using Prism 6, a statistical software. Results. LIA group showed better postoperative flexion angle until day 7 (Fig. 1). Then the discrepancy became smaller and came to the same degree at day14. The peak torque at 30° and 60° flex is higher in LIA group compared to epidural anesthesia alone. The LIA group showed less peak torque decrease at 2 weeks after surgery than epidural anesthesia alone group (Fig. 2, 3). No adverse events such as were observed in each group. Discussion. This paper demonstrated that LIA in addition to the continuous epidural anesthesia after TKA provides better quadriceps function and early recovery in knee range of motion. In this study we also used continuous epidural anesthesia, thus this study can not evaluate the stand alone LIA effects on quadriceps function and range of motion recovery. Furthermore the patients were not randomly assigned in this study, this might be another limitation of this study. In conclusion, LIA provide better quadriceps function and early recovery of range of motion in addition to the pain relief. To view tables/figures, please contact authors directly

Our aim in this audit was to determine whether intensive rehabilitation post-operatively influenced length of stay and readmission rates for patients undergoing primary total knee arthroplasty. In September 2007, a dedicated weekend physiotherapy service was set up in our Trust for patients following joint arthroplasty at a cost of £30,000 per annum. A prospective audit was conducted over two six-month periods, before and after the introduction of this service, including 202 and 240 patients respectively. Patient demographics including ASA grade and strict inclusion and exclusion criteria were used. The effect of anaesthetic type on post-operative pain control was also reviewed. Chi-squared and Mann-Whitney tests were used to analyse non-parametric data. In the second cohort, with intensive rehabilitation, a statistically significantly higher number of patients were discharged within seven days of admission (64% vs 36%, p<0.01). This was despite there being a significantly higher number of patients with high ASA grades 3-4 in this cohort (37% vs 27%, p<0.05). The median length of stay in the second cohort was seven days compared to eight in the first cohort. There was a slight increase in rate of readmission within the second cohort but this was not statistically significant. We found that the addition of a femoral nerve block significantly reduced post-operative pain. We concluded that an annual financial saving to the Trust of approximately £118,000 could be made by the addition of an additional dedicated physiotherapist in our unit. Patients can be safely discharged sooner with intensive rehabilitation and may benefit in the longer term by improved knee function

STUDY PURPOSES. To evaluate the role of “top up” intra-articular local anaesthetic injection in patients who have had UKR. METHOD AND RESULTS. 43 patients scheduled to have a cemented Oxford UKR were prospectively recruited and randomised. All patients had the same initial anaesthetic regime of general anaesthesia, femoral nerve block and intra-operative intra-articular infiltration. All patients had a multi-holed epidural catheter placed intra-articularly prior to wound closure. Patients had the same operative technique, post operative rehabilitation and rescue analgesia. An independent, blinded observer recorded post-operative pain scores using a visual analogue score every 6 hours and any rescue analgesia. On the morning after surgery, 22 patients, (Group I), received 20 mls of 0.5% bupivicaine through the catheter whilst 21, (Group II), patients had 20 mls of normal saline by the same observer, after which the catheter was removed. No statistical difference was found in pain scores on the day of operation between the groups. However, patients in Group I had a significantly better pain score initially post top up and at 6 hours (2.4 (0-8) vs 5.7 (2-9), p<0.001). This cohort of patients required less rescue analgesia (p<0.001). In addition, Group I had statistically significant higher patient satisfaction outcome scores after the infiltration, (p<0.001). CONCLUSION. Our study has shown that injection of local anaesthesia via an intra-articular catheter does reduce pain scores when compared to placebo. This implies that this technique may have a role in providing optimal pain relief after UKR

Purpose: After surgeons at a regional centre for orthopaedics began to use a simplified version of multimodal analgesia protocol in total knee arthroplasty (TKA), using intra-operative periarticular infiltration of bupivacaine and epinephrine, it was decided to review which methods of anaesthesia and analgesia were being used in the unit and how effective these were in terms of postoperative analgesic requirements and patient mobility. Methods: A retrospective casenote review was conducted of 67 consecutive patients undergoing primary TKA. Data were collected in the areas of demographics, anaesthetic analgesia, mobility and length of stay. Results: Of 67 patients, 31 received periarticular local anaesthetic, 23 underwent femoral nerve block and 13 had neither. Patients who had the periarticular injection required significantly less morphine. In addition, length of stay was shorter and mobility was achieved sooner in these patients. Discussion: Our technique of periarticular injection is the simplest to be described to date, using injection of bupivacaine and epinephrine alone. Unlike most previous studies, we have shown a significant improvement in postoperative mobility and a reduction in length of hospital stay, as well as confirming previous findings of a reduction in the use of opioids. This study also confirms the efficacy of bupivacaine in periarticular injections, as most previous trials have used ropivacaine, and shows that the technique is practical for use in an NHS orthopaedic unit. Conclusion: This study has described the use of a simple technique of analgesia by periarticular injection, which has reduced the amount of opiate analgesia required postoperatively, as well as showing benefits in mobility and length of hospital stay

Dexmedetomidine, an alpha 2 agonist, has been approved for providing sedation in the intensive care unit. Along with sedative properties, it has analgesic activity through its highly selective action on alpha 2 receptors. Recent studies have examined the use of dexmedetomidine as an adjuvant to prolong the duration of peripheral nerve blocks. Studies showing effectiveness of dexmedetomidine for adductor canal block in knee surgery are small. Also, its effectiveness has not been compared to Epinephrine which is a strong alpha and beta receptor agonist. In a previous study, we showed that motor sparing knee blocks significantly increased the duration of analgesia compared with periarticular knee infiltration using local anesthetic mixture containing Epinephrine following total knee arthroplasty (TKA). In this study, we compared two local anesthetic mixtures: one containing Dexmedetomidine and the other Epinephrine for prolongation of motor sparing knee block in primary TKA patients. After local ethics board approval and gaining Notice of Compliance (NOC) from Health Canada for use of Dexmedetomidine perineurally, 70 patients between the ages 18 – 95 of ASA class I to III undergoing unilateral primary total knee arthroplasty were enrolled. Motor sparing knee block − 1) Adductor canal continuous catheter 2) Single shot Lateral Femoral Cutaneous Nerve block 3) Single shot posterior knee infiltration was performed in all patients using 60 ml mixture of 0.5% Ropivacaine, 10 mg Morphine, 30 mg Ketorolac. Patients randomized into the Dexmedetomidine group (D) received, in addition to the mixture, 1mcg/kg Dexmedetomidine and the Epinephrine (E) group received 200mcg in the mixture. The primary outcome was time to first rescue analgesia as a surrogate for duration of analgesia and secondary outcomes were NRS pain scores up to 24 hours and opioid consumption. The time to first rescue analgesia was not significantly different between Epinephrine and dexmedetomidine groups, Mean and SD 18.45 ± 12.98 hours vs 16.63 ± 11.80 hours with a mean difference of 1.82 hours (95% CI −4.54 to 8.18 hours) and p value of 0.57. Pain scores at 4, 6, 12, 18 and 24 hours were comparable between groups. Mean NRS pain scores Epinephrine vs Dexmedetomidine groups were 1.03 vs 0.80 at 4 hours, 1.48 vs 3.03 at 6 hours, 3.97 vs 4.93 at 12 hours, 5.31 vs 6.18 and 6.59 v 6.12 at 24 hours. Opioid consumption was also not statistically significant between both groups at 6, 12 18, 24 hours (p values 0.18, 0.88, 0.09, 0.64 respectively). Dexmedetomidine does not prolong the duration of knee motor sparing blocks when compared to Epinephrine for total knee arthroplasty. Pain scores and opioid consumption was also comparable in both groups. Further studies using higher dose of dexmedetomidine are warranted

Purpose: While several studies have reported improved pain control with use of femoral nerve blocks (FNB) following ACL reconstruction, there are few studies that have evaluated the effect of continuous perineural infusion on quadriceps activation and recovery of range of motion after ACL reconstruction. The purpose of this prospective randomized placebo-controlled clinical trial was to determine if the use of continuous infusion of levobupivacaine for pain control following ACL reconstruction had an adverse effect on postoperative quadriceps activation and recovery of ROM. Method: Two-hundred-seventy patients underwent ACL reconstruction and were randomly assigned to one of three FNB groups (placebo bolus and infusion, active bolus with placebo infusion, or active bolus and continuous infusion). The patients’ ability to perform a SLR was assessed daily for the first four post-operative days. Range of motion of the knee was measured with a goniometer 1, 4, 8 and 12 weeks after surgery. Range of motion complications requiring arthroscopic debridement, manipulation under anesthesia, or application of a drop-out cast were recorded. Results: There were no significant differences between groups in their ability to perform a SLR on postoperative day 1 through 4. There were also no differences between active and passive ROM values between groups at each follow-up period. There were 7 (3.2%) early ROM complications, but no detectable differences between groups. Conclusion: Continuous perineural infusion of levobupivacaine (0.25% at 5mL/hr for 50 hours) following ACL reconstruction does not appear to negatively influence quadriceps activation as evidenced by the inability to perform a SLR or adversely affect recovery of range of motion in the early postoperative period after ACL reconstruction. Continuous perineural infusion can provide effective pain relief without adversely affecting post-operative recovery following ACL reconstruction

Introduction: Day-stay anterior cruciate ligament (ACL) reconstruction is commonly performed in North America. We report our experience in New Zealand. Methods: One hundred and sixteen arthroscopic ACL reconstructions were performed by one surgeon with the same anaesthetist over a period of 14 months. One hundred and four were performed as day-stay procedures. Children and patients who had no social support stayed overnight. All patients underwent spinal anaesthesia with a femoral nerve block. Patients were discharged with oral analgesia, a brace and a cryocuff. One hundred and three patients were prospectively evaluated after two weeks by a visual analogue pain scores (0–10) and a self-administered patient satisfaction questionnaire. Results: One hundred and two patients (99%) were happy to go home. One patient was admitted from the day-stay unit. One patient was re-admitted in the middle of the night. Ninety eight patients (93%) coped on the night of surgery and did not think they should have been in hospital. The mean visual analogue pain score at discharge was 1.0, in the middle of the first night was 1.8 and was 2.1 on the first day post op. Patients experienced significantly more pain the day after surgery than the night of surgery (p= 0.04). Conclusion: Day-stay ACL reconstruction was well tolerated by most patients

Aims

Single-shot adductor canal block (ACB) after total knee arthroplasty (TKA) for postoperative analgesia is a common modality. Patients can experience breakthrough pain when the effect of ACB wears off. Local anaesthetic infusion through an intra-articular catheter (IAC) can help manage breakthrough pain after TKA. We hypothesized that combined ACB with ropivacaine infusion through IAC is associated with better pain relief compared to ACB used alone.

Introduction. The peri-operative analgesic management of patients having either Total Knee Replacement (TKR) or Unicompartmental Knee Replacement (UKR) is an area that continues to have prominence, driven in part by the desire to reduce hospital stay, while maintaining high patient satisfaction. This is particularly relevant in the current climate of healthcare cost savings. We evaluated the role of “top up” intra-articular local anaesthetic injection after identifying that an appreciable number of patients in the unit suffered “breakthrough pain” on the first post-op day, when the effects of local analgesia are wearing off. Method. 43 patients, who were scheduled to have a cemented Oxford UKR, were prospectively recruited and randomised. All patients had the same initial anaesthetic regime of general anaesthesia, femoral nerve block and intra-operative intra-articular infiltration of the cocktail. All patients had a 16G multi-holed epidural catheter placed intra-articularly prior to wound closure. Patients had the same operative technique, post operative rehabilitation and rescue analgesia. An independent observer recorded post-operative pain scores using a visual analogue score (1–10) every 6 hours and any rescue analgesia that was required. On the morning after surgery, 22 patients, (Group I), received 20 mls of 0.5% bupivicaine through the catheter whilst 21 patients, (Group II), had 20 mls of normal saline by the same observer, (who was blinded to the contents of the solution being injected), after which the catheter was removed. Results. When comparing these two groups there was no statistical difference found in their pain scores on the day of operation. However, patients in Group I had a significantly better pain score initially post top up and then at 6 hours (2.4 (0–8) vs 5.7 (2–9), Mann-Whitney p<0.001). This cohort of patients required less rescue analgesia (22% vs 75%, Mann-Whitney p<0.001). In addition, Group I had statistically significant higher patient satisfaction outcome scores after the infiltration, (p<0.001), with 16 reporting very good satisfaction in comparison to 1 in Group II. There were no complications in either group. Discussion. Our study has shown that injection of local anaesthesia via an intra-articular catheter does reduce pain scores when compared to placebo. This implies that this technique may have a role in providing optimal pain relief after UKR

Introduction. In Japan, edoxaban has been used for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) since June 2011. Edoxaban is an oral direct factor Xa inhibitor, expected to be more convenient for the postoperative treatment of TKA. Enoxaparin, a II and Xa inhibitor, was approved in Japan for the prevention of VTE in patients undergoing orthopedics surgery from 2008. In this study, the effect for the prevention of VTE after TKA was compared between these two drugs in Japanese patients. Patients and Methods. We studied 42 Japanese patients who underwent TKA from May 2011 to April 2012. The operations were performed under general anesthesia, continuous femoral nerve block, an air tourniquet, and using cements for implant fixation. These patients were divided in two groups, use of 30 mg edoxaban once daily (ED group), and use of 1000 IU of enoxaparin twice daily (EN group). The initial dose was administered between 12 and 21 hours after surgery. We compared the incidence of VTE, bleeding complications, D dimer levels, and hemoglobin (Hb) loss. The screening of VTE was performed by enhanced CT scan screening from the chest to the foot on postoperative day 5 or 6 in all patients. The bleeding complication was divided into major bleeding and minor bleeding with Japanese guideline for the prevention of VTE. D dimer levels and Hb levels were preoperatively and postoperative day 1, 3, 5, 7, and 14. The loss of Hb was calculated from preoperative Hb level minus lowest postoperative Hb level. Results. The following results is showed in the order as ED group, EN group. The incidence of VTE was 45%, 32%, that was higher in ED group (see figure 1). There were almost no differences between both groups about D dimer levels and Hb loss in follow up period (see figure 2, 3). There were no major bleeding in both groups. The incidence of minor bleeding were 20%, 32%, that was higher in EN group (see figure 4). Discussion. We compared the effect of edoxaban and enoxaparin for the prevention of VTE. These two drugs are different way of administration. Edoxaban is administered orally, on the other enoxaparin requires with hypodermic injection. Therefore edoxaban is expected to be more convenient and less complaints than enoxaparin for the prevention of VTE. However our study showed that the use of 30 mg edoxaban once daily was less efficacy than the use of enoxaparin 1000 IU twice daily. The bleeding complication was lower incidence in the edoxaban, thus consideration should be given to the administration dosage of edoxaban to Japanese patients