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The Bone & Joint Journal
Vol. 103-B, Issue 7 | Pages 1247 - 1253
1 Jul 2021
Slullitel PA Oñativia JI Zanotti G Comba F Piccaluga F Buttaro MA

Aims

There is a paucity of long-term studies analyzing risk factors for failure after single-stage revision for periprosthetic joint infection (PJI) following total hip arthroplasty (THA). We report the mid- to long-term septic and non-septic failure rate of single-stage revision for PJI after THA.

Methods

We retrospectively reviewed 88 cases which met the Musculoskeletal Infection Society (MSIS) criteria for PJI. Mean follow-up was seven years (1 to 14). Septic failure was diagnosed with a Delphi-based consensus definition. Any reoperation for mechanical causes in the absence of evidence of infection was considered as non-septic failure. A competing risk regression model was used to evaluate factors associated with septic and non-septic failures. A Kaplan-Meier estimate was used to analyze mortality.


The Bone & Joint Journal
Vol. 103-B, Issue 7 | Pages 1222 - 1230
1 Jul 2021
Slullitel PA Garcia-Barreiro GG Oñativia JI Zanotti G Comba F Piccaluga F Buttaro MA

Aims

We aimed to compare the implant survival, complications, readmissions, and mortality of Vancouver B2 periprosthetic femoral fractures (PFFs) treated with internal fixation with that of B1 PFFs treated with internal fixation and B2 fractures treated with revision arthroplasty.

Methods

We retrospectively reviewed the data of 112 PFFs, of which 47 (42%) B1 and 27 (24%) B2 PFFs were treated with internal fixation, whereas 38 (34%) B2 fractures underwent revision arthroplasty. Decision to perform internal fixation for B2 PFFs was based on specific radiological (polished femoral components, intact bone-cement interface) and clinical criteria (low-demand patient). Median follow-up was 36.4 months (24 to 60). Implant survival and mortality over time were estimated with the Kaplan-Meier method. Adverse events (measured with a modified Dindo-Clavien classification) and 90-day readmissions were additionally compared between groups.


The Bone & Joint Journal
Vol. 103-B, Issue 1 | Pages 79 - 86
1 Jan 2021
Slullitel PA Oñativia JI Cima I Zanotti G Comba F Piccaluga F Buttaro MA

Aims

We aimed to report the mid- to long-term rates of septic and aseptic failure after two-stage revision surgery for periprosthetic joint infection (PJI) following total hip arthroplasty (THA).

Methods

We retrospectively reviewed 96 cases which met the Musculoskeletal Infection Society criteria for PJI. The mean follow-up was 90 months (SD 32). Septic failure was assessed using a Delphi-based consensus definition. Any further surgery undertaken for aseptic mechanical causes was considered as aseptic failure. The cumulative incidence with competing risk analysis was used to predict the risk of septic failure. A regression model was used to evaluate factors associated with septic failure. The cumulative incidence of aseptic failure was also analyzed.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_11 | Pages 26 - 26
1 Aug 2018
Buttaro M Slullitel P Sánchez M Greco G McLoughlin S García-Ávila C Comba F Zanotti G Piccaluga F
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Although there is some clinical evidence of ceramic bearings being associated with a lower infection rate after total hip arthroplasty (THA), available data remains controversial since this surface is usually reserved for young, healthy patients. Therefore, we investigated the influence of five commonly-used biomaterials on the adhesion potential of four biofilm-producing bacteria usually detected in infected THAs.

In this in-vitro research, we evaluated the ability of S. aureus, S. epidermidis ATCC 35984, E. coli ATCC 25922 and P. aeruginosa to adhere to the surface of solid biomaterials, including a 28mm cobalt-chromium metal head, a 28mm fourth-generation ceramic head, a 48mm fourth-generation ceramic insert, a 48mm highly-crossed linked polyethylene insert and a 52mm titanium porous-coated acetabular component. After an initial vortex step, a bacterial separation from the surface of each specimen was done until no remaining attached bacteria were observed by digital optical microscope. The colony-forming units were counted to determine the number of viable adherent bacteria and the bacterial density.

We found no differences on global bacterial adhesion between the different surfaces. E. coli presented the least adherence potential among the analysed pathogens (p<0.001). The combination of E. coli and S. epidermidis generated an antagonist effect over the adherence potential of S. epidermidis individually (58±4% vs. 48±5%; p=0.007). The combination of P. aeruginosa and S. aureus presented a trend to an increased adherence of P. aeruginosa independently, suggesting an agonist effect (71% vs. 62%; p=0.07).

In this study, ceramic bearings appeared not to be related to a lower bacterial adhesion than other biomaterials. However, different adhesive potentials among bacteria may play a major role on infection's inception.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 33 - 33
1 Jan 2018
Buttaro M Slullitel P Estefan M Ramírez W Comba F Zanotti G Piccaluga F
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Following a total hip arthroplasty (THA), early hospital readmission rates of 3–8% are considered as ‘acceptable’ in terms of medical care cost policies. Surprisingly, the impact of readmissions on mortality has not been priorly portrayed. Therefore, we aimed to analyse the mortality of unplanned readmissions after primary THA at a high-volume Argentinian center.

We prospectively analysed 90-day readmissions of 815 unilateral, elective THA patients operated between 2010–2014 whose medical insurance was the one offered by our institution. Mean follow-up was 51 months (range, 37–84). Median age was 69 (IQR, 62–77). We stratified our sample into readmitted and non-readmitted cohorts. Through a Cox proportional hazard model, we compared demographic characteristics, clinical comorbidities, surgical outcomes and laboratory values between both groups in order to determine association with mortality.

We found 37 (4.53%) readmissions at a median time of 40.44 days (IQR: 17.46–60.69). Factors associated with readmission were: hospital stay (p=0.00); surgical time (p=0.01); chronic renal insufficiency (p=0.03); ASA class 4 (p=0.00); morbid obesity (p=0.006); diabetes (p=0.04) and a high Charlson Index (p=0.00). Overall mortality rate of the series was 3.31% (27/815). Median time to mortality was 455.5 days (IQR: 297.58–1170.65). One-third (11/37) of the readmitted patients died, being sepsis non-related to the THA the most common cause of death. After adjusting for confounders, 90-day readmissions remained associated with mortality with an adjusted HR of 3.14 (CI95%: 1.05–9.36, p=0.04).

Unplanned readmissions were an independent risk factor for future mortality, increasing 3 times the risk of a decease eventuality.


The Bone & Joint Journal
Vol. 99-B, Issue 11 | Pages 1435 - 1441
1 Nov 2017
Buttaro MA Oñativia JI Slullitel PA Andreoli M Comba F Zanotti G Piccaluga F

Aims

The Corail stem has good long-term results. After four years of using this stem, we have detected a small group of patients who have presented with symptomatic metaphyseal debonding. The aim of this study was to quantify the incidence of this complication, to delineate the characteristics of patients presenting with this complication and to compare these patients with asymptomatic controls to determine any important predisposing factors.

Patients and Methods

Of 855 Corail collarless cementless stems implanted for osteoarthritis, 18 presented with symptomatic metaphyseal debonding. A control group of 74 randomly selected patients was assembled. Clinical and radiological parameters were measured and a logistic regression model was created to evaluate factors associated with metaphyseal debonding.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 21 - 21
1 Jun 2017
Buttaro M Zanotti G Comba F Slullitel P Piccaluga F
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Femoral offset restoration is related to low rates of wear and dislocation. Replication of the native hip anatomy improves prosthesis survival, whereas increasing the femoral offset elevates the torque stresses, thus inducing a risk of suboptimal stem fixation.

Although the Corail (DePuy Synthes, St Priest, France) uncemented stem has an excellent record of fixation, an unexpectedly number of aseptic loosenings has been noted in our institution.

We sought to characterize the clinical parameters observed in a group of patients who have experienced metaphyseal aseptic loosenings with the collarless version of the Corail uncemented femoral component; describe the radiographic findings in this group of patients; expose the intraoperative findings in the cases that needed revision surgery and to calculate a possible frequency of this complication.

We present a series of 15 metaphyseal debondings of the collarless version of the Corail uncemented stem in primary total hip arthroplasty. Eleven men and four woman with an average age of 60 years old (range: 42 to 81 years old) and a previous history of osteoarthritis presented with thigh pain and limping at an average of 33 months postoperative (range: 5 to 100 months). Seven cases presented a Dorr´s classification type A femur and 8 cases a type B femur. In 10 of the 15 cases a 36 mm ceramic on ceramic bearing surface was implanted and in 5 a 28 mm diameter ceramic on polyethylene pair. Radiographic assessment of the failures evidenced an increase in femoral offset of 6.2 mm in average (range: 0 to 17 mm). Nine of the 15 cases had a standard offset stem and 3 an extended offset stem. Leg length discrepancy was in average 2.4 mm (range: 0 to 8 mm). None of the failures presented a more than 2 mm subsidence. Alignment of these stems was in average 2.1 degrees of varus (range: 0 to 5 degrees).

Six cases were revised to a long cemented or uncemented stem, 2 cases were lost and 7 cases are awaiting revision surgery. Although the incidence of this complication was low (15 failures in 855 cases in 10 years = 1.75%), we are concerned about the real magnitude of this problem, as this mode of failure was observed up to 8 years after implantation.

Enhanced lateralization of the hip, independently of the type of stem, may have played a role in the infrequent early failures of this popular design. Routine use of “fine tunning” preoperative planning in order to avoid offset enhancement is strongly reccommended, as this was the only suspected factor that was present in almost all the failures we observed.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 2 | Pages 167 - 172
1 Feb 2012
Buttaro MA Costantini J Comba F Piccaluga F

We determined the midterm survival, incidence of peri-prosthetic fracture and the enhancement of the width of the femur when combining struts and impacted bone allografts in 24 patients (25 hips) with severe femoral bone loss who underwent revision hip surgery. The pre-operative diagnosis was aseptic loosening in 16 hips, second-stage reconstruction in seven, peri-prosthetic fracture in one and stem fracture in one hip. A total of 14 hips presented with an Endoklinik grade 4 defect and 11 hips a grade 3 defect. The mean pre-operative Merle D’Aubigné and Postel score was 5.5 points (1 to 8).

The survivorship was 96% (95% confidence interval 72 to 98) at a mean of 54.5 months (36 to 109). The mean functional score was 17.3 points (16 to 18). One patient in which the strut did not completely bypass the femoral defect was further revised using a long cemented stem due to peri-prosthetic fracture at six months post-operatively. The mean subsidence of the stem was 1.6 mm (1 to 3). There was no evidence of osteolysis, resorption or radiolucencies during follow-up in any hip. Femoral width was enhanced by a mean of 41% (19% to 82%). A total of 24 hips had partial or complete bridging of the strut allografts.

This combined biological method was associated with a favourable survivorship, a low incidence of peri-prosthetic fracture and enhancement of the width of the femur in revision total hip replacement in patients with severe proximal femoral bone loss.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 531 - 531
1 Oct 2010
Tanoira I Buttaro M Comba F Marcos L Garrido CP Piccaluga F Rial P Zanotti G
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Background: Infection diagnosis in THA remains difficult in some cases. Intraoperative analysis of frozen sections is related to the high sensitivity, specificity, positive predictive value, negative predictive value and accuracy. However, it is a technically demanding procedure and is not a universally accepted method. In the present study, we compared interleukin-6 (IL6) serum level with the erythrocyte sedimentation rate (ESR), the level of C-reactive protein (CRP) and the analysis of frozen sections of intraoperative specimens (FS).

Materials: Sixty-nine patients with a THA needing a reoperation due to a suspected infection or another aseptic failure were studied. Patients with chronic inflam-matory diseases, antibiotic treatment prior to surgery, Paget’s diseases and immunodeficiency syndromes were excluded from the study. The mean age at the time of the operation was 68 years old (range: 39 to 91). ESR, CRP and the serum level of IL6 were measured in blood samples before surgery. The cut-off levels were: ESR: ≥ 32 mm/hr, CRP: ≥ 3.2 mg/dl and interleukin-6 ≥ 12 pg/ml. Intraoperatively, samples of tissues were taken to be analyzed immediately on FS, to be routinely processed at the moment and to be referred for bacteriological cultures and histological study.

Results: Eleven (16%) of the 69 hips were infected. ESR showed a sensitivity of 0.72 (0.41 to 1.00), a specificity of 0.86 (0.76 to 0.95), a positive predictive value of 0.50 (0.22 to 0.77), and a negative predictive value of 0.94 (0.84 to 1.00).CRP showed a sensitivity of 0.72 (0.41 to 1.00), a specificity of 0.91 (0.83 to 0.99), a positive predictive value of 0.61 (0.31 to 0.91), and a negative predictive value of 0.94 (0.87 to 1.00). IL6 showed a sensitivity of 0.36 (0.30 to 0.69), a specificity of 0.94 (0.88 to 1.00), a positive predictive value of 0.57 (0.13 to 1.00), and a negative predictive value of 0.88 (0.80 to 0.97). The evaluation of the FS showed a sensitivity of 0.81 (0.54 to 1.00), a specificity of 0.98 (0.94 to 1.00), a positive predictive value of 0.90 (0.66 to 1.00), and a negative predictive value of 0.96 (0.91 to 1.00).The combination of CRP and IL6 identified all patients with deep infection of the implant and showed a sensitivity of 0.57 (0.13 to 1.00), a specificity of 1.00 (0.99 to 1.00), a positive predictive value of 1.00 (0.87 to 1.00), and a negative predictive value of 0.94 (0.87 to 1.00).

Conclusion: In this study, we obtained similar results combining CRP and IL6 as with the analysis of the frozen sections, which has been in the past our first option to determine whether a THA is infected or not. IL6 and CRP may be used as a valuable routine diagnostic tool in revision THA.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 171 - 171
1 Mar 2009
Buttaro M Guala A Comba F Piccaluga F
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Containment of bone defects is one of the main requisites for using the bone impaction grafting technique. When the proximal femur is absent, circumferential meshes in combination with impacted bone allografts and long stems could be an alternative method. However, the initial stability of this femoral stems has not been evaluated and we were not able to find any series in the literature that includes a group of patients treated with this method.

This study has two purposes: one is to analyze the initial resistance in vitro to axial and rotational forces of a fresh frozen bovine model with a complete loss of the proximal femur reconstructed with a circumferential metal mesh containing impacted bone allografts and a long polished cemented stem. The second is to present the short-term clinical and radiographic evaluation in a group of patients with massive bone loss of the proximal femur that were reconstructed with this method.

Four femurs with an 8 cm proximal bone defect were reconstructed with a circumferential metal mesh, impacted bone grafts and a cemented long stem (group 1). Results were compared with 4 cases presenting an intact proximal femur in which the same stem was implanted (group 2).

Thirteen patients with complete massive proximal femoral bone defects (average 12 cm long) were reconstructed with a circumferential metal mesh, impacted bone allografts and a long cemented stem (average 217 cm long).

Failure mode was characterized by subsidence under axial load in group one at 617 kg and by periprosthetic fracture in control group at 1335 kg. Under rotational load, group 1 femurs failed at the cement interface at an average of 79 kg and the intact femurs presented a fracture at an average of 260 kg.

At 25 months follow-up, 6 patients had to be reoperated. We observed 2 fractures of the metal mesh at 31 and 48 months in cases reconstructed with a Charnley stem that did not by pass the mesh. Three patients presented one dislocation that needed open reduction in 2 cases. Two acute deep infections were treated with debridement, antibiotics and component retention.

This model presented a 50% resistance to axial load and 30% resistance to rotational load compared to an intact femur with the same implant. However, this resistance is by far higher than the physiologic load occurring in a normal femur during gait.

Although the incidence of complications in this patients was high, this was related to the complexity of the cases. Failures of the system were not observed except in the 2 cases presenting technical defects.

This experimental initial stability and early clinical as well as radiographic results encourage the use of circumferential meshes to contain impacted bone allografts combined with long cemented stems in complex revision hip surgery.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 2 | Pages 228 - 231
1 Feb 2008
Buttaro M Araujo GS Araujo ES Comba F Piccaluga F

Metal meshes are used in revision surgery of the hip to contain impacted bone grafts in cases with cortical or calcar defects in order to provide rotational stability to the stem. However, the viability of bone allografts under these metal meshes has been uncertain.

We describe the histological appearances of biopsies obtained from impacted bone allografts to the calcar contained by a metal mesh in two femoral reconstructions which needed further surgery at 24 and 33 months after the revision procedure.

A line of osteoid and viable new bone was observed on the surface of necrotic trabeculae. Active bone marrow between these trabeculae showed necrotic areas in some medullary spaces with reparative fibrous tissue and isolated reactive lymphocytes. This is interpreted as reparative changes after revascularisation of the cancellous allografts.

These pathological findings are similar to those reported in allografts contained by cortical host bone and support the hypothesis that incorporation of morcellised bone under metal meshes is not affected by these devices.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 7 | Pages 865 - 869
1 Jul 2006
Comba F Buttaro M Pusso R Piccaluga F

We reviewed the clinical and radiological results of 131 patients who underwent acetabular revision for aseptic loosening with impacted bone allograft and a cemented acetabular component. The mean follow-up was 51.7 months (24 to 156).

The mean post-operative Merle D’Aubigné and Postel scores were 5.7 points (4 to 6) for pain, 5.2 (3 to 6) for gait and 4.5 (2 to 6) for mobility. Radiological evaluation revealed migration greater than 5 mm in four acetabular components. Radiological failure matched clinical failure. Asymptomatic radiolucent lines were observed in 31 of 426 areas assessed (7%). Further revision was required in six patients (4.5%), this was due to infection in three and mechanical failure in three. The survival rate for the reconstruction was 95.8% (95% confidence interval 92.3 to 99.1) overall, and 98%, excluding revision due to sepsis.

Our study, from an independent centre, has reproduced the results of the originators of the method.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 68 - 68
1 Mar 2006
Farfalli G Buttaro M Piccaluga F
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Background: The use of impacted morselized allograft bone and cement in hip revision arthroplasty has proved to be a useful technique for reconstructing femoral bone stock. Studies that specifically address intraoperative and early postoperative femoral fractures and their relationship with bone deficiency, surgical approach or events, fixation of removed implant as well design of implanted stem have been scarce.

Methods: Two hundred and eighty five consecutive hip revision arthroplasties with impacted morselized allograft bone were studied.

Clinical and radiographic follow-up evaluation was performed and all kind of femoral fractures and incidental perforations during the surgery and within the first year after were analysed.

Results: Sixty four (22,4 %) femurs were affected with an incidental perforation or fracture during the surgery and within the first year after. Intraoperative fracture was present in forty femurs. Twenty three were diaphyseal vertical cracks, eight proximal vertical cracks, four fractures of the greater trochanter and two complete diaphyseal fractures. Incidental femoral perforation was present in twenty five femurs.

Six fractures occurred during the first year. Four patients of the femoral incidental perforation group suffered a complete diaphyseal fracture at the perforation level. No patient with a diaphyseal femoral crack suffered a complete diaphyseal fracture. Two additional complete fractures occurred during the first year without previous intraoperative complication.

Multivariate analysis showed the risk factors for femoral fractures during or after revision to be grater according to preoperative deficiency of the femoral bone stock, or the presence of an intraoperative femoral perforation. Vertical cracks, surgical approach, removal of a cemented or uncemented stem as well as design of the implanted stem showed no difference regarding this complication.

Conclusions: Even though a high rate of femoral complications (22,4 %) was observed we found that vertical cracks regardless their location and trochanteric fractures (12,2%) account for almost all of them but have no clinical relevance. Incidental perforation occurred in 9% of the cases and it was found to be related to complete femoral fractures as well as bone stock deficiency. This serious complication requiring revision occurred in only 2.8% of the cases. Due to this results we encourage the use of this technique.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 66 - 66
1 Mar 2006
Comba F Buttaro M Piccaluga F
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Acetabular bone stock loss represents one of the main challenges in revision hip surgery.

We present 149 consecutive aseptic acetabular reconstructions with impacted bone allograft technique and a cemented cup followed clinically and radiographically for an average of 52 months (range 24–156 months). Patients requiering reinforcement rings were not included in this series. Seven reconstructions in six patients were lost to follow-up.

The average postoperative Merle DAubigne and Postel score was 5.7 points for pain, 4.5 points for mobility and 5.2 points for gait. Radiographic analysis evidenced incorporation of the grafts in all but in four cups with more than 5 mm migration, demonstrating radiographic failure. All of these patients presented clinical failure as well. Non progressive radiolucent lines were observed in 29 non symptomatic patients. mainly in Zone 1 according to De Lee and Charnley. Six patients were reoperated (4.5%), 3 of them because of deep infection and 3 patients for aseptic failure related to massive segmental and cavitary defects. Overall survival rate of the acetabular reconstruction was 95.8% (CI 95%:92.3–99.1). When infected cases were excluded, this rate was 98%.

Providing precise indications, acetabular reconstruction with impacted morsellized bone allografts and cemented cups is an excellent biologic reconstructive technique in patients with bone stock deficiency


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 12 | Pages 1684 - 1687
1 Dec 2005
Buttaro MA Morandi A Rivello HG Piccaluga F

Vancomycin-supplemented allografts provide biological restoration of bone stock and sound fixation with a low incidence of re-infection. Experimental incorporation of these grafts is similar to allografts without vancomycin. However, the underlying biology remains unknown.

We report the first histological observations of vancomycin-supplemented impacted bone allografts in two reconstructions performed 14 and 20 months after revision surgery because of a periprosthetic fracture.

Areas of active bone remodelling (creeping substitution), as well as calcified bone trabeculae and graft particles embedded in dense fibrous tissue, were observed with osteoid and fibroconnective tissue surrounding polymethylmethacrylate particles.

These pathological findings are similar to those reported in allografts without vancomycin and support the hypothesis that high levels of vancomycin do not affect the incorporation of bone graft.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 255 - 255
1 Sep 2005
Buttaro M Valentini R Piccaluga F
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Introduction: Maximum effort should be taken during surgical debridement of an infected hip arthroplasty to remove all implants and cement, as also granulation, devitalized and necrotic tissue. Nevertheless, this process is sometimes technically demanding, risky for bone stock and prolongs the procedure. Residual unremoved polymethylmethacrylate (PMMA) after the resection of infected prosthetic components constitutes a controversial issue.

Material and Methods: We analyzed 10 patients with infected total hip prosthesis that had been previously treated with resection arthroplasty and antibiotics who presented persistent infection with residual cement. In 9 patients, surgical debridement with resection of all the PMMA was performed, and adequate intravenous antibiotics were administered. One patient refused surgical treatment, but accepted antibiotics.

Results: At an average 4 (1–18) years follow-up, 8 patients evolved with no signs or symptoms of recurrent infection. One severely immunodeficient patient died 2 years after the removal of residual cement for reasons other than his hip with an intermitent fistula. The patient who refused surgical treatment continues to have an active sinus 4 years after first consultation.

Conclusions: Residual cement could be responsible for chronic infection. Resection arthroplasty as part of the treatment of an infected hip arthroplasty must be precise and thorough, and all devitalized or foreign material must be removed.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 3 | Pages 314 - 319
1 Mar 2005
Buttaro MA Pusso R Piccaluga F

Bone allografts can store and release high levels of vancomycin. We present our results of a two-stage treatment for infected hip arthroplasty with acetabular and femoral impaction grafting using vancomycin-loaded allografts. We treated 29 patients (30 hips) by removal of the implants, meticulous debridement, parenteral antibiotic therapy and second-stage reconstruction using vancomycin-supplemented impacted bone allografts and a standard cemented Charnley femoral component. The mean follow-up was 32.4 months (24 to 60). Infection control was obtained in 29 cases (re-infection rate of 3.3%; 95% confidence interval 0.08 to 17) without evidence of progressive radiolucent lines, demarcation or graft resorption. One patient had a further infection ten months after revision caused by a different pathogen. Associated post-operative complications were one traumatic periprosthetic fracture at 14 months, a single dislocation in two hips and four displacements of the greater trochanter. Vancomycin-supplemented allografts restored bone stock and provided sound fixation with a low incidence of further infection.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 296 - 296
1 Mar 2004
Buttaro M Pusso R Piccaluga F
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Aims: To present a two-stage treatment protocol for a septic hip replacement that addresses infection control while restoring acetabular and femoral bone stock utilizing impaction grafting techniques with Vancomycin loaded allografts. Methods: We report 30 consecutive cases in 29 patients with a deep infected hip arthroplasty treated by excision of implants, meticulous debridement, parenteral antibiotic therapy and second-stage reconstruction with Vancomycin-supplemented impacted bone allografts implanting a Charnley prosthesis. Results: The mean follow-up was 32.4 months (24 to 60). Infection control was obtained in 29 cases (97%) without evidence of progressive radiolucent lines, demarcation or graft resorption. One case presented an overinfection 10 months after reimplantation due to a different pathogen. Associated postoperative complications were 1 traumatic periprosthetic fracture at 14 months, single dislocation in 2 cases and 4 greater trochanter migrations. Conclusions: Vancomycin-supplemented allografts biologically restored bone stock and provided sound þxation without increasing the recurrence of infection in most of the patients. Observing these results we consider that an infected hip arthroplasty can be successfully treated following this suggested protocol.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 4 | Pages 544 - 549
1 May 2002
Piccaluga F Valle AD Fernández JCE Pusso R

Impacted morcellised bone allograft and a Charnley stem was used to revise 59 loose femoral components in 57 consecutive patients. Femoral bone loss was rated as Endo-Klinik grade 2 in nine patients, grade 3 in 41, and grade 4 in nine. The immediate postoperative radiographs and those taken at the most recent follow-up were compared for radiolucencies, subsidence and incorporation of the graft. One patient was lost to follow-up and two were not available for radiological analysis.

The mean clinical follow-up in 58 procedures was 56.7 months (24 to 144) and the mean radiological review of 56 reconstructions was 54.4 months (24 to 144). An intraoperative femoral fracture occurred in one patient (1.7%) and was successfully treated by strut grafting and cerclage wiring. Extrusion of cement through perforations or incomplete hoop fractures was detected in the postoperative radiographs of ten procedures (17%); none of these patients sustained a complete fracture. Three patients had dislocations (5%) and two (3.5%) developed painful subsidence of the stem which required a further revision. The latest follow-up radiographs in 56 reconstructions showed a well fixed stem and radiological healing of the graft in 52 (93%), and definite loosening in four (7%). Of these four, two were revised again and two were asymptomatic after a follow-up of 120 months each. The mean subsidence in the 52 successful revisions was 0.38 mm (0 to 4). Impaction allografting with a Charnley stem restored bone stock and provided adequate fixation of the stem in 93% of the hips. There was a low rate of rerevision (3.5%) and a low incidence of intraoperative and postoperative complications.