Background: There are several methods to reduce anterior shoulder dislocations but only few studies compare the efficacy, safety and reliability of the different techniques. As a result, deciding which technique to use is seldom based on objective criteria. Aim of this prospective, randomized study is to introduce a new method of reduction of the anterior dislocation of the shoulder (“Fares”) and to compare it with the “Hippocrates” and “Kocher” methods, as far as its efficacy, safety and intensity of the pain felt by the patient during the reduction, are concerned.

Methods: Between September 2006 and June 2008, a total of 154 patients suffering from acute anterior shoulder dislocation (accompanied by a fracture of the greater tuberosity or not) were enrolled in the study. Patients were randomly assigned to one of the three study groups (“Fares”, “Hippocrates” and “Kocher”) and underwent reduction of their dislocation performed by first and second-year residents orthopaedic surgeons. A Visual Analogue Scale (VAS) was used to determine the intensity of the pain felt during reduction.

Results: The groups were statistically comparable (age, male/female ratio, mechanism of dislocation, mean time interval between injury and first attempt of reduction). Reduction was achieved with the “Fares” method in 88.6%, with the “Hippocrates” in 72.5% and with the “Kocher” in 68% of the patients. This difference was statistically significant, favoring the “Fares” method (p=0.033). The mean duration of the reduction (p=0.000) and the mean reported by the patients VAS with the “Fares” method (p=0.000) were also statistically significantly lower than those of the other methods. No complications were noted in any group.

Discussion: The “Fares” method was statistically proven to be a significantly more effective, faster and less painful method of reduction of the anterior shoulder dislocation, when compared with the “Hippocrates” and the “Kocher” methods. It is easily performed by only one physician, it is applicable both to anterior shoulder dislocations and fractures-dislocations and it is not more morbid that the other two methods.

Introduction: Aim of this prospective study was the evaluation of the impact of TKA on the serum level of I-PTH, as continuously elevated levels of the latter may potentially play a negative role in an orthopaedic implant’s incorporation process.

Methods: The study-group was formed by 119 post-menopausal women suffering from end-stage idiopathic knee osteoarthritis scheduled to undergo TKA. Another 110 women that underwent elective non-orthopaedic operations were used as a control-group. The serum levels of I-PTH, Ca, P & creatinine were evaluated and the clearance of creatinine was calculated one day preoperatively and on the seventh postoperative day. Patients with abnormal preoperative values, suffering from endocrinopathies, rheumatoid or other secondary arthritis, osteoporosis or diseases interfering with bone homeostasis, as well as patients receiving medication affecting bone metabolism, were excluded. None had suffered any fracture or underwent any orthopaedic operation during the 36 months prior to her enrollment.

Results: The two groups were statistically comparable [age (p=0.72), weight (p=0.43), duration of menopause (p=0.31), serum creatinine level (p=0.49), creatinine clearance (p=0.74), preoperative serum I-PTH value (p=0.67)]. Sixteen patients of the study- (13.4%) and one of the control-group had abnormally elevated post-operative I-PTH values. Further analysis showed a statistically non-significant trend towards decrease in the post-operative I-PTH values of the study-group (p=0.16) compared with the control-group’s results were the I-PTH values remained statistically unchanged (p=0.55). No statistically significant difference was found in the postoperative serum I-PTH values between the two groups (p=0.21). The patients’ weight (p=0.76), age (p=0.77), serum creatinine (p=0.92) and creatinine clearance (p=0.96) did not have a statistically significant impact on the observed alteration of I-PTH values after TKA (study-group).

Discussion/Conclusion: The serum levels of I-PTH slightly decrease following TKA. This may attributed to the necrosis or apoptosis initiated immediately after implantation, leading to increased bone resorption and increased serum calcium concentrations that may well decrease the endogenous PTH production. Another possible explanation is the temporary immobilization of the patients undergoing TKA. A substantial number of our study-group’s women had abnormally elevated post-operative I-PTH values. Regardless of what actually caused it, the negative impact of continuously elevated PTH on bone formation, may interfere with the implant’s incorporation procedure, hence the evaluation of serum I-PTH before and after TKA is strongly recommended.

Introduction: Parathyroid hormone (PTH) is a major regulator of bone metabolism. Continuously elevated levels of PTH activate osteoclasts, whereas its intermittent administration principally induces osteoblastic activity. There is increasing evidence that intermittent treatment with PTH may enhance the early fixation of orthopaedic implants. Aim of this study was the evaluation of the impact of Total Knee Replacement (TKR) on the serum level of Intact-Parathyroid Hormone (I-PTH), as continuously elevated levels of the latter may potentially play a negative role in the implant’s incorporation process.

Methods: During a period of 29 months, one hundred and nineteen postmenopausal women suffering from end-stage idiopathic knee osteoarthritis, scheduled to undergo TKR, were enrolled in this prospective study. Their mean age was 69.8 (±6.01) years. The serum levels of I-PTH, Calcium, Phosphorus & Creatinine were evaluated and the clearance of creatinine was calculated one day pre-operatively and on the seventh post-operative day. Patients with abnormal preoperative values were excluded from the study. Furthermore, patients suffering from any endocrine disorder, rheumatoid or any other secondary arthritis, osteoporosis or any other disease that could interfere with their bone homeostasis as well as patients receiving medication affecting bone metabolism, were also excluded from the study. None had suffered any fracture or underwent any orthopaedic surgical operation during the 36 months prior to their enrollment.

Results: Sixteen patients (13.4%) had abnormally elevated post-operative I-PTH values. However, statistical analysis revealed a statistically significant trend towards decrease in post-operative I-PTH values (p=0.018). The weight (p=0.763), age (p=0.776), serum creatinine level (p=0.922) and creatinine clearance of the patients (p=0.963) did not have a statistically significant impact on the observed alteration of I-PTH values after TKR.

Discussion and Conclusion: The serum levels of I-PTH seem to decrease following a TKR. This is more or less expected, as immediately after implantation, bone cells adjacent to the implant are likely to be dead due to necrosis or apoptosis. The latter is a strong stimulus for bone resorption that probably leads to increased serum calcium concentrations that may well decrease the endogenous PTH production. Another possible explanation could be the temporary immobilization of the patients undergoing TKR. However, a substantial number of women had abnormally elevated post-operative I-PTH values. Regardless of what actually caused that increase, the negative impact of continuously elevated PTH on bone formation, may interfere with the implant’s incorporation procedure, hence the evaluation of serum I-PTH before and after TKR is strongly recommended.

The use of polymethylmethacrylate (PMMA) bone cement loaded with antibiotics has become increasingly common in orthopaedic surgery. However, bacterial resistance in antibiotics is an increasing and emerging problem. PMMA bone cements containing different antibiotics, such as gentamicin plus vancomycin may be effective in prevention and treatment of infections (particularly from MRSA and MRSE).

The purpose of this study was to determine the in vitro elution characteristics of gentamicin and vancomycin when combined in acrylic cement.

Three groups of ten cement disks were prepared. Group I (control group) contained 0.5g of gentamicin per 40-g packet of Palacos-R+G powder. Group II contained 0.5g of gentamicin and 1g of powdered vancomycin and group III contained 0.5g of gentamicin and aqueous solution of vancomycin. Each cement disc (25mm x 20mm) was immersed in a 50-mL bath of normal saline at 37oC. Samples were taken at specific sampling intervals (1, 3, 7, 15, 30, 60, 90, 120, 150, 180 days). Antibiotic concentrations were measured using fluorescence polarisation immunoassay.

With regards to gentamicin release, high but rapidly decreasing antibiotic levels were detected within the first week and low concentration after the first month. Samples from Group II eluted significantly more gentamicin (120%–20% during the first month). The influence on the gentamicin release was significant but minor when aqueous solution of vancomycin (Group III) was added. With regards to vancomycin release, high antibiotic levels were detected within the first 3 days and low concentrations after the first week. Cement samples from Group II eluted significantly more antibiotic in comparison with samples from Group III.

Bone cements loaded with combinations of gentamicin and vancomycin are more effective in releasing gentamicin than bone cements with gentamicin as a single drug. Powdered vancomycin in cement samples has better elution characteristics in comparison with aqueous solution of vancomycin.

Introduction. This prospective cohort study aimed at the assessment of the incidence of indolent SH among otherwise ‘healthy’ and symptoms’ free postmenopausal women suffering from primary KOA.

Methods. During a period of 23 months (November 2004 – Sepetember 2006), two hundred and forty-two postmenopausal women suffering from primary KOA were enrolled. None of them had suffered any osteoporotic fracture, received any anti-osteoporosis treatment or suffered from any disease interfering with their bone mass/quality. The serum levels of Intact-Parathyroid Hormone (I-PTH), Calcium and Phosphorus were evaluated and Creatinine Clearance was calculated. The latter was performed in order to determine a possible relation between the patients’ renal function and the I-PTH level.

Results. The patients’ mean age was 70,20 years (range: 49–81). The years that had passed since their menopause ranged from 7 to 31 (mean of 18,7 years). The patients were divided into three groups according to their age: Group A (n=41) age < 64 years, Group B (n=140) age 65–74 years and Group C (n=61) age > 75. The overall incidence of SY in all three groups was 35,95% (87 out of 242 patients). Group C patients were most likely to suffer from SY (25 out of 61 patients or 40,98%). The I-PTH values of Group A patients were normal in 27 out of 41 patients (68,85%) and of Group B in 92 out of 140 patients (65,71%). One group B patient suffered from Primary Hyperparathyroidism. No statistically significant relation between the patient’s renal function and the I-PTH level was found.

Discussion/Conclusion. SH appears to be a ‘silent’ epidemic among elderly postmenopausal women. According to our results, women 75 years-old and older are most likely to suffer from SY. One of the main reasons for that seems to be the insufficient calcium and/or vitamin D intake. It is our belief that anti-osteoporosis diagnosis and treatment modalities should be focused on this group of patients.

Introduction: Infections with multiresistant bacteria have become a serious problem in joint arthroplasty. Vancomycin and teicoplanin showed high effectiveness against multiresistant bacteria as methicillin-resistant S.epidermidis (MRSE) and methicillin-resistant S.aureus (MRSA).

Objective: The purpose of the present study was to determine the mechanical properties of Palacos R+G cement (containing gentamicin) mixed with:

i) powdered vancomycin or teicoplanin,

Material and methods: Five groups of ten cements specimens were prepared. Group I (control group) consisting of Palacos-R+G cement samples (contained 0.5g of gentamicin sulphate). Group II consisting of Palacos-R+G cement mixed with 1g of finely powdered vancomycin. Group III contained 400mg powdered teicoplanin. Group IV cement samples contained aqueous solution of vancomycin (2mL water for injection plus 1g vancomycin) and Group V contained aqueous solution of teicoplanin (2mL water for injection plus 400mg teicoplanin). All cement specimens were prepared using vacuum mixing technique. In order to examine the mechanical properties of the specimens (25mm diameter × 20mm height), impact and compression tests were applied. The impact test is a well-established method for the characterization of materials’ fatigue properties, as well as of creep behavior determination in case of porous materials. The size of the produced impression after a certain number of impacts reveals the material strength. Furthermore, the compression resistance, i.e. the Young’s modulus and the yield strength are properties that can be calculated by the compression tests.

Results: The compression tests showed that the specimens from Group III (containing 400mg of teicoplanin) had overall better mechanical properties, having approximately 10% higher Young’s modulus in comparison with specimens from Group II (containing van-comycin) and specimens from Group III (control group). Yield strength had no significant difference between the three groups. The impact test revealed a corresponding tendency, with the specimens containing 400mg of teicoplanin having the smaller impression (increased fatigue strength) when compared with specimens from the other groups.

With regards to samples from Groups IV and V (aqueous solutions of antibiotics) mechanical properties were significant deteriorated in comparison with cement samples from the other groups.

Conclusions: The experimental data showed that the addition of 400mg teicoplanin in Palacos R+G bone cement had better mechanical properties compared with addition of 1g vancomycin or than Palacos R+G cement with gentamicin as a single drug.

Aqueous solutions of antibiotics must not be added to the bone cement because they dramatically impair mechanical properties of the cement.

Background. The postoperative salvage and re-infusion of autologous blood, has become a very attractive alternative to allogenic transfusion, especially in patients that undergo primary Total Knee Arthroplasty (TKA). The increased demand for blood that is required during this operation, the fear of transfusion-related diseases and the continuingly increasing pressure that is forced on hospitals’ blood depots has rendered this procedure quite popular. In order to assess the efficacy of autologous blood drainage and re-transfusion as far as the amount of salvaged blood, the need for allogenic transfusion and the effect of this procedure on the postoperative haemoglobin value are concerned, we conducted a prospective study.

Methods. One hundred and fifty five patients suffering from primary osteoarthritis of the knee that were treated with TKA in 2002 were included in this study. A tourniquet was used in all cases. In Group A» (n=77) it was released prior to the wound closure in order to achieve haemostasis and 2 standard suction drains were then placed. In Group B» (n=78) it remained until the completion of the operation, an auto-transfusion system was placed and the salvaged blood was re-transfused within 6 hours postoperatively. Group’s «B» patients were further divided into 2 subgroups according to the administration or not of methylprednisolone before the auto-transfusion. The patients’ haemoglobin and platelets were measured before, at 8 and 24 hours after surgery. The days of postoperative fever were also noted.

Results. Over 170 units of blood were salvaged and re-transfused. No Group B» patient received allogenic blood preoperatively. Group’s B» patients received only 42 while Group’s A» 124 units of allogenic blood. Patients who received autologous blood had higher levels of haemoglobin at 8 (p< 0.05) and at 24 hours postoperatively (p< 0.01) and needed less allogenic blood (p< 0.01). The administration of methylprednisolone ameliorated the postoperative febrile movement (p=0.01).

Conclusions. Postoperative blood salvage and re-tperfusion in patients undergoing TKA, was found to be an efficient, safe and patient-beneficial method.

Percutaneous vertebroplasty is an effective procedure for the treatment of osteoporotic vertebral compression fractures, spinal metastasis and other pathologic spinal diseases. However, there has been no mention in the relevant literature of the use of percutaneous vertebroplasty for the treatment of spinal pseudarthrosis in ankylosing sponyloarthritis. A 58-year-old male with a long standing ankylosing spondylitis presented with increasing, intolerable and non-intractable back pain. There was a 16- month-old history of a non-significant minor fall. Various radiological imaging technicques showed spinal pseudarthrosis with extensive discovertebral destruction and fracture of the posterior elements at the level T11–T12. Under local anaesthesia, and through a transpedicular approach with the guidance of CT, the cannula of a large bore needle was introduced into the level of spinal pseudarthrosis. Bone cement was then instilled into the affected spinal level. Results were documented by spiral CT and with sagittal reconstructions. Extraosseous cement leakage was seen at the puncture site of the vertebra and in the epidural veins and the paravertebral vessels. However, the patient did not present any immediate or late neurological and systemic complications. Percutaneous vertebroplasty of spinal pseudarthrosis in patients with ankylosing spondylitis is an effective procedure for stabilization of the affected spine segments and pain management.

Aims: In order to assess the potential pathologic inßuence of any Parathyroid Hormone (PTH) disturbances on the development of Slipped Capital Femoral Epiphysis (SCFE) during adolescence, we conducted a prospective clinical study. Methods: Nineteen patients in total were included in the study. Fourteen patients, 7 boys and 7 girls (16 hips), suffering from SCFE during the proceedings of this study, formed group ÔAñ. Another 5 patients that had been treated for SCFE a few years before the study, were used as a control group (group ÔBñ). We measured the level of I-PTH, along with serum Calcium (Ca) and Phosphorus (P) levels. Furthermore we checked all the necessary anthropometrical characteristics of the patients (age, height, weight and sexual maturation). Each patient of group ÔAñ was categorized from grade I to grade V according to the progress of the slipping. Results: An increased incidence (9 out of 14 patients), of serum PTH level abnormalities (both decrease and increase) in group ÔAñ was detected. Group ÔBñ patients had normal results. It is interesting that the detected I-PTH serum level abnormalities were not in any pattern related to the Ca and P serum levels. Conclusions: We believe that a temporary Parathyroid Hormone disorder or imbalance (along with others etiologic factors) during the early years of adolescence, may play a potentially signiþcant role in the development of SCFE.

Aims. The assessment of the potential pathological influence of Growth Hormone (hGH), Testosterone, Estradiol, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone in the development of SCFE and the re-evaluation of the Harris theory (increased quotient of hGH/sex hormones in patients suffering from SCFE).

Methods. Nineteen patients in total were included in the study. Fourteen patients (7 boys, 7 girls, 16 hips) suffering from SCFE during the proceeding of this study, formed group ‘A’. Another 5 patients (4 boys, 1 girl), that had been treated for SCFE a few years before the study, formed group ‘B’. We measured serum hGH, FSH, LH, Testosterone and Estradiol levels. Furthermore we checked all necessary anthropometrical and clinical characteristics (age, height & weight, sexual maturation, grade of slipping).

Results. Thirty six out of 95 in total measurements (37,9%) revealed pathological values. The majority of group A patients had pathological values (43% of measurements). The Harris theory seems to be true in 7 out of 19 in total patients: 5 group A patients (2 boys and 3 girls) and 2 group B patients (1 boy and 1 girl).

Conclusions. We believe that a temporary (?) disorder or imbalance of hGH and sexhormones, under the possible influence of FSH and LH (along with other etiologic factors) during the early years of adolescence, may play a potentially significant role in the development of SCFE.

The aim of this paper is to present our experience from the surgical treatment of lower limb fractures in the developing skeleton with the use of bio-absorbable PLLA implants as a means of internal fixation.

From 1997 until 2002, twenty-three patients (15 boys and 8 girls, ages ranging from 7 to 15 years old, mean of 12 years) who had suffered from 30 lower limb fractures were operated on in our department, with the use of PLLA screws as a means of internal fixation that followed the standard open reduction procedure.

We surgically treated 20 tibial fractures (distal metaphysis:1,medial malleolar:6,distal epiphysis lesions:9,tibial spine:2, lateral tibial condyle:1, tibial shaft:1), 8 fibular fractures (distal metaphysis:2, distal epiphysis lesions:5, fibular shaft:1), one transtrochanteric fracture and 1 patellar fracture.

All patients were operated on under constant radiographic control. A cast was applied, post-operatively, to all patients, for a period of 3–4 weeks. Gradual and assisted weight-bearing and ambulation, was commencing immediately after the cast removal.

All patient’s (with the exception of 1 case of delayed callus formation) post-operative period was completely normal. However, follow-up revealed the development of osteolytic lesions (bone absorption cysts) in 3 of our patients. All lesions were located in the border between epiphysis and metaphysis, at the exact position were the PLLA screws had been placed.

The use of PLLA implants in the treatment of fractures renders unnecessary a second operation for the removal of the osteosynthesis’ material. Nevertheless, we should be quite reluctant when deciding to use the PLLA screws in the treatment of these fractures in the developing skeleton, especially of the lower limbs, were the applied weight bearing forces are quite powerful.