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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XIV | Pages 22 - 22
1 Apr 2012
Gomez-Brouchet A Mourcin F Gourault P Bouvier C De Pinieux G Le Guellec S Brousset P Delisle M Schiff C
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Aim and purpose

The clinical management of osteosarcoma differs significantly from that of chondrosarcoma;

Therefore it is extremely important to diagnose these two types of bone tumour accurately. In the absence of a specific marker, differential diagnosis by histochemistry is sometimes impossible, especially between chondroblastic osteosarcoma and conventional chondrosarcoma. The aim of the study was to find an useful diagnostic marker, simple to use for distinguishes chondroblastic osteosarcoma from conventional chondrosarcoma.

Method

We analysed 165 bone sarcomas by immunohistochemical staining of tissue microarrays for expression of the galectin-1 (GAL1) lectin and by Western Blot experiments.