Purpose: 2–5 years results in the treatment of deep infection of total knee arthroplasty (TKA) after two-stage reimplantation are presented. An articulating antibiotic spacer prosthesis and a standardized antibiotic therapy were used.

Material and Methods: In a prospective study 33 consecutive patients were treated with the articulating spacer, which was made on the table by cleaning and autoclaving removed parts of the infected TKA. A parenteral double antibiotic therapy in combination with rifampin was given for 10 days, followed by oral therapy for 4 weeks.

Results: At a mean follow-up period of 47 months (31 to 67) three patients had reinfection (success rate 91 %). We could increase the average Hospital for Special Surgery knee score from 67 points (44 to 84) to 87 points (53 to 97) after reimplantation.

Based on these results, 25 knees (76 %) were rated excellent, 5 knees (15 %) were rated good, 2 knees (6 %) were rated fair and one patient (3 %) had a poor result. Complications were one temporary peroneal palsy, one luxation of the spacer due to insufficient extensor mechanism and one fracture of the tibia due to substantial primary metaphyseal bone loss.

Conclusion: Using articulating spacer prosthesis disadvantages of joint fixation between the two stages could be reduced. There is no difference in the reinfection rate compared to procedures using fixed spacer blocks. It facilitates the reimplantation and gives good functionel results.