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Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_11 | Pages 25 - 25
1 Nov 2022
DOES SURGICAL APPROACH AND TECHNIQUE INFLUENCE THE INFLAMMATORY MARKERS POST TOTAL KNEE ARTHROPLASTY? A STUDY OF 100 OSTEOARTHRITIC KNEES
Shah N Bagaria V Deshmukh S Tiwari A Shah M
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Abstract

Aim

To study and compare the rise of Inflammatory markers post TKR operated by Medial parapatellar approach with tourniquet (MP) and by Subvastus approach used without tourniquet. (SV)

Materials and Methods

100 patients were operated for a TKR by two experienced Arthroplasty surgeons utilising either the MP approach or the SV approach. (50 knees each). The groups were well matched as regards age, degree of deformity, obesity, pre-op knee scores and co-morbidities. The patients were managed peri-operatively in an identical manner .5 inflammatory markers viz: IL-6, AST, LDH, CRP and ESR were measured pre-operatively and at 12, 24,48 and 72 hours postoperatively. Additionally, the patients' VAS score at these intervals and Morbidity Index was determined.

Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XIV | Pages 65 - 65
1 Apr 2012
EXTRASKELETAL OSTEOSARCOMA: CLINICO-PATHOLOGIC FEATURES AND RESULTS OF MULTIMODAL MANAGEMENT
Fabbri N Tiwari A Umer M Vanel D Alberghini M Ruggieri P Ferrari S Picci P Mercuri M
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Aim

Purpose of this study was to review a single Institution experience and results of management of extraskeletal osteosarcoma (OGS), with emphasis on the role of combined treatment consisting of surgery and adjuvant chemotherapy.

Method

Retrospective study of 48 patients observed 1966- 2007 was undertaken: 36 patients were managed at our Institution while 12 cases were consultations and not included in this study. Clinico-pathologic features and details of treatment of all 36 patients were correlated with outcome. Updated follow-up was available in all patients.

Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 200 - 200
1 May 2011
EXTRASKELETAL OSTEOSARCOMA: CLINICO-PATHOLOGIC FEATURES AND RESULTS OF MULTIMODAL MANAGEMENT
Fabbri N Tiwari A Umer M Vanel D Alberghini M Mercuri M
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Introduction: Extraskeletal osteosarcoma is a rare malignant tumor of the soft tissues. Overall, this malignancy has been associated with worse local control and overall survival rates than its skeletal counterpart despite multimodal approach. Purpose of this study was to review a single Institution experience and analyse results of management to identify factors affecting the outcome.

Methods: Retrospective study of 48 patients observed between 1966 and 2007 was undertaken. Of the total, 36 patients were admitted and managed at our Institution while 12 patients were sent for consultation and therefore not included in this study. Clinico-pathologic features and details of treatment of all 36 patients were reviewed and correlated with outcome. Updated follow-up was available in all patients.

Results: There were 21 males and 15 females, mean age was 53.6+/−19.3 years (range 14–84 yrs); 23 patients (63.9%) presented with localised disease while distant metastases were present in 13 patients (36.1%). Surgery consisted of a limb-salvage procedure in 25 patients (69.4%), amputation in 9 patients (25%) and 2 patients were considered inoperable (5.6%). Postoperative radiation therapy was given to 6 patients (16.7%) and multiagent chemotherapy administered to 19 patients (52.8%). At mean follow-up of 5.8 years, 23 patients had died of disease, expected 5 and 10 year overall survival rates were 41% and 31%. Tumor size and age at presentation were the most important predictors of survival while chemotherapy showed a trend towards improved survival in patients with localised disease.

Discussion and Conclusion: Extraskeletal osteosarcoma was associated with substantially worse prognosis than skeletal osteosarcoma despite multimodal management.