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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 146 - 146
1 May 2016
IN VITRO STUDY COMPARING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS INHIBITION BY VANCOMYCIN AND FOSFOMYCIN IMPREGNATED KNEE ARTICULATING CEMENT SPACER
Yuenyongviwat V Ingviya N Pathaburee P Tangtrakulwanich B
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Background

Vancomycin and fosfomycin are antibiotic commonly used in Methicillin-resistant Staphylococcus aureus (MRSA) infection. This study compares the efficacy of articulating cement spacer implegnated with vancomycin and articulating cement spacer implegnated with fosfomycin to inhibit MRSA.

Methods

Vancomycin implegnated articulating cement spacers and Fosfomycin implegnated articulating cement spacers were immersed in sterile phosphate buffered saline(PBS) and then incubated at 37 C. The samples were collected and change daily. Aliquots were tested for MRSA inhibition by disc diffusion method. The inhibition zones diameters were measured.