We carried out a prospective study of 118 hydroxyapatite-coated, cementless total knee replacements in patients who were ≤ 55 years of age and who had primary (92; 78%) or post-traumatic (26; 22%) osteoarthritis. The mean period of follow-up was 7.9 years (5 to 12.5). The Knee Society clinical scores improved from a pre-operative mean of 98 (0 to 137) to a mean of 185 (135 to 200) at five years, and 173 (137 to 200) at ten years. There were two revisions of the tibial component because of aseptic loosening, and one case of polyethylene wear requiring further surgery. There was no osteolysis or progressive radiological loosening of any other component. At 12 years, the overall rate of implant survival was 97.5% (excluding exchange of spacer) and 92.1% (including exchange of spacer). Cementless total knee replacement can achieve excellent long-term results in young, active patients with osteoarthritis. In contrast to total hip replacement, polyethylene wear, osteolysis and loosening of the prosthesis were not major problems for these patients, although it is possible that this observation could change with longer periods of follow-up.
Various clinical outcome studies have consistently reported high dissatisfaction rate (25–33%) among the patients after hallux valgus surgery. We believe that a patient’s pre-operative expectations may play a major role in post-operative satisfaction.
Questionnaires were sent to 104 patients anonymously who were given a list of reasons and asked which they hoped to improve by having the surgery. They were also asked to list, in the order of priority, goals that they hoped to achieve from surgery.
Overall, improvement in the ability to walk was the most important reason. Most patients also wished to reduce pain over bunion and to regain the ability to wear daily shoes. However, the expectations of patients vary significantly according to age. Patients under 40 placed more importance on their ability to wear dress shoes and improvement in functional activities. Patients between the age of 40 and 60 were more interested to improve physical appearance. Pain on other toes, and the abilities to squat and climb stairs are the main concerns for patients above 60. For the male patients, to be able to continue work is the second most important reason after improvement in walking ability. This is in contrast to the female group where the ability to wear shoes of their choice is more important. Occupation did not make any significant difference.
This study shows that patients have different expectations that can influence the choice of operation. We believe that understanding patients preoperative expectation is crucial in achieving better patient satisfaction, and it should be an important consideration in planning appropriate operation for the patients.
Antibiotics are often administrated prophylactically in spinal procedures to reduce the risk of infection of the disc space. It is still not known which antibiotics are able to penetrate the intervertebral disc effectively. In a prospective, randomised, double-blind clinical study, we examined the penetration of the intervertebral discs of two commonly used antibiotics, cefuroxime and gentamicin. The patients, randomised into two groups, received either 1.5 g of cefuroxime or 5 mg/kg of gentamicin prophylactically two hours before their intervertebral discs were removed. A specimen of blood, from which serum antibiotic levels were determined, was obtained at the time of discectomy. Therapeutic levels of antibiotic were detectable in the intervertebral discs of the ten patients who received gentamicin. Only two of the ten patients (20%) who received cefuroxime had a quantifiable level of antibiotic in their discs although therapeutic serum levels of cefuroxime were found in all ten patients. Our results show that cefuroxime does not diffuse into human intervertebral discs as readily as gentamicin. It is possible that the charge due to ionisable groups on the antibiotics can influence the penetration of the antibiotics. We therefore recommend the use of gentamicin in a single prophylactic dose for all spinal procedures in order to reduce the risk of discitis.
