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Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 360 - 360
1 Sep 2005
Straw R Wilson M Scammell B Howell C Szypryt E
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Introduction and Aims: This is a prospective randomised trial comparing the ABG uncemented total hip replacement with the Charnley in 243 patients less than 65 years of age. A standardised protocol and anterolateral approach was used.

Method: The ABG I cup was used in combination with a polyethylene liner. All stems were templated and a 28mm cobalt chrome head was used. Early mobilisation with partial weightbearing for six weeks was allowed. In the Charnley group, Elite polyethylene cups were used in conjunction with 22mm monoblock stems. All hips were inserted with pressurised CMW cement. Patients were followed up annually. Standardised radiographs were taken at each visit and the Harris hip score and Merle d’Aubigné outcome measures recorded.

There were 222 hips available for follow-up, 96 ABG hips and 126 Charnley hips (17 died and 10 were lost to follow-up), with the mean age at surgery and mean length of follow-up comparable. Most hips were replaced due to osteoarthritis.

There was no significant difference in the mean Harris hip or Merle d’Aubigné scores at one year and at latest follow-up.

Results: Radiographic results demonstrated accelerated polyethylene wear in the ABG hips with mean polyethylene wear at seven years being 2.1mm compared with 0.9mm for Charnley hips. Wear associated lysis around the ABG cup was the major reason for failure, with a total of eight cups (8.3%) undergoing revision.

Conclusion: There was no evidence of subsidence of the stem or osteolysis around the stem despite the polyethylene wear. Conversely, in the Charnley group the stem was the major reason for failure with 12 stems (9.5%) being revised for aseptic loosening. The Kaplan Meier Survivorship at 10 years was 66.6% ± 19.1% for the ABG and ± 82% for the Charnley group. This was not significant.


The Journal of Bone & Joint Surgery British Volume
Vol. 70-B, Issue 5 | Pages 717 - 722
1 Nov 1988
Szypryt E Twining P Wilde G Mulholland R Worthington B

Forty-two consecutive patients with suspected lumbar disc protrusions were studied prospectively to compare the diagnostic accuracy of low-field strength MRI with that of radiculography. Thirty patients subsequently underwent surgical exploration at 33 levels and the operative findings were compared to both methods of diagnostic imaging. All patients had MRI studies, whilst 29 patients also had radiculography. Both studies were evaluated without prior knowledge of the clinical signs, operative findings or the results of other imaging techniques. MRI predicted the correct diagnosis in 29 of the 33 levels explored, an accuracy of 88%. All discs proven to be abnormal demonstrated a reduced signal from the nucleus pulposus. There were two false positive results and two doubtful cases but no false negatives. Radiculography predicted the correct diagnosis in 24 of 32 levels explored, an accuracy of 75%. There were two false positive results, five doubtfuls and one false negative. The overall accuracy when both tests were considered rose to 94%. Of the remaining 12 patients all except one showed good correlation between the MRI and radiculographic findings. These results indicate that low field strength MRI is slightly better than radiculography in diagnosing lumbar disc protrusions.


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 5 | Pages 737 - 742
1 Nov 1987
Szypryt E Clement D Colton C

Forty-eight consecutive patients (53 hips) were treated for moderate or severe slips of the upper femoral epiphysis between 1974 and 1984; 46 patients (96%) returned for clinical and radiological assessment at a mean of five years after operation. Twenty-three patients (23 hips) underwent a Dunn's open reduction and 25 patients (30 hips) were treated by epiphysiodesis and surgical osteoplasty as advocated by Heyman and Herndon. The results of the two methods of treatment are compared. Analysis revealed that 11 hips with moderate slip (30 degrees to 50 degrees) treated by the Heyman-Herndon procedure did significantly better than the 18 hips with severe slip (greater than 50 degrees) treated by the same method. Furthermore, when these hips with severe slip were compared to the hips treated by Dunn's open reduction, all of which were displaced greater than 50 degrees, the latter fared significantly better. The authors conclude that the Heyman-Herndon procedure gave consistently good results for moderate slips, but Dunn's open reduction gave better results for hips with severe slips.


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 5 | Pages 699 - 703
1 Nov 1987
Gibson M Szypryt E Buckley J Worthington B Mulholland R

Magnetic resonance imaging (MRI) was used to compare the appearance of the spine in 20 adolescents with proven symptomatic intervertebral disc herniations with that in 20 asymptomatic patients who acted as controls. Abnormality in the signal from the nucleus pulposus of one or more discs was present in all patients, while only four of the 20 controls had any abnormal signals. In all the patients the symptomatic disc produced an abnormal signal and in most a herniated fragment of the nucleus pulposus was identified. Fifteen of the 20 patients had multiple-disc abnormality: six had three abnormal discs and nine had two. This suggests there was an underlying diathesis in patients who later developed disc herniation.


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 1 | Pages 141 - 144
1 Jan 1987
Szypryt E Morris D Mulholland R

Surgical treatment of hydatid bone disease is rarely completely successful because radical excision is only possible at certain sites and secondary infection frequently occurs. Antihelmintic drugs have in the past been only palliative due to poor absorption and consequent low concentration in serum or cysts. We report five patients with Echinococcus granulosus infestation treated with a new chemotherapeutic agent albendazole; in two it was given postoperatively, in two pre-operatively and one child is being followed expectantly. We believe that a combination of chemotherapy and surgery may be efficacious in the treatment of hydatid bone disease.


The Journal of Bone & Joint Surgery British Volume
Vol. 68-B, Issue 4 | Pages 643 - 646
1 Aug 1986
Szypryt E Hardy J Colton C

Radiopharmaceuticals have been successfully used to detect occult neoplasms and infective lesions. Bone scans using 99mTc-labelled methylene diphosphonate located osteoid osteomas accurately in a series of 30 symptomatic patients. A portable radiation detector system has been designed to help intra-operative localisation and facilitate complete excision of the lesions with minimal damage to normal tissue. A sodium iodide detector with a fibre-optic link was used at first, but a cadmium telluride system has provided a more durable, reliable and sensitive sterilisable probe.