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The Bone & Joint Journal
Vol. 98-B, Issue 4 | Pages 548 - 554
1 Apr 2016
Midbari A Suzan E Adler T Melamed E Norman D Vulfsons S Eisenberg E

Aims

Amputation in intractable cases of complex regional pain syndrome (CRPS) remains controversial.

The likelihood of recurrent Complex Regional Pain Syndrome (CRPS), residual and phantom limb pain and persistent disability after amputation is poorly described in the literature. The aims of this study were to compare pain, function, depression and quality of life between patients with intractable CRPS who underwent amputation and those in whom amputation was considered but not performed.

Patients and Methods

There were 19 patients in each group, with comparable demographic details. The amputated group included 14 men and five women with a mean age of 31 years (sd 12) at the time of CRPS diagnosis. The non-amputated group consisted of 12 men and seven women and their mean age of 36.8 years (sd 8) at CRPS diagnosis. The mean time from CRPS diagnosis to (first) amputation was 5.2 years (sd 4.3) and the mean time from amputation to data collection was 6.6 years (sd 5.8).

All participants completed the following questionnaires: Short-Form (SF) 36, Short Form McGill Pain questionnaire (SF-MPQ), Pain Disability Index (PDI), the Beck Depression Inventory (BDI) and a clinical demographic questionnaire.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 497 - 497
1 Oct 2010
Melamed E Angel D Gotfried Y
Full Access

Background: Percutaneous compression plating (PCCP) is used for the fixation of intertrochanteric hip fractures by a minimally invasive technique. While offering several advantages compared to classic open reduction and internal fixation, the technique does not allow direct hemostasis. We aimed to assess the effect of regular aspirin use on blood loss, transfusion requirements and wound complications in patients undergoing urgent fixation using this technique.

Methods: The study involved 326 patients who presented to our hospital with an intertrochanteric fracture. Parameters recorded included time to surgery, blood loss (assessed by pre and post operative hemoglobin concentrations), and transfusion requirements. The status of wound healing was evaluated, with specific reference to hematoma formation. The influence of regular pre-operative aspirin use was analyzed with respect to these outcome measures.

Results: 32% of patients were regular aspirin users, and were comparable to the non aspirin group. There was no significant difference between the aspirin and non aspirin groups in terms of preoperative hemoglobin concentrations, perioperative changes in hemoglobin levels, and transfusion requirements. The severity of wound hematoma and the number of drainage procedures was not significantly different between the two groups. In a multivariate logistic regression analysis (composite complications* versus no complications as the dependent variable. R2=0.108, P< 0.001), only delay to surgery was associated with a higher complication rate.

Composite complications defined as transfusion ≥3 units, abnormal wound hematoma and length of stay ≥ 10 days.

Conclusion: Regular aspirin use pre-operatively is not associated with increased blood loss, transfusion requirements and wound complications in patients treated with this percutaneous fixation technique. Rather, it is the delay to surgery that is associated with a composite bad outcome. Our data suggest that patients on aspirin can safely undergo urgent non-delayed fracture fixation using the PCCP.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 511 - 511
1 Aug 2008
Melamed E Salai M Korengreen A Bloomenfeld A
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Purpose: A retrospective analysis was conducted of 82 orthopedic injury cases sustained by IDF military personnel during the recent low intensity conflict (the second Palestinian uprising) which is characterized by many casualties and high availability of medical services and evacuation means.

Methods: Records of all orthopaedic combat casualties evacuated to two level–I trauma centers between November 2002 and October 2005 were reviewed. Data included demographics, evacuation time, location of wounds, wounding agents, associated injuries, early/ late care and complications.

Results: There were 51 patients (62%) injured by fire-arms and 31 patients (38%) by fragments and explosives. Mean evacuation time was 60 (± 22) minutes. The spectrum of injuries included soft tissue injury −43 (52%), open fracture−40 (48%), neurologic injury-19 (23%), vascular injury-7 (8%) and amputation −1 (1%). The most common procedure was debridement and irrigation (D& I) which was performed on 70 patients (85%). 19% of the open fracture patients underwent primary internal fixation.

The mean length of hospitalization was 5 days (range 1–36). A multivariate statistical analysis was done, and it was found that being included in more than one category stands alone as the only predictor for prolonged hospitalization. Infection rate was 9.7%, with length of stay being the only parameter associated with infection.

Conclusion: The recent low intensity conflict is an excellent example of early and aggressive trauma care, with an increased use of primary internal fixation. There is a high incidence of open fractures (48% of all extremity injuries) and a low amputation rate (1%). Multiple operative procedures have been shown to be successful at limb salvage, but are time intensive.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 518 - 518
1 Aug 2008
Brin Y Lebel D Yafe D Melamed E Nyska M
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Purpose: To report our experience in diagnosis and treatment of Osteoid Osteoma in the foot and ankle.

Material and Methods: Six patients, 4 males and 2 females, mean age 24 (range 17–40), were diagnosed, suffering of osteoid osteoma of the foot and ankle in our outpatients clinic. All the patients had typical spontaneous pain and night pain improved by NSAIDs. In all patients, the diagnosis was delayed for one – two years. Treatment by Computed Tomography guided percutaneous radiofrequency ablation was performed in 4 patients, one patient underwent CT guided curettage and one underwent open excision and local bone graft of the lesion. In patients treated by RF, the lesions were heated three times to 90° for 2 minutes. All the procedures were done under ankle block and local anesthesia. Patients were evaluated in our outpatients foot and ankle clinic 1–2 years following the procedure.

Results: The Osteoid Osteoma was found in the talus of two patients and one in the cuboid, one in the base of third metatarsus, one in the calcaneus and one in the ankle. In all patients most of the pain was resolved within 3 days of the procedure. In 3 patients after a year there was still mild pain at tremendous physical efforts attributed to minimal damage to adjacent joint. Three patients completely recovered including pain free physical efforts. CT at follow-up in 2 patients revealed no pathology of the involved bones.

Conclusions: OO is an uncommon affection in the foot and ankle. The diagnosis is difficult and usually there is delayed. CT guided percutaneous radiofrequency of the foot is a safe and effective. The procedure can be performed under ankle block and local anesthesia.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 334 - 334
1 May 2006
Melamed E Keidar Z Militianu D Bar-Shalom R Israel O Zinman C
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Background: The occurrence of osteomyelitis in diabetic foot often dictates different treatment approach. The diagnosis of osteomyelitis, though, is sometimes difficult. When X rays are not diagnostic or equivocal, a nuclear medicine studies are often performed. In common practice bone scan with Tc99m-MDP combined with In111 labeled leucocytes scintigraphy are used. Although highly sensitive, these procedures may be hampered by coexisting pathological processes such as neuroarthropathy, trauma, or cellulites. In addition, poor resolution of the In111 images, complicates the interpretation weather the observed uptake (e.g. infection) is in the soft tissue or within the bone. Positron emission tomography (PET) using 2-Deoxy-2-[18F]-Fluoro-D-Glucose (FDG) is a useful clinical tool for the assessment of malignancies. FDG, a nonspecific tracer of increased intracellular glucose metabolism, accumulates in sites of infection and inflammation as well. PET is highly sensitive but may lack the ability to define the anatomic location of a focus of increased FDG accumulation. The hybrid PET/CT technology, providing precise registration of metabolic and structural imaging data, obtained in one session on a single device, may improve diagnosis and localization of infection.

Goals: The present study assesses the role of PET/CT imaging using FDG for the diagnosis of diabetic foot osteomyelitis.

Methods: Fourteen diabetic patients (M=10, F=4; age range 29–70 years) with 18 clinically suspected sites of infection underwent PET/CT following the injection of 185–370 MBq FDG for suspected osteomyelitis complicating diabetic foot. PET, CT and hybrid images were independently evaluated for the diagnosis and localization of an infectious process. Additional data provided by PET/CT for localization of infection in the bone or soft tissues was recorded. The final diagnosis was based on histopathological findings and bacteriological assays obtained at surgery or clinical and imaging follow up.

Results: PET detected 14 foci of increased FDG uptake suspected as infection in 10 patients. PET/CT correctly localized 8 foci in 4 patients to bone, indicating osteomyelitis. PET/CT correctly excluded osteomyelitis in 5 foci in 5 patients, with the abnormal FDG uptake limited to infected soft tissues only. One site of mildly increased focal FDG uptake was localized by PET/CT to diabetic osteoarthropathy changes demonstrated on CT. Four patients showed no abnormal increased FDG uptake, and no further evidence for an infectious process in the foot on clinical and imaging follow up.

Conclusion: FDG-PET can be used for diagnosis of diabetes-related infection. The precise anatomic localization of increased FDG uptake provided by PET/CT enables accurate differentiation between osteomyelitis and soft tissue infection.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 386 - 386
1 Sep 2005
Melamed E Nof M
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Purpose: The current study assessed the post-operative long-term outcome of up to 9 years follow-up of tarsal coalition treated with resection, utilizing the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score. To the best of our knowledge this is the first study utilizing that score in regard to Tarsal coalition resection as a sole treatment.

Materials and Methods: Between 1988 and 1999, 36 patients (36 feet) with painful flatfoot and restricted range of motion attributable to talocalcaneal and calcaneonavicular coalition were treated with resection of the coalition in multiple medical centers in Israel. Thirty-one patients were male and five female. Twentyfive patients had unilateral coalition and eleven patients had bilateral coalition. Coalition types were talocalcaneal(29) and calcaneonavicular(7). The patients were interviewed and examined during a follow-up period of 12 to 108 months, with an average of 51.6 months.

Results: Outcome was based on the ankle hindfoot clinical rating system of the American Orthopaedic Foot and Ankle Society. The clinical results were also evaluated statistically. Favorable outcome was evident in only 50% of cases. Average score was 79.2 in talocalcaneal coalition patients and 85.4 in calcaneonavicular coalition patients (not statistically significant). A multivariate statistical analysis was done and an equation was found, which elucidates the connection between age, gender and diagnosis, and AOFAS score.

Conclusions: On the basis of these results, three parameters were found to affect the operative outcome: age, type of coalition and gender. Age itself stands alone as a predictive tool to the postoperative outcome. The equation that was found to correlate age, type of coalition and gender with the score can act as a predictive tool of the outcome and aid in preoperative patient selection for tarsal coalition resection.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 382 - 382
1 Sep 2005
Peled E Melamed E Zinman C
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Purpose of Study: Assessing short and long term eficacy of Extracorporal Shock Wave Therapy (ESWT) as a treatment for recalcitrant plantar fasciitis (PF).

Methods: Prospective follow up of 63 heels among 50 patients with persistent PF patients, (mean age 57.2±10.5); symptoms’ duration 15.8±14.3 months, resistant to non-operative treatment modalities including steroid injections.

All patients underwent thorough physical examination and AOFAS Hindfoot score was obtained before treatment and a follow-up examination one week and one year after applicaton of ESWT course. Pain was assessed by Visual Analog Scale (VAS) relating to six parameters: pain on first step in the morning, maximum pain intensity, pain during prolonged walking, standing, at the end of the day and night pain. ESWT was applied in five consecutive courses of 1500 impulses of 0.32mj/mm² once a week in a routine previously described manner.

Results:. All the six VAS parameters decreased significantly post treatment. The Vas parameter of the first steps in the mornining was the most severe before 8.6±1.8 and after treatment 4.2±2.0 and 1.4±1.9 one year after tretment (p< 0.0001). Night pain was the less intenes before treatment 3.9±3.7 and was nearly eliminated to 0.9±1.6 and 0.2±0.8 after one week and a one year post treatment (p< 0.0001). AOFAS hind-foot Score increased from 49.7±15.8 before ESWT to 87.7±10.9 and 86.3±10.7 one week and year after the courses (p< 0.0001). Three patients couldn’t complete the ESWT course one, one of them with bilateral PF. From those patients two had tarsal tunnel syndrome and one with the tibial nerve first branch which was fassing through the plantar fascia. There were no side effects other than minimal local discomfort during the session time.

Conclusion: ESWT is a safe, efficient treatment modality for resistant PF.