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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_14 | Pages 76 - 76
1 Dec 2019
Torres IL Ruiz PS Matas-Díaz J Fraguas A Navarro-García F Vaquero J
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Aim

The demonstration of the in vivo bactericidal efficacy of a new bone cement with rifampicin contained in microcapsules and its intra-articular release profile.

Method

Fifteen New Zealand White rabbits were employed to reproduce periprosthetic infection by intra-articular inoculation of 105 CFU/mL of Staphylococcus aureus ATCC® 29213 using as a target implant a 3D printed stainless steel tibial insert. 7 days after inoculation, the first stage of the two stage exchange was carried out and at this time the animals were divided into two study groups: group C (7 rabbits) that received a spacer with gentamicin and group R (8 rabbits) that received a spacer with gentamicin and rifampicin microcapsules. Response to infection was monitored by clinical (weight and temperature), hematological (leukocyte, lymphocyte and platelet counts) and biochemical (erythrocyte sedimentation rate) analyses at the time of inoculation, at the first stage of exchange, 4 days after first stage and weekly until the fourth week when animals were euthanized. Microbiological counts were performed at the first stage of exchange and at the end of the study.