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Bone & Joint Research
Vol. 7, Issue 8 | Pages 511 - 516
1 Aug 2018
Beverly M Mellon S Kennedy JA Murray DW

Objectives

We studied subchondral intraosseous pressure (IOP) in an animal model during loading, and with vascular occlusion. We explored bone compartmentalization by saline injection.

Materials and Methods

Needles were placed in the femoral condyle and proximal tibia of five anaesthetized rabbits and connected to pressure recorders. The limb was loaded with and without proximal vascular occlusion. An additional subject had simultaneous triple recordings at the femoral head, femoral condyle and proximal tibia. In a further subject, saline injections at three sites were carried out in turn.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 135 - 135
1 Mar 2013
Beverly M
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Intraosseous pressure measurements (IOP) are not new. Several authors have struggled to interpret static IOP and to understand arthritis and osteonecrosis pathology. This work uses a combination of simple experiments in vivo to reassess bone and joint physiology. Joint replacement needs to take into account the hydrodynamic conditions that are present in bone. Intraosseous pressure measurements were carried out with vascular occlusion, activity and saline injection in experimental conditions and then in man during walking.

RESULTS

Basal IOP has a pulse wave and an underlying respiratory wave (RW).

IOP closely reflects systemic vascular changes.

Proximal arterial occlusion causes loss of IOP (IOPa) and pulse volume (PV).

Proximal vein occlusion causes a rise in IOP (IOPv) with preservation of PV and RW.

Physical loading raises IOP with preservation of PV and RW.

Load with arterial occlusion caused minimal rise in IOP.

Loading with venous occlusion caused an augmented rise in IOP with preservation of the PV.

Simultaneous recordings from the femoral head, condyle and upper tibia during vascular occlusion and loading show that the same effects occur at all sites.

Simultaneous recording from the femoral head, condyle and upper tibia during saline injection shows pressure is transmitted through bone but not across joints.

The Ficat bolus test destroys local circulation. Aspiration is better and preserves local perfusion.

Bone health at the needle tip is better assessed by IOPv – IOPa, the perfusion ‘bandwidth’.

Upper tibial pressure during standing, slow walking and fast walking shows large IOP changes in vivo.

There is probably a physiological subchondral bone blood pump.

Anatomical features are present which support this idea.

CONCLUSIONS

IOP measurement in isolation is meaningless. With arterial and venous occlusion, perfusion at the needle tip can be studied.

Compartment syndrome testing should be similar.

Subchondral bone is a compressible perfused sponge with a ‘pumped’ microcirculation.

Very high pressures arise in subchondral bone during activity.

There are protective modifications of the microcirculation.

Failure of subchondral circulation causes arthritis. Arthritis is mainly a ‘vasculo-mechanical’ disease. This work explains the spectrum of arthritis and osteonecrosis, and Perthes, caisson and sickle cell disease patterns. It explains why osteoporosis might protect against arthritis.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 317 - 318
1 Jul 2008
Ndzenque A Beverly M
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Introduction: We present our results after 10 years use of the Kent hip.

Methods: Between 1994 and 2004, 58 patients (m19, f39) aged 52 to 90 (mean 76) had a Kent hip. Indications were for a loose implant (22), recurrent dislocation (6), femoral or stem fracture (9), and other causes (13). An antero-lateral approach with an antero-lateral longitudinal femoral window was used to remove the previous stem and cement. The window was re-attached by cross screws. An average of 7 (4–10) cross screws were used. An uncemented Biomex cup and polythene liner was used in 48 cases and 10 cups were cemented. A modular 28 mm head and variable length neck was used. Recorded anaesthetic grade was ASA Grade II for 33 patients and ASA Grade III in 13 patients.

Results: Operative time was 130 +/− 37.5 min. Mean recorded blood loss was 1300ml (300–4000ml). Patients were up partial weight bearing at a mean of 5 days (2–80). Hospital stay was 19 days (7–212). There were 3 hospital deaths, one from MRSA sepsis, one chest infection and one MI.

Complications included dislocation (13 out of 53 patients or 24.5%), heterotopic ossification (47%), screw fracture (8%), superficial infection (11%) and deep infection (5.7%). Survival tables show an implant survival rate of 85% at 5 years.

Discussion: Most dislocations settled without further surgery. Heterotopic ossification was minor. The Kent hip system is a flexible and robust solution for a wide range of difficult revision cases. It allows early full weight bearing. We prefer the Kent implant to massive re-cementing, bone grafting or Girdlestone excision. We recommend this device for wider use.