1. The natural history of cryptococcal infection is discussed in relation to the findings in a woman of fifty-six with lesions in the right radius and right fourth metatarsal. A diffuse lesion found in the right lung with a calcified gland at the right hilum was believed to represent the initial site of infection.

2. There was a general tendency for normal bone architecture to be restored after the destructive phase of the disease had finished.

3. Specific treatment with the fungicide amphotericin B had to be stopped because of severe systemic reaction.

4. The significance of the rare association of Boeck's sarcoid with torulosis is discussed.