The modified Dunn procedure has the potential to restore the anatomy in hips with slipped capital femoral epiphyses (SCFE) while protecting the blood supply to the femoral head. However, there is controversy about the risks associated with the procedure especially in the most severe capital slips.

Therefore, we report on (1) clinical outcome, (2) the cumulative survivorship with endpoints AVN and/or OA progression and (3) radiographic anatomy of the proximal femur at followup in patients treated with a modified Dunn procedure for severe SCFE.

We performed a retrospective analysis involving 46 hips of 46 patients treated with a modified Dunn procedure for severe SCFE (slip angle >60°) between 1999 and 2016.

Followup averaged 8 years, (range 1–17) with 2 patients lost to followup after one year.

The mean age was 13 years (range 9–19 years). Mean preoperative slip angle was 64° (range 60–90) and 14 out of 46 hips (30%) presented with unstable slips.

Clinical scores and PROMs were evaluated and the hips were followed standard x-rays. Cumulative survivorship (Kaplan-Meier) with three defined endpoints: (1) AVN; (2) progression by at least one OA grade according to Tönnis; (3) non-preserved hip joint.

(1)Mean Harris Hip score (HHS) was 93 points (66–100) and mean Hip Disability and Osteoarthritis Outcome Score (HOOS) was 90 points (67–100) at last followup.

(2)Cumulative survivorship was 93% at 10-year followup. Three hips reached an endpoint. Two hips (4%) had AVN, one of them underwent hip arthrodesis. One hip had OA progression.

(3)Postoperative slip angle was 7° (1–16). Alpha angle on axial radiograph was 39° (26–71) at followup. 41/44 hips (93%) had no OA (Tönnis 0).

The modified Dunn procedure largely corrected slip deformities with low apparent risk of progression to avascular necrosis or osteoarthritis at mean 8-years followup. The AVN rate in severe and unstable (30%) capital slip was 4% (2 hips) with this procedure.

Posterior extraarticular ischiofemoral hip impingement can be caused by high femoral torsion and is typically located between the ischium and the lesser trochanter. We asked if patients undergoing derotational femoral osteotomies for posterior FAI have (1) decreased hip pain and improved function and evaluated (2) subsequent surgeries and complications?

Thirty-three hips undergoing derotational femoral osteotomies between 2005 and 2016 were evaluated retrospectively. Of them 15 hips underwent derotational femoral osteotomies and 18 hips underwent derotational femoral osteotomies combined with varisation (neck-shaft angle >139°). Indication for derotational osteotomies was a positive posterior impingement test in extension and external rotation, high femoral torsion (48° ± 9) on CT scans and limited external rotation. Offset improvement was performed to avoid intraarticular impingement in hips with a cam-type FAI. All patients were female and mean followup was 3 ± 2 (1 – 11) years.

At latest followup the positive posterior and anterior impingement test decreased from preoperatively 100% to 5% (p< 0.001) and from preoperatively 85% to 30% (p< 0.001). The mean Merle d'Aubigné Postel score increased from 14 ± 1 (11 – 16) to 16 ± 1 (13 – 17) at latest followup (p< 0.001). At followup 32/33 hips had been preserved and one hip had been converted to a total hip arthroplasty (THA). In two hips (6%) revision osteosynthesis was performed for delayed healing of the femoral osteotomy.

Derotational femoral osteotomies for the treatment of posterior extraarticular ischiofemoral impingement caused by high femoral torsion result in decreased hip pain and improved function at midterm followup but had 6% delayed healing rate requiring revision surgery.

Purpose

To validate a small, easy to use and cost-effective augmented marker-based hybrid navigation system for peri-acetabular osteotomy [PAO] surgery.

Introduction

Acetabular retroversion is an accepted cause of Pincer-type femoroacetabular impingement. There is increasing evidence that acetabular retroversion is rather a rotational abnormality of the pelvis than an overgrowth of the acetabular wall or even a dysplasia of the posterior wall. Initially, patients with a retroverted acetabulum were treated with an open rim trimming through a surgical hip dislocation (SHD) based on the early understanding of the pathomorphology. Theoretically, the reduction of the anterior wall can decrease the already small joint contact area in retroverted hips to a critical size. Based on the most recent literature, anteverting periacetabular osteotomy (PAO) seems to be the more appropriate surgical treatment. With this technique, the anterior impingement conflict can be treated efficiently without compromising the joint contact area. However, it is unknown whether this theoretical advantage in turn results in better mid term results of treatment.

Introduction

Torsional deformities are increasingly recognized as an additional factor in young patients with hip pain resulting from pincer- and cam-deformities. For example decreased femoral torsion can worsen an anterior Femoroacetabular impingement (FAI) conflict while an increased torsion can be beneficial with the same configuration.

It is unknown how often torsional deformities are present in young patients presenting with hip pain that are eligible for joint preserving surgery. We questioned (1) what is the prevalence of a pathological femoral torsion in hips with FAI or hip dysplasia? (2) which hip disorders are associated with an abnormal torsion?

Introduction

Hips following in-situ pinning for slipped capital femoral epiphysis (SCFE) have an altered morphology of the proximal femur with cam type deformity. This deformity can result in femoroacetabular impingement and early joint degeneration. The modified Dunn procedure allows to reorientate the slipped epiphysis to restore hip morphology and function.

Introduction

The limited field of view with less-invasive hip approaches for total hip arthroplasty can make a reliable cup positioning more challenging. The aim of this study was to evaluate the accuracy of cup placement between the traditional transgluteal approach and the anterior approach in a routine setting.

Objectives

Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a novel MRI-based technique with intravenous contrast agent that allows an objective quantification of biochemical cartilage properties. It enables a ‘monitoring' of the loss of cartilage glycosaminoglycan content which ultimately leads to osteoarthritis. Data regarding the longitudinal change of cartilage property after joint preserving hip surgery is sparse. We asked (1) if and how the dGEMRIC-index changes in patients undergoing open/arthroscopic treatment of femoroacetabular impingement (FAI) one year postoperatively compared to a control group of patients with non-operative treatment; (2) and if a change correlates with the clinical short term outcome.

Introduction

Since its first description in 1988, periacetabular osteotomy has become the gold-standard worldwide in surgical treatment of developmental dysplasia of the hip. Several long-term studies have proven the efficacy of this procedure. In this study, we evaluated the mean 30-years results of this procedure of the first 63 patients (75 hips) operated at the institution where this procedure had been developed.

Introduction

Magnetic resonance imaging with intraarticular contrast (arthro-MRI) and radial cuts is the gold standard to quantify labral and chondral lesions in the setting of femoroacetabular impingement. To date, no study exists that has evaluated these findings as potential predictors of outcome for the long term follow-up after surgical treatment of FAI.

Introduction & Objective

Labral refixation has established as a standard in open or arthroscopic treatment for femoroacetabular impingement (FAI). The rationale for this refixation is to maintain the important suction seal in the hip. To date, only few short-term results are available which indicate a superior result in FAI hips with labral refixation compared to labral resection. Scientific evidence of a beneficial effect of labral refixation in the long-term follow-up is lacking.

Aim of this study was to evaluate if labral refixation can improve the cumulative 10-year survivorship in hips undergoing surgical hip dislocation for FAI compared to labral resection.

Introduction

Torsional deformities of the femur have been recognized as a cause of femoroacetabular impingement (FAI) and hip pain. High femoral antetorsion can result in decreased external rotation and a posterior FAI, which is typically located extraarticular between the ischium and trochanter minor. Femoral osteotomies allow to correct torsional deformities to eliminate FAI. So far the mid-term clinical and radiographic results in patients undergoing femoral osteotomies for correction of torsional deformities have not been investigated.

Traumatic hip dislocation is a rare injury in orthopaedic practice and typically occures in high energy trauma. The goal of this study was to analyze hip morphology in patients with low energy traumatic hip dislocations and to compare it with a control group.

We performed a retrospective comparative study. The study group included 45 patients with 45 traumatic posterior hip dislocation. Inclusion criteria were traumatic hip dislocation with simple acetabular rim or Pipkin I or II fracture. Traumatic dislocations combined with other acetabular or femoral fractures were excluded. The control group consisted of 90 patients (180 hips) that underwent radiographic examination for urogenital indication and had no history of hip pain. Hip morphology was assessed on antero-posterior and axial views.

The study group showed significantly increased incidence (p<0.001) of positive cross-over sign (82% vs. 27%) with a increased retroversion index (26 ± 17 [0–56] vs. 6 ± 12 [0–53]), positive ischial spine sign (70% vs. 34%), and positive posterior wall sign (79% vs. 21).

Hips that underwent an low energy posterior traumatic hip dislocation show significanly more radiographic signs for acetabular retroversion compared to a control group. Therefore, acetabular retroversion seems to be a contributing factor for posterior traumatic hip dislocation.

Introduction

Significant access morbidity with intercostal neuralgia and post-thoracotomy pain syndrome was reported in case that an anterior approach for spondylodesis of fractures of the thoracolumbar spine was used. We describe our experience with thoracoscopical fusion from anterior as a less invasive approach.

The Bernese Periacetabular Osteotomy (PAO) has become the established method for treating developmental dysplasia of the hip. In the 1990s, the surgical technique was modified to avoid postoperative cam impingement due to uncorrected head neck offset or pincer impingement due to acetabular retroversion after reorientation. The goal of the study was to compare the survivorship of two series of PAOs with and without the modifications of the surgical technique and to calculate predictive factors for a poor outcome.

A retrospective, comparative study of two consecutive series of PAOs with a minimum follow-up of 10 years was carried out. Series A included 75 PAOs performed between 1984 and 1987 and represent the first cases of PAO. Series B included 90 hips that underwent PAO between 1997 and 2000. In this series, emphasis was put on an optimal acetabular version next to the correction of the lateral coverage. Additionally, a concomitant arthrotomy was performed in every hip to check impingement-free range of motion after reorientation and in 50 hips (56%) an additional offset correction was performed. Survivorship analyses according to Kaplan and Meier were carried out and the endpoint was defined as conversion to a total hip arthroplasty, progression of osteoarthritis, or a Merle d'Aubign score 14. Predictive factors for poor outcome were calculated using the Cox-regression analysis.

The cumulative 10-year survivorship of Series A was significantly decreased (77%; 95%-confidence interval [CI] 72–82%) compared to Series B (86%; 95%-CI 82–89%, p=0.005). Hips with an aspherical head showed a significantly increased survivorship if a concomitant offset correction was performed intraoperatively (90% [95%-CI 86–94%] versus 77% [95%-CI 71–82%], p=0.003). Preoperative factors predicting poor outcome included a high age at surgery, a Merle d'Aubign score 14, a positive impingement test, a positive Trendelenburg sign, limp, an increased grade of osteoarthritis according to Tönnis, and (sub-) luxation of the femoral head (Severin > 3). In addition, predictive factors related to the three dimensional orientation of the acetabular fragment were identified. These included total, anterior, and posterior acetabular over-coverage or under-coverage, acetabular retroversion or excessive anteversion, a lateral center edge angle < 22 °, an acetabular index > 14 °, and no offset correction in aspherical femoral heads.

A good long term result after PAO mainly depends on optimal three-dimensional orientation of the acetabulum and impingement-free range of motion with correction of an aspherical head neck junction if necessary.

Purpose

The purpose of this retrospective study was to investigate the acetabular morphology of pincer impingement hips in order to better understand damage pattern in these patients. We compared MRI measurements made at different postions from anterior to posterior on the acetbulum in patients with pure pincer type FAI to those made in patients with pure cam-type to collect parameters that may be useful in the diagnosis and classification of pincer impingement.

Introduction

Infection of endoprostheses is a serious complication in orthopedic surgery. As silver is known for its antibactierial effects, silver-coated endoprostheses have gained increased attention to decrease infection rates. However, cytotoxic effects of silver on bone cells have not been investigated in detail. We aimed to investigate whether silver nano-/microparticles and ionic silver exert cytotoxic effects on osteoblasts and osteoclasts in vitro and to correlate potential effects with the antibacterial effect on Staph. epidermidis.

Femoroacetabular impingement (FAI) is a pathologic condition of the hip that leads to osteoarthrosis. The goal of the surgical hip dislocation is to correct the bony malformations to prevent the progression of osteoarthrosis. We investigated the topographical cartilage thickness variation in patients with FAI and early stage osteoarthrosis using an ultrasonic probe during surgical hip dislocation.

We performed a prospective case-series of 38 patients (41 hips) that underwent surgical hip dislocation. The mean age at operation was 30.6 (range, 18–48) years. Indication for surgery was symptomatic FAI with 4 hips (10%) with pincer-type, 7 hips (17%) with cam-type, and 20 hips (73%) with mixed-type of FAI. Cartilage thickness was measured intraoperatively using an A-mode 22 MHz ultrasonic probe at 8 locations on the acetabular cartilage.

The thickest acetabular cartilage was found in the weight bearing zone (range 2.8–3.5mm), whereas the thinnest cartilage was in the posterior acetabular horn (1.0–2.2 mm). In all hips, cartilage was thicker in the periphery area compared to the central area. In the anterior and posterior acetabular horn, the anterior area, and the superior area (central parts) a significantly decreased cartilage thickness in pincer-type compared to cam-type of FAI was found (p<0.05).

Cartilage thickness shows topographical differences in all types of FAI with pincer-type of FAI having generally thinner cartilage than cam-type FAI. This is the first study measuring in vivo cartilage thickness in the human hip.

Aim

Synovial sarcoma (SS) is a malignant soft tissue sarcoma with a poor prognosis because of late local recurrence and distant metastases. To our knowledge, no studies have minimum follow-up of 10 years that evaluate long-term outcomes for survivors.

Acetabular component malpositioning increases the risk of impingement, dislocation, and wear. The goal of computer-assisted techniques is to improve the accuracy of component positioning, in particular optimizing the orientation of the acetabular cup.

The goal of the current study was to measure accuracy of cup placement in a large clinical series of hips that underwent CT-based computer-assisted THA.

146 hips in 140 patients underwent CT-based computer-assisted THA between 2006 and 2008. In all cases cup orientation was planned according to the individual preoperative CT and the anterior pelvic plane with an inclination of 41° and anteversion of 30°. For the procedure, all patients were placed in the lateral position and the cup was implanted using angled instruments. Intra-operatively all cases were navigated using an optoelec-tronic camera and tracked instruments (Vector Vision prototype, BrainLab, Germany).

Post-operatively, cup orientation was measured using a previously validated technique of 2D/3D-matching using the preoperative CT and post-operative radiographs. This technique allows for accurate measurement of cup position from plain radiographs corrected for individual pelvic orientation.

The mean accuracy for inclination was −2.5° ± 4.0° (−12° – 10°) and for anteversion it was 0.7° ± 5.3° (−11° – 15°). In 2 hips (1.4%) a deviation of more then 10° in inclination and in 4 hips (2.7%) a deviation of more then 10° in anteversion were found.

The current study demonstrates that the acetabular component can routinely be implanted with the assistance of CT-based navigation with reasonable agreement between the navigation measurements of component orientation at the time of surgery. Nonetheless, outliers still occasionally occur. These might be due to unrecognized loosening of the pelvic reference base, inaccurate registration or the use of the ipsilateral surface-based registration algorithms which rely heavily on points near the center of rotation of the hip.

Acetabular retroversion is a well-documented cause of femoro-acetabular impingement (FAI). There are few reports of long-term outcomes following correction of retroversion. We hypothesized that correction of acetabular retroversion with peri-acetabular osteotomy (PAO) in young adults with symptomatic FAI can lead to symptomatic relief, improvement of function and thus potentially delay the progression of osteoarthritis.

Twenty-two patients (29 hips) underwent Bernese PAO for treatment of symptomatic FAI with acetabular retroversion between April 1997 and August 1999. Mean age at surgery was 23 years (14–41). Mean duration of symptoms was 17 months (6–24). All pre-operative radiographs demonstrated Tönnis grade 0 of degenerative changes. Mean follow up was 127 months (109–142). Clinical, functional and radiographic outcomes are presented.

The overall mean Merle d’Aubigné score improved from 14.0 points (12–16) pre-operatively to 16.3 points (14 to 18) at the time of last follow-up. There were three reoperations due to loss of correction, posterior impingement and cam impingement. There were no major vascular or neurologic complications and none related to non- healing of the osteotomies. All patients had symptomatic relief at final follow-up. Range of motion and functional scores improved in all cases (even in those with repeat procedures). The vast majority of patients continued to demonstrate no signs of osteoarthritis (Tönnis greade 0) at final follow-up.

Acetabular retroversion is a mechanical factor that can lead to FAI. In symptomatic cases, PAO is a safe and reliable method for correction of the retroversion and can relief symptoms, improve function and prevent rapid progression of osteoarthritis.

Femoroacetabular impingement (FAI) is a pathologic condition of the hip joint that leads to hip pain and osteoarthrosis (OA), especially in the young and active patient population. It is characterized by an early pathologic contact during hip motion between osseous malformation of the femoral neck and acetabular rim. The goal of the surgical dislocation of the hip is to prevent the development of OA by correcting these malformations. We investigated the clinical and radiographic outcome, the survivorship, and factors predicting poor outcome at 5-year followup.

We retrospectively evaluated 101 hips in 78 patients that underwent surgical hip dislocation at a mean age of 32 ± 8.4 (range, 15 – 52) years. The mean followup was 5.7 ± 1.0 (0.9 – 7.1) years. The series included pincer type impingement in 5 hips (5%), cam type in 9 hips (9%), and mixed type of FAI in 87 hips (87%). Pre-operatively, the patients presented with a mean Merle d’Aubigné score of 14.3 ± 3.3 (8 – 17) and a mean osteoarthrosis score according to Tönnis of 0.13 ± 0.34 (0 – 1). At followup, the clinical results were graded using the Merle d’Aubigné score and the radiographic results using the Tönnis score. Failure was defined as a conversion to a total hip arthroplasty (THA), a Merle d’Aubigné score of less than 15 or a progression of osteoarthrosis with a Tönnis score ≥2 at last followup. Demographic, clinical, radiographic, and surgical factors were tested for predictive factors for poor outcome using the Cox regression.

At followup the mean Merle d’Aubigné score was 17.2 ± 1.2 (12 – 18) and the mean Tönnis score was 0.19 ± 0.47 (0 – 2). Failures (13 hips, 13%) included 6 hips (6%) with a progression of osteoarthrosis, 5 hips (5%) hips that converted to a THA, and 2 (2%) hips presenting with a Merle d’Aubigné score of less than 15. This resulted in a cumulative survivor ship at 5 years of 97.0 ± 3.3 % (95%-confidence interval, 93.6 – 100%). Factors predicting poor outcome were a preoperative Tönnis score of 1, a cartilage tear in the Arthro-MRI, and increased age or BMI at operation.

Surgical hip dislocation has the potential to prevent the progression of osteoarthrosis and to decrease hip pain in patients with FAI. The optimal patient is young, with a decreased BMI and no sign of degeneration in the conventional radiograph or Arthro-MRI.

The iliocapsularis muscle is a little known muscle that originates in part from the inferior border of the anterior-inferior iliac spine, but the main origin arises from an elongated attachment of the anteromedial hip capsule and inserts just distal to the lesser trochanter. Nevertheless, this muscle is an important landmark for exposure of the anteromedial hip capsule and psoas tendon interval during performance of the Bernese periacetabular osteotomy. Speculations about the function of this muscle as a tightener of the hip capsule and femoral head stabilisator have grown when an apparent hypertrophy of this muscle was encountered in patients with dysplasia of the hip. The aim of this study was to compare the morphology of the iliocapsularis muscle between patients with decreased (developmental dysplasia of the hip) and increased acetabular coverage (pincer-type of femoroac-etabular impingement) using Arthro-MRIs.

Dysplasia of the hip (Group I) was defined as an LCE angle of less than 25° with a minimal acetabular index of 14° and pincer type of FAI (Group II) was defined as and LCE angle exceeding 39° on conventional radiographs. This resulted in 37 hips in Group I and 45 hips in Group II. The morphology of the iliocapsularis muscle was measured on axial slices of Arthro-MRIs. The parameters were muscle thickness, width and cross section at 4cm distal of the spina iliaca anterior inferior and also distal of the femoral head. Additionally, the volume of the muscle from its origins to the cross section distal of the femoral head was computed.

All parameters were significantly increased in Group I compared to Group II (p< 0.05). In Group I the mean thickness was 20 ± 4.5 (range, 12 – 29) mm, width 25 ± 5.2 (range, 17 – 37), and cross section 281 ± 10.7 (range, 139 – 591) mm2 compared to Group II with a mean thickness of 17 ± 4.4 (range, 10 – 27) mm, width 22 ± 5.0 (range, 11 – 31), and cross section 235 ± 10.3 (range, 90 – 535) mm2. The muscle volume in Group I was 6.8 ± 2.9 (range, 2.2 – 13.0) cm3 compared to Group II with 8.7 ± 3.7 (range, 3.4 – 18.1) cm3. The results differed more when corrected for gender with the largest differences found for women.

In hip dysplasia the anterior acetabular coverage is decreased. Because of the iliocapsularis muscle’s origination on the hip capsule, contrition of the muscle theoretically can tighten the anterior hip capsule, thus helping to stabilized the femoral head within the dysplastic acetabular. Although the true function of the iliocapsularis muscle remains unknown, constant use of this muscle in attempting to stabilize the femoral head in hip dysplasia theoretically would explain the apparent hypertrophy of this muscle.

Sufficient vascularization is essential for osseointegration of biomaterials and their substitution by new bone. Angiogenic growth factors such as VEGF are promising agents to promote the vascularization of bone substitutes. To optimize the efficacy of VEGF delivery a continuous administration of low concentrations of VEGF seems to be beneficial. We hypothesized that a long-term release of VEGF from calcium phosphate ceramics may induce a sustained angiogenic response and sufficiently promote biomaterial vascularization in vivo.

Vascular endothelial growth factor (VEGF, Genentech Inc., South San Francisco, USA.) was co-precipitated onto biphasic calcium phosphate ceramics (BCP, 80% HA, 20% β-TCP) at a concentration of 1μg/ml and 5μg/ml. The passive release and the cell-mediated release of VEGF were analyzed over 19 days by ELISA. For in vivo investigations BCP ceramics were implanted into a cranial window preparation in Balb/c mice. Angiogenesis and vascularization were investigated over 28 days by means of intravital microscopy. Functional capillary density (FCD, mm/mm²) served as parameter of biomaterial vascularization.

Co-precipitation of VEGF onto BCP ceramics resulted in a significant improvement of protein retention as compared to conventional adsorption of the growth factor [Cumulative VEGF release: Adsorption: 320 ± 2.6 ng/ml, Co-precipitation 116 ± 14.6 ng/ml (p< 0.05)]. Murine bone marrow cells differentiated towards osteoclasts mediated a sustained release of co-precipitated VEGF. Preliminary in vivo results showed a significant increase of functional capillary density after implantation of BCP ceramics co-precipitated with VEGF as compared to negative controls [day 7: 1.7 ± 0.2 mm/mm² vs. 0.9 ± 0.5 mm/mm²; day 14: 6.1 ± 0.3 mm/mm² vs. 2.1 ± 0.6 mm/mm²; day 28: 8.7 ± 0.3 mm/mm² vs. 3.9 ± 0.7 mm/mm², p< 0.05]. At 14 and 28 days after implantation, FCD induced by BCP ceramics co-precipitated with VEGF was significantly higher as compared to FCD induced by ceramics adsorbed with the VEGF [day 14: 6.1 ± 0.3 mm/mm² vs. 4.0 ± 1.4 mm/mm²; day 28: 8.7 ± 0.3 mm/mm² vs. 5.9 ± 0.7 mm/mm², p< 0.05].

The release kinetics critically influences the efficacy and the risks of local VEGF administration. By applying a co-precipitation technique the initial high liberation rate of VEGF was reduced and a sustained cell-mediated release at low concentrations was achieved. In vivo, VEGF promoted angiogenesis and vascularization of BCP ceramics. Vessel formation was more pronounced if VEGF was co-precipitated onto ceramics as compared to superficial adsorption of the growth factor, indicating that VEGF delivery at later stages of the healing process is beneficial. The present study provides evidence that, by delivering VEGF in a sustained manner at low local concentrations biomaterial vascularization can be markedly enhanced.

Pelvic tilt is a characteristic feature of the individual patients’ posture. Large differences in pelvic tilt are well known among individuals, over time or related to activity. To our knowledge, it is unknown how patients with developmental dysplasia of the hip (DDH) behave in terms of pelvic tilt. One can assume that patients with a dysplastic acetabulum might compensate for their acetabular under coverage by functionally increasing pelvic tilt. Theoretically, this effect should be reversible when an acetabular redirection osteotomy is performed. We therefore hypothesized that pelvic tilt decreases after periacetabular osteotomy.

Sixty-three consecutive patients (67 hips) with documented PAO at our institution were analyzed. 39 patients (40 hips) were excluded because of indications than other DDH (e.g. acetabular retroversion), incomplete radiographic documentation or insufficient follow-up leaving us 24 patients (27 hips) for evaluation. Preoperative, intraoperative (under general anesthesia), and at least 1 year postoperative anteroposterior radiographs were analysed. All x-rays were done in a standardized manner. Two distances were measured: the vertical/horizontal distance between the mid point of the sacrococcygeal joint and the symphysis. The change of these distances allows exact determination of the pelvic tilt.

A significant decrease for pelvic tilt was found between the preoperative x-ray and the one after at least one year. Pelvic tilt did not change significantly between the pre- and the intraoperative x-ray, and between the intra- and follow-up x-ray.

Our findings support the hypothesis that patients with DDH try to compensate for their insufficient acetabular coverage by increasing the tilt of their pelvis. After PAO, i.e. after iatrogenically increasing acetabular coverage, the patients’ pelvis significantly turns back in to less lordosis.

The reconstruction of bone defects with biomaterials represents a potential alternative to the transplantation of autologous and allogenic bone. Ceramic materials can be combined with growth factors (i.e. BMPs) to render them osteoinductive. Coating of biomaterials with growth factors has mostly been attempted by adsorption onto the material’s surface. The superficial deposition usually results in an immediate passive release of the proteins, thus restricting their temporal availability during bone healing. It was hypothesized that a co-precipitation of proteins onto calcium phosphate ceramics may provide the possibility to achieve a prolonged release of proteins from the material without impairing the biologic activity of growth factors.

Tritium labelled bovine serum albumin ([3H]BSA) and recombinant human BMP2 (rhBMP2) were coated onto biphasic calcium phosphate (BCP) ceramics using a coprecipitation technique of proteins together with calcium phosphate (Liu Y et al. 2001). The co-precipitation was compared to conventional adsorption of proteins to ceramic materials. The passive and cell-mediated release of [3H]BSA was investigated during 19 days. To analyze the cell-mediated protein release, murine bone marrow cells were seeded onto ceramics and differentiated to osteoclasts or to monocytes/macrophages. To assess whether rhBMP2 co-precipitated to BCP ceramics retained its biologic activity the growth factor’s ability to induce the differentiation of primary murine osteoblasts was studied.

After 19 days 71.7±5.3% of the adsorbed [3H]BSA was passively released (63.0±6.0% within 4 days). The passive liberation of [3H]BSA was effectively reduced using the coprecipitation technique (12.5±2.0% within 19 days, 10.1±2.3% within 4 days, p< 0.001). Further analysis demonstrated a sustained, osteoclast-mediated release of coprecipitated [3H]BSA from calcium phosphate ceramics which was blocked by the addition of calcitonin. Passive release of adsorbed and co-precipitated BMP2 led to a temporally restricted stimulation of murine osteoblasts. Cell-mediated liberation of co-precipitated BMP2 induced a sustained stimulation of the differentiation of osteoblasts.

The successful application of exogenously added growth factors depends critically on the mode of delivery. It has been shown that a sustained availability of BMP2 is beneficial for bone healing. Application of the co-precipitation technique resulted in a long-term release of proteins from BCP ceramics mediated by active resorbing osteoclasts without impairing the biologic activity of rhBMP2. Co-precipitating growth factors onto BCP ceramics provides a potential to shift the initial extensive liberation to a sustained release of bioactive proteins. This method of protein delivery may represent a possibility to achieve a more physiological availability of growth factors during bone regeneration.

Since 1984, more than 1000 Bernese periacetabular osteotomies (PAO) have been performed for the treatment of developmental dysplasia of the hip (DDH) in adolescents and adults at the institution where this technique was developed. We present a concise 20-year follow-up of the first 75 PAOs whose initial and 10-year results had been published previously.

A retrospective study of the first 75 consecutive hips (63 patients) treated with PAO for DDH between April 1984 and December 1987 was performed. The mean patient age at surgery was 29.3 years ± 11.4 (13 – 56) and in 31% of all hips a previous surgical attempt to achieve sufficient coverage had been performed. Preoperatively, 58% of all hips presented with osteoarthritis and 49% with dysplasia Class 4 or higher according to Severin. Four patients (5 hips) were lost-to-follow-up and 1 patient (2 hips) died unrelated to surgery. The remaining 58 patients (68 hips) were followed for a mean of 20.4 years ± 1.1 (18.8 – 22.9) and 41 hips (60%) were preserved at last follow-up. Regarding the surviving hips with preoperatively no or slight osteoarthritis (52 hips), the survivor ship rate was 75%.

Twenty-seven hips were converted to a THA (26 hips) or hip arthrodesis (1 hip) which were defined as endpoints. The cumulative Kaplan-Meier survivorship at 20 years was 61%. The Cox regression analysis was performed to detect predictive factors for poor outcome and to calculate the corresponding hazard ratios. Six predictive factors for poor outcome were found: age over 30, a preoperative Merle d’Aubigné score less than 15, a positive preoperative anterior impingement test and limp, preoperative OA grade of more than 1, and a postoperative extrusion index of more than 20%.

Despite the fact that this series represented the learning curve of a technically demanding intervention of a very inhomogeneous patient group with various previous surgical attempts to achieve sufficient coverage and several concomitant intertrochanteric osteotomies, the 20-year results on the first 75 hips are promising.

Increased survivorship rates are expected for more recent series after identification of relative contraindications based on or analysis. PAO is an effective and successful surgical technique for correction of DDH.

Introduction: Recently, the correct interpretation of anteroposterior (AP) pelvic radiographs has regained increased attention, particularly in the field of joint preserving hip surgery. The diagnosis of acetabular retroversion associated with femoroacetabular impingement or hip dysplasia is made regardless the individual pelvic orientation due to the lack of a method of correction. Furthermore, it is known that a substantial number of the most common radiographical hip parameters can vary with the individual pelvic orientation. The goal of the study was to evaluate which parameter can be measured accurately on an AP radiograph.

Methods: Digital AP pelvic radiographs of 100 consecutive hips were used for evaluation. The blinded and randomized x-rays were examined by two independent observers with special software that has been validated previously. The software is able to correct the projected acetabular rim and the associated parameters for pelvic malpositioning. The following parameters were investigated: femoral head coverage in craniocaudal and anteroposterior direction (in total and for each single quadrant of the femoral head), the lateral center edge angle, the acetabular index, the ACM-angle, the extrusion index, the cross-over sign, the retroversion index, and the posterior wall sign. All parameters were first measured regardless to the individual tilt and rotation. These non-standardized values were then compared to the standardized values for a neutral pelvic orientation. This was defined with a pelvic inclination of 60 degrees which was detected with one single strong lateral pelvic radiograph.

Results: There were no differences in evaluation of the radiographs between the two observers concerning the significance of standardized and non-standardized values for the measured features. All but three parameters were significantly different when measured to the anatomically reference neutral orientation. The only parameters that did not change after standardization were the total femoral coverage, the acetabular index and the ACM.

Discussion: Except from the ACM and the acetabular index, basically all parameters change when standardized to a neutral orientation. Although from a statistical point of view, the total craniocaudal femoral coverage did not change, it is likely that this is due to an inverse effect of the anterior and posterior part of the acetabulum. We conclude that the most common hip parameters can not be reliably measured without standardization. It remains to be proven that the standardization of the parameters correlates with the clinical symptoms.

Purpose: The purpose of this study was to examine the arthroscopy findings in the hips of patient with persistent pain after surgical hip dislocation for femoroacetabular impingement syndrome.

Type of study: Retrospective, consecutive series of patients

Patients and Methods: Sixteen consecutive patients (6 male/10 female; average age 33,5 years 19–60y) with persistent pain after surgical hip dislocation for the treatment of femoroacetabular impingement were included. At the index surgery, all patients had an osteo-chondroplasty of the head neck junction and a resection of the acetabular rim with reattachment of the labrum in 9 cases. All patients had a preoperative arthro-MRI and were treated with arthroscopy of the hip.

Results: At arthroscopy all reattached labra were stable. In the cases without preservation of the labrum, the joint capsule was attached level with the acetabular rim and had important synovitis. All patients had adhesions between the neck of the femur and joint capsule or between labrum and capsule. In 3 patients the arthroscopic procedure was technically limited by massive thickening of the capsule. Overall 75% (12 of 16) patients showed less pain or were pain free. MDA improved from preoperatively 13 to 16 points at last follow up.

Conclusions: Persistent pain after surgical dislocation of the hip could result from intraarticular adhesions that can be shown in the MRI. Hip arthroscopy after previous surgery can be demanding due to scarring. If the adhesions can be released good results can be achieved. Hip arthroscopy is a save therapeutical tool to treat patients with intraarticulary adhesions after surgical dislocation of the hip for femoroacetabular impingement.

Introduction: It could be shown that an ample number of classical hip parameters for radiographic quantification of hip morphology on anteroposterior (AP) pelvic radiographs vary significantly with individual pelvic tilt and rotation. This could be proven not only for classical hip parameters (e.g. the lateral centre edge angle) but also for more recently described radiographic features such as acetabular retroversion. The resulting misdiagnosis and misinterpretation can potentially impair a correct therapy for the patient.

We developed fast and easy-to-use computer software to perform three-dimensional (3D) analysis of the individual hip joint morphology using two-dimensional (2D) AP pelvic radiographs. Landmarks extracted from the radiograph were combined with a cone beam x-ray projection model and a strong lateral pelvic radiograph to reconstruct 3D hip joints. Twenty-five parameters including quantification of femoral head coverage can be calculated for a neutral orientation. The aim of the study was to evaluate the validity of this method for tilt and rotation correction of the acetabular rim and associated radiographic parameters.

Methods: The validation comprised three steps:

External validation;

A series of x-rays of 30 cadaver pelves mounted on a flexible holding device were available for step 1 and 2. External validation comprised the comparison of radiographical parameters of the cadaver hips when determined with our software in comparison with CT-based measurements or actual radiographs in a neutral pelvic orientation as gold standard. Internal validation evaluated the consistency of the parameters when each single pelvis was calculated back from different random orientations to the same neutral pelvic position. The intra-/interobserver analysis investigated the reliability and reproducibility of all parameters with the help of 100 randomized, blinded AP pelvic radiographs of a consecutive patient series.

Results:

All but one parameter (acetabular index) showed a substantial to almost perfect correlation with the CT-measurements.

Conclusion: The software could be shown to be an accurate, reliable and reproducible method for correction of AP pelvic radiographs. This computer-assisted method allows standardized evaluation of all relevant radiographic parameters for detection of anatomic morphologic differences. It will be used to study the influence of pelvic malorientation on the radiographic appearance of each individual parameter. In addition, it allows evaluating the clinical significance of standardizing pelvic parameters.

Introduction: In the treatment of polytraumatised patients acetabular fractures are challenging because of the necessity of perfect open reduction of the articular surface over an anatomy respecting approach. Luxation of the femoral head with accompanying Pikin fracture, interponated fragments and labral lesions are relevant additional injuries compromising a good result after correct operative treatment. The choice of the approach is a limiting factor for the visualization of the hip joint and is of capital importance for adequate internal fixation. A modified Kocher-Langenbeck- approach with osteotomy of the grater trochanter allows an anatomic reduction under perfect visualization with protection of the soft tissue.

Patients and Methods: This prospective study was accomplished from 1995–2003 including 60 patients (16 female, 16–80years) with an actabulary fracture (posterior wall-, T-type-, and transverse fracture) treated over a modified Kocher-Langenbeck-appraoch with osteotomy of the grater tro-chanter. The included patients had a minimum follow-up of 2 years with clinical and radiological examination. The outcome was assessed with the Merle d’Aubigné-score and degenerative changes with the Tönnis classification.

Results: Within 57 patients an anatomic reduction was achieved. In 3 patients the reduction was not anatomical but satisfactory (1–3mm). Arthrotic changes in the minimujm follow-up of 2 years were observed in 14 patients (8 Ps grade I, 3 Ps grade II, 3 Ps grade III). In 3 patients posttraumatic arthritis had to be treated with THR (1, 3, 8 years postoperatively). A avascular necrosis was not objected.

Conclusion: The treatment of suitable acetabular fractures over a modified Kocher-Langenbeck-approach with a osteotomy of the greater trochanter and dislocation of the femoral head is a safe method for anatomic reduction and internal fixation

Complete debridement for synovial chondromatosis of the hip joint is difficult to achieve by standard surgical approaches. The goal of this study was to report preliminary experiences and results for treatment of this disease by a recently developed technique for surgical dislocation of the hip. The technique offers a safe and entire access to the hip joint in order to perform a synovectomy and complete joint debridement. This technique was applied in 8 patients with mean age of 38 years (24–65yrs.). This was done as the initial treatment in 6 patients and for recurrent disease after previous surgery in 2 patients. The mean follow-up was 4.3 years (2–10yrs.). None of the patients had recurrence of synovial chondromatosis. Six of 8 patients showed a good or excellent clinical result without progressive radiographic signs of osteoarthritis (OA). None of the patients developed avascular necrosis. 2 patients underwent total hip joint replacement after 5 and 10 years. One of these two patients had three previous surgeries for recurrence. The other one had the surgical dislocation as initial treatment. Both presented with distinct radiographic signs of OA prior to the index surgery. The technique of surgical dislocation allowed a safe and reliable joint debridement for synovial chondromatosis of the hip. The results indicate that this approach is successful when performed at an early stage without distinct signs of OA.

Acetabular dysplasia is the most common cause of secondary osteoarthritis of the hip joint resulting in many young adults requiring total hip replacement (THR). Although THR has a predictably good functional result, the longevity of prosthetic replacement in this young cohort of patients has been notably inconsistent. Therefore, there has been an increasing interest in better methods for treating acetabular dysplasia in young adults with the emphasis shifting from the femoral to the acetabular side during the last 10 years.

For reorientation of the acetabular fragment to improve coverage, various pelvic and periacetabular osteotomies have been proposed. Most necessitate more than one incision and change of patient position. The Bernese periacetabular osteotomy (PAO) combines complete and incomplete osteotomies, as well as a controlled fracture requiring only one approach. This is beneficial for the vascular supply of the acetabular fragment and allows an additional anterior capsulotomy without restrictions.

The osteotomies of the PAO are close to the joint and therefore allow a pronounced acetabular reorientation similar to juxta-articular triple osteotomies. Moreover, anteversion and medialization/lateralization of the center of rotation can be corrected with only minimal changes of the pelvic geometry. This enables a normal delivery in young females. The partially remaining posterior column protects the sciatic nerve from iatrogenic damage. The polygonal shape of the osteotomy and avoidance of soft tissue stripping (abductors) are advantageous for the stabilization of the reoriented fragment, thus facilitating early mobilization and rehabilitation.

Seventy-five dysplastic hips with a minimal follow-up of 10 years after PAO were evaluated. There were good to excellent result in 73% of these patients. The mean lateral center edge angle increased from 6° to 34° and the mean anterior center edge angle improved from 4° to 28°. The post-osteotomy index angle was successfully reduced from an average of 26° to 6°. Lateralisation of the femoral head was reduced from an average 16° to 10° compared to 11° on the contralateral side. Femoral head cranialisation also normalized from 9° to 4° compared to 5° on the opposite hip. Poor results were correlated with older patients, pre-existing arthritis, labral pathology, and mal-correction. Treatment of labral lesions was performed only as a supplementary measure if the labrum was unstable and included either refixation or resection.

The PAO is a technically demanding procedure, and is unforgiving of seemingly minor imprecision. With the fact that 85% of our major complications occurred within the first fifty osteotomies, it is obvious that a learning curve exists for this procedure. It is imperative that surgeons undertaking this procedure do so with a full understanding of each stage and have the necessary patience, attention to detail and adequate cadaveric experience with the technique.

The study reviews 24 patients with 27 total hip arthroplasties in which an acetabular reinforcement ring with hook was used for primary total hip arthroplasty (THA) due to underlying hip dysplasia.

There were 19 female and 5 male patients with a mean age of 50.6 years (31 to 70) at the time of surgery. A bulk autograft for acetabular reconstruction was used in four cases with Crowe Type III and IV dysplasia. In eight cases cancellous bone alone was used to fill the gap between the reinforcement ring and the acetabulum. All patients had a polyethylene cup cemented into the ring and 22 cases had a straight Müller CDH stem cemented into the shaft.

Mean follow-up was 10.7 years (range: 8.1 to 12.7). No clinical or radiographic signs of loosening of the reinforcement ring were found in 24 (88.9 %) of the 27 THAs. Two revisions (7.4%) were performed for aseptic loosening and one acetabular component had radiographic signs of loosening. The Merle D`Aubigné score had increased from 7 to 15 points.

The acetabular reinforcement ring continues to have favourable results in this specific patient group and may also prevent graft resorption and cup migration.

The study reviews 24 patients with 27 total hip arthroplasties in which an acetabular reinforcement ring with hook was used for primary total hip arthroplasty (THA) due to underlying hip dysplasia.

There were 19 female and 5 male patients with a mean age of 50.6 years (31 to 70) at the time of surgery. A bulk autograft for acetabular reconstruction was used in four cases with Crowe Type III and IV dysplasia. In eight cases cancellous bone alone was used to fill the gap between the reinforcement ring and the acetabulum. All patients had a polyethylene cup cemented into the ring and 22 cases had a straight Müller CDH stem cemented into the shaft.

Mean follow-up was 10.7 years (range: 8.1 to 12.7). No clinical or radiographic signs of loosening of the reinforcement ring were found in 24 (88.9 %) of the 27 THAs. Two revisions (7.4%) were performed for aseptic loosening and one acetabular component had radiographic signs of loosening. The Merle D`Aubigné score had increased from 7 to 15 points.

The acetabular reinforcement ring continues to have favourable results in this specific patient group and may also prevent graft resorption and cup migration.